Bracalenti M, Zen M, Bianchi B, Bortoluzzi A, Brussino L, Castrignanò P, Cauli A, Cavagna L, Chessa E, Chiara E, De Angelis R, De Marchi G, Di Carlo M, Emmi G, Galvagni I, Gasparotto M, Gatto M, Gerli R, Govoni M, Lo Gullo A, Nano A, Negrini S, Noviello S, Orsolini G, Pazzola G, Piga M, Quartuccio L, Rossini M, Salvarani C, Silvagni E, Silvestri E, Tamussin M, Tizian M, Tomietto P, Urban ML, Vacca A, Doria A, Iaccarino L

Biologics: Targets and Therapy 2025, 19:651-663

Published Date: 30 October 2025

Review

Antibody-Based Therapeutics for Hypercholesterolemia

Tomlinson B, Chan P

Biologics: Targets and Therapy 2025, 19:631-649

Published Date: 27 October 2025

Review

The Dual Role of the TRAIL-DR5 Signaling Axis in Cardiovascular Disease: From Molecular Mechanisms to Targeted Therapies

Cao R, Qi W, Huang X, Zheng Y, Zheng R, Ma Y, Zhang H

Biologics: Targets and Therapy 2025, 19:613-629

Published Date: 25 October 2025

Original Research

Irisin Research Landscape (2012–2024): A Bibliometric and Visual Analysis of Evolving Hotspots and Future Trends

Gao L, Sun W, Shi H, Zhu W, Wang H, Wang J

Biologics: Targets and Therapy 2025, 19:595-611

Published Date: 22 October 2025

Case report

The Potential of Telitacicept in Treating Lupus erythematosus panniculitis: A Case Report

Xie X, Tang S, Huang M

Biologics: Targets and Therapy 2025, 19:585-593

Published Date: 7 October 2025

Case report

Dual Blocking of IL17A and IL36R for the Treatment of Refractory Hidradenitis Suppurativa: A Case Report

Yu Y, Li J, Liu H, Sun Y, Zhang F

Biologics: Targets and Therapy 2025, 19:581-584

Published Date: 3 October 2025

Review

Migrasomes: A New Role in Disease Diagnosis and Treatment

Zhang X, Wang S, Jiang Y, Zhu W, Yang Y, Huo L, Zhang Y, Zhou Y, Yang Z, Wang X

Biologics: Targets and Therapy 2025, 19:561-579

Published Date: 2 October 2025

Review

siRNAs, tRNAs, and rRNAs in Osteoarthritis: Biological Functions and Therapeutic Opportunities

Wang M, Dai Y, Ge X, Zheng L, Zhai M, Li W, Liu G, Cheng X, Wei J, Yang X, Liu L, Liu H, Sun J, Li B, Yuan F

Biologics: Targets and Therapy 2025, 19:539-560

Published Date: 3 September 2025

Original Research

Comparative Cancer Incidence by Organ Site in Rheumatoid Arthritis Treated with Janus Kinase Inhibitors versus Tumor Necrosis Factor Inhibitors: A Retrospective Real-World Cohort Analysis

Xu C, Wang SI, Leung YY, Wei JCC

Biologics: Targets and Therapy 2025, 19:525-538

Published Date: 30 August 2025

Review

Enhancing Early Detection of Pancreatic Cancer in Genetically Predisposed Individuals: Integrating Advanced Imaging Modalities with Emerging Biomarkers and Liquid Biopsy

Abdel-Razeq R, Mansour A, Barbar M, Abu Shanap M, Sharaf B, Tamimi F, Mansour R, Muhanna A, Al-Othman Y, Hammad H, Shakhatreh M, Mahafdah S, Bani Hani H, Abdel-Razeq H

Biologics: Targets and Therapy 2025, 19:511-523

Published Date: 30 August 2025

Original Research

Therapeutic Potential of Compounds with High Affinity to BAG2 in Inhibiting Keloid Disease

Wang Y, Yuan Z, Zhou R, Lu L, Wang X, Yang J

Biologics: Targets and Therapy 2025, 19:497-510

Published Date: 24 August 2025

Review

What’s New and What’s Next in Fecal Microbiota Transplantation?

Baydoun H, Hussain N, Wu KO, Kelly CR, Fischer M

Biologics: Targets and Therapy 2025, 19:481-496

Published Date: 21 August 2025

Original Research

Activated Growth Factor (AGF) as a Superior Biological Therapy for Osteoarthritis: Comparative Efficacy in Modulating Cartilage Degeneration and Inflammation in vivo

Hidayat R, Harun Z

Biologics: Targets and Therapy 2025, 19:463-479

Published Date: 21 August 2025

Original Research

Investigating the Oncogenic and Immunological Implications of YTHDF1 in Ovarian Cancer

Yin B, Zhou H

Biologics: Targets and Therapy 2025, 19:443-462

Published Date: 12 August 2025

Review

Update on Biologic Therapy in Juvenile Idiopathic Arthritis: A Five-year Narrative Review

