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Breast Cancer: Targets and Therapy

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ISSN: 1179-1314

Archive: Volume 17, 2025

Introducing a New Hypothesis in the Genesis of Breast Cancer: An Integrative Review

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Andrade Pachnicki JP, Cayet CM, dos Santos DAH, Junkes GB, Petry J, Hibarino MEM, Lodi Carvalho VL

Breast Cancer: Targets and Therapy 2025, 17:1493-1504

Published Date: 31 December 2025

Noncoding RNAs, Vital Players in Breast Cancer Metastasis

Kang Y, Wang X, Liu Y, Cao J, Lin J, Qiao G

Breast Cancer: Targets and Therapy 2025, 17:1463-1492

Published Date: 30 December 2025

Integrated Pan-Cancer Profiling and Breast Cancer Validation Identify BEND3 as a Potential Prognostic and Immune Biomarker

Gou Y, Li Y, Wang Y, Ma H, Li H, Geni R, Ismtula D, Guo C

Breast Cancer: Targets and Therapy 2025, 17:1439-1461

Published Date: 30 December 2025

Inetetamab-Based Regimens for Patients with HER2-Positive Metastatic Breast Cancer: A Real-World Retrospective Study

Chen L, Huang J, Chen X, Lan X, Song L, Xie X, Bai X, Du C

Breast Cancer: Targets and Therapy 2025, 17:1427-1437

Published Date: 30 December 2025

Neuregulin-1 Secreted by Cancer-Associated Fibroblasts Promotes Growth of Triple-Negative Breast Cancer

Xu L, Xu H, Jiang D, Song S, Wang G, Zhang X, Zhang Y, Qian J, Kang J, Cai F

Breast Cancer: Targets and Therapy 2025, 17:1413-1425

Published Date: 26 December 2025

Down-Regulation of lncRNA CKMT2-AS1 Predicts Poor Prognosis and Promotes Breast Cancer Progression

Xue D, Hou R, Xu H, Li X

Breast Cancer: Targets and Therapy 2025, 17:1397-1411

Published Date: 26 December 2025

Inavolisib-Based Therapy for PIK3CA-Mutated Advanced Male Breast Cancer: A Cost-Effectiveness Analysis

Huang X, Lin S, Lin R, Luo S, Huang P, Zeng D

Breast Cancer: Targets and Therapy 2025, 17:1385-1396

Published Date: 26 December 2025

Differential TGF-β1/SMAD4 Signaling Regulates PMN-MDSC Differentiation and Reshapes the Immune Microenvironment in Breast Cancer

Cao J, Qiao E, Shao H, Wang C, Xia M, Qin B

Breast Cancer: Targets and Therapy 2025, 17:1369-1383

Published Date: 26 December 2025

The Landscape of Potential Targeted Treatments and Chemotherapy Efficacy Biomarkers for TNBC

Kang Y, Liu Y, Liang Z, Zhang S, Qiao G

Breast Cancer: Targets and Therapy 2025, 17:1341-1367

Published Date: 26 December 2025

Exploratory Research of Intraductal Chemotherapy to Control the Focal Breast Lesion of Breast Cancer

Lin X, Li X, Wei Q, Yuan H, Zhong M, Qiao J, Gong J, Li Y

Breast Cancer: Targets and Therapy 2025, 17:1321-1339

Published Date: 25 December 2025

Management Strategies and Outcomes in HR+/HER2− Metastatic Breast Cancer Receiving CDK4/6 Inhibitors and Subsequent Therapies

Pogoda K, Pawlik H, Balata A, Czopowicz M, Bak A, Twardowska I, Meluch M, Wojda M, Mlodzinska A, Szombara E, Sienkiewicz R, Konieczna A, Brewczynska E, Lemanska I, Majstrak-Hulewska A, Gorniak A, Niwinska A, Nowecki Z

Breast Cancer: Targets and Therapy 2025, 17:1307-1319

Published Date: 24 December 2025

Clinical Prognostic Value of C-Reactive Protein-Albumin-Lymphocyte Index (CALLY) in Patients with Stage III Breast Cancer

