Dong F, Wang Z, Li C, Li X, Zhu D, Li J, Wang Z, Gong J, Zhou J, Liu H, Zhang Y, Zhang X, Chen X, Yu M, Tan X, Qian M, Luo Y, Guo WJ, Xie S, Huang J, Zhao J, Wan J, Shan Y, Li N, Wang J, Ju Y, Wang J, Bian Q, Wang G

Drug Design, Development and Therapy 2026, 20:561494

Published Date: 25 February 2026

Original Research

Low-Dose Sevoflurane Restores Prefrontal Excitatory/Inhibitory Balance and Improves Autism-Like Social Behavior: A Preclinical and Pilot Clinical Study

Xu H, Shi Z, Guo X, Deng S, Wu M, Chen B, Qin J, Xu N, Zhao T, Chang Y, Song X

Drug Design, Development and Therapy 2026, 20:534484

Published Date: 25 February 2026

Original Research

Uncovering Thyroid Vulnerability to Doxorubicin: Integrative Cellular and in vivo Evidence of Mitochondrial Dysfunction

Huang W, Wang Y, Wang H, Chen R, Gu H, Yu S, Bao Z, Luo L, Sun D, Zheng B

Drug Design, Development and Therapy 2026, 20:576622

Published Date: 25 February 2026

Clinical Trial Report

Liposomal Bupivacaine versus Ropivacaine with Dexamethasone in Rectus Sheath Block for Laparoscopic Gastrectomy: A Randomized Controlled Trial

Yi K, Zhan Y, Wei A, Chen S, Zhang Y

Drug Design, Development and Therapy 2026, 20:574724

Published Date: 25 February 2026

Original Research

Association Between Perioperative Dexmedetomidine Exposure and Post-Transplant Renal Outcomes: A Retrospective Analysis

Hung KC, Yu TS, Ho CN, Yu CH, Lai YC, Chang YJ, Chen IW

Drug Design, Development and Therapy 2026, 20:581944

Published Date: 25 February 2026

Original Research

Benzodiazepine Use Among Patients Receiving Methadone Maintenance Treatment: A Descriptive Study

Liu Y, Hong Q, Shen W, Li L, Li Z, Zhou W, Xie X

Drug Design, Development and Therapy 2026, 20:579917

Published Date: 24 February 2026

Review

Beyond Organ-Specific Therapies: A Unified Approach to Multi-Organ Fibrosis

Pan Z, Zerehpoosh S, Wang SC, Örmeci N, Kim W, Eslam M

Drug Design, Development and Therapy 2026, 20:566319

Published Date: 24 February 2026

Review

Fibroblast Growth Factor Receptor (FGFR) Inhibitors for the Treatment of Cholangiocarcinoma: Key Therapeutic Developments and Knowledge Gaps

Erul E, Cifuentes-Canaval S, Santhosh A, Sokolović E, Della Mura M, Cazzato G, Kubilay Tolunay P, Rizzo A

Drug Design, Development and Therapy 2026, 20:559328

Published Date: 24 February 2026

Original Research

Association of Perioperative Dexmedetomidine Exposure with Flap Failure After Head and Neck Surgery Flap Reconstruction: A Retrospective Study

Hung KC, Yu TS, Liu WC, Lai YC, Hung IY, Wu JY, Chen IW

Drug Design, Development and Therapy 2026, 20:575963

Published Date: 24 February 2026

Commentary

Beyond Oncogenes: Selectively Targeting Whole-Tumor Cell Growth Regulation

Qin A

Drug Design, Development and Therapy 2026, 20:574224

Published Date: 23 February 2026

Review

Drug Polymer Nanoparticles: An Advancement in Biomedical Solutions and Targeted Drug Delivery

Rananaware P, Narayan M, Brahmkhatri V

Drug Design, Development and Therapy 2026, 20:562785

Published Date: 23 February 2026

Review

Neutrophil Extracellular Traps in Diabetic Kidney Disease: Mechanisms of Pathogenesis and Emerging Therapeutic Strategies