Civino A, Diomeda F, Burrone M, Natoli V, Ravelli A

Biologics: Targets and Therapy 2025, 19:425-441

Published Date: 23 July 2025

Response to Letter

Regarding “Effectiveness and Persistence of Anti-TNFα Treatment in Patients with Rheumatoid Arthritis – A 7 Years Real-World Cohort Study” [Response to Letter]

Santos-Moreno P

Biologics: Targets and Therapy 2025, 19:423-424

Published Date: 17 July 2025

Review

Brodalumab for Moderate-to-Severe Psoriasis: A Comprehensive Review of Efficacy, Safety, and Clinical Positioning

Babaei N, Gill M, Cervantes M, Kim D, Yang S, Wu JJ

Biologics: Targets and Therapy 2025, 19:415-422

Published Date: 15 July 2025

Letter

Regarding “Effectiveness and Persistence of Anti-TNFα Treatment in Patients with Rheumatoid Arthritis - A 7 Years Real-World Cohort Study” [Letter]

Borrás-Blasco J, Valcuende-Rosique A, Cornejo-Uixeda S

Biologics: Targets and Therapy 2025, 19:413-414

Published Date: 7 July 2025

Original Research

Effects of Dulaglutide in Doxorubicin Induced Renal Toxicity in Rats

Hama Said HJ, Ahmed ZA

Biologics: Targets and Therapy 2025, 19:399-412

Published Date: 3 July 2025

Review

IRAK4 Targeting: A Breakthrough Approach to Combat Hidradenitis Suppurativa

Zhang H, Liu Z, Qin B, Cheng D, Chen P, Bi X

Biologics: Targets and Therapy 2025, 19:387-397

Published Date: 30 June 2025

Review

Marstacimab for the Treatment of Hemophilia A or B

Mahlangu J

Biologics: Targets and Therapy 2025, 19:379-386

Published Date: 24 June 2025

Review

Adebrelimab in Small Cell Lung Cancer: From Current Advances to Emerging Combination Strategy and Challenge

Yang H, Yang L, Liu Y, Wang L

Biologics: Targets and Therapy 2025, 19:365-377

Published Date: 31 May 2025

Review

Positioning Guselkumab in The Treatment Algorithm of Patients with Crohn’s Disease

D’Amico F, Bencardino S, Magro F, Dignass A, Gutiérrez Casbas A, Verstockt B, Hart A, Armuzzi A, Peyrin-Biroulet L, Danese S

Biologics: Targets and Therapy 2025, 19:351-363

Published Date: 31 May 2025

Review

Targeting CREBRF in Cancer: Mechanistic Insights and Future Directions

Lv B, Zhang D

Biologics: Targets and Therapy 2025, 19:341-350

Published Date: 30 May 2025

Original Research

From Conventional to Advanced Therapies: A National Health Registry Report (2016-2022) on DMARDs in Rheumatoid Arthritis Treatment in Turkey

Ata N, Satış H, Küçükşahin O, Karabulut E, Ayan G, Erden A, Bilgin E, Armağan B, Tecer D, Babaoğlu H, Sarı A, Kılıç L, Ülgü MM, Ayvalı MO, Birinci Ş, Kalyoncu U

Biologics: Targets and Therapy 2025, 19:331-339

Published Date: 26 May 2025

Case report

Generalized Pustular Psoriasis with Cushing’s Syndrome: A Case of Effective Spesolimab Treatment

Peng G, Zhang Y, Zhang S, Li Y, Luo L, Luo J, Nie X, Zhang H, Liao C

Biologics: Targets and Therapy 2025, 19:321-329

Published Date: 10 May 2025

Original Research

Boswellia carteri Birdw. Resin Extract Induces Phase-I Cytochrome P-450 Enzyme Gene Expressions in Human Hepatocarcinoma (Hep G2) Cells: In vitro and in silico Studies

Alghamdi SS, Albahlal HN, Alajmi RS, Alsharidah A, Almogren A, Suliman R, Alehaideb ZI

Biologics: Targets and Therapy 2025, 19:289-320

Published Date: 5 May 2025

Review

OX40/OX40L as a Therapeutic Target in Atopic Dermatitis: A Scoping Review

Valenzuela F, Meza V

Biologics: Targets and Therapy 2025, 19:281-288

Published Date: 2 May 2025

Original Research

Adalimumab Biosimilars Demonstrate Long-Term Durability and Cost-Effectiveness in Paediatric Inflammatory Bowel Disease: A Real-World Two-Centre European Cohort Study

Ancona S, Armstrong K, Longo C, Rabone R, Merrick V, Henderson P, Gandullia P, Wilson DC, Arrigo S, Russell RK

Biologics: Targets and Therapy 2025, 19:265-279

Published Date: 29 April 2025

Original Research

Epigenetic Regulation of Sorbitol Dehydrogenase in Diabetic Retinopathy Patients: DNA Methylation, Histone Acetylation and microRNA-320

