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Drug Design, Development and Therapy
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Archive: Volume 18, 2024
- default (430)
- Advances in design and development of ophthalmic drugs (9)
- Beyond Brain Boundaries: Overcoming the Blood-Brain Barrier to Reach the Central Nervous System (1)
- Using Innovative Drug Delivery Systems to Improve the Efficacy and Applicability of Poorly Water-soluble Drugs (4)
- Advances in p53 Drug Discovery (4)
EC50 and EC95 of Remifentanil for Inhibiting Bronchoscopy Responses in Elderly Patients During Fiberoptic Bronchoscopy Under Ciprofol Sedation: An Up-and-Down Sequential Allocation Trial
Lan H, Liu S, Liao Y, Xu B, Lin Y, Wu X, Chen Q, Chen H, Guan X
Drug Design, Development and Therapy 2024, 18:6487-6497
Published Date: 31 December 2024
Traditional Uses, Phytochemistry, Pharmacology and Toxicology of Ruta graveolens L.: A Critical Review and Future Perspectives
Luo P, Feng X, Liu S, Jiang Y
Drug Design, Development and Therapy 2024, 18:6459-6485
Published Date: 30 December 2024
Comparison of Remimazolam-Flumazenil and Propofol on Psychomotor Function and Emergence Following General Anesthesia in Surgical Abortion: A Randomized Controlled Trial
Gu J, Liu Y, Lin X, Fu L, Liu J, Sun B, Li X, Lu B
Drug Design, Development and Therapy 2024, 18:6447-6457
Published Date: 30 December 2024
Baolier Capsule’s Secret Weapon: Piperine Boosts Cholesterol Excretion to Combat Atherosclerosis
Wei M, LYu P, Li P, Hu J, Wu R, Ouyang Q, Guo K
Drug Design, Development and Therapy 2024, 18:6427-6446
Published Date: 28 December 2024
Garlic-Derived Quorum Sensing Inhibitors: A Novel Strategy Against Fungal Resistance
Li N, Zhang J, Yu F, Ye F, Tan W, Hao L, Li S, Deng J, Hu X
Drug Design, Development and Therapy 2024, 18:6413-6426
Published Date: 28 December 2024
Qingre Huoxue Decoction Alleviates Atherosclerosis by Regulating Macrophage Polarization Through Exosomal miR-26a-5p
He W, Zhao H, Xue W, Luo Y, Yan M, Li J, Qing L, Wu W, Jin Z
Drug Design, Development and Therapy 2024, 18:6389-6411
Published Date: 28 December 2024
Dosing Regimen Recommendations for Sirolimus in Adult Liver Transplant Recipients: Insights from a Population Pharmacokinetic Model
Mao J, Cheng Y, Liu D, Zhang B, Li X
Drug Design, Development and Therapy 2024, 18:6379-6388
Published Date: 28 December 2024
Modified Zuo Gui Wan Ameliorates Ovariectomy-Induced Osteoporosis in Rats by Regulating the SCFA-GPR41-p38MAPK Signaling Pathway
Song C, Yan Q, Ma Y, Li P, Yang Y, Wang Y, Li W, Wan X, Li Y, Zhu R, Liu H, Zhang Z
Drug Design, Development and Therapy 2024, 18:6359-6377
Published Date: 27 December 2024
External Validation of the Population Pharmacokinetic Models of Amisulpride and Remedial Strategies for Delayed or Missed Doses
Yan D, Ju G, Liu X, Shao Q, Zhang Y, Wang N, Yan K
Drug Design, Development and Therapy 2024, 18:6345-6358
Published Date: 27 December 2024
CXCR2 Activated JAK3/STAT3 Signaling Pathway Exacerbating Hepatotoxicity Associated with Tacrolimus
Chen X, Hu K, Zhang Y, He SM, Wang DD
Drug Design, Development and Therapy 2024, 18:6331-6344
Published Date: 28 December 2024
Tomatidine Alleviates Intervertebral Disc Degeneration by Activating the Nrf2/HO-1/GPX4 Signaling Pathway
Li Z, Cheng P, Xi H, Jiang T, Zheng X, Qiu J, Gong Y, Wu X, Mi S, Hong Y, Hong Z, Zhou W
Drug Design, Development and Therapy 2024, 18:6313-6329
Published Date: 27 December 2024
Comprehensive Assessment of PCSK9 Inhibitors for Lipid Management: Scientific Guidance Based on Drug Selection Recommendations for Chinese Medical Institutions
Li J, Huang S, Hu X, Chen J
Drug Design, Development and Therapy 2024, 18:6297-6312
Published Date: 27 December 2024
RETRACTED ARTICLE: Oxyresveratrol Alleviates Irinotecan-Induced Diarrhea and Enhances Antitumor Effects in Colorectal Cancer
Yang X, Yu H, Zhou L
Drug Design, Development and Therapy 2024, 18:6283-6295
Published Date: 27 December 2024
Unveiling the Mechanisms and Therapeutic Effects of Xiaoyao Sanjie Decoction in Triple-Negative Breast Cancer: A Network Pharmacology and Experimental Validation Approach
Qi Y, Xu B, He J, Jiang B, Yan L, Zhou H, Chen S
Drug Design, Development and Therapy 2024, 18:6263-6281
Published Date: 27 December 2024
Using Network Pharmacology and in vivo Experiments to Uncover the Mechanisms of Radix Paeoniae Rubra and Radix Angelicae Sinensis Granules in Treating Diabetes Mellitus-Induced Erectile Dysfunction
Wang J, Guo Y, Huang J, Yan J, Ma J
Drug Design, Development and Therapy 2024, 18:6243-6262
Published Date: 25 December 2024
Network Pharmacology and Metabolomics Reveal Anti-Ferroptotic Effects of Curcumin in Acute Kidney Injury
Liu X, Zhou Y, Lu Z, Yang F, Wang Y, Zhang S, Zhang J, Zou H, Lin M
Drug Design, Development and Therapy 2024, 18:6223-6241
Published Date: 21 December 2024
The Efficacy of Chaihu-Guizhi-Ganjiang Decoction on Chronic Non-Atrophic Gastritis with Gallbladder Heat and Spleen Cold Syndrome and Its Metabolomic Analysis: An Observational Controlled Before-After Clinical Trial [Response to Letter]
Wen T, Liu X, Pang T, Li M, Jiao G, Fan X, Tang J, Zhang C, Wang Z, Yue X, Chen W, Zhang F
Drug Design, Development and Therapy 2024, 18:6221-6222
Published Date: 21 December 2024
Effect of Position-Based Dosing Strategy for Metaraminol on Neonatal Acid–Base Status During Elective Caesarean Delivery: A Noninferiority Randomised Controlled Trial
Liu T, Jiang H, Xu C, Li L, Zhang H, Feng Y
Drug Design, Development and Therapy 2024, 18:6209-6219
Published Date: 20 December 2024
A Novel Quaternary Ammonium N-Propylamiodarone Bromide Provides Long-Lasting Analgesia Against Corneal Pain
Kotoda Y, Hishiyama S, Shim J, Kobayashi H, Takamino A, Abe M, Kashiwagi K, Matsukawa T, Kotoda M
Drug Design, Development and Therapy 2024, 18:6199-6208
Published Date: 20 December 2024
Factors Affecting Vancomycin Trough Concentration; a Population Pharmacokinetic Model in Non-Critical Care Saudi Patients
Alqurain AA, Alrashidi LN, Aloraifej SK, Alkhalifah M, Alsayed HA, Abohelaika S, Alshabeeb MA, Aldhafeeri AS, Almuslim M, Bumozah TN, Alomar MJ, Alshehab AA, Alamer AA, Al-Matouq J, Bidasee KR, Alomar FA
Drug Design, Development and Therapy 2024, 18:6185-6198
Published Date: 21 December 2024
Cubosomes as Delivery System to Repositioning Nitrofurantoin in Breast Cancer Management
Louis D, Rizkalla CMZ, Rashad A
Drug Design, Development and Therapy 2024, 18:6173-6184
Published Date: 19 December 2024
The Effect of Intravenous Lidocaine on EC50 of Remifentanil for Preventing Cough During Emergence in Female for Thyroid Surgery Anesthesia
Lin ZL, Liu L, Shi K, Chen TJ, Chen LM, Cai HD
Drug Design, Development and Therapy 2024, 18:6165-6172
Published Date: 20 December 2024
Pyroptosis the Emerging Link Between Gut Microbiota and Multiple Sclerosis
Fan H, Shen R, Yan J, Bai Y, Fu Q, Shi X, Du G, Wang D
Drug Design, Development and Therapy 2024, 18:6145-6164
Published Date: 19 December 2024
Intrathecal Morphine and Ropivacaine for Quality of Recovery After Laparoscopic Colorectal Surgery: A Randomized Controlled Trial
Yang Y, Lin W, Zhuo Y, Luo Y, Wu X, Li J, Yao Y
Drug Design, Development and Therapy 2024, 18:6133-6143
Published Date: 18 December 2024