Wang B, Zhang R, Liu X, Shang Y, Jin T, Gao C, Yang N, Jin J, He Q

Drug Design, Development and Therapy 2026, 20:583077

Published Date: 21 February 2026

Clinical Trial Report

Dexmedetomidine May Reduce the Incidence of Acute Kidney Injury in Elderly Patients Undergoing Orthopedic Surgery: A Randomized, Double-Blind Clinical Trial

Zheng XY, Su Z, Zhang Y, Yan J, Li XY, Peng K, Liu H, Shan XS, Ji FH

Drug Design, Development and Therapy 2026, 20:571990

Published Date: 20 February 2026

Clinical Trial Report

The 90% Minimum Effective Dose of Oxycodone for Thoracoscopic Lobectomy in Elderly Patients: A Double-Blind Study Using a Biased-Coin Design

Li S, Pan X, Zhu Y, Liu J, Li Z, Gao X, Chai J

Drug Design, Development and Therapy 2026, 20:560051

Published Date: 19 February 2026

Original Research

**Preclinical Assessment of HLA-A*02:01-Restricted PSMA and STEAP1 Epitopes for Peptide-Based Immunotherapy in Prostate Cancer**

Huang Y, Yang Y, Xie Y, Shu Y, Yang S, Long X, Wen Z, Duan X, Fu L, Gu D, Huang T

Drug Design, Development and Therapy 2026, 20:576346

Published Date: 18 February 2026

Original Research

Untargeted Metabolomics Investigating the Intracellular Metabolic Alterations of HaCaT Cells Treated with Isotretinoin

Zhu S, He Y, Wu L, Ouyang X, Wei Q, Ye F, Li C

Drug Design, Development and Therapy 2026, 20:585422

Published Date: 18 February 2026

Original Research

Real-World Outcomes and Safety of PD-1 Blockade Rechallenge Strategies After Prior Immunotherapy in Advanced NSCLC: A Retrospective Cohort Study

Zheng LJ, Shen YL, Zhao HW, Ma YC, Wang AF

Drug Design, Development and Therapy 2026, 20:572625

Published Date: 18 February 2026

Original Research

Preliminary Exploration of Fluvastatin Inhibiting Proliferation, Migration and Invasion of Lung Cancer Cells and Reversing Paclitaxel Resistance: Mechanism Exploration Based on Multi-Omics Analysis

Xu H, Du Z, Shui J, Li X, Tang J, Li G

Drug Design, Development and Therapy 2026, 20:579427

Published Date: 16 February 2026

Clinical Trial Report

Preferable Concentration-Volume Combination of Ropivacaine for Femoral Nerve Block in Arthroscopic Meniscoplasty: A Prospective, Double-Blind, Randomized Clinical Trial

Yue J, Wang Q, Zhou R, Zhou L

Drug Design, Development and Therapy 2026, 20:577722

Published Date: 16 February 2026

Clinical Trial Report

EC50 of Remifentanil for Inhibiting Cardiovascular Responses to Tracheal Intubation in Patients Treated by Different Doses of Oliceridine: A Randomized Controlled Trial Using Up-and-Down Sequential Allocation Methodology

Zhao Z, Ge L, Wang X, Wang X, Huang J, Xiao Y, Zhang Y, Zhou Y, Bao R, Wang JF

Drug Design, Development and Therapy 2026, 20:571007

Published Date: 13 February 2026

Clinical Trial Report

Effect of Remimazolam on Postoperative Cough in Patients Undergoing Thyroid Surgery: A Randomized Double-Blind Controlled Clinical Trial

Liu X, Zhang T, Zhao L, Zhou X, Zhang L, Mao W, Chen L, Xie Y, Li L

Drug Design, Development and Therapy 2026, 20:575369

Published Date: 13 February 2026

Original Research

Lycopene Enhances the Sensitivity of Oral Squamous Cell Carcinoma to Cisplatin Through Inhibition of the PI3K/Akt Signaling Pathway and Reversal of Epithelial-Mesenchymal Transition

Wang R, Lu X, Yu R, Shan Z

Drug Design, Development and Therapy 2026, 20:557101

Published Date: 13 February 2026

Review

Tumor Targeting with Peptide-Drug Conjugates: Showcasing Key Progress and Hurdles

