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Drug Design, Development and Therapy
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- Volume 15, 2021 (399)
- Volume 14, 2020 (477)
- Volume 13, 2019 (387)
- Volume 12, 2018 (382)
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- Volume 7, 2013 (143)
- Volume 6, 2012 (42)
- Volume 5, 2011 (40)
- Volume 4, 2010 (35)
- Volume 3, 2009 (27)
- Volume 2, 2008 (29)
- Volume 1, 2007 (1)
Journal Articles:
- 5,535 records -
Is Rituximab Suitable for Patients with Idiopathic Membranous Nephropathy Who are Seronegative for Anti-PLA2R Antibody?
Yang Y, Xie X, Yuan F, Zeng F, Wang Y, Zhang R, Yan W, Luo K, Ren D, Xu G
Drug Design, Development and Therapy 2026, 20:601777
Published Date: 13 May 2026
The Crosstalk Between Epithelial-Mesenchymal Transition and Anoikis Resistance: A New Perspective of Traditional Chinese Medicine to Prevent Tumor Metastasis
Cui Z, Xu M, Liu J, Zhang K, Huang B
Drug Design, Development and Therapy 2026, 20:596194
Published Date: 13 May 2026
EC50 and EC95 of Epidural Ropivacaine for Intraoperative Analgesia During High-Intensity Focused Ultrasound for Adenomyosis: A Prospective Double-Blind Up-and-Down Concentration-Finding Study
Yang S, Zhang Y, Yang F, Luo L
Drug Design, Development and Therapy 2026, 20:594039
Published Date: 12 May 2026
Anterior Quadratus Lumborum Block with Liposomal Bupivacaine versus Ropivacaine for Postoperative Recovery in Laparoscopic Colorectal Surgery: A Randomized Controlled Trial
Liu D, Luo C, Zhang Y, Huang H, Yang Y
Drug Design, Development and Therapy 2026, 20:611347
Published Date: 12 May 2026
Competing Death and Absolute Benefit in Dexmedetomidine-Exposed Patients with Dialysis-Requiring Acute Kidney Injury [Letter]
Wang Y, Wang G, Wang C
Drug Design, Development and Therapy 2026, 20:622743
Published Date: 12 May 2026
Development Trends of Janus Kinase Inhibitors (JAKi) Over Three Decades: From Common to Rare Diseases
Dai R, Lou N, Zheng X, Han X
Drug Design, Development and Therapy 2026, 20:597046
Published Date: 12 May 2026
GBVAM as a Novel NHE1 Inhibitor Alleviates Doxorubicin-Induced Cardiotoxicity via PI3K/Akt/mTOR Pathway
Xu Y, Li Y, Cheng Z, Shao C, Zhao X, Liu Y, Gou X, Li C
Drug Design, Development and Therapy 2026, 20:585989
Published Date: 12 May 2026
Intravenous Tranexamic Acid Reduces the Incidence of Postoperative Delirium in Elderly Patients Undergoing Hip Arthroplasty: A Retrospective Cohort Study
Chu J, Liu Y, Xie L, Zhang H, Chen Y, Li Z, Deng K
Drug Design, Development and Therapy 2026, 20:587510
Published Date: 12 May 2026
Effect of Subanesthetic Doses of Esketamine on Early Postoperative Pain Sensitivity in Patients Undergoing Salpingectomy: A Randomized Clinical Trial
Wu Y, Wu H, Dong J, Lei L, Zhou L, Yan B, Chen L, Zhou M, Ke P, Liu F, Lin X, Zheng S, Chen Y, Wu X
Drug Design, Development and Therapy 2026, 20:596251
Published Date: 11 May 2026
Effect of Oliceridine Pretreatment on Etomidate-Induced Myoclonus: A Proof-of-Concept Randomized Trial
Guo M, Duan P, Yang X, M’Djanga Jnr M, Wang T, Bian J, Bo L
Drug Design, Development and Therapy 2026, 20:611682
Published Date: 9 May 2026
Mechanistic Physiologically Based Pharmacokinetic Modeling to Predict CYP3A4-Mediated Drug–Drug Interactions of Flumatinib as Both a Victim and a Perpetrator
Alifu M, Chu X, Zhu X, Mak WY, Zheng A, Pan C, He Q, Zhu X, Kuai Z, Xiang X
Drug Design, Development and Therapy 2026, 20:574169
Published Date: 9 May 2026
