Drug Design, Development and Therapy

Using Innovative Drug Delivery Systems to Improve the Efficacy and Applicability of Poorly Water-soluble Drugs

Failure of the conventional delivery of poorly water-soluble drugs could be attributed to their low solubility and hence their limited bioavailability that hinder their pharmacological applications. The improvement of drug solubility is of a critical concern in boosting the dissolution rate and bioavailability. Recently, different techniques have been used to increase the solubility and bioavailability of poorly water-soluble drugs. Using novel drug delivery systems and nano-based drug delivery systems can improve their solubility. Moreover, many of these systems act as drug reservoirs that also improve the drug permeability and stability. Accordingly, these delivery systems are important in improving the efficacy and applicability of poorly water-soluble drugs.