Parang K, Do T, Dinh C, Davani-Davari D, Foroughi M, Khong T, Moazen M, Nasrolahi Shirazi A

Drug Design, Development and Therapy 2026, 20:562135

Published Date: 12 February 2026

Review

Inhalation: A Smart Strategy and Increasing Potential for Drug Delivery

Wang SC, Kuo TH, Rai CI, Chen YC

Drug Design, Development and Therapy 2026, 20:575392

Published Date: 12 February 2026

Review

From Ancient Spice to Advanced Science: Therapeutic, Nutraceutical and Nanotechnological Insights into the Fruits of Piper Longum Linn for Modern Drug Development

Bhatia A, Mehta J, Hashmi AR, Sekar M, Bandyopadhyay A, Pal T, Kumar BRP, Mat Rani NNI, Wong LS, Kumarasamy V

Drug Design, Development and Therapy 2026, 20:556602

Published Date: 12 February 2026

Review

Phytochemical and Anti-Ischemic Stroke Properties from the Vitex L. Genus

Xie C, Wu J, Huang P

Drug Design, Development and Therapy 2026, 20:585338

Published Date: 11 February 2026

Review

The Application Prospects and Future Outlook of Kadsura coccinea (Lem). A.C.Sm. in Rheumatoid Arthritis

Ouyang F, Xi X, Liang Y, Wang M, Liu M, Jin X, Li H, Liu J, Hu X

Drug Design, Development and Therapy 2026, 20:569093

Published Date: 11 February 2026

Review

Bixin Beyond Colour: Expanding Therapeutic Horizons Through the Integration of Pharmacological Potential with Modern Drug Design and Delivery Strategies

Hashmi AR, Sekar M, Wong LS, Prashantha Kumar BR, Mat Rani NNI, Kumarasamy V

Drug Design, Development and Therapy 2026, 20:556587

Published Date: 11 February 2026

Clinical Trial Report

Efficacy and Safety of Ciprofol for Sedation in Critically Ill Patients After Cardiac Surgery: A Single-Center, Prospective, Randomized Controlled Trial

Guo L, Hong M, Li P, Du W, Li Y, Li J

Drug Design, Development and Therapy 2026, 20:568956

Published Date: 10 February 2026

Review

Moringa oleifera Lamk. as a Promising Adjunct Therapeutic Candidate: A Narrative Review of Human Studies and Published Case Reports

Sianipar EA, Sumiwi SA, Susilawati Y, Levita J

Drug Design, Development and Therapy 2026, 20:586556

Published Date: 10 February 2026

Original Research

Psychiatric, Cardiovascular and Skeletal Risks of Codeine versus Oxycodone in Hip Osteoarthritis: A Population-Based Cohort Study

Lee J, Kim Y, Choo E, Shin S, Choi YJ

Drug Design, Development and Therapy 2026, 20:572083

Published Date: 10 February 2026

Review

Chinese Herbal Medicine in Ulcerative Colitis-Associated Carcinogenesis Treatment: Mechanisms, Progress, and Future Directions

Gu F, Chen Z, Lim X, Zhang T, Yuan J, Li L

Drug Design, Development and Therapy 2026, 20:574142

Published Date: 8 February 2026

Review

Potential Antiarrhythmic Mechanisms of Glucagon-Like Peptide-1 Receptor Agonists (GLP-1RAs)

Li J, Fu K, Zhao J, Zou Y, Li L, Huang Q, Long L, Ou X, Lei M, Zhang C, Tan X, Chen T

Drug Design, Development and Therapy 2026, 20:579419

Published Date: 8 February 2026

Original Research

Deciphering Multitarget Mechanisms of Cardiac Glycosides in Acute Myeloid Leukemia Using a Network Pharmacology and Molecular Docking

Samart P, Poohadsuan J, Chanthateyanonth S, Issaragrisil S, Luanpitpong S

Drug Design, Development and Therapy 2026, 20:561050

Published Date: 7 February 2026

Clinical Trial Report

Nalbuphine as a Bridge to Delayed Epidural Analgesia: A Randomized Trial on First-Stage Labor Duration