Olanzapine-Associated Hepatotoxicity in Bipolar Disorder: A Multicenter Real-World Study of Prevalence, Risk Factors, and Outcomes
Wang F, Lai X, Zhou S, Lin J, Xin H, Tao Z, Wang X, Zhang S, Liu Z, Tan H, Xiong Y
Drug Design, Development and Therapy 2026, 20:598447
Published Date: 8 May 2026
The Median Effective Dose of Phenylephrine Infusion for Prevention of Spinal-Induced Hypotension During Cesarean Delivery in the 15° Left-Tilt vs. Supine Positions: A Randomised Control Study
Yu XQ, Drzymalski DM, Qian J, Hu HJ, Xiao F, Yu L
Drug Design, Development and Therapy 2026, 20:591446
Published Date: 8 May 2026
Cannabidiol-Induced Tumor Cell Death: Molecular Mechanisms and Translational Perspectives in Cancer Therapy
Wang CY, Tan JX, Chen LL, Li QZ, Liu J, He X, Qin QZ, Deng T, Ruan GT, Gong YZ
Drug Design, Development and Therapy 2026, 20:597740
Published Date: 8 May 2026
Drug-Drug Interaction of Chiglitazar with Empagliflozin, Atorvastatin, and Valsartan: An Open-Label, Single-Center, Self-Control, 3-Period Study
Sheng L, Li X, Yu J, Yang X, Li H, Xu H
Drug Design, Development and Therapy 2026, 20:588573
Published Date: 8 May 2026
Efficacy and Safety of Oliceridine for Patient-Controlled Intravenous Analgesia in Elderly Patients Undergoing Laparoscopic Radical Resection Surgery for Gastrointestinal Malignant Tumors: A Prospective Randomized Controlled Non-Inferiority Clinical Trial
Wang J, Shang Y, Wang C, Zhang D, Li H, Yu Q, Tao L, Sun L, Gao C
Drug Design, Development and Therapy 2026, 20:593111
Published Date: 8 May 2026
Formulation Progress, Challenges, and Perspectives of Anti-Inflammatory Natural Products
Fang H, Wu A, Zhao M, Nan X, Yang L, Liu H
Drug Design, Development and Therapy 2026, 20:606531
Published Date: 7 May 2026
Remimazolam versus Sevoflurane for Paediatric Circumcision: A Randomised Controlled Trial Evaluating Emergence Delirium
Zhang Y, Guo S, Wang L, Zeng Q, Cui H, Mo Y
Drug Design, Development and Therapy 2026, 20:602836
Published Date: 7 May 2026
The Satisfactory Analgesia and Minimal Emesis of Elderly Patients After Thoracoscopic Lung Surgery: Oliceridine versus Sufentanil in a Randomized Controlled Trial
Cai Y, Jiang Y, Zhang Q, Yang J, Wang Z, Sun H
Drug Design, Development and Therapy 2026, 20:593306
Published Date: 7 May 2026
An Interpretable PK-Informed Hybrid Model for Voriconazole Exposure Prediction: Roles of CYP2C19 Genotype and Inflammation
Zhou Y, Yun Y, Chen S, Liu X, Liu H, Ren J, Lu M, Ling J, Yang X, Zhou Z, Osei JA, Soheili R, Zou J, Hu N
Drug Design, Development and Therapy 2026, 20:489712
Published Date: 7 May 2026
The Effect of Intraoperative Infusion of Different Doses of Esketamine on the Quality of Recovery in Elderly Patients Undergoing Knee Arthroplasty
Fang C, Hu Z, Lv G, Fan X, Zhang X, Li W, Tian T, Yuan Y, Wang J, Chen X
Drug Design, Development and Therapy 2026, 20:590805
Published Date: 6 May 2026
Effects of Oliceridine versus Sufentanil on Postoperative Nausea and Vomiting in Patients Undergoing Modified Radical Mastectomy: A Double-Blind Randomized Controlled Trial
Lu L, Zhou Y, Xu K, Zhao Z, Ge L, Wang Y, Wang C, Bao R
Drug Design, Development and Therapy 2026, 20:602305
Published Date: 6 May 2026
Advances in PARP Inhibition in Improving Outcomes of Breast Cancer, Ovarian Cancer, and Other Solid Tumors: Journey of Discovery, Development, and Clinical Updates of Talazoparib
Latif M, Mazhar S, Tasleem M, Alqurashi A, Arfan M, Ashraf Z, Zafar MS
Drug Design, Development and Therapy 2026, 20:575152
Published Date: 6 May 2026