Amin R, Permana H, Kartasasmita AS, Hilmanto D, Hidayat R

Biologics: Targets and Therapy 2025, 19:251-264

Published Date: 28 April 2025

Original Research

Whole Transcriptome-Based ceRNA Regulatory Network Analysis of Radiation-Induced Esophageal Epithelial Cell Injury

Lin H, Feng Y, Liu H, Zhang J, Zhang X, Ying X, Shi Y, Tan H, Tu W

Biologics: Targets and Therapy 2025, 19:231-249

Published Date: 22 April 2025

Review

Targeted Therapy for Skeletal Muscle Fibrosis: Regulation of Myostatin, TGF-β, MMP, and TIMP to Maintain Extracellular Matrix Homeostasis

Dewi NM, Meiliana A, Defi IR, Amalia R, Sartika CR, Wijaya A, Barliana MI

Biologics: Targets and Therapy 2025, 19:213-229

Published Date: 17 April 2025

Original Research

Expression of lncRNA NEAT1, miR-21, and IL17 in Rheumatoid Arthritis Patients

Haroon MM, Hegazy GA, Hassanien MA, Shaker OG, Labib S, Hussein WH

Biologics: Targets and Therapy 2025, 19:201-211

Published Date: 15 April 2025

Review

Antibody-Based Therapeutics in Small Cell Lung Cancer: A Narrative Review

Torchia A, Ciappina G, Giammaruco M, Monteferrante I, Landi L, Cappuzzo F

Biologics: Targets and Therapy 2025, 19:189-199

Published Date: 15 April 2025

Review

Advancing Monoclonal Antibody Manufacturing: Process Optimization, Cost Reduction Strategies, and Emerging Technologies

Ranbhor R

Biologics: Targets and Therapy 2025, 19:177-187

Published Date: 9 April 2025

Original Research

RNA Sequencing Identifies Novel Signaling Pathways and Potential Drug Target Genes Induced by FOSL1 in Glioma Progression and Stemness

Guo S, Sidhu R, Ramar V, Guo AA, Wang G, Liu M

Biologics: Targets and Therapy 2025, 19:157-176

Published Date: 5 April 2025

Case Series

Telitacicept: A New Therapy for the Treatment of Optic Neuromyelitis Spectrum Disease Associated with Other Autoimmune Disorders

Zuo S, Yang W, Zhang S, Sun S, Lu S, Lu C, Li W

Biologics: Targets and Therapy 2025, 19:149-155

Published Date: 3 April 2025

Original Research

Platelet-Derived Growth Factor as Biomarker of Clinical Outcome for Autologous Platelet Concentrate Therapy in Grade I Knee Osteoarthritis

Di Tolla MF, Romano S, Vassetti P, Perugini D, Filoso I, Cabaro S, Ferraro G, Oriente F, Perruolo G, Arvonio F, D’Esposito V, Formisano P

Biologics: Targets and Therapy 2025, 19:137-147

Published Date: 25 March 2025

Original Research

Evaluating Biosimilar Development Projects: An Analytical Framework Utilizing Net Present Value

Ranbhor R, Kulkarni P

Biologics: Targets and Therapy 2025, 19:125-135

Published Date: 25 March 2025

Original Research

Targeting DNA Topoisomerase IIα in Retinoblastoma: Implications in EMT and Therapeutic Strategies

Wei Q, Lin N, Wang L

Biologics: Targets and Therapy 2025, 19:113-123

Published Date: 18 March 2025

Review

Escalation and De-Escalation Strategies for Endocrine Therapy in Early-Stage Breast Cancer

Al-Batsh T, Abdel-Razeq N, Al-Masri Y, El-Khatib O, Sharaf B, Tamimi F, Abdel-Razeq H

Biologics: Targets and Therapy 2025, 19:97-111

Published Date: 13 March 2025

Original Research

Circulating PGC-1α and MOTS-c Peptide as Potential Mitochondrial Biomarkers in Patients Undergoing Aortic Valve Replacement

Sánchez-Quintero MJ, Iboleón A, Martín Chaves L, Pozo Vilumbrales B, Carmona-Segovia ADM, Martínez López P, Romero-Cuevas M, Rodríguez-Capitán J, Becerra-Muñoz VM, Pavón-Morón FJ, Murri M

Biologics: Targets and Therapy 2025, 19:87-96

Published Date: 13 March 2025

Review

The Mechanisms and Therapeutic Implications of PI3K Signaling in Airway Inflammation and Remodeling in Asthma

Song B, Hu J, Chen S, Zhang Y

Biologics: Targets and Therapy 2025, 19:73-86

Published Date: 7 March 2025

Original Research

Dual Anti-HER2 Therapy Vs Trastuzumab Alone with Neoadjuvant Anthracycline and Taxane in HER2-Positive Early-Stage Breast Cancer: Real-World Insights

Sharaf B, Tamimi F, Al-Abdallat H, Khater S, Salama O, Zayed A, El Khatib O, Qaddoumi A, Horani M, AL-Masri Y, Asha W, Altalla’ B, Bani Hani H, Abdel-Razeq H

Biologics: Targets and Therapy 2025, 19:59-71

Published Date: 5 March 2025

Review