Xu Y, Song C, Xu Y, Luo H, Chen K, Peng S, Guo L, Yu J

Drug Design, Development and Therapy 2026, 20:574810

Published Date: 7 February 2026

Review

Matrine in Liver Diseases: Mechanistic Insights and Therapeutic Potential

Wen W, Xia J, Liu G, Wang C

Drug Design, Development and Therapy 2026, 20:577265

Published Date: 7 February 2026

Original Research

Sugammadex and Postoperative Respiratory Failure in Head and Neck Surgery: A Cohort Study

Hung KC, Yu TS, Lai YC, Chen IW

Drug Design, Development and Therapy 2026, 20:580072

Published Date: 7 February 2026

Clinical Trial Report

Remimazolam Reduces the Cough Reflexes in Elderly Patients Undergoing Fiberoptic Bronchoscopy Under Remifentanil/Cipepofol-Based Anaesthesia: A Randomized Clinical Trial

Wang X, Qin Y, Wei Y, Xu B, Lan H, Huang X, Chen Q, Cao H, Wu X, Chen H, Liu S, Guan X

Drug Design, Development and Therapy 2026, 20:580302

Published Date: 7 February 2026

Clinical Trial Report

ED95 of Liposomal Bupivacaine for Postoperative Local Infiltration Analgesia in Women Undergoing Cesarean Section: A Randomized Controlled Trial

Liu J, Zhang Y, Liu L, Zhang W

Drug Design, Development and Therapy 2026, 20:571871

Published Date: 6 February 2026

Original Research

Evidence Based on Sleep Disorder Exacerbating Postoperative Pain via Kynureninase

Huang N, Chen Y, Yang X, Tao C, Zhang Y, Yang Y, Shu B, Duan G, Chen Y

Drug Design, Development and Therapy 2026, 20:565401

Published Date: 5 February 2026

Clinical Trial Report

Determination of Median Effective Concentration (EC50) of Ropivacaine with Adjuvant Dexmedetomidine When Using the Dural Puncture Epidural Technique for Labor Analgesia: An Up-Down Sequential Allocation Study

Wang XY, Liu H, Zhang J, Shi J, Zhao Y, Liang Y

Drug Design, Development and Therapy 2026, 20:571808

Published Date: 5 February 2026

Review

Properties of Approved Antitumour Chinese Herbal Medicines: Integrating Evidence and Tradition

Qi L, Qian S, Wang L, Liu Z, Jiang J, Liu C, Pan Y, Wang B, Han X, Chen J

Drug Design, Development and Therapy 2026, 20:575608

Published Date: 5 February 2026

Clinical Trial Report

Comparison of the Effects of Glycopyrrolate and Atropine on Postoperative Delirium in Older Adult Patients Undergoing Laparoscopic Colorectal Surgery: A Randomized Controlled Trial

Wu J, Liu J, Wang C, Wu J, Lin Y, Wang G, Zhang S, Ding M, Liang C

Drug Design, Development and Therapy 2026, 20:580157

Published Date: 5 February 2026

Review

Anti-Inflammatory Properties of Agarwood (Aquilaria Spp.): An Integrated Review of Phytochemistry, Molecular Mechanisms, and Therapeutic Applications

Zhang MM, Wen T, Cui MW, Guo ZL

Drug Design, Development and Therapy 2026, 20:559380

Published Date: 5 February 2026

Clinical Trial Report

ED95 of Ciprofol Combined with Esketamine or Sufentanil in Elderly Patients Undergoing Endoscopic Submucosal Dissection: A Dose-Finding and Randomized Controlled Trial

Qin X, Jiang H, Xie Y, Liu Q, Zhang Y, Mamtili I

Drug Design, Development and Therapy 2026, 20:595458

Published Date: 4 February 2026

Original Research

Modified Jie-Yu-He-Huan Capsule in Post-Stroke Depression Treatment: Insights from DIA Proteomic and PRM Validation

Wang X, Gao Q, Liu C, Hu M, Liu Z, Li Z, Zhang H, Wu L, Chen K, Xu K, Geng X, Liu W, Wei S

Drug Design, Development and Therapy 2026, 20:565281

Published Date: 4 February 2026

Review

Research Progress on the Application and Mechanisms of Baihe Dihuang Decoction in Major Depressive Disorder

Yang L, Wang Y, Wan H, Feng H, Liu Y, Xue G, Zhi Y, Zhang F, Liu Y, Zhang Z

Drug Design, Development and Therapy 2026, 20:579207

Published Date: 4 February 2026

Clinical Trial Report

Comparative Effectiveness of Single-Dose Epidural Esketamine versus Hydromorphone in Thoracic and Upper Abdominal Surgery: A Randomized Trial

Song Y, Wang C, Huang N, He H, Hong W, Wu J, Yao M, Miao C, Liang C

Drug Design, Development and Therapy 2026, 20:580521

Published Date: 3 February 2026

Original Research

A Multi-Center Study of Population Pharmacokinetics of Polymyxin B in Critically Ill Patients

Wang Y, Wang X, Lei L, Sun W, Wu Z, Lan J, Chen J, Wang Y, Yao F, Hu L, Bai Y, Chen C

Drug Design, Development and Therapy 2026, 20:521070

Published Date: 3 February 2026

Review

Dendrophthoe pentandra (L.) Miq. as a Source of Anticancer Agents: A Review of Phytochemical Constituents and Preclinical Efficacy

Anggraini L, Febriyanti RM, Muhaimin M, Endrini S

Drug Design, Development and Therapy 2026, 20:559286

Published Date: 3 February 2026

Original Research

Proteome Microarray-Guided Global View: Multiple Pharmacological Targets of Icariin

Gong G, Tang X, Yuan G, Yang X, Wang G, Zhang F

Drug Design, Development and Therapy 2026, 20:581728

Published Date: 3 February 2026

Review

Pharmacological Treatment for Diabetic Macular Edema: A 2025 Update on Durability and Multi-Target Therapies

Tao Y, Zhang Y, Xu W, Liu G, Liu H

Drug Design, Development and Therapy 2026, 20:583837

Published Date: 3 February 2026

Original Research

A Pharmacist-Driven Closed-Loop Stewardship Model of Meropenem: Impact on Stability and Efficacy in Neurosurgery Patients

Li T, Chen X, Xu J, Qian J, Deng P, Xue C, Yang L, Huang S, Zhang Q, Ma M, Yu Y, Tang L

Drug Design, Development and Therapy 2026, 20:569180

Published Date: 2 February 2026

Review

Pharmacological Interventions in the Management of Sports Injuries: A Review of Clinical Use, Dosage Forms, and Anti-Doping Considerations

Alorfi NM

Drug Design, Development and Therapy 2026, 20:587793

Published Date: 2 February 2026

Clinical Trial Report

Optimal Interval for Intermittent Epidural Bolus with Ropivacaine-Dexmedetomidine Using the Epidural Dural Puncture Technique for Labour Analgesia: A Coin Bias Up-Down Study

Yin QL, Yu B, Yang ZZ, Li HP, Li X, Kong H

Drug Design, Development and Therapy 2026, 20:576768

Published Date: 2 February 2026

Review

Protective Effect of Chinese Herbal Medicine on Cerebral Ischemia-Reperfusion Injury by Regulating Ferroptosis

Luo S, Zhu J, Yang L, Liu J, Deng Y

Drug Design, Development and Therapy 2026, 20:563534

Published Date: 31 January 2026

Clinical Trial Report

Effect of Intraoperative Intravenous Lidocaine on Postoperative Delirium in Elderly Patients Undergoing Posterior Lumbar Interbody Fusion

Feng X, Jia J, Sang Y, Zhao Y, Wang Z, Wang P, Chen L, Zhu J, Li C, Liu S, Gao P, Gong T, Hu X, Su X

Drug Design, Development and Therapy 2026, 20:571032

Published Date: 30 January 2026

Original Research

Efficacy and Safety of Different Colistin Administration Routes for Nosocomial Pneumonia Caused by Carbapenem-Resistant Organisms: A Single Centre, Open Label, Prospective Cohort Study

Wei QY, Shen W, Chen ZY, Chen XX, Xu F, Fan H

Drug Design, Development and Therapy 2026, 20:577270

Published Date: 30 January 2026

Original Research

Hematological Safety of Contezolid versus Linezolid in Stage 5 Chronic Kidney Disease: An Active-Comparator New-User Retrospective Cohort Study

Zhang W, Cai X, Hou R, Guo J, Ma Y, Kang J, Li X

Drug Design, Development and Therapy 2026, 20:576881

Published Date: 30 January 2026

Original Research

Pharmacokinetic Model Based on Stochastic Simulation and Estimation for Therapeutic Drug Monitoring of Teicoplanin in Korean Neutropenic Hematopoietic Stem Cell Transplant Recipients

Chae H, Cha HJ, Kang M, Han S, Lee DG

Drug Design, Development and Therapy 2026, 20:550736

Published Date: 29 January 2026

Original Research

Real-World Pharmacokinetic and Exposure–Response Characterization of Venetoclax in Chinese Patients with Hematological Malignancies

Liu Z, Liu X, Gong Q, Qin S, Zhu X, Kuan IHS, Mak WY, Xiang X, Jia C, Wang Q, Cheng L, Li L

Drug Design, Development and Therapy 2026, 20:563629

Published Date: 29 January 2026

Original Research

Timing of Effect Onset After Restarting Anti CGRP-(Receptor)-Monoclonal Antibodies Following a Mandatory Cessation After One year of Use–A Single Center Retrospective Cohort Study

Panos LD, Scutelnic A, Plüss SE, Bracher J, Rossel JB, Branca M, Riederer F, Schankin CJ

Drug Design, Development and Therapy 2026, 20:567680

Published Date: 28 January 2026

Original Research

Paroxetine as a Therapeutic Agent in Inflammatory Osteolysis: Mechanistic Insights and Efficacy

Huang J, Wang Z, Liu J, Zhang J, Deng K, Huang S, Zhou S

Drug Design, Development and Therapy 2026, 20:561725

Published Date: 27 January 2026

Original Research

Esketamine-Based Opioid-Free versus Opioid-Based Anesthesia for Recovery Quality After Laparoscopic Transabdominal Preperitoneal Repair: A Randomized Noninferiority Trial

Liu H, Xing X, Jiang F, Zhang L, Chen L

Drug Design, Development and Therapy 2026, 20:572431

Published Date: 27 January 2026

Original Research

Efficacy and Safety of Finerenone Combined with Dapagliflozin in the Treatment of Non-Diabetic Chronic Kidney Disease: A Single-Center Retrospective Study

Ma J, Su Q, Wang H, Xu J, Yuan C, Fan G, Ying J, Bian X

Drug Design, Development and Therapy 2026, 20:564942

Published Date: 24 January 2026

Original Research

Remimazolam and Postoperative Delirium in Patients with Hyperlipidemia: A Retrospective Cohort Study with Target Trial Emulation Analysis

Tang Y, Long M, Gao Y, Kowark A, Coburn M, Wan H, Li Y, Duan X

Drug Design, Development and Therapy 2026, 20:568452

Published Date: 24 January 2026

Original Research

Patient-Controlled Sedation with Remimazolam Enables More Precise Intraoperative Sedation in Elderly Patients Under Spinal Anesthesia: A Randomized Controlled Trial

Wang M, Wang T, Wu N, Zhang Y, Jia J, Zhao S, Yan J, Wang A, Yuan D

Drug Design, Development and Therapy 2026, 20:573714

Published Date: 24 January 2026

Clinical Trial Report

Determination of ED50 and ED95 for Ciprofol in Morbidly Obese Patients During Induction of General Anesthesia: A Single-Center, Up-and-Down Study Based on Lean Body Weight

Wu CM, Wu JM, Jiang JX, Xu QM, Han XH, Duan GC

Drug Design, Development and Therapy 2026, 20:568472

Published Date: 24 January 2026

Original Research

Targeted Degradation of Histone Deacetylase 8 Using Proteolysis Targeting Chimeras Technology: A Promising Approach for Glioblastoma Treatment

Chotitumnavee J, Seemaung P, Settacomkul R, Sukprasert R, Itoh Y, Suzuki T, Srihirun S, Power C, Vivithanaporn P