Effect of Rho Kinase Inhibitor RKI-1447 on Dexamethasone-Induced Ocular Hypertension and Its Molecular Mechanisms in Sprague-Dawley Rats
Wu J, Dang Y, Lei F
Drug Design, Development and Therapy 2026, 20:605489
Published Date: 6 May 2026
Optimal Piperacillin/Tazobactam Dosing in Adults with Low Body Weight: A Population Pharmacokinetic and Simulation-Based Study
Tseng YJ, Juan L, Tai CH, Wu CC
Drug Design, Development and Therapy 2026, 20:602835
Published Date: 5 May 2026
Pathogenesis of Osteoarthritis: Mechanisms of Action of Disulfidptosis and Targeted Therapeutic Strategies
Liang Y, Wang K, Yang C, Huang J, Huang Z, Chen Y
Drug Design, Development and Therapy 2026, 20:606941
Published Date: 5 May 2026
Integrating Therapeutic Drug Monitoring and Metabolomics to Explore Interindividual Variability in Lamotrigine Response in Epilepsy
Shen X, Jin R, Xu N, Miao Y, Zheng Z, Wang J, You M, Lin F, Hu L
Drug Design, Development and Therapy 2026, 20:593268
Published Date: 5 May 2026
Identification of a Quinolone-Based Scaffold as a Dual SARS-COV-2 PLᵖʳᵒ and Mᵖʳᵒ Inhibitor: An Integrated Molecular Modeling and In-vitro Evaluation Approach
Atatreh N, Bustanji L, Ferreira JC, Rabeh WM, Mahgoub RE, Ghattas MA
Drug Design, Development and Therapy 2026, 20:593126
Published Date: 4 May 2026
Preserving Airway Reflexes During Awake Intubation: A Cautionary Note on Deep Sedation Protocols [Letter]
Yuksek A, Yılmaz M
Drug Design, Development and Therapy 2026, 20:615555
Published Date: 4 May 2026
The Effects of Remimazolam Tosylate on Postoperative Memory Function in Young and Middle-Aged Patients Undergoing Laparoscopic Surgery [Corrigendum]
Liu J, Li M, Zhao K, Wang H, Wu P, Yin T, He K, Yang X, Wang S
Drug Design, Development and Therapy 2026, 20:620897
Published Date: 4 May 2026
Effect of Different Doses of Esketamine on the Propofol Effect-Site Concentration Required to Suppress Cervical Dilation-Associated Movement During Hysteroscopy: A Prospective, Randomised, Controlled, Parallel-Group Dose-Response Trial
Shen Y, Yin L, Xu S, Hu B, Zhang L
Drug Design, Development and Therapy 2026, 20:602098
Published Date: 4 May 2026
Rotenone Inhibited Osteosarcoma Cell Growth Through USP47-Induced Decreases in FEN1 Stability and DNA Integrity
Li Z, Ma X, Ma H, Chen B, Jiang K, Zhu Z, Wang J, Wang B, Wang Y, Dong S
Drug Design, Development and Therapy 2026, 20:590613
Published Date: 4 May 2026
The Regulatory Landscape of Ferroptosis and Iron Homeostasis: Pathophysiological Mechanisms and Therapeutic Horizons in Cardiovascular Disease
Zhang T, Xiao S, Xia Y, Chen K, Liu H, Zhang P, Luo L
Drug Design, Development and Therapy 2026, 20:581236
Published Date: 1 May 2026
Pharmacokinetic Drug–Drug Interactions of DA-8010 with Clarithromycin or Rifampicin: Influence of CYP2D6 Phenotype on the Extent of These Interactions
Lee S, Won H, Yu KS, Lee DY, Lee S
Drug Design, Development and Therapy 2026, 20:592783
Published Date: 1 May 2026
Minimum Effective Volume of 0.25% Ropivacaine for Ultrasound-Guided Superior Trunk Block with Dexmedetomidine Sedation in Shoulder Arthroscopy: A Biased Coin Up-and-Down Trial
Wang K, Zhang S, Lv Z, Chen W, Li Y
Drug Design, Development and Therapy 2026, 20:597074
Published Date: 1 May 2026
Effects of Desflurane and Propofol General Anesthesia on Postoperative Recovery Quality in Elderly Patients Undergoing Spinal Surgery: A Randomized Non-Inferiority Trial
Shi D, Liang X, Xi C, Pei C, Wang G
Drug Design, Development and Therapy 2026, 20:601299
Published Date: 30 April 2026
Quantum Computing and Quantum Technologies in Drug Discovery and Therapeutics: Evidence, Benchmarking, and Translational Integration
Niazi SK
Drug Design, Development and Therapy 2026, 20:590730
Published Date: 30 April 2026
The Impact of Sex on the Median Effective Dose of Dexmedetomidine for Preoperative Sedation in Adults Undergoing Upper Limb Surgery: An Up-and-Down Sequential Allocation Study
Fan G, Han M, Wang S, Zhang M, Kang F, Li J
Drug Design, Development and Therapy 2026, 20:576010
Published Date: 29 April 2026
Linoleic Acid Reduces Paclitaxel Chemosensitivity in Colorectal Cancer
Zhou B, Pan J, Wang M, Zhou P, Li Z, Cui J, Huang C, Wang L, Fan Z
Drug Design, Development and Therapy 2026, 20:577058
Published Date: 28 April 2026
Fibroblast Growth Factor 21: Mechanisms, Therapeutic Potential, and Clinical Translation in Metabolic Dysfunction
Rama K, Jahagirdar V, Sanyal AJ
Drug Design, Development and Therapy 2026, 20:560034
Published Date: 28 April 2026
Cuproptosis in Sepsis: Cell Type-Specific Mechanisms and Clinical Prospects
Fang S, Li W, Chang Z, Tang X, Niu X, Chen Y, Hu X
Drug Design, Development and Therapy 2026, 20:600729
Published Date: 28 April 2026
Association of Dexmedetomidine Exposure with Long-Term Mortality in Patients with Dialysis-Requiring Acute Kidney Injury: A Propensity Score–Matched Retrospective Cohort Study
Hung KC, Chang LC, Chang YJ, Lai YC, Lin CM, Chen IW
Drug Design, Development and Therapy 2026, 20:598443
Published Date: 27 April 2026
Vasopressor Regimens and Maternal Core Temperature During Cesarean Delivery: A Randomized, Double‑blind, Non‑inferiority Trial
Tao W, Bao J, Cao H, Dong Y, Fang Q, Jiang M, Wu Y, Song J, Xie Y, Wang X, He W, Zhang Y, Hu X
Drug Design, Development and Therapy 2026, 20:598964
Published Date: 27 April 2026
Comparison of the Effect of Different Administration Sequence of Propofol and Remifentanil on Sedation/Anesthesia During Gastroscopy in Obese Patients
Tang J, Zhong Z, Jiang H, Li J, Liu J, Duan S, Liang S, Wu Z, Wang M, Hu D
Drug Design, Development and Therapy 2026, 20:594697
Published Date: 25 April 2026
Beyond Symptom Suppression: The Multitargeted Reversal of Chronic Pain by Maresin1
Wang F, Yang Y, Wang W, Shi Q, Fan B
Drug Design, Development and Therapy 2026, 20:585597
Published Date: 25 April 2026
Atorvastatin Attenuates Vancomycin-Induced Nephrotoxicity via PPARα-Associated Regulation of SLC Transporters
Lin K, Li T, Kong X, Li T, Zuo Y, Dong D, Yang S, Zhu Y
Drug Design, Development and Therapy 2026, 20:571916
Published Date: 24 April 2026
Perioperative Flurbiprofen Axetil Administration and Acute Kidney Injury After Non-Cardiac Surgery: A Retrospective Cohort Study
Wang S, Zhong YQ, Zhao BC, Hou XM, Yin BY, Liu KX, Liu HM
Drug Design, Development and Therapy 2026, 20:597928
Published Date: 23 April 2026
Biomarker Variants of Dopamine Receptor Genes Influence the Binding Interaction Between Dopamine Receptor and Risperidone
Almandil NB, AbdulAzeez S, Gomaa MS, Ibrahim AM, John SJ, Prathas S, Dhas TS, Borgio JF
Drug Design, Development and Therapy 2026, 20:587705
Published Date: 23 April 2026
Cellular and Molecular Mechanisms of Hyperglycemia-Induced Atherosclerosis and Intervention Strategies of Chinese Herbal Medicine
Luo S, Zhu J, Zeng Q, Yang L, Liu J, Deng Y
Drug Design, Development and Therapy 2026, 20:602453
Published Date: 23 April 2026
Structure-Based Discovery of Glyoxalase-I Inhibitors: Evaluating the Role of Active Site Water Molecules
Anaam R, Isawi IH, Al-Balas Q
Drug Design, Development and Therapy 2026, 20:575242
Published Date: 23 April 2026