Zhu M, Cheng R, Zhang K, Yue C, Guan S, Chen L, Wang J, Wang Y, Zhang B

Breast Cancer: Targets and Therapy 2025, 17:1293-1305

Published Date: 22 December 2025

IDO1, IL4I1: Novel Immune Checkpoints in Breast Cancer Tumor-Associated Macrophages

Shi A, An Y, Yun F, Liu X, Jia Y

Breast Cancer: Targets and Therapy 2025, 17:1279-1292

Published Date: 21 December 2025

Mendelian Randomization Integrating GWAS and eQTL Data Reveals DAAM1, a Potential Immune-Related Biomarker for Breast Cancer Prognosis

Chen G, Zhang K, Wang Y, Zhang Z, Cao J, Gao G, Yu C, Dai Y, Qiao G, Cong Y

Breast Cancer: Targets and Therapy 2025, 17:1247-1263

Published Date: 17 December 2025

Beyond The Age Limit: A Comparative Study (<70 Vs ≥70 Years) in Breast Cancer Characteristics and Surgical Management in Women

Buyukasik S, Kankaya B, Altundal YE, Ozgul M, Kapan S

Breast Cancer: Targets and Therapy 2025, 17:1231-1246

Published Date: 12 December 2025

ST6GAL1 Promotes Epithelial-to-Mesenchymal Transition in Breast Cancer via the HIF-HK2 Signaling Pathway

Ren D, Xue D, Hou Z, Xu H, Li X

Breast Cancer: Targets and Therapy 2025, 17:1199-1211

Published Date: 9 December 2025

Common Biomarkers and Pathogenesis of Inflammatory Bowel Disease and Breast Cancer: Mendelian Randomization and Multi-Omics Studies

Zhang D, Guan Y, Tang H, Xue Q, Li X, Bin X, You F

Breast Cancer: Targets and Therapy 2025, 17:1183-1197

Published Date: 8 December 2025

Dual Receptor Targeting Ensures Uptake and Anticancer Efficacy of Low-Density Lipoprotein-Docosahexaenoic Acid Nanoparticles Across Breast Cancer Cell Subtypes

Bower J, Anwar A, Chaudhary J, Chen Z, Schumacher M, Debose-Boyd R, Corbin IR

Breast Cancer: Targets and Therapy 2025, 17:1159-1182

Published Date: 6 December 2025

Circular RNA DENND4C Regulates Cell Malignant Behaviors in Breast Cancer Through the miR-26a-5p/HSPA8 Axis

Guo M, Chang Y, Dai Y, Liu X, Shi S, Li J, Liu W, Han J

Breast Cancer: Targets and Therapy 2025, 17:1145-1157

Published Date: 2 December 2025

Delayed Cardiac Dysfunction During Prolonged Use of Trastuzumab for the Treatment of HER2-Positive Metastatic Breast Cancer

Chen X, Lan X, Xiao L, Song L, Huang J, Xie X, Chen L, Bai X, Du C

Breast Cancer: Targets and Therapy 2025, 17:1101-1110

Published Date: 25 November 2025

Comprehensive Analysis and Experimental Validation of Single-Cell and Transcriptome Sequencing Reveal SGO2 as a Novel Biomarker for Breast Cancer

Li YF, Yuan Y, Chen C, Zhu ML, Xu SY, Wu SQ, Gao Y, Meng LW

Breast Cancer: Targets and Therapy 2025, 17:1083-1100

Published Date: 24 November 2025

Circuit Weight Training Enhances Quality of Life and Functional Outcomes in Breast Cancer Survivors: A Randomized Controlled Trial

Helal ASF, Ali SM, Hassan MHI, Elrefaey BH, Zaki RM, Ibrahim ZM, Abdel Ghaffar HA

Breast Cancer: Targets and Therapy 2025, 17:1025-1039

Published Date: 8 November 2025

Ambra1 Deficiency Inhibits the Proliferation of Breast Cancer Cells Through the Akt-FoxO1-p27 Pathway

Qin Y, Chen S, Tao D, Lin Q, Sun W

Breast Cancer: Targets and Therapy 2025, 17:949-965

Published Date: 21 October 2025

Exploring AI Approaches for Breast Cancer Detection and Diagnosis: A Review Article

Ali A, Alghamdi M, Marzuki SS, Tengku Din TADAA, Yamin MS, Alrashidi M, Alkhazi IS, Ahmed N

Breast Cancer: Targets and Therapy 2025, 17:927-947

Published Date: 21 October 2025

LINC00917 Promotes Bone Metastasis of Breast Cancer by Targeting the miR-491-5p/FOXP4 Axis

Qu X, Wang C, Xu Y, Yang X, Sun AB, Liu XY, Li JZ, Nie JY

Breast Cancer: Targets and Therapy 2025, 17:913-925

Published Date: 17 October 2025

Ki-67 Prediction in Breast Cancer: Integrating Radiomics From Automated Breast Volume Scanner and 2D Ultrasound Images via Machine Learning

Wei W, Xia F, Zhou W, Lu W, Zhang D, Ma Q, Xu X, Zhang C

Breast Cancer: Targets and Therapy 2025, 17:897-912

Published Date: 11 October 2025

Triple-Negative Breast Cancer on the Rise: Breakthroughs and Beyond [Response to Letter]

Agelidis A, Ter-Zakarian A, Jaloudi M

Breast Cancer: Targets and Therapy 2025, 17:877-881

Published Date: 29 September 2025

Triple-Negative Breast Cancer on the Rise or…? [Letter]

Lønning PE, Nikolaienko O, Knappskog S

Breast Cancer: Targets and Therapy 2025, 17:875-876

Published Date: 25 September 2025

Efficacy of Trastuzumab Deruxtecan in HER2-Positive and HER2-Low Metastatic Breast Cancer: A Real-World Retrospective Cohort Study in China

Yan Y, Jin Y, Lin M, Zeng C, Guo Q, Zhou T, Li DD, Zhang J

Breast Cancer: Targets and Therapy 2025, 17:863-873

Published Date: 25 September 2025

ANXA2 Regulates RANKL-Induced Osteoclast Differentiation Through STAT3 Signaling in Breast Cancer

Yuan J, Xin F, Wang R

Breast Cancer: Targets and Therapy 2025, 17:837-849

Published Date: 18 September 2025

Effects of Clinacanthus nutans Extracts on Cell Proliferation and Apoptosis in Triple-Negative Breast Cancer: Mechanistic Insights

Xu J, Long J, Li ZY, Wang C, Zhang Y, He H, Hu Q, Yin S, Li H, Wang N, Gao Q, Tang S, Zhu Y, Wang P, Feng R, Liu Y

Breast Cancer: Targets and Therapy 2025, 17:819-835

Published Date: 15 September 2025

Utility of Volatile Organic Compounds and Electronic Nose Technology for Breast Cancer Detection: A Systematic Review

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Orduña-Medina FM, Díaz de León-Martinez L, Alarcón-Rivera GDD, Prieto-Gómez NA, Mizaikoff B, Alcántara-Quintana LE

Breast Cancer: Targets and Therapy 2025, 17:805-817

Published Date: 11 September 2025

Bystin is a Prognosis and Immune Biomarker: From Pan-Cancer Analysis to Validation in Breast Cancer

Aimaiti X, Wang Y, Ismtula D, Li Y, Ma H, Wang J, Elihamu D, Guo C

Breast Cancer: Targets and Therapy 2025, 17:755-779

Published Date: 29 August 2025

Age and Education Influencing Willingness in Men to Recommend Breast Cancer Screening: A Comparative Study of University Personnel and Clinical Attendees

Buyukasik S, Kankaya B, Altundal YE, Ozgul M, Atashbari F, Osman AAH, Alis H, Kapan S

Breast Cancer: Targets and Therapy 2025, 17:741-754

Published Date: 25 August 2025

Safety Profile and Predictors of Adverse Events of Incadronate Disodium in Treating Breast Cancer Patients with Bone Metastases: A Retrospective Study

Zhou S, Jiang M, Liu J, Zhang M, Li M, He M, Abudureheiyimu N, Wang W, Guan X, Ma F, Xu B, Li Q

Breast Cancer: Targets and Therapy 2025, 17:727-739

Published Date: 20 August 2025

Mechanisms and Management of Albumin-Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer

Xu X, Han Q, Qiu S, Gao S, Ren C, Li X

Breast Cancer: Targets and Therapy 2025, 17:693-709

Published Date: 13 August 2025

Late Breast Cancer Recurrence Prediction: The Role of CTS5 and Progesterone Receptor Status

Carvalho GS, Gomes DM, Bretas GDO, Teixeira VBG, Bines J

Breast Cancer: Targets and Therapy 2025, 17:683-691

Published Date: 28 July 2025

Peripheral TNF-α and CD8+/CD28+ T Lymphocytes as Alternatives for PD-L1 Prediction in Breast Cancer Tumor Microenvironment: Stratified by Neoadjuvant Therapy

Wu J, Ou X, Yuan K, Shi F, Zhou Q, Lyu S, Li Y, Zhao Y, Cao Y, Sun J, Song Q

Breast Cancer: Targets and Therapy 2025, 17:627-637

Published Date: 19 July 2025

A Machine-Learning Model for the Prediction of Triple-Negative Breast Cancer Based on Multiparameter MRI

Cai Y, Li Y, Wang W, Zhou Y, Wang J, Zhang L, Lu H

Breast Cancer: Targets and Therapy 2025, 17:611-625

Published Date: 15 July 2025

Exploring the Mechanism of Lianqiao Jinbei Decoction Inhibiting HER2-Positive Breast Cancer Based on Network Pharmacology and Experimental Verification

Li D, Liu X, Fan H, Dong J, Wei L, Guo N, Wang Z, Du Z, Liu J, Zhao X, Tian X, Han C, Yao X

Breast Cancer: Targets and Therapy 2025, 17:583-598

Published Date: 14 July 2025

Male Breast Cancer: Evaluating the Current Landscape of Diagnosis and Treatment

Ter-Zakarian A, Agelidis A, Jaloudi M

Breast Cancer: Targets and Therapy 2025, 17:567-572

Published Date: 5 July 2025

Advancements in Dalpiciclib for the Treatment of Breast Cancer Patients: A Review

Chen Z, Xie P, Chen Q, Ouyang J

Breast Cancer: Targets and Therapy 2025, 17:557-565

Published Date: 30 June 2025

Current Strategies to Reducing Interval Breast Cancers: A Systematic Review

Goh RSJ, Chong B, Yeo S, Neo SY, Ng QX, Goh SSN

Breast Cancer: Targets and Therapy 2025, 17:531-544

Published Date: 27 June 2025

Triple-Negative Breast Cancer on the Rise: Breakthroughs and Beyond

Agelidis A, Ter-Zakarian A, Jaloudi M

Breast Cancer: Targets and Therapy 2025, 17:523-529

Published Date: 26 June 2025

Research Progress of PROTAC-Degraded CDKs in the Treatment of Breast Cancer

Zhao K, Zhang J, Yang Z, Wang R, Shi Y, Ji Y, Zhang S, Liu M

Breast Cancer: Targets and Therapy 2025, 17:511-521

Published Date: 13 June 2025

Radiation-Based Multi-Modal Therapy Combining with Immunotherapy to Develop a Vaccine-Like Effective Treatment for Triple-Negative Breast Cancer

Dai M, Tian Z, Xu F, Yao B, Liang H, Li D, Wang J, Rong J, Liu T, Tang H, Lu H, Zhang W

Breast Cancer: Targets and Therapy 2025, 17:483-496

Published Date: 10 June 2025

CD151 Promotes Cancer Progression in Triple-Negative Breast Cancer by Inducing EMT through the MAPK Signaling Pathway

Lv H, Zhang B, Weng X, Li Y, Deng C, Wang R, Shi L, Yin Y

Breast Cancer: Targets and Therapy 2025, 17:455-470

Published Date: 28 May 2025

Promising Response to Neoadjuvant Chemotherapy Plus Immunotherapy in Metaplastic Breast Carcinoma

Tan Q, Li N, Wang Y, Du T, Liang G, Zhao Z, Tang J, Wu H

Breast Cancer: Targets and Therapy 2025, 17:447-454

Published Date: 23 May 2025

Barriers to Early Breast Cancer Diagnosis in Sudanese Women Before the War

Elamin HES, Elamin HES, Abd El-Raheem GOH, Noma M

Breast Cancer: Targets and Therapy 2025, 17:433-445

Published Date: 20 May 2025

Naples Prognostic Score (NPS) as a Novel Prognostic Score for Stage III Breast Cancer Patients: A Real-World Retrospective Study

Miao Y, Yang R, Zhang B, Yang J, Yao L, Wang W, Liu X, Guo X, Jia H

Breast Cancer: Targets and Therapy 2025, 17:403-421

Published Date: 12 May 2025

A Comparative Analysis of Mobile versus Stationary Mammography Units: Performance and Outcomes in a Breast Cancer Screening Program

Tari DU, De Lucia DR, Santonastaso R, Santarsiere M, Blasotti A

Breast Cancer: Targets and Therapy 2025, 17:373-383

Published Date: 7 May 2025

Immune and Metabolic Reprogramming Induced by Paclitaxel, Capecitabine and Eribulin in Breast Cancer: Insights into Therapeutic Targets

Hsiao HH, Patel R, Kalinski P, Takabe K, Ernstoff MS, Rosario SR, Gandhi S

Breast Cancer: Targets and Therapy 2025, 17:359-372

Published Date: 29 April 2025

Unveiling the Landscape of PD-L1 Expression and Tumor-Infiltrating Lymphocyte Subtypes in Advanced Triple-Negative Breast Cancer in Brazil

Dos Santos ALS, Da Silva JL, De Albuquerque LZ, Neto ALA, Da Silva CF, Cerva LAM, Small IA, Rodrigues FR, De Macedo FC, Marcelino CP, Batista PDM, Rego MADC, Borba MACSM, De Melo AC

Breast Cancer: Targets and Therapy 2025, 17:349-358

Published Date: 15 April 2025

Current Status of Breast Cancer Immunotherapy and Prognosis-Related Markers

Xu Y, Zhang B, Wu H, Wu Y

Breast Cancer: Targets and Therapy 2025, 17:339-348

Published Date: 15 April 2025

Exploration of Traditional Chinese Medicine Comprehensive Treatment of Triple Negative Breast Cancer Based on Molecular Pathological Mechanism

Zhu M, Liu Y, Wen Z, Tan H, Li S, Yu X, Luo H, Li D, Wang J, Qin F

Breast Cancer: Targets and Therapy 2025, 17:289-304

Published Date: 10 April 2025

Shear Wave Elastography: A Non-Invasive Approach for Assessing TGF-β1/MAPK Signaling Molecules and EMT in Breast Cancer

Huang S, Wang B, Jiang Y, Li S, Li J, Wang Z

Breast Cancer: Targets and Therapy 2025, 17:275-287

Published Date: 26 March 2025

Genetic Alterations in HER2-Positive and Equivocal Breast Cancer by Immunohistochemistry

Tsai YF, Hsu CY, Chiu YN, Huang CC, Chou SH, Lin YS, Chao TC, Liu CY, Chiu JH, Tseng LM

Breast Cancer: Targets and Therapy 2025, 17:253-263

Published Date: 12 March 2025

Telomere Maintenance-Related Genes are Essential for Prognosis in Breast Cancer

Huang W, Wang W, Dong TZ

Breast Cancer: Targets and Therapy 2025, 17:225-239

Published Date: 24 February 2025

Tumor Microenvironment Modulation by Tumor-Associated Macrophages: Implications for Neoadjuvant Chemotherapy Response in Breast Cancer

Oner G, Praet MM, Stoop H, Devi GR, Canturk NZ, Altintas S, Van Berckelaer C, Berneman Z, Tjalma W, Koljenovic S, van Dam PA

Breast Cancer: Targets and Therapy 2025, 17:211-224

Published Date: 21 February 2025

Real-World Analysis of the Efficacy and Adverse Events of T-DM1 in Chinese Patients With HER2-Positive Breast Cancer

Gu H, Zhu T, Ding J, Yang Z, Qi S, Guo G

Breast Cancer: Targets and Therapy 2025, 17:201-210

Published Date: 21 February 2025

Radiomics Integration of Mammography and DCE-MRI for Predicting Molecular Subtypes in Breast Cancer Patients

Yang X, Li J, Sun H, Chen J, Xie J, Peng Y, Shang T, Pan T

Breast Cancer: Targets and Therapy 2025, 17:187-200

Published Date: 18 February 2025

Quality of Life in Breast Cancer Patients in Saudi Arabia: A Systematic Review

Aljadani FF, Nughays RO, Alharbi GE, Almazroy EA, Elyas SK, Danish HE, Alanazi RT, Aldrees BA, Jadkarim GA, Mikwar Z

Breast Cancer: Targets and Therapy 2025, 17:171-186

Published Date: 18 February 2025

Lactate Dehydrogenase-A-Forming LDH5 Promotes Breast Cancer Progression

Fang T, Hu L, Chen T, Li F, Yang L, Liang B, Wang W, Zeng F

Breast Cancer: Targets and Therapy 2025, 17:157-170

Published Date: 12 February 2025

Programmed Cell Death Ligand 1 (PD-L1) and Major Histocompatibility Complex Class I (MHC Class I) Expression Patterns and Their Pathologic Associations in Triple-Negative Breast Cancer

Kaewkedsri P, Intarawichian P, Jessadapattarakul S, Kunprom W, Koonmee S, Thanee M, Somintara O, Wongbuddha A, Chadbunchachai P, Nawapun S, Aphivatanasiri C

Breast Cancer: Targets and Therapy 2025, 17:123-143

Published Date: 6 February 2025

Analysis of Mammography BI-RADS Distribution and Follow-up Ultrasound Assessment: A Single-Center Study

Kankaya B, Buyukasik S, Altundal YE, Topcu FS, Rahmanbakhsh P, Etemad A, Kapan S, Alis H

Breast Cancer: Targets and Therapy 2025, 17:115-122

Published Date: 6 February 2025

Predicting Axillary Lymph Node Metastasis in Young Onset Breast Cancer: A Clinical-Radiomics Nomogram Based on DCE-MRI

Dong X, Meng J, Xing J, Jia S, Li X, Wu S

Breast Cancer: Targets and Therapy 2025, 17:103-113

Published Date: 27 January 2025

Adipokines in Breast Cancer: Decoding Genetic and Proteomic Mechanisms Underlying Migration, Invasion, and Proliferation

Ließem A, Leimer U, Germann GK, Köllensperger E

Breast Cancer: Targets and Therapy 2025, 17:79-102

Published Date: 25 January 2025

Update on Pulmonary Toxicity Induced by New Breast Cancer Treatments

Belluzzi L, Martinelli G, Medici B, Farina A, Martinelli E, Canino F, Caggia F, Molinaro A, Barbolini M, Tamburrano F, Moscetti L, Piacentini F, Dominici M, Omarini C

Breast Cancer: Targets and Therapy 2025, 17:53-66

Published Date: 21 January 2025

From Pioneering Discoveries to Innovative Therapies: A Journey Through the History and Advancements of Nanoparticles in Breast Cancer Treatment

Basingab FS, Alshahrani OA, Alansari IH, Almarghalani NA, Alshelali NH, Alsaiary AH, Alharbi N, Zaher KA

Breast Cancer: Targets and Therapy 2025, 17:27-51

Published Date: 21 January 2025

Functional Analysis and Experimental Validation of the Prognostic and Immune Effects of the Oncogenic Protein CDC45 in Breast Cancer

Zhang JN, Li LW, Cao MQ, Liu X, Yi ZL, Liu SS, Liu H

Breast Cancer: Targets and Therapy 2025, 17:11-25

Published Date: 9 January 2025