Drug Design, Development and Therapy 2026, 20:555228

Published Date: 23 January 2026

Original Research

Ursodeoxycholic Acid Alleviates DSS/AOM-Induced Colorectal Cancer in Mice by Inhibiting PI3K/Akt/mTOR Signaling Pathway

Huang Z, Hong H, Yang H, He C

Drug Design, Development and Therapy 2026, 20:556850

Published Date: 23 January 2026

Original Research

Development of Membrane-Targeting Cannabigerol Derivatives as Potent Broad-Spectrum Antibacterial Agents

Yin Z, Zhang T, Wang Y, Wang Y, Xie X, Zhang F, Wang C, Hu W

Drug Design, Development and Therapy 2026, 20:558606

Published Date: 23 January 2026

Original Research

Therapeutic Efficacy of Curcumin Nanoparticles in Parkinson’s Disease: An Integrated Analysis of Network Pharmacology, Experimental Validation, and Gut Microbiota

Mu R, Liu T, Zhang Y, Xiu K, Guo X, Xia W

Drug Design, Development and Therapy 2026, 20:566113

Published Date: 22 January 2026

Review

The Dual Role of IP-10/CXCL10 in Liver Injury: From Pathogenic Mediator to Clinical Biomarker and Therapeutic Target

Yang J, Huang Y, Yuan Y, Yan D

Drug Design, Development and Therapy 2026, 20:544545

Published Date: 22 January 2026

Original Research

Circulating Butyrate Attenuates Cetuximab Efficacy in Colorectal Cancer Through EGFR and AMPK–Wip1 Signaling

Zhang J, Zhang M, Wu X, Jing H, Li P, Wang W, Guo X, Zhao Z, Zhu S, Wang Y

Drug Design, Development and Therapy 2026, 20:574116

Published Date: 22 January 2026

Review

The Potential Role of SGLT2 Inhibitors in the Treatment of Depression: Mechanisms and Clinical Prospects

Cheng H, Jing Y, Xu C, Chen M, Su H, Yang X, Zhang L

Drug Design, Development and Therapy 2026, 20:567851

Published Date: 22 January 2026

Review

Advances and Therapeutic Potential of Anthraquinone Compounds in Neurodegenerative Diseases: A Comprehensive Review

Liu Z, Zhang H, Wan B, Yin S, Yue R

Drug Design, Development and Therapy 2026, 20:580330

Published Date: 22 January 2026

Retraction

SIRT1/FOXO1 Axis-Mediated Hippocampal Angiogenesis Is Involved in the Antidepressant Effect of Chaihu Shugan San [Retraction]

Zhang S, Lu Y, Shi W, Ren Y, Xiao K, Chen W, Li L, Zhao J

Drug Design, Development and Therapy 2026, 20:596162

Published Date: 21 January 2026

Original Research

Formulation and Physicochemical Characterization of Capecitabine-Loaded Cubosomes for Enhanced Drug Delivery System

Salawi A

Drug Design, Development and Therapy 2026, 20:574417

Published Date: 21 January 2026

Original Research

Rosamultin Alleviates LPS-Induced Acute Kidney Injury by Promoting Autophagy and Inhibiting the NF-κB Signaling Pathway

Huang X, Cai W, Zhang Z

Drug Design, Development and Therapy 2026, 20:574424

Published Date: 21 January 2026

Retraction

Protective Effect of Picroside II on Myocardial Ischemia Reperfusion Injury in Rats [Retraction]

Wu N, Li W, Shu W, Jia D

Drug Design, Development and Therapy 2026, 20:596161

Published Date: 21 January 2026

Original Research

Camrelizumab Combined with Gemcitabine and Albumin-Bound Paclitaxel in Pancreatic Cancer Patients with Liver Metastases: A Prospective, Pilot Trial

Zhang J, Zhao K, Zhou W, Jiang G, Ding Y, Zhang Y, Dong X, Hong D, Liu X

Drug Design, Development and Therapy 2026, 20:568812

Published Date: 20 January 2026

Review

Role of Sodium-Glucose Transport Protein-2 Inhibitors in Renal Protection: A Narrative Review from the Cardiovascular-Kidney-Metabolic Interconnection

Ye N, Cheng H

Drug Design, Development and Therapy 2026, 20:540082

Published Date: 20 January 2026

Clinical Trial Report

Liposomal Bupivacaine for Adductor Canal Block Combined with IPACK Block in Total Knee Arthroplasty: A Prospective, Double-Blind, Randomized Controlled Trial

Yuan Q, Shen W, He W, Wang X, Liu F, Zhang Y, Lu X, Guan Z, Zhang J, Yang L

Drug Design, Development and Therapy 2026, 20:566411

Published Date: 14 January 2026

Clinical Trial Report

Effects of Cipepofol on Cardiac Depolarization and Repolarization in Healthy Subjects: A Single-Center, Randomized, Placebo and Positive-Controlled Thorough QT Study

Kleiman R, Rudo T, Daley W, Hu M, Yan P, Zhou R, Hou J

Drug Design, Development and Therapy 2026, 20:565051

Published Date: 14 January 2026

Original Research

Regulation of Periodontal Ligament Autophagy by Super-Activated Platelet Lysate in a Rat Maxillary Expansion Model

Liu Y, Li J, Lu H, Liu X, Li Y, Zhang Y, Wang P

Drug Design, Development and Therapy 2026, 20:571754

Published Date: 14 January 2026

Original Research

Association Between Diclofenac Sodium Use and Reduced Cycle Cancellation from Premature Ovulation in Women with Diminished Ovarian Reserve Undergoing IVF: A Retrospective Cohort Study

Song JY, Ma YJ, Cao XL, Sun ZG

Drug Design, Development and Therapy 2026, 20:575150

Published Date: 14 January 2026

Review

Integrated Western and Traditional Chinese Medicine Approaches for Herpes Zoster and Post-Herpetic Neuralgia: A Narrative Review

Li L, Xu J, Al-Danakh A, Xing Q

Drug Design, Development and Therapy 2026, 20:570847

Published Date: 13 January 2026

Original Research

Population Pharmacokinetics and Dosing Regimen Optimization of Piperacillin in Critically Ill Patients

Dong Z, Shi H, Yang Y, Yi Q, Jiang Z, Li Y

Drug Design, Development and Therapy 2026, 20:551307

Published Date: 13 January 2026

Clinical Trial Report

Comparison of the Effective Dose 90 (ED90) and Clinical Outcomes of Fentanyl Versus Esketamine for Analgesia in Hysteroscopy: A Two-Part, Randomized, Double-Blind Trial

Du J, Li C, Huang M, Qin X

Drug Design, Development and Therapy 2026, 20:574516

Published Date: 13 January 2026

Original Research

Simultaneous Determination of Venetoclax and Posaconazole in Human Plasma by UPLC-MS/MS: Application to Therapeutic Drug Monitoring in Acute Myeloid Leukemia Patients

Chen X, Wu H, Fu H, Wang P, Cao L, Li R, Zhan R, Xu RA

Drug Design, Development and Therapy 2026, 20:537699

Published Date: 12 January 2026

Review

The Role of Microemulsions in Enhancing the Stability of Biopharmaceuticals

Yu X, Jin Y, Sun J, Jin M, Bai S, Zhu R, Zhang Y, Lu Y, Song JY, Ma Y

Drug Design, Development and Therapy 2026, 20:551864

Published Date: 12 January 2026

Clinical Trial Report

Intravitreal Ranibizumab versus Vitreous Lavage for Postoperative Vitreous Hemorrhage in Proliferative Diabetic Retinopathy: A Randomized Controlled Trial

Chi J, Zhang X, Nie Z, Pan Y, Li W, Hu B

Drug Design, Development and Therapy 2026, 20:557400

Published Date: 12 January 2026

Review

Cardiac Myosin Activators in Heart Failure: Experimental Advances Amid Clinical Uncertainty

Hou L, Lin B, Ji X, Huang A

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Published Date: 12 January 2026

Original Research

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Zhao Y, Huang B, Yang Z, Kuang H, Chen J

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Published Date: 9 January 2026

Review

Exploring the Antibacterial Properties of Acmella Species: A Systematic Literature Review

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