Ciprofol Ameliorates Myocardial Ischemia/Reperfusion Injury by Inhibiting Ferroptosis Through Upregulating HIF-1α
Ding J, Wang BY, Yang YF, Kuai LY, Wan JJ, Zhang M, Xia HY, Wang Y, Zheng Z, Meng XW, Peng K, Ji FH
Drug Design, Development and Therapy 2024, 18:6115-6132
Published Date: 18 December 2024
Research Progress on the Anti-Liver Cancer Mechanism and Toxicity of Rhubarb Anthraquinone
Yu L, Qin J, Zhang M, Gao Y, Zhao Y
Drug Design, Development and Therapy 2024, 18:6089-6113
Published Date: 18 December 2024
RETRACTED ARTICLE: Panax notoginseng Saponins Improve Angiogenesis in Coronary Heart Disease Based on the microRNA 200a Methylation Pathway
Wang J, Dong Y, Li Z, Zhang Y, Liu L, Yang G, Liu Y, Li J, Duan L
Drug Design, Development and Therapy 2024, 18:6075-6087
Published Date: 18 December 2024
Intranasal Dexmedetomidine for the Management of Preoperative Anxiety-Related Insomnia: A Randomized, Three-Blinded, Clinical Trial Compared with Lorazepam and Placebo
Yang WY, Huang K, Lin ZJ, Zeng W, Liu X, Liu HB, Zhong ML, Wei J, Liang WD, Wang LF, Chen L
Drug Design, Development and Therapy 2024, 18:6061-6073
Published Date: 17 December 2024
Pharmacological Mechanisms of Cryptotanshinone: Recent Advances in Cardiovascular, Cancer, and Neurological Disease Applications
Zheng Z, Ke L, Ye S, Shi P, Yao H
Drug Design, Development and Therapy 2024, 18:6031-6060
Published Date: 15 December 2024
Progress and Frontiers of Research on Dexmedetomidine in Perioperative Medicine: A Bibliometric Analysis
Zheng T, Pei Z, Huang X
Drug Design, Development and Therapy 2024, 18:6017-6029
Published Date: 12 December 2024
Chaihu-Shugan-San Ameliorated Osteoporosis of Mice with Depressive Behavior Caused by Chronic Unpredictable Mild Stress via Repressing Neuroinflammation and HPA Activity
He MC, Xia SH, Pan H, Zhou TT, Wang XL, Li JM, Li XM, Zhang Y
Drug Design, Development and Therapy 2024, 18:5997-6015
Published Date: 12 December 2024
Profile of Ofatumumab in the Treatment of Multiple Sclerosis: Design, Development and Place in Therapy
Awada Z, Hameed N, Harel A
Drug Design, Development and Therapy 2024, 18:5985-5996
Published Date: 12 December 2024
Recent Developments in Drug Design of Oral Synthetic Free Fatty Acid Receptor 1 Agonists
Liu L, Zhang Q, Ma Y, Lin L, Liu W, Ding A, Wang C, Zhou S, Cai J, Tang H
Drug Design, Development and Therapy 2024, 18:5961-5983
Published Date: 11 December 2024
Determination of Nemonoxacin in Small Volumes of Rat Plasma and Bile by a Novel HPLC-Fluorescence Assay and Its Application to Disposition and Biliary Excretion Kinetics
Wu RL, Wang WC, Cheng CL, Tsai CY, Chou CH
Drug Design, Development and Therapy 2024, 18:5947-5960
Published Date: 11 December 2024
Portulaca Oleracea L. as a Potential Therapeutic Drug Intervention in Ulcerative Colitis: Mechanisms of Action and Clinical Studies
Liu XY, Liu ZX, Tan WW, Zhang WB, Zhang YL, Zheng L, Que RY, Wen HZ, Dai YC
Drug Design, Development and Therapy 2024, 18:5931-5946
Published Date: 11 December 2024
Zuojin Pill Alleviates Precancerous Lesions of Gastric Cancer by Modulating the MEK/ERK/c-Myc Pathway: An Integrated Approach of Network Pharmacology, Molecular Dynamics Simulation, and Experimental Validation
Liang L, He C, Han X, Liu J, Yang L, Chang F, Zhang Y, Lin J
Drug Design, Development and Therapy 2024, 18:5905-5929
Published Date: 11 December 2024
Effect of Remimazolam vs Midazolam on Early Postoperative Cognitive Recovery in Elderly Patients Undergoing Dental Extraction: A Prospective Randomized Controlled Study
Liu B, Wang P, Liang L, Zhu W, Zhang H
Drug Design, Development and Therapy 2024, 18:5895-5904
Published Date: 9 December 2024
Intraoperative Use of Sodium Bicarbonate Ringer’s Solution Instead of Sodium Lactate Ringer’s Solution to Reduce Endothelial Glycocalyx Degradation and Improve Postoperative Recovery During Cardiopulmonary Bypass Cardiac Surgery: A Single-Center Prospective Cohort Study
Shi Y, Shi Y, Tao Y, Xu B, Wang X, Xie Y, Zhang M
Drug Design, Development and Therapy 2024, 18:5881-5893
Published Date: 10 December 2024
Effect of Intravenous Lidocaine Infusion on Propofol Dose and Perioperative Pain During Moderate Sedation-Analgesia for Hysteroscopy: A Randomized Controlled Trial
Yang F, Wang J, Zhang H, Zhang Y, Yang W, Gao R, Yu J, Chen X, Ma H
Drug Design, Development and Therapy 2024, 18:5873-5880
Published Date: 7 December 2024
Preoperative Anxiety’s Impact on the Median Effective Dose of Esketamine for Alleviating Propofol Injection Pain in Patients Undergoing Painless abortion: A Randomized, Double-Blind, Controlled Trial
Shen Y, Yin L, Hu B, Xia Y, Zhang L
Drug Design, Development and Therapy 2024, 18:5863-5872
Published Date: 7 December 2024
Safety, Tolerability and Pharmacokinetics of Intravenous Sodium Taurodeoxycholate, HY209, a GPCR19 Agonist Inhibiting Inflammasomal Activation
Chung WK, Jeon I, Jang IJ, Seong SY, Han SA, Yu KS
Drug Design, Development and Therapy 2024, 18:5853-5861
Published Date: 8 December 2024
Magnetic-Powered Spora Lygodii Microrobots Loaded with Doxorubicin for Active and Targeted Therapy of Bladder Cancer
Yang Q, Yuan W, Zhao T, Jiao Y, Tang M, Cong Z, Wu S
Drug Design, Development and Therapy 2024, 18:5841-5851
Published Date: 7 December 2024
Clinical Utility of Various Formulations of Calcipotriene and Betamethasone Dipropionate for the Treatment of Plaque Psoriasis in Patients Aged 12 Years or Older
Kędra K, Reich A
Drug Design, Development and Therapy 2024, 18:5827-5839
Published Date: 8 December 2024
The Latest Progress in the Application of Telitacicept in Autoimmune Diseases
Liu B, Zhao Y, Liu D, Li X, Ma Z, Yang Q
Drug Design, Development and Therapy 2024, 18:5811-5825
Published Date: 7 December 2024
OmpH is Involved in the Decrease of Acinetobacter baumannii Biofilm by the Antimicrobial Peptide Cec4
Qiu Z, Ran J, Yang Y, Wang Y, Zeng Y, Jiang Y, Hu Z, Zeng Z, Peng J
Drug Design, Development and Therapy 2024, 18:5795-5810
Published Date: 7 December 2024
Potential Cardiovascular Risks Associated with Naltrexone-Bupropion Treatment in Overweight Patients [Letter]
Wu L, Hu J, Yao P
Drug Design, Development and Therapy 2024, 18:5793-5794
Published Date: 7 December 2024
Prescribing Trends of Fixed-Dose Combination Antibiotics Not Recommended by the WHO (FNRs) for ICU Patients in Six Major Areas of China During a Seven-Year Period
Zhou L, Zhao Y, Zhu J, Liu J, Liang G, Yang Y, Han G, Yu Z
Drug Design, Development and Therapy 2024, 18:5781-5791
Published Date: 6 December 2024
Effect of Pretreatment with a Small Dose of Esketamine on Myoclonus Induced by Etomidate: A Randomized Controlled Trial
Gao L, Lu X, Tan A, Liufu J, Xu Y, Wei L
Drug Design, Development and Therapy 2024, 18:5773-5779
Published Date: 7 December 2024
From the Formation of Conceptual Framework to Regulatory Decision-Making: Considerations for the Developments of Patient-Reported Outcome Instruments
Cao K, Quan XY, Hou Y
Drug Design, Development and Therapy 2024, 18:5759-5771
Published Date: 6 December 2024
Bibliometric Analysis of Curcumin Based on CiteSpace: Landscapes, Hotspots, and Frontiers
Lai Y, Jiang J, Zhang H, Gong K
Drug Design, Development and Therapy 2024, 18:5743-5758
Published Date: 6 December 2024
Safety and Effectiveness of a Biosimilar Recombinant Growth Hormone in Adults with Growth Hormone Deficiency: Analysis of Final Data from PATRO Adults, an International Post-Marketing Surveillance Study
Beck-Peccoz P, Höybye C, Simsek S, Stalla G, Murray RD, Esmael A, Urosevic D, Boldea A, Zabransky M
Drug Design, Development and Therapy 2024, 18:5729-5741
Published Date: 5 December 2024
Quercetin: A Flavonoid with Potential for Treating Acute Lung Injury
Huang M, Liu X, Ren Y, Huang Q, Shi Y, Yuan P, Chen M
Drug Design, Development and Therapy 2024, 18:5709-5728
Published Date: 6 December 2024
Comparison of the Effects of Ciprofol and Propofol on Postoperative Nausea and Vomiting in Patients Undergoing Outpatient Hysteroscopy
Zhang H, Zhang M, Hao L, Li Q, Li Q, Yang J, Xie Y
Drug Design, Development and Therapy 2024, 18:5701-5707
Published Date: 5 December 2024
Effects of Oltipraz on the Glycolipid Metabolism and the Nrf2/HO-1 Pathway in Type 2 Diabetic Mice
Luo Y, Sun S, Zhang Y, Liu S, Zeng H, Li JE, Huang J, Fang L, Yang S, Yu P, Liu J
Drug Design, Development and Therapy 2024, 18:5685-5700
Published Date: 5 December 2024
Adagrasib in the Treatment of KRAS p.G12C Positive Advanced NSCLC: Design, Development and Place in Therapy
Warnecke B, Nagasaka M
Drug Design, Development and Therapy 2024, 18:5673-5683
Published Date: 5 December 2024
Geraniol Ameliorates Pentylenetetrazol-Induced Epilepsy, Neuroinflammation, and Oxidative Stress via Modulating the GABAergic Tract: In vitro and in vivo studies
Younis NS, Almostafa MM, Mohamed ME
Drug Design, Development and Therapy 2024, 18:5655-5672
Published Date: 5 December 2024
Integrating Metabolomics, Histopathology, and Cardiac Marker Analysis to Assess Valsartan’s Efficacy in Mitigating Dasatinib-Induced Cardiac Toxicity in Sprague-Dawley Rats
Alhazzani K, Mohammed H, Algahtani MM, Aljerian K, Alhoshani A, As Sobeai HM, Ahamad SR, Alotaibi MR, Alhamed AS, Alasmari F, Alqinyah M, Alhamami HN, Alanazi AZ
Drug Design, Development and Therapy 2024, 18:5641-5654
Published Date: 5 December 2024
Exploring the Mechanisms, Biomarkers, and Therapeutic Targets of TRIM Family in Gastrointestinal Cancer
Weng C, Jin R, Jin X, Yang Z, He C, Zhang Q, Xu J, Lv B
Drug Design, Development and Therapy 2024, 18:5615-5639
Published Date: 5 December 2024
Identification of Coumarin-Chalcone and Coumarin-Pyrazoline Derivatives as Novel Anti-Toxoplasma gondii Agents
Ebaid MS, Chyb M, Furlan V, Ibrahim HAA, Bren U, Gatkowska J, Dziadek J, Eldehna WM, Sabt A
Drug Design, Development and Therapy 2024, 18:5599-5614
Published Date: 4 December 2024
Levistolide a Attenuates Acute Kidney Injury in Mice by Inhibiting the TLR-4/NF-κB Pathway
Shi J, Li S, Yi L, Gao M, Cai J, Yang C, Ma Y, Mo Y, Wang Q
Drug Design, Development and Therapy 2024, 18:5583-5597
Published Date: 4 December 2024
The Clinical Efficacy of Gegen Qinlian Decoction in Treating Type 2 Diabetes is Positively Correlated with the Dose of Coptidis rhizoma: Three Randomized, Doubleblind, Dose-Parallel Controlled Clinical Trials
Kang X, Jin D, Ji H, An X, Zhang Y, Duan L, Yang C, Zhou R, Duan Y, Zhang Y, Sun Y, Jiang L, Lian F, Tong X
Drug Design, Development and Therapy 2024, 18:5573-5582
Published Date: 3 December 2024
Optimal Programmed Intermittent Epidural Bolus Interval Timing When Using 10 mL of 0.1% Ropivacaine and 0.5 mcg/mL Sufentanil for Labor Analgesia in Patients Without Breakthrough Pain: A Prospective, Randomized Study
Xu DC, Ying J, Zhao J, Chen XD, Deng GP, Zhao YP, Xiao F
Drug Design, Development and Therapy 2024, 18:5563-5571
Published Date: 3 December 2024
Exploring the Effect and Mechanism of DaYuan Yin Against Acute Lung Injury by Network Pharmacology, Molecular Docking, and Experimental Validation
Zhang L, Zhu W, Zhang C
Drug Design, Development and Therapy 2024, 18:5541-5561
Published Date: 3 December 2024
Evaluation of Olaparib Tablet Safety and Pharmacokinetics in Healthy Chinese Male Subjects
Dong R, Chen J, Guo N, Yang Y, Wu J, Wang X, Song Y, Zhang X
Drug Design, Development and Therapy 2024, 18:5529-5539
Published Date: 3 December 2024
Population Pharmacokinetics and Dosing Regimen Analysis of Nirmatrelvir in Chinese Patients with COVID-19 Infection
Zhang R, Fan J, Han L, Mao J, Sun L, Yu Y, Fan W, Xie J, Lin B, Lin N
Drug Design, Development and Therapy 2024, 18:5517-5527
Published Date: 2 December 2024
Semaglutide Reduces Cardiomyocyte Damage Caused by High-Fat Through HSDL2
Yang L, Pan X, Pan Z, Gao H, Ban J, Chen S
Drug Design, Development and Therapy 2024, 18:5501-5515
Published Date: 30 November 2024
Cardiometabolic Modulation by Semaglutide Contributes to Cardioprotection in Rats with Myocardial Infarction
Yan H, Yao W, Li Y, Li T, Song K, Yan P, Dang Y
Drug Design, Development and Therapy 2024, 18:5485-5500
Published Date: 30 November 2024
Effect of Ropivacaine in Combined Costoclavicular Brachial Plexus - Cervical Plexus Blocks on Hemidiaphragmatic Paralysis for Humeral Fracture Surgery: A Prospective Single - Centre Cohort Study
Zhu M, Yuan L, Mei Z, Sheng Z, Ge Y, Zhang L, Liu G
Drug Design, Development and Therapy 2024, 18:5473-5483
Published Date: 28 November 2024
Effects of Esketamine Combined with Dexmedetomidine on Early Postoperative Cognitive Function in Elderly Patients Undergoing Lumbar Spinal Surgery: A Double-Blind Randomized Controlled Clinical Trial
Tao QY, Liu D, Wang SJ, Wang X, Ouyang RN, Niu JY, Ning R, Yu JM
Drug Design, Development and Therapy 2024, 18:5461-5472
Published Date: 27 November 2024
The Therapeutic Potential of Pristimerin in Osteoarthritis: Mechanistic Insights from in vitro and in vivo Studies
Yin L, Fan Y, Zhong X, Meng X, He Z, Hong Z, Chen J, Zhang Q, Kong M, Wang J, Tong Y, Bi Q
Drug Design, Development and Therapy 2024, 18:5445-5459
Published Date: 27 November 2024
16S rRNA Gene Sequencing Combined with Metabolomics to Explore Intestinal Flora and Metabolic Changes in Young Febrile Rats and the Mechanism of Xiangqin Jiere Granules
He X, Pan M, Wu X, Li H, Xi Y, Zhang L, Zhang Y, Tian Y, Wang R, Xiong L
Drug Design, Development and Therapy 2024, 18:5423-5444
Published Date: 27 November 2024
Effect of Low-Dose Esketamine on Postoperative Delirium in Elderly Patients Undergoing Total Hip or Knee Arthroplasty: A Randomized Controlled Trial
Ma CB, Zhang CY, Gou CL, Liang ZH, Zhang JX, Xing F, Yuan JJ, Wei X, Zhang YB, Wang ZY
Drug Design, Development and Therapy 2024, 18:5409-5421
Published Date: 26 November 2024
A Comparative Study of Esketamine-Propofol and Sufentanil-Propofol for Analgesia and Sedation During Breast Minimally Invasive Rotary Resection with Local Anesthesia: A Randomized Double-Blind Clinical Trial
Li N, Qi X, Bao J, Gu Y, Zhou X, Wang T, Jiang N, Wang Y, Ye Q
Drug Design, Development and Therapy 2024, 18:5397-5407
Published Date: 25 November 2024
Alkannin Induces G2/M-Phase Arrest, Apoptosis, and Inhibition of Invasion by Targeting GSK3β in Esophageal Squamous Cell Carcinoma
Ma H, Xu P, Jia Y, Zhou Y, Li X, Wang Y, Ma K
Drug Design, Development and Therapy 2024, 18:5377-5395
Published Date: 25 November 2024
Effects of Dexamethasone Intravitreal Implant on Multifocal Electroretinography in Diabetic Macular Oedema
Tranos P, Koukoula S, de Politis PB, Tranou M, Giamouridou O, Stavrakas P, Panos GD
Drug Design, Development and Therapy 2024, 18:5367-5375
Published Date: 25 November 2024
Dexmedetomidine Attenuated Neuron Death, Cognitive Decline, and Anxiety-Like Behavior by Inhibiting CXCL2 in CA1 Region of AD Mice
Ma K, An C, Li M, Zhang Y, Ren M, Wei Y, Xu W, Wang R, Bai Y, Zhang H, Liu X, Ji S, Chen X, Zhu K
Drug Design, Development and Therapy 2024, 18:5351-5365
Published Date: 23 November 2024
Exploiting the Zebrafish Model for Sepsis Research: Insights into Pathophysiology and Therapeutic Potentials
He J, Xu P, Chen R, Chen M, Wang B, Xie Y, Yang Q, Sun D, Ji M
Drug Design, Development and Therapy 2024, 18:5333-5349
Published Date: 22 November 2024
Bioactivities and Anti-Cancer Activities of NKT-Stimulatory Phenyl-Glycolipid Formulated with a PEGylated Lipid Nanocarrier
Hung JT, Chiou SP, Tang YH, Huang JR, Lo FY, Yu AL
Drug Design, Development and Therapy 2024, 18:5323-5332
Published Date: 20 November 2024
Imperatorin Suppresses Aberrant Hedgehog Pathway and Overcomes Smoothened Antagonist Resistance via STAT3 Inhibition
Wang J, Cheng H, Zhao X, Zhang X, Ding X, Huang T
Drug Design, Development and Therapy 2024, 18:5307-5322
Published Date: 20 November 2024
Evaluating the Efficacy of Oral Ivermectin on Clinical Symptoms and Demodex Densities in Patients with Demodicosis
Paichitrojjana A, Chalermchai T
Drug Design, Development and Therapy 2024, 18:5299-5306
Published Date: 19 November 2024
Discovery of a Novel and Potent Dual-Targeting Inhibitor of ATM and HDAC2 Through Structure-Based Virtual Screening for the Treatment of Testicular Cancer
Ruan Y, Guan L, Wang Y, Geng Y, Wang X, Niu MM, Yang L, Xu C, Xu Z
Drug Design, Development and Therapy 2024, 18:5283-5297
Published Date: 20 November 2024
Aqueous Extract of Rhubarb Promotes Hepatotoxicity via Facilitating PKM2-Mediated Aerobic Glycolysis in a Rat Model of Diethylnitrosamine-Induced Liver Cancer [Letter]
Geng S, Zhu Y, Zheng Y
Drug Design, Development and Therapy 2024, 18:5281-5282
Published Date: 19 November 2024
Comparative Analysis of Hemodynamic Effects of Remimazolam and Propofol Combined with Esketamine in Colonoscopic Procedures in the Elderly
Deng BR, Zhang Y, Xie ZF, Wang DD, Zeng T, Zhang DB, Huang L, Wang QY, Shen T, Wu QL
Drug Design, Development and Therapy 2024, 18:5269-5280
Published Date: 19 November 2024
Safety and Effectiveness of Naltrexone-Bupropion in Korean Adults with Obesity: Post-Marketing Surveillance Study
Lyu YS, Ahn H, Hong S, Park CY
Drug Design, Development and Therapy 2024, 18:5255-5268
Published Date: 19 November 2024
Fenofibrate as an Adjunct Therapy for Ulcerative Colitis: Targeting Inflammation via SIRT1, NLRP3, and AMPK Pathways: A Randomized Controlled Pilot Study
Alarfaj SJ, Bahaa MM, Elmasry TA, Elberri EI, El-Khateeb E, Hamouda AO, Salahuddin MM, Kamal M, Gadallah ANAA, Eltantawy N, Yasser M, Negm WA, Hamouda MA, Alsegiani AS, Alrubia S, Eldesoqui M, Abdallah MS
Drug Design, Development and Therapy 2024, 18:5239-5253
Published Date: 16 November 2024
Comparison of Remimazolam and Propofol for Intravenous Anesthesia on Trigeminocardiac Reflex in Percutaneous Balloon Compression for Trigeminal Neuralgia: A Randomized Controlled Trial
Long D, Chen K, Li Y, He P, Li X, Qin X, Wang Y, Xiao Y
Drug Design, Development and Therapy 2024, 18:5225-5237
Published Date: 15 November 2024
Novel Agonists of Adenosine Receptors in Animal Model of Acute Myocardial Infarction
Beltrame F, Nascimento-Carlos B, da Silva JS, Maia RC, Montagnoli TL, Barreiro EJ, Zapata-Sudo G
Drug Design, Development and Therapy 2024, 18:5211-5223
Published Date: 15 November 2024
Profile of Fruquintinib in the Management of Advanced Refractory Metastatic Colorectal Cancer: Design, Development and Potential Place in Therapy
Syaj S, Saeed A
Drug Design, Development and Therapy 2024, 18:5203-5210
Published Date: 15 November 2024
Catecholamine Vasopressors and the Risk of Atrial Fibrillation After Noncardiac Surgery: A Prospective Observational Study
Li W, Liu Y, Gu X
Drug Design, Development and Therapy 2024, 18:5193-5202
Published Date: 15 November 2024
Effect of Remimazolam- Vs Propofol-Based Intravenous Anesthesia on Surgical Stress Response and Post-Operative Immune Function in Patients with Gastric Radical Surgery
Xu Q, Cheng X, Sun H, Su G, Fei Y, Wang C, Han C
Drug Design, Development and Therapy 2024, 18:5183-5192
Published Date: 13 November 2024
Protective Effect of Modified Suanmei-Tang on Metabolic-Associated Fatty Liver Disease: An Integrated Strategy of Network Pharmacology, Metabolomics, and Transcriptomics
Wang C, Zhao M, Yue Y, Hu C, Zhou C, Zhang Z, He Y, Luo Y, Shen T, Dang S, Yang Y, Zhang Y
Drug Design, Development and Therapy 2024, 18:5161-5182
Published Date: 13 November 2024
Effect-Site Concentration of Remimazolam by Age Groups During Target-Controlled Infusion for Total Intravenous Anesthesia: A Retrospective Comparative Study
Park J, Seo KH, Kwak J, Baek H
Drug Design, Development and Therapy 2024, 18:5149-5159
Published Date: 12 November 2024
Proteomic Insights into the Effects of Jianweixiaoshi Tablets on Functional Dyspepsia with Spleen Deficiency in Rats
Cheng X, Wan J, Sun D, Zhan Y, Yu J, Li Y, Xiong Y, Liu W
Drug Design, Development and Therapy 2024, 18:5129-5148
Published Date: 12 November 2024
Design, Synthesis, Pharmacological Evaluation of Quinazolin-4(3H)-Ones Bearing Urea Functionality as Potential VEGFR-2 Inhibitors
Al-Sanea MM, Hafez HM, Mohamed AA, El-Shafey HW, Elgazar AA, Tawfik SS, Ewes WA, Hussein S, Alsahli TG, Hamdi A
Drug Design, Development and Therapy 2024, 18:5109-5127
Published Date: 12 November 2024
Integrative Lipid Pseudotargeted Metabolomics and Amino Acids Targeted Metabolomics Unravel the Therapeutic Mechanism of Rhizoma Paridis Saponins on Experimental Colitis of Damp-Heat Type
Wu Q, Liu K, Hou R, Wu X, Ruan X, Wang M, Sun Z, Meng L, Dai G, Li C, Wu J, Mu G
Drug Design, Development and Therapy 2024, 18:5087-5108
Published Date: 12 November 2024
Population Pharmacokinetic/Pharmacodynamic Study of Linezolid in Hospital-Acquired Pneumonia Patients with Renal Insufficiency
Xu J, Chen X, Zhang Q, Zhuang Z, Yuan Y, Duan L, Shi L, Zhu C, Li J, Lu J, Yu Y, Tang L
Drug Design, Development and Therapy 2024, 18:5073-5086
Published Date: 8 November 2024
Programmed Intermittent Epidural Bolus vs Manual Epidural Bolus for Labor Analgesia Initiation: A Randomized Non-Inferiority Trial
Lu Y, Zhang Y, Zheng Y, Song Y, Zang Y, Liu Z, Xu Z
Drug Design, Development and Therapy 2024, 18:5063-5072
Published Date: 7 November 2024
Optimizing Pharmacological and Immunological Properties of Therapeutic Proteins Through PEGylation: Investigating Key Parameters and Their Impact
Gonçalves J, Caliceti P
Drug Design, Development and Therapy 2024, 18:5041-5062
Published Date: 7 November 2024
Profile of Trofinetide in the Treatment of Rett Syndrome: Design, Development and Potential Place in Therapy
Camillo L, Pozzi M, Bernardo P, Pisano S, Nobile M
Drug Design, Development and Therapy 2024, 18:5023-5040
Published Date: 6 November 2024
Current Status and Future Prospects of TROP-2 ADCs in Lung Cancer Treatment
Li M, Jin M, Peng H, Wang H, Shen Q, Zhang L
Drug Design, Development and Therapy 2024, 18:5005-5021
Published Date: 6 November 2024
Bispectral Index-Monitored Anesthesia Induction in Older Adults Undergoing Elective Surgery: Comparing Ciprofol and Propofol in a Prospective, Single-Center, Double-Blind, Randomized Controlled Study
Zou H, Xi F, Fu Y, Xu J, Zhang P, Li D, Luo H
Drug Design, Development and Therapy 2024, 18:4993-5003
Published Date: 5 November 2024
Protopine Exerts Neuroprotective Effects on Neonatal Hypoxic-Ischemic Brain Damage in Rats via Activation of the AMPK/PGC1α Pathway
Lu L, Pang M, Chen T, Hu Y, Chen L, Tao X, Chen S, Zhu J, Fang M, Guo X, Lin Z
Drug Design, Development and Therapy 2024, 18:4975-4992
Published Date: 5 November 2024
A Bibliometric Analysis of the WoSCC Literature on the Use of Selective Serotonin Reuptake Inhibitors as Antidepressants
Li J, Fei X, Wang S, Xu Z, Xu F, Wang J, Gao Y, Hu Y
Drug Design, Development and Therapy 2024, 18:4961-4974
Published Date: 4 November 2024
Catalpol Enhances Osteogenic Differentiation of Human Periodontal Stem Cells and Modulates Periodontal Tissue Remodeling in an Orthodontic Tooth Movement Rat Model
Hu J, Song Y, Zhang Y, Yang P, Chen S, Wu Z, Zhang J
Drug Design, Development and Therapy 2024, 18:4943-4960
Published Date: 4 November 2024
Targeting Macrophage Phenotype for Treating Heart Failure: A New Approach
Shi M, Yuan H, Li Y, Guo Z, Wei J
Drug Design, Development and Therapy 2024, 18:4927-4942
Published Date: 5 November 2024
Intraoperative Non-Opiate Anesthesia for Patients Undergoing Arthroscopic Temporomandibular Joint Surgery: A Randomized Controlled Trial
Ma H, Perez J, Bertsch J, Albanese ML, Korn EG, Mueller A, Houle T, Burris BJ, McCain J, Wang J
Drug Design, Development and Therapy 2024, 18:4915-4925
Published Date: 4 November 2024
Review of Microneedle Technology for Targeted Therapeutics in Vitiligo: Design Principles, Application Prospects
Yu Y, Li W, Li Q, Liu W, Zhang S, Zhang X, Liang J
Drug Design, Development and Therapy 2024, 18:4901-4914
Published Date: 3 November 2024
Rapid Detection of SLCO1B1 Polymorphisms Using Duplex Fluorescence Melting Curve Analysis: Implications for Personalized Drug Dosing in Clinical Settings
Yu Z, Shang Z, Huang Q, Wu H, Patil S
Drug Design, Development and Therapy 2024, 18:4889-4899
Published Date: 3 November 2024
A Rapid and Simple HPLC-MS/MS Method for the Quantitative Determination of Colistin for Therapeutic Drug Monitoring in Clinical Practice
Zhang N, Xu Y, Liang B, Zeng J, Wang R, Cai Y
Drug Design, Development and Therapy 2024, 18:4877-4887
Published Date: 1 November 2024
Integrated Metabolomics and Network Pharmacology Study on the Mechanism of Rehmanniae radix Extract for Treating Thrombosis
Du H, Zhang S, Yuan K, Yang Z, Wu M
Drug Design, Development and Therapy 2024, 18:4859-4875
Published Date: 31 October 2024
The Culprit Behind HBV-Infected Hepatocytes: NTCP
Li S, Hao L, Deng J, Zhang J, Yu F, Ye F, Li N, Hu X
Drug Design, Development and Therapy 2024, 18:4839-4858
Published Date: 28 October 2024
Ginsenoside Rb1 Alleviates DSS-Induced Ulcerative Colitis by Protecting the Intestinal Barrier Through the Signal Network of VDR, PPARγ and NF-κB
Zhou Y, Xiong X, Cheng Z, Chen Z, Wu S, Yu Y, Liu Y, Chen G, Li L
Drug Design, Development and Therapy 2024, 18:4825-4838
Published Date: 29 October 2024
Topical hADSCs-HA Gel Promotes Skin Regeneration and Angiogenesis in Pressure Ulcers by Paracrine Activating PPARβ/δ Pathway
Jin C, Zhao R, Hu W, Wu X, Zhou L, Shan L, Wu H
Drug Design, Development and Therapy 2024, 18:4799-4824
Published Date: 26 October 2024
Bu Shen Huo Xue Formula Provides Neuroprotection Against Spinal Cord Injury by Inhibiting Oxidative Stress by Activating the Nrf2 Signaling Pathway
Luo D, Hou Y, Zhan J, Hou Y, Wang Z, Li X, Sui L, Chen S, Lin D
Drug Design, Development and Therapy 2024, 18:4779-4797
Published Date: 25 October 2024
Integrating Network Pharmacology and Metabolomics to Reveal the Immunomodulatory Mechanism of Ethnomedicine Rodgersia sambucifolia Hemsl
Zhou J, Wu Y, Lu Z, Wang Y
Drug Design, Development and Therapy 2024, 18:4749-4778
Published Date: 24 October 2024
Updating the Pharmacological Effects of α-Mangostin Compound and Unraveling Its Mechanism of Action: A Computational Study Review
Suhandi C, Wilar G, Narsa AC, Mohammed AFA, El-Rayyes A, Muchtaridi M, Shamsuddin S, Safuan S, Wathoni N
Drug Design, Development and Therapy 2024, 18:4723-4748
Published Date: 24 October 2024
Nephroprotective Activity of Angelica keiskei (Miq). Koidz. on Cisplatin-Induced Rats: Reducing Serum Creatinine, Urea Nitrogen, KIM-1, and Suppressing NF-kappaB p65 and COX-2
Wahyuni I, Aulifa DL, Rosdianto AM, Levita J
Drug Design, Development and Therapy 2024, 18:4707-4721
Published Date: 24 October 2024
Apigenin Attenuates Transverse Aortic Constriction-Induced Myocardial Hypertrophy: The Key Role of miR-185-5p/SREBP2-Mediated Autophagy [Letter]
Purnamasari I, Wahyuni YS, Basir H
Drug Design, Development and Therapy 2024, 18:4705-4706
Published Date: 23 October 2024
Intranasal Dexmedetomidine-Esketamine Combination Premedication versus Monotherapy for Reducing Emergence Delirium and Postoperative Behavioral Changes in Pediatric Tonsillectomy and/or Adenoidectomy: A Randomized Controlled Trial
Liao Y, Xie S, Zhuo Y, Chen S, Luo Y, Wei Y, Yao Y
Drug Design, Development and Therapy 2024, 18:4693-4703
Published Date: 23 October 2024
Global Trends in Oliceridine (TRV130) Research from 2013 to 2024: A Bibliometrics and Knowledge Graph Analysis
Wang C, Liu L, Bai X
Drug Design, Development and Therapy 2024, 18:4681-4692
Published Date: 21 October 2024
Novel Dichloroacetophenone-Based PDHK1 Inhibitors as Potent Anticancer Agents
Wu P, Zhang Z, Zhou Y, Liu Q, Tam KY, Su Z
Drug Design, Development and Therapy 2024, 18:4661-4679
Published Date: 18 October 2024
Novel Strategies Enhancing Bioavailability and Therapeutical Potential of Silibinin for Treatment of Liver Disorders
Selc M, Macova R, Babelova A
Drug Design, Development and Therapy 2024, 18:4629-4659
Published Date: 19 October 2024
Comparing Remimazolam and Propofol for Postoperative Anesthesia Satisfaction in Outpatient Gynecological Surgery: A Randomized Clinical Trial
Wang XL, Dai LL, Li YN, Zhang JW, Qu MC, Zhou YY, Xing N
Drug Design, Development and Therapy 2024, 18:4615-4627
Published Date: 18 October 2024
Phytochemical Characterization and Synergistic Antibacterial Effects of Colebrookea Oppositifolia Essential Oil as Adjuvants to Modern Antibiotics in Combating Drug Resistance
Shang Z, Sharma V, Kumar T, Dev K, Patil S
Drug Design, Development and Therapy 2024, 18:4601-4614
Published Date: 15 October 2024
Prediction of Pharmacokinetic Drug–Drug Interactions Involving Anlotinib as a Victim by Using Physiologically Based Pharmacokinetic Modeling
Bu F, Cho YS, He Q, Wang X, Howlader S, Kim DH, Zhu M, Shin JG, Xiang X
Drug Design, Development and Therapy 2024, 18:4585-4600
Published Date: 15 October 2024
Jujuboside A Regulates Calcium Homeostasis and Structural Plasticity to Alleviate Depression-Like Behavior via Shh Signaling in Immature Neurons
Zhong Z, Liu J, Luo Y, Wu M, Qiu F, Zhao H, Liu Y, Wang Y, Long H, Zhao L, Wang Y, Han Y, Meng P
Drug Design, Development and Therapy 2024, 18:4565-4584
Published Date: 12 October 2024
A Comparative Discussion on the Selection of Cardiac Hypertrophy Models: TAC Surgery Vs Ang II Infusion [Letter]
Yang H, Wang X
Drug Design, Development and Therapy 2024, 18:4563-4564
Published Date: 11 October 2024
Addition of Dexmedetomidine to the Anesthesia Regimen Attenuates Pain and Improves Early Recovery After Esophageal Endoscopic Submucosal Dissection: A Randomized Controlled Trial
Luo X, Hou HJ, Chen PS, Chang XL, Li Y, An LX, Liu FK, Xue FS
Drug Design, Development and Therapy 2024, 18:4551-4562
Published Date: 11 October 2024
Network Pharmacology and Experimental Verification: SanQi-DanShen Treats Coronary Heart Disease by Inhibiting the PI3K/AKT Signaling Pathway
Zhao M, Feng L, Li W
Drug Design, Development and Therapy 2024, 18:4529-4550
Published Date: 9 October 2024
The Efficacy of Chaihu-Guizhi-Ganjiang Decoction on Chronic Non-Atrophic Gastritis with Gallbladder Heat and Spleen Cold Syndrome and Its Metabolomic Analysis: An Observational Controlled Before-After Clinical Trial [Letter]
Zhu Y, Geng S, Zhu F
Drug Design, Development and Therapy 2024, 18:4527-4528
Published Date: 9 October 2024
Investigation of a Radio-Iodinated Alpha-Mangostin for Targeting Estrogen Receptor Alpha (ERα) in Breast Cancer: In Silico Design, Synthesis, and Biological Evaluation
Muchtaridi M, Nurhidayah W, Fakih TM, Kannaka K, Suzuki H, Subroto T, Uehara T
Drug Design, Development and Therapy 2024, 18:4511-4526
Published Date: 9 October 2024
Aqueous Extract of Rhubarb Promotes Hepatotoxicity via Facilitating PKM2-Mediated Aerobic Glycolysis in a Rat Model of Diethylnitrosamine-Induced Liver Cancer
Zhao A, Liu X, Chen X, Na S, Wang H, Peng X, Kong P, Li L
Drug Design, Development and Therapy 2024, 18:4497-4510
Published Date: 9 October 2024
Dexmedetomidine and Dexamethasone as Adjuvants to the Local Anesthetic Mixture in Rhomboid Intercostal and Sub-Serratus Block for Video-Assisted Thoracoscopic Surgery: A Randomized, Double-Blind, Controlled Trial
Liu QF, Shi CN, Tong JH, Li KP, Yang JJ, Ji MH, Liu QR
Drug Design, Development and Therapy 2024, 18:4485-4496
Published Date: 7 October 2024
Mesenchymal Stem Cell-Based NK4 Gene Therapy in Nude Mice Bearing Gastric Cancer Xenografts [Corrigendum]
Zhu Y, Cheng M, Yang Z, Zeng C, Chen J, Xie Y, Luo S, Zhang K, Zhou S, Lu N
Drug Design, Development and Therapy 2024, 18:4481-4483
Published Date: 7 October 2024
Comparison of the ED50 of Ciprofol Combined With or Without Fentanyl for Laryngeal Mask Airway Insertion in Children: A Prospective, Randomized, Open-Label, Dose-Response Trial
Wang S, Li Y, Chen F, Liu HC, Pan L, Shangguan W
Drug Design, Development and Therapy 2024, 18:4471-4480
Published Date: 5 October 2024
Population Pharmacokinetics of Tigecycline for Critically Ill Patients Undergoing Continuous Renal Replacement Therapy
Song S, Liu J, Su W, Yu H, Feng B, Wu Y, Guo F, Yu Z
Drug Design, Development and Therapy 2024, 18:4459-4469
Published Date: 5 October 2024
Sivelestat Sodium Alleviates Ischemia-Reperfusion-Induced Acute Kidney Injury via Suppressing TLR4/Myd88/NF-κB Signaling Pathway in Mice
Wang J, Wu Y, Mao M, Bing H, Sun L, Xu W, Tian W, Xia Z, Jin X, Chu Q
Drug Design, Development and Therapy 2024, 18:4449-4458
Published Date: 5 October 2024
Review on Cassia alata Bioactive Compounds: In silico, in vitro, and in vivo Studies
Colin MN, Claudiana NSE, Kaffah AU, Hasanah AN, Megantara S
Drug Design, Development and Therapy 2024, 18:4427-4447
Published Date: 4 October 2024
A Comprehensive Review of Coptidis Rhizoma and Magnoliae Officinalis Cortex Drug Pair and Their Chemical Composition, Pharmacological Effects and Pharmacokinetics Analysis
Xie Q, Chen J, Yang H, Liang J, Ma R, Guo J, Zeng X
Drug Design, Development and Therapy 2024, 18:4413-4426
Published Date: 2 October 2024
Minimum Local Anesthetic Dose of Ropivacaine in Cesarean Section for Real-Time Ultrasound-Guided Spinal Anesthesia Using 24-Gauge versus 26-Gauge Needles Based on Fluid Simulation Technology: A Randomized Controlled Trial
Zheng C, Fan H, Ye P, Zhang X, Zheng X, Zheng T
Drug Design, Development and Therapy 2024, 18:4401-4412
Published Date: 1 October 2024
Oral Bacterial Lysate OM-85: Advances in Pharmacology and Therapeutics
Zhu LL, Wang YH, Feng JH, Zhou Q
Drug Design, Development and Therapy 2024, 18:4387-4399
Published Date: 1 October 2024
Dauricine: Review of Pharmacological Activity
Chen KQ, Wang SZ, Lei HB, Liu X
Drug Design, Development and Therapy 2024, 18:4371-4385
Published Date: 27 September 2024
Follitropin Alpha versus Follitropin Beta in IVF/ICSI Cycle: A Retrospective Cohort Study
Cao JX, Song JY
Drug Design, Development and Therapy 2024, 18:4359-4369
Published Date: 26 September 2024
Copolymerized Polymers Based on Cyclodextrins and Cationic Groups Enhance Therapeutic Effect of Rebamipide in the N-Acetylcysteine-Treated Dry Eye Model
Otake H, Kobayashi K, Kadowaki R, Kosaka T, Itahashi M, Tsubaki M, Matsuda M, Iwakiri N, Harata E, Nagai N
Drug Design, Development and Therapy 2024, 18:4345-4358
Published Date: 27 September 2024
Deciphering the Dynamics of EGFR-TKI Resistance in Lung Cancer: Insights from Bibliometric Analysis
Zhou Y, Wu T, Sun J, Bi H, Xiao Y, Shao Y, Han W, Wang H
Drug Design, Development and Therapy 2024, 18:4327-4343
Published Date: 26 September 2024
Protective Effect of Fasudil on Testicular Ischemia-Reperfusion Injury in Rats
Kaya C, Kapisiz A, Eryilmaz S, Karabulut R, Turkyilmaz Z, Inan MA, Aydin GY, Sonmez K
Drug Design, Development and Therapy 2024, 18:4319-4326
Published Date: 25 September 2024
Comparison of Remimazolam and Propofol in Recovery of Elderly Outpatients Undergoing Gastrointestinal Endoscopy: A Randomized, Non-Inferiority Trial
Lu L, Chen B, Zhao X, Zhai J, Zhang P, Hua Z
Drug Design, Development and Therapy 2024, 18:4307-4318
Published Date: 28 September 2024
Effects of Propofol, Low and High Doses of Remimazolam on Hemodynamic and Inflammatory Response in Laparoscopic Surgery [Response to Letter]
Deng W, Zeng Z, Liu Q, Deng J, Wang L, Li H, Zhang Y
Drug Design, Development and Therapy 2024, 18:4303-4305
Published Date: 25 September 2024
An Evaluation of Amoxicillin/Clavulanate Stability in Aqueous Systems, Including Its Suitability for Outpatient Parenteral Antimicrobial Therapy (OPAT)
Kamalpersad K, Luna G, Sunderland B, Czarniak P
Drug Design, Development and Therapy 2024, 18:4291-4301
Published Date: 24 September 2024
Combining Metagenomics, Network Pharmacology and RNA-Seq Strategies to Reveal the Therapeutic Effects and Mechanisms of Qingchang Wenzhong Decoction on Inflammatory Bowel Disease in Mice
Yuan Y, Hu H, Sun Z, Wang W, Wang Z, Zheng M, Xing Y, Zhang W, Wang M, Lu X, Li Y, Liang C, Lin Z, Xie C, Li J, Mao T
Drug Design, Development and Therapy 2024, 18:4273-4289
Published Date: 24 September 2024
New Perspectives on Obesity-Associated Nephropathy from Pathophysiology to Therapeutics: Revealing the Promise of GLP-1 RA Therapy
Ren L, Ju F, Liu S, Cai Y, Gang X, Wang G
Drug Design, Development and Therapy 2024, 18:4257-4272
Published Date: 23 September 2024
Unveiling the Renoprotective Mechanisms of Schisandrin B in Ischemia-Reperfusion Injury Through Transcriptomic and Pharmacological Analysis
Xu C, Deng Y, Man J, Wang H, Che T, Ding L, Yang L
Drug Design, Development and Therapy 2024, 18:4241-4256
Published Date: 21 September 2024
Cytokine Storm-Induced Thyroid Dysfunction in COVID-19: Insights into Pathogenesis and Therapeutic Approaches
Attiq A, Afzal S, Wahab HA, Ahmad W, Kandeel M, Almofti YA, Alameen AO, Wu YS
Drug Design, Development and Therapy 2024, 18:4215-4240
Published Date: 20 September 2024
Ozone Administration Reduces Myocardial Ischemia Reperfusion Injury in Streptozotocin Induced Diabetes Mellitus Rat Model
Gülcan MB, Demirtaş H, Özer A, Yığman Z, Dursun AD, Arslan M, Oktar GL
Drug Design, Development and Therapy 2024, 18:4203-4213
Published Date: 20 September 2024
Guanxinning Tablet Alleviates Post-Ischemic Stroke Injury Via Regulating Complement and Coagulation Cascades Pathway and Inflammatory Network Mobilization
Wang Y, Li Y, Zhou Y, Gao Y, Zhao L
Drug Design, Development and Therapy 2024, 18:4183-4202
Published Date: 18 September 2024
Revisiting Niclosamide Formulation Approaches – a Pathway Toward Drug Repositioning
Jug M, Laffleur F, Millotti G
Drug Design, Development and Therapy 2024, 18:4153-4182
Published Date: 17 September 2024
Feasibility and Safety of PD-1 Blockades Among Elderly Patients with Metastatic Esophageal Squamous Cell Carcinoma: A Real-World Study
Bai M, Wang WX, Deng T, Duan JJ, Ba Y
Drug Design, Development and Therapy 2024, 18:4135-4151
Published Date: 16 September 2024
Huangqi-Danshen Decoction Against Renal Fibrosis in UUO Mice via TGF-β1 Induced Downstream Signaling Pathway
Huang X, Peng Y, Lu L, Gao L, Wu S, Lu J, Liu X
Drug Design, Development and Therapy 2024, 18:4119-4134
Published Date: 14 September 2024
Comparison Between Esketamine and Alfentanil for Hysteroscopy: A Prospective, Double-Blind, Randomized Controlled Trial [Response to Letter]
Weng M, Jin Y
Drug Design, Development and Therapy 2024, 18:4117-4118
Published Date: 13 September 2024
Cardiotoxicity of Anticancer Drugs: Molecular Mechanisms, Clinical Management and Innovative Treatment
Gao F, Xu T, Zang F, Luo Y, Pan D
Drug Design, Development and Therapy 2024, 18:4089-4116
Published Date: 12 September 2024
Identification of Potential Therapeutics for Infantile Hemangioma via in silico Investigation and in vitro Validation
Lu W, Yang Z, Wang M, Zhang Y, Qi Z, Yang X
Drug Design, Development and Therapy 2024, 18:4065-4088
Published Date: 12 September 2024
Research Hotspots in Mitochondria-Related Studies for AKI Treatment: A Bibliometric Study
Yang M, Huang Y, Tang A, Zhang Y, Liu Y, Fan Z, Li M
Drug Design, Development and Therapy 2024, 18:4051-4063
Published Date: 11 September 2024
Integrating Network Pharmacology and Experimental Validation to Investigate the Mechanism of Qushi Huatan Decoction Against Coronary Heart Disease
Yin C, Lan T, Wu Y, Cai J, Li H, Kuang X, Jiao L, Ou X, Yang H, Liu B, Lu W
Drug Design, Development and Therapy 2024, 18:4033-4049
Published Date: 11 September 2024
Metformin’s Enigma: Bridging Gaps in Research on Potential Benefits & Associated Risks - A Critical Plea for Comprehensive Investigation [Response to Letter]
Dutta S, Shah RB, Singhal S, Dutta SB, Bansal S, Sinha S, Haque M
Drug Design, Development and Therapy 2024, 18:4029-4031
Published Date: 7 September 2024
Ciprofol in Children Undergoing Adenoidectomy and Adenotonsillectomy: A Retrospective Cohort Study
Zeng C, Li L, Wang M, Xiong J, Pang W, Yu H, He J, Wang X, Chen Y, Sun Y
Drug Design, Development and Therapy 2024, 18:4017-4027
Published Date: 6 September 2024
Untargeted Lipidomics Analysis to Discover Lipid Profiles and Biomarkers of Rabbit Acne Model and Reveal Action Mechanism of Isotretinoin
Wu L, Zhu Y, Zhu S, Zhang D, Wang X, Xiao Z, Tan Y, Ouyang X, Li C
Drug Design, Development and Therapy 2024, 18:4003-4016
Published Date: 6 September 2024
Current Perspectives on Letermovir and Maribavir for the Management of Cytomegalovirus Infection in Solid Organ Transplant Recipients
Razonable RR
Drug Design, Development and Therapy 2024, 18:3987-4001
Published Date: 6 September 2024
Trimetazidine Alleviates Bleomycin-Induced Pulmonary Fibrosis by Targeting the Long Noncoding RNA CBR3-AS1-Mediated miRNA-29 and Resistin-Like Molecule alpha 1: Deciphering a Novel Trifecta Role of LncRNA CBR3-AS1/miRNA-29/FIZZ1 Axis in Lung Fibrosis
Alzahrani AR, Mohamed DI, Abo Nahas HH, Alaa El-Din Aly El-Waseef D, Altamimi AS, Youssef IH, Ibrahim IAA, Mohamed SM, Sabry YG, Falemban AH, Elhawary NA, Bamagous GA, Jaremko M, Saied EM
Drug Design, Development and Therapy 2024, 18:3959-3986
Published Date: 5 September 2024
Efficacy and Safety of General Anesthesia Induction with Ciprofol in Hip Fracture Surgery of Elderly Patients: A Randomized Controlled Trial
Lu YF, Wu JM, Lan HY, Xu QM, Shi SQ, Duan GC
Drug Design, Development and Therapy 2024, 18:3951-3958
Published Date: 4 September 2024
Clinical Utility of Rilonacept for the Treatment of Recurrent Pericarditis: Design, Development, and Place in Therapy
Vlachakis PK, Theofilis P, Soulaidopoulos S, Lazarou E, Tsioufis K, Lazaros G
Drug Design, Development and Therapy 2024, 18:3939-3950
Published Date: 4 September 2024
Semaglutide Alleviates Ovary Inflammation via the AMPK/SIRT1/NF‑κB Signaling Pathway in Polycystic Ovary Syndrome Mice
Liu M, Guo S, Li X, Tian Y, Yu Y, Tang L, Sun Q, Zhang T, Fan M, Zhang L, Xu Y, An J, Gao X, Han L, Zhang L
Drug Design, Development and Therapy 2024, 18:3925-3938
Published Date: 4 September 2024
Flavopereirine Suppresses the Progression of Human Oral Cancer by Inhibiting the JAK-STAT Signaling Pathway via Targeting LASP1 [Letter]
Raičević V
Drug Design, Development and Therapy 2024, 18:3923-3924
Published Date: 30 August 2024
Effects of Propofol, Low and High Doses of Remimazolam on Hemodynamic and Inflammatory Response in Laparoscopic Surgery [Letter]
Yang G, Chu Q
Drug Design, Development and Therapy 2024, 18:3921-3922
Published Date: 30 August 2024
ED-71 Ameliorates Bone Loss in Type 2 Diabetes Mellitus by Enhancing Osteogenesis Through Upregulation of the Circadian Rhythm Coregulator BMAL1
Liu T, Wang L, Shi T, Liu H, Liu B, Guo J, Li M
Drug Design, Development and Therapy 2024, 18:3903-3919
Published Date: 29 August 2024
A Randomized, Double-Blind, Parallel-Group Phase I Study Comparing the Pharmacokinetics, Safety, and Immunogenicity of CMAB015, a Candidate Secukinumab Biosimilar, with Its Reference Product Cosentyx® in Healthy Chinese Male Subjects
Yao F, Wang C, Ding J, Zhang Q, Zheng L, Zhang Q, Yang T, Zhang X, Shan Y, Hou S, Wang H, Zhou R, Hu W
Drug Design, Development and Therapy 2024, 18:3891-3901
Published Date: 29 August 2024
Based on UPLC-Q-TOF/MS and Network Pharmacology to Explore the Mechanism of Qingre Lishi Decoction in the Treatment of Psoriasis
Wei J, Liu Z, Li M, Du L, Zhu X, Leng Y, Han C, Xu Q, Zhang C
Drug Design, Development and Therapy 2024, 18:3871-3889
Published Date: 28 August 2024
Mechanism of YJKL Decoction in Treating of PCOS Infertility by Integrative Approach of Network Pharmacology and Experimental Verification
Zhang R, Xu W, Wei H, Li B, Wang Y, He X, Cao J, He X, Xu M, Lu W, Xu Y
Drug Design, Development and Therapy 2024, 18:3853-3870
Published Date: 28 August 2024
Apigenin Attenuates Transverse Aortic Constriction-Induced Myocardial Hypertrophy: The Key Role of miR-185-5p/SREBP2-Mediated Autophagy
Yan N, Wang X, Xu Z, Zhong L, Yang J
Drug Design, Development and Therapy 2024, 18:3841-3851
Published Date: 27 August 2024
Erythrina subumbrans (Hassk) Merr. (Fabaceae) Inhibits Insulin Resistance in the Adipose Tissue of High Fructose-Induced Wistar Rats
Susilawati E, Levita J, Susilawati Y, Sumiwi SA
Drug Design, Development and Therapy 2024, 18:3825-3839
Published Date: 27 August 2024
Enhance the Antimycobacterial Activity of Streptomycin with Ebselen as an Antibiotic Adjuvant Through Disrupting Redox Homeostasis
Dong C, Wang Y, Cai Y, Wu Y, Chen W, Wang L, Liu X, Zou L, Wang J
Drug Design, Development and Therapy 2024, 18:3811-3824
Published Date: 27 August 2024
Combining Network Pharmacology and Transcriptomics to Investigate the Mechanisms of Yujiang Paidu Decoction in the Treatment of Chronic Rhinosinusitis with Nasal Polyps
Li Y, Yin Y, Xiong J, Zhang Z, Li L, Zhang B, Zhang F, Mao D
Drug Design, Development and Therapy 2024, 18:3791-3809
Published Date: 27 August 2024
Polydopamine-Based Biomaterials in Orthopedic Therapeutics: Properties, Applications, and Future Perspectives
Zhang M, Mi M, Hu Z, Li L, Chen Z, Gao X, Liu D, Xu B, Liu Y
Drug Design, Development and Therapy 2024, 18:3765-3790
Published Date: 26 August 2024
Chemistry, Pharmacology and Therapeutic Potential of Decursin: A Promising Natural Lead for New Drug Discovery and Development
Muralikrishnan A, Sekar M, Kumarasamy V, Gan SH, Ravi S, Subramaniyan V, Wong LS, Wu YS, Khattulanuar FS, Mat Rani NNI
Drug Design, Development and Therapy 2024, 18:3741-3763
Published Date: 23 August 2024
Cyanidin-3-O-Glucoside Improves Colonic Motility During Severe Acute Pancreatitis by Inhibiting the H2S-Regulated AMPK/mTOR Pathway [Retraction]
Lian W, Chen W
Drug Design, Development and Therapy 2024, 18:3739-3740
Published Date: 23 August 2024
The Impact of Fentanyl on the Effective Dose of Remimazolam-Induced Sedation in Elderly Female Patients: An Up-and-Down Sequential Allocation Trial
Huang XD, Chen JB, Dong XY, Wang WL, Zhou J, Zhou ZF
Drug Design, Development and Therapy 2024, 18:3729-3737
Published Date: 22 August 2024
Comparison Between Esketamine and Alfentanil for Hysteroscopy: A Prospective, Double-Blind, Randomized Controlled Trial [Letter]
Yang G
Drug Design, Development and Therapy 2024, 18:3727-3728
Published Date: 22 August 2024
The Effect of Low-Dose Dexmedetomidine on Perioperative Neurocognitive Dysfunction in Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP): A Randomized, Controlled, Double-Blind Trial
Sun Z, Shi J, Liu C, Zhang J, Liu Y, Wu Y, Han X, Dai H, Wu J, Bo L, Wang F
Drug Design, Development and Therapy 2024, 18:3715-3725
Published Date: 23 August 2024
Saikosaponins Targeting Programmed Cell Death as Anticancer Agents: Mechanisms and Future Perspectives
Xiao X, Gao C
Drug Design, Development and Therapy 2024, 18:3697-3714
Published Date: 21 August 2024
Therapeutic Potential of Natural Resources Against Endometriosis: Current Advances and Future Perspectives
Gu X, Zhou H, Miao M, Hu D, Wang X, Zhou J, Teichmann AT, Yang Y, Wang C
Drug Design, Development and Therapy 2024, 18:3667-3696
Published Date: 21 August 2024
Treatment of Melasma with Tranexamic Acid Essence Combined with Iontophoresis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Guo L, Liu X, Liu Q, Xie X, Jiang X
Drug Design, Development and Therapy 2024, 18:3659-3666
Published Date: 20 August 2024
Subanesthetic Dose of Esketamine Improves the Sedative and Analgesic Effects of Dexmedetomidine and Remifentanil in Liposuction Anesthesia: A Prospective, Double-Blinded, Randomized Controlled Trial
Chen H, Zhi J, Wang L, Jin Z, Xu J, Xing F, Wen C, Wang Q, Chen C, Li W, Xu E, An J, Wei L
Drug Design, Development and Therapy 2024, 18:3645-3658
Published Date: 20 August 2024
Metformin’s Enigma: Bridging Gaps in Research on Potential Benefits & Associated Risks - A Critical Plea for Comprehensive Investigation [Letter]
Iqbal F, Khanzada ZH, Qasim Q
Drug Design, Development and Therapy 2024, 18:3643-3644
Published Date: 15 August 2024
Comparison Between Esketamine and Alfentanil for Hysteroscopy: A Prospective, Double-Blind, Randomized Controlled Trial
Weng M, Wang D, Zhong J, Qian M, Zhang K, Jin Y
Drug Design, Development and Therapy 2024, 18:3629-3641
Published Date: 14 August 2024
The Role of Plasma Trough Concentration of Voriconazole and Voriconazole N-Oxide in Its Hepatotoxicity in Adult Patients
Cheng L, You X, Wang X, Yu M, Jia C
Drug Design, Development and Therapy 2024, 18:3617-3628
Published Date: 13 August 2024
The Anti-Diabetic Effects of Medicinal Plants Belonging to the Liliaceae Family: Potential Alpha Glucosidase Inhibitors
Ramadaini T, Sumiwi SA, Febrina E
Drug Design, Development and Therapy 2024, 18:3595-3616
Published Date: 13 August 2024
Combinational Antitumor Strategies Based on the Active Ingredients of Toad Skin and Toad Venom
Tian H, Zhao F, Yue BS, Zhai BT
Drug Design, Development and Therapy 2024, 18:3549-3594
Published Date: 9 August 2024
Protective Effects of Chlorogenic Acid on Cerebral Ischemia/Reperfusion Injury Rats by Regulating Oxidative Stress-Related Nrf2 Pathway [Retraction]
Liu D, Wang H, Zhang Y, Zhang Z
Drug Design, Development and Therapy 2024, 18:3547-3548
Published Date: 8 August 2024
Sinomenine Alleviates Rheumatoid Arthritis by Suppressing the PI3K-Akt Signaling Pathway, as Demonstrated Through Network Pharmacology, Molecular Docking, and Experimental Validation
Liu Q, Wang J, Ding C, Chu Y, Jiang F, Hu Y, Li H, Wang Q
Drug Design, Development and Therapy 2024, 18:3523-3545
Published Date: 6 August 2024
Transforming Healthcare with Nanomedicine: A SWOT Analysis of Drug Delivery Innovation
Zhang H, Li S, Ma X
Drug Design, Development and Therapy 2024, 18:3499-3521
Published Date: 5 August 2024
Remimazolam in General Anesthesia: A Comprehensive Review of Its Applications and Clinical Efficacy
Zhang H, Li H, Zhao S, Bao F
Drug Design, Development and Therapy 2024, 18:3487-3498
Published Date: 5 August 2024
Effect of Alleviating Preoperative Anxiety on Gastrointestinal Function Recovery After Laparoscopic High Ligation of the Hernia Sac in Children with Indirect Inguinal Hernia
Chen X, Zhang X, Gao R, Huang Y, Mao S, Wang B, Feng J
Drug Design, Development and Therapy 2024, 18:3477-3486
Published Date: 5 August 2024
CaMK II in Cardiovascular Diseases, Especially CaMK II-δ: Friends or Enemies
Tan YQ, Zhang W, Xie ZC, Li J, Chen HW
Drug Design, Development and Therapy 2024, 18:3461-3476
Published Date: 5 August 2024
Isolation and Quantification of Palmatine from Fibraurea tinctoria Lour: In Vitro Antioxidant Activity and In Silico Antidiabetic Activity Evaluation
Purwaningsih I, Maksum IP, Sumiarsa D, Sriwidodo S
Drug Design, Development and Therapy 2024, 18:3443-3459
Published Date: 2 August 2024
The Effect of Lidocaine-Prilocaine Cream Combined with or Without Remimazolam on VAS and APAIS Anxiety Score in Patient Undergoing Spinal Anesthesia
Liang S, Li S, Zhong Z, Luo Q, Nie C, Hu D, Li Y
Drug Design, Development and Therapy 2024, 18:3429-3441
Published Date: 1 August 2024
Insights on Nefecon®, a Targeted-Release Formulation of Budesonide and Its Selective Immunomodulatory Effects in Patients with IgA Nephropathy
Barratt J, Kristensen J, Pedersen C, Jerling M
Drug Design, Development and Therapy 2024, 18:3415-3428
Published Date: 31 July 2024
Ceftazidime-Avibactam as a Salvage Treatment for Severely Infected Immunosuppressed Children
Zhu L, Hