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Clinical Epidemiology

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ISSN: 1179-1349

Archive: Volume 17, 2025

Validity of the Leading Causes of Death Classification for Premature Mortality in Inflammatory Bowel Disease: A Population-Based Comparison with ICD-10 Coding in Ontario, Canada

Postill G, Kuenzig ME, Olivera PA, Itanyi IU, Harish V, Tang F, Buajitti E, Rosella LC, Benchimol EI

Clinical Epidemiology 2025, 17:1163-1175

Published Date: 28 December 2025

Risk of Second Primary Cancer Among Patients with Thyroid Carcinoma in Finland: A Nationwide Population-Based Study

Nikkilä R, Hirvonen E, Mäkitie A, Pitkäniemi J, Malila NK, Mäkitie RE

Clinical Epidemiology 2025, 17:1147-1162

Published Date: 25 December 2025

The Impact of Low EHR-Continuity on Effect Estimates: Evidence from Two EHR-Medicare Linked Databases

Jin Y, Tong AY, Wyss R, Yang J, Lin KJ

Clinical Epidemiology 2025, 17:1131-1145

Published Date: 25 December 2025

A Multi-Country Study of the Clinical Course of Extensive-Stage Small Cell Lung Cancer: A Six-Study Analysis of Real-World Treatment Patterns and Outcomes

Pundole X, Younan D, Critchlow CW, Puntis SR, Soohoo M, Anderson ES, Najdi R, Horinouchi H, Calvo V, Cobo M, Lopez-Castro R, Bernabe R, Cho J, Desai PA, Ahn MJ, Provencio M

Clinical Epidemiology 2025, 17:1117-1129

Published Date: 20 December 2025

Enhanced Risk Stratification in Infective Endocarditis Surgery: A Comprehensive External Validation of All Available Mortality Prediction Scores

Mikus E, Sangiorgi D, Calvi S, Fiorentino M, Tenti E, Dalle Mura F, Savini C

Clinical Epidemiology 2025, 17:1087-1097

Published Date: 19 December 2025

Refined Algorithm for Identifying Recurrence Among Patients with Non-Metastatic Colorectal Cancer Based on Danish National Health Data Registries

Gögenur M, Bräuner KB, Löffler L, Olsen ASF, Gundestrup AK, Jakobsen PCH, Kleif J, Bertelsen CA, Gögenur I

Clinical Epidemiology 2025, 17:1075-1086

Published Date: 11 December 2025

Healthcare Use Patterns for High Volume Musculoskeletal Shoulder Disorders: A Longitudinal Cohort from the US Military Health System

George SZ, Morton-Oswald S, Lee HJ, Horn ME, Bhavsar NA, Rhon DI

Clinical Epidemiology 2025, 17:1049-1060

Published Date: 10 December 2025

Self-Measured Blood Pressure Monitoring in Primary Care: Retrospective Analysis from a Large US Healthcare System

Guzman I, Glowacki N, Chase J, Brill J, Biskis A, Khatib R

Clinical Epidemiology 2025, 17:1039-1047

Published Date: 9 December 2025

Impact of Changes in Patient Reported Outcomes on Healthcare Use After a Self-Management Supportive Intervention for Individuals with Low Back Pain

Grøn S, Kongsted A, Olsen KR, Koes B, Johansson MS

Clinical Epidemiology 2025, 17:1011-1023

Published Date: 28 November 2025

Risk Signals of Antibody-Drug Conjugates in Bladder Cancer: A Real-World FAERS Study

Liu J, Li G, Yang J, Sun B, Guo S

Clinical Epidemiology 2025, 17:995-1009

Published Date: 28 November 2025

Taiwan’s National Health Insurance Research Database (NHIRD): in the Era of Artificial Intelligence, Causal Inference, and Data Security

Hsieh CY, Shao SC, Sung SF, Hsieh MHC, Tsai DHT, Lin SJ, Lai ECC

Clinical Epidemiology 2025, 17:967-981

Published Date: 25 November 2025

The Association Between Socioeconomic Position and Infection Risk After Hip Fracture Surgery: A Nationwide Cohort Study of 54,853 Patients

Gadgaard NR, Varnum C, Nelissen R, Vandenbroucke-Grauls C, Sørensen HT, Pedersen AB

Clinical Epidemiology 2025, 17:953-965

Published Date: 15 November 2025

Performance of Different Comorbidity Indices in Predicting Mortality in Danish Pancreatic Cancer Patients

Kirkegård J, Riahi E, Ilkjær R, Mortensen FV, Heide-Jørgensen U

Clinical Epidemiology 2025, 17:945-952

Published Date: 12 November 2025

A Claims-Based Algorithm for Identifying Hidradenitis Suppurativa Severity

Schneeweiss MC, Anand P, Mostaghimi A, Landon J, Shay D, Davies OMT, Kumar AM, Shang A, Tran T, Glynn RJ, Lin KJ, Wyss R

Clinical Epidemiology 2025, 17:935-944

Published Date: 7 November 2025

Esophageal and Gastric Cancer Incidence and Mortality Trends in Norway, 1993–2022: A Registry-Based Study

Seyyedsalehi MS, Boffetta P, Trewin-Nybråten CB, Langseth H, Robsahm TE

Clinical Epidemiology 2025, 17:917-933

Published Date: 7 November 2025

Leveraging a Bayesian Approach in a Comparative Effectiveness Trial of Major Adverse Cardiovascular Events

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Lwin CT, Roumie CL, Greevy RA Jr, Beck C, Snyder KD, Hackstadt AJ

Clinical Epidemiology 2025, 17:903-915

Published Date: 7 November 2025

The Epidemiology of Alpha-1 Antitrypsin Deficiency in Norway

Ghanima W, Vágó EK, Acquavella J, Horváth-Puhó E

Clinical Epidemiology 2025, 17:891-901

Published Date: 5 November 2025

Regression Discontinuity Designs in Epidemiology: A Practical Guide

O’Keeffe AG, Petersen I

Clinical Epidemiology 2025, 17:845-862

Published Date: 30 October 2025

Accounting for Comorbidity in Etiologic Research

Khachadourian V, Janecka M

Clinical Epidemiology 2025, 17:837-844

Published Date: 22 October 2025

Design and Protocol of the Biobank for Metabolic Syndrome Consequences (BMSC): A Prospective Cohort Study in Northwest China

Yang X, Li Q, He Y, Yin G, Li M, Zhu W, Fan X, Gong Y, Wang Y, Qiang W, Wang Y, Willems van Dijk K, Rensen PCN, Guo H, Shi B, Wang Y

Clinical Epidemiology 2025, 17:823-835

Published Date: 14 October 2025

Light to Moderate Alcohol Consumption and Cancer Incidence: The Norwegian Women and Health Cohort Study

Llaha F, Licaj I, Sharashova E, Ferrari P, Lukic M, Benjaminsen Borch K

Clinical Epidemiology 2025, 17:807-821

Published Date: 10 October 2025

Sodium–Glucose Cotransporter 2 Inhibitors and Lower Risk of Depression in Population with Type 2 Diabetes Mellitus: A Population-Based Active Comparator, New-User Design

Kao MJ, Huang YC, Huang YC, Yang HW, To SY, Liao CC, Wen YL, Kao LT

Clinical Epidemiology 2025, 17:797-806

Published Date: 3 October 2025

Association Between Pneumonia Risk and Anticholinergic Burden Among Patients with Different Frailty Levels

Yang ASH, Fan Chiang HY, Tsai DHT, Chuang ATM, Lai ECC

Clinical Epidemiology 2025, 17:787-796

Published Date: 30 September 2025

Sex Differences in Antihypertensive Medications and PTSD Incidence

Selbe SM, Szentkúti P, Evans TC, Lash TL, Sumner JA, Gradus JL

Clinical Epidemiology 2025, 17:779-786

Published Date: 17 September 2025

Systematic Review and Development of Recommended Code Lists to Identify Smoking and Vaping Status in Electronic Health Records (EHR)

Ding R, Cook S, Stone PW, Srirathan D, Shyam Y, Anand R, Sudharshan P, Quint JK

Clinical Epidemiology 2025, 17:753-764

Published Date: 9 September 2025

Positive Predictive Value of ICD-10 Codes for Identifying Hypocalcemia in Women with Postmenopausal Osteoporosis in Swedish Patient Register: A Validation Study

Kjellman A, Kim M, Lundgren PO, Thiel T, Thor A, Thulin H, Hägg D, Ehrenstein V

Clinical Epidemiology 2025, 17:747-752

Published Date: 2 September 2025

Existing Data Sources in Clinical Epidemiology: The Danish Prehospital Medical Record System

Rosenkrantz O, Benson CS, Lindskou TA, Fuglsang CH, Pedersen L, Mikkelsen S, Christensen HC, Christensen EF, Steinmetz J, Sørensen HT

Clinical Epidemiology 2025, 17:735-745

Published Date: 30 August 2025

Prevalence and Data-Driven Exploration of Pre-Diagnostic Symptoms and Features of Gilbert’s Syndrome in the UK Primary Care Population

Veeravalli RS, Horsfall LJ, Direk K, Petersen I

Clinical Epidemiology 2025, 17:721-733

Published Date: 28 August 2025

Predictors, Healthcare Utilization and Costs Related to Short-Term Stays in Patients with COPD: A Registry-Based Analysis in Norway

Moger TA, Holte JH, Amundsen O, Haavaag SB, Døhl Ø, Bragstad LK, Hellesø R, Tjerbo T, Vøllestad NK

Clinical Epidemiology 2025, 17:707-719

Published Date: 26 August 2025

Mortality Outcomes in People with Lung Cancer with and without Type2 Diabetes: A Cohort Study in England

Igbinosa EG, Dharmasekara B, Quint JK, Popat S, Bhaskaran K, Morganstein D, Cook S

Clinical Epidemiology 2025, 17:681-692

Published Date: 17 July 2025

Adaptation of the WHO COVID-19 Clinical Progression Scale for Registry-Based Data: A Whole-Population Study in Sweden

Jerndal H, Kalucza S, Jakobsson F, Hviid A, Grove Krause T, Ahlm C, Normark J, Fonseca-Rodríguez O, Eriksson M, Fors Connolly AM

Clinical Epidemiology 2025, 17:663-679

Published Date: 15 July 2025

Association of Birthweight Discordance with Adverse Birth Outcomes Among Live-Born Twins: A Multi-Center Study in China

Shi B, Tan X, Chen Q, Lu D, Ren S, Huang K, Shen W, Chen Z, Liu J, You C, Li G, Jiang H, Rao H, Qiu J, Wei X, Zhang Y, Lin X, Jiang H, Han S, Wang F, Yang X, Wang Y, Lin N, Lin L, Lin X, Cui Q

Clinical Epidemiology 2025, 17:625-634

Published Date: 8 July 2025

SEPLINE: Socioeconomic Position in Epidemiological Research—A National Guideline on Danish Registry Data

Hjorth CF, Kjærulff TM, Thomsen MK, Cronin-Fenton D, Dalton SO, Olsen MH

Clinical Epidemiology 2025, 17:593-624

Published Date: 4 July 2025

Two-Year Mortality and Prognostic Factors in Sepsis: A Prospective Cohort Study of 714 Danish Emergency Department Patients

Nielsen FE, Chafranska L, Sørensen RH, Schmidt TA, Abdullah OB

Clinical Epidemiology 2025, 17:581-592

Published Date: 28 June 2025

The Hydrocephalus Association Patient-Powered Interactive Engagement Registry (HAPPIER): Design and Initial Baseline Report

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Jakopin NE, Lanjewar SN, Garzon A, Gross P, Holubkov R, Moghekar A, Preston J, Romanoski M, Shannon CN, Tamber MS, Van der Willigen T, Sloan M, Chau MJ, Koschnitzky JE

Clinical Epidemiology 2025, 17:567-579

Published Date: 24 June 2025

Framework for Exploration of Statistical Heterogeneity in Multi-Database Studies: A Case Study Using EXACOS-CV Studies

Rhodes KM, Garbe E, Müllerová H, Ekwaru P, Kossack N, Baak BN, Lobier M, Hawkins NM, Nordon C

Clinical Epidemiology 2025, 17:551-565

Published Date: 14 June 2025

Real-World Assessment of the Association Between PCSK9i Adherence and LDL Reduction and Variability in a Chinese Clinical Practice

Ye X, Zhang S, Zhong X, Li M, Liu M, Zhuang X, Liao X

Clinical Epidemiology 2025, 17:537-546

Published Date: 9 June 2025

Plasma Aldosterone Elevation in Hypertensive Patients and Association with Urinary Stone Formation: A Large-Scale Population Study from Northwest China

Song S, Li N, Shen D, Hu J, Cai X, Zhu Q, Zhang Y, Ma R, Zhou P, Zhang Z, Jiang W, Hong J

Clinical Epidemiology 2025, 17:497-512

Published Date: 30 May 2025

Cohort Profile: The Danish Venous Thromboembolism Cohort – A Linkage Between Danish National Health Surveys and Health Registers

Horváth-Puhó E, Pedersen L, Martiny SK, Amdisen L, Viuff JH, Ekholm O, Sørensen HT

Clinical Epidemiology 2025, 17:485-495

Published Date: 29 May 2025

Celiac Disease and Incident Dupuytren’s Contracture: A Matched Nationwide Cohort Analysis

Yuan S, Furniss D, Larsson SC, Leffler DA, Ludvigsson JF

Clinical Epidemiology 2025, 17:481-484

Published Date: 24 May 2025

High Validity and Completeness of the Septoplasty Surgical Procedure Code in the Danish National Patient Registry

Bredahl JØ, Rønnegaard AB, Larsen KS, Kjeldsen AD

Clinical Epidemiology 2025, 17:435-440

Published Date: 28 April 2025

Effect of SGLT2 Inhibitors on Diabetes Progression in Statin-Treated Patients: A Population-Based Cohort Study

Cheng JSC, Lin F, Fu CM, Lin S, Wang CY, Huang HY, Wang CC

Clinical Epidemiology 2025, 17:421-433

Published Date: 21 April 2025

Statin Therapy in Early Breast Cancer: The MASTER Trial; A Randomized Phase III, Placebo-Controlled Comparison of Standard (Neo)Adjuvant Therapy Plus Atorvastatin versus Standard (Neo)Adjuvant Therapy Plus Placebo

Borgquist S, Jensen MB, Bendorff CL, Christiansen P, Offersen BV, Kodahl AR, Ewertz M, Jensen AB, Ahern TP, Cronin-Fenton D, Ejlertsen B

Clinical Epidemiology 2025, 17:409-419

Published Date: 17 April 2025

Mental Disorders in Danish Hospital Registers: A Review of Content and Possibilities for Epidemiological Research

Plana-Ripoll O, Liu X, Köhler-Forsberg O, Sørensen HT, Momen NC

Clinical Epidemiology 2025, 17:387-407

Published Date: 16 April 2025

Extracting Cognitive Impairment Assessment Information From Unstructured Notes in Electronic Health Records Using Natural Language Processing Tools: Validation with Clinical Assessment Data

Wang KY, Mahesri M, Novoa-Laurentiev J, Bessette LG, York C, Zakoul H, Lee SB, Ngan K, Zhou L, Kim DH, Lin KJ

Clinical Epidemiology 2025, 17:353-365

Published Date: 15 April 2025

Dispensing Patterns of Inhaled Asthma Medication Before and During COVID-19 Among Young Adults in the Netherlands: A Retrospective Inception Cohort Study

Zhou G, Mommers I, Schuilinga-Veninga CC, Bos JH, Oude Rengerink K, Pasmooij AMG, Mol PG, van Baarle D, de Bock GH, van Boven JF, Hak E

Clinical Epidemiology 2025, 17:337-352

Published Date: 9 April 2025

Validation of Medication Proxies for the Identification of Hospitalizations for Major Adverse Cerebro-Cardiovascular Events

Steenhuis D, Li X, Feenstra TL, Hak E

Clinical Epidemiology 2025, 17:327-336

Published Date: 28 March 2025

Risk of Depression and Anxiety in Those Who Gave Birth to Children Who Developed Invasive Group B Streptococcal Disease: A Population-Based Cohort Study

Horváth-Puhó E, Chandna J, Paul P, Wilson CA, Sørensen HT, Lawn JE

Clinical Epidemiology 2025, 17:315-325

Published Date: 28 March 2025

Non-Attendance in Hospital Appointments Based on Data From the Entire Region of Southern Denmark: Descriptive Analyses and Predictive Factors

Nørgård BM, Iachina M, Ammentorp J, Schwalbe DM, Waidtløw KY, Richardt L, Sodemann M

Clinical Epidemiology 2025, 17:303-314

Published Date: 25 March 2025

The Mediation Role of Insulin Resistance and Chronic Systemic Inflammation in the Association Between Obesity and NAFLD: Two Cross-Sectional and a Mendelian Randomization Study

Huang X, Chen Q, Su Q, Gong J, Wu L, Xiang L, Li W, Chen J, Zhao H, Huang W, Du S, Ye W

Clinical Epidemiology 2025, 17:287-302

Published Date: 24 March 2025

Comparing Methods for Classification of Hospital Visits in the Danish National Patient Registry (DNPR): DNPR3 Versus DNPR2

Duch KS, Magnussen B, Skjøth F, Westermann R, Dreyer LW

Clinical Epidemiology 2025, 17:277-285

Published Date: 21 March 2025

Modelling Asthma Treatment Dynamics: Insights from the g-Formula

Mommers I, van Boven JF, Bos JH, Mubarik S, Hak E, Bijlsma MJ

Clinical Epidemiology 2025, 17:265-276

Published Date: 13 March 2025

Hospital-Treated Infections and 15-year Incidence of Musculoskeletal Disorders: A Large Population-Based Cohort Study

Gao Y, McGagh D, Ding L, Hong S, Ouyang Z, Wei J, Zeng C, Lei G, Xie J

Clinical Epidemiology 2025, 17:251-264

Published Date: 11 March 2025

Postoperative Adverse Outcomes in Patients With Frailty Undergoing Urologic Surgery Among American Patients: A Propensity-Score Matched Retrospective Cohort Study

Hsu CW, Chang CC, Lam F, Liu MC, Yeh CC, Chen TL, Lin CS, Liao CC

Clinical Epidemiology 2025, 17:241-250

Published Date: 12 March 2025

Explainable Prediction of Long-Term Glycated Hemoglobin Response Change in Finnish Patients with Type 2 Diabetes Following Drug Initiation Using Evidence-Based Machine Learning Approaches

Chandra G, Lavikainen P, Siirtola P, Tamminen S, Ihalapathirana A, Laatikainen T, Martikainen J, Röning J

Clinical Epidemiology 2025, 17:225-240

Published Date: 8 March 2025

Occupational Physical Activity Among Pregnant Employees in the Danish Workforce: The PRECISE Occupational Cohort Profile

Frankel HN, Hærvig KK, Flachs EM, Korshøj M, Bertelsen C, Backhausen M, Sejbaek CS, Begtrup LM

Clinical Epidemiology 2025, 17:211-224

Published Date: 1 March 2025

Cohort Update: ESPRESSO (Epidemiology Strengthened by Histopathology Reports in Sweden)

Ludvigsson JF, Lashkariani M

Clinical Epidemiology 2025, 17:193-196

Published Date: 25 February 2025

Mental Health Disorders in Patients with Inflammatory Bowel Disease Onset in Childhood or Youth – A Nationwide Cohort Study from Denmark

Rasmussen J, Hansen ASK, Nørgård BM, Nielsen RG, Qvist N, Bøggild H, Fonager K

Clinical Epidemiology 2025, 17:177-192

Published Date: 25 February 2025

Interaction Between Multimorbidity and Hip Fracture Surgery Leads to Excess Risk of Infection: A Danish Registry-Based Cohort Study of 92,599 Patients With Hip Fracture

Hansen CM, Gadgaard NR, Vandenbroucke-Grauls C, Hailer NP, Pedersen AB

Clinical Epidemiology 2025, 17:167-176

Published Date: 24 February 2025

Data-Driven Algorithms for Classification of In- and Outpatients in the Danish National Patient Register

Buchardt AS, Madsen PV, Jensen A

Clinical Epidemiology 2025, 17:147-163

Published Date: 21 February 2025

The Danish Lymphoid Cancer Research (DALY-CARE) Data Resource: The Basis for Developing Data-Driven Hematology

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Brieghel C, Werling M, Frederiksen CM, Parviz M, Lacoppidan T, Faitova T, Teglgaard RS, Vainer N, da Cunha-Bang C, Rotbain EC, Agius R, Niemann CU

Clinical Epidemiology 2025, 17:131-145

Published Date: 20 February 2025

Impact of Population-Based Screening for Diabetes and Prediabetes Among 67-Year-Olds Using Point-of-Care HbA1c on Healthcare Ultilisation, Results from the VISP Cohort

Andersen JW, Høgh A, Lindholt JS, Søgaard R, Støvring H, Yderstræde KB, Sandbæk A, Dahl M

Clinical Epidemiology 2025, 17:75-85

Published Date: 5 February 2025

Risk of Subclinical Hypothyroidism in Breast Cancer Patients Treated With CT-Guided Radiation Therapy: A Prospective Observational Study

Amdisen L, Brink C, Lorenzen EL, Roenlev JD, Ewertz M, Cronin-Fenton D

Clinical Epidemiology 2025, 17:41-49

Published Date: 25 January 2025

Increased Mortality After Lower Extremity Amputation in a Danish Nationwide Cohort: The Mediating Role of Postoperative Complications

Brix ATH, Petersen TG, Nymark T, Schmal H, Lindberg-Larsen M, Rubin KH

Clinical Epidemiology 2025, 17:27-40

Published Date: 25 January 2025

Similar Survival Between Non-Western Immigrant Patients and Danish-Born Patients with Lymphoma: A Danish Population-Based Study

Simonsen MR, Maksten EF, Jakobsen LH, Severinsen MT, Dann EJ, Frederiksen H, Niemann CU, Jørgensen JM, Clausen MR, Starklint J, Johnsen SP, El-Galaly TC, Baech J

Clinical Epidemiology 2025, 17:19-25

Published Date: 23 January 2025

Treatment of Proximal Humeral Fractures in Older Patients During COVID-19 Pandemic in Germany

Sußiek J, Koeppe J, Fischhuber K, Iking J, Marschall U, Raschke MJ, Katthagen JC, Stolberg-Stolberg J

Clinical Epidemiology 2025, 17:9-18

Published Date: 17 January 2025

Acetaminophen Use in Pregnancy: A Comparison of Self-Reported Intake with Maternal and Newborn Biomarker Measures

Guo P, Johnson CH, Yan H, Xiao J, Dennis C, Pierce KA, DeWan AT, Liew Z

Clinical Epidemiology 2025, 17:1-6

Published Date: 3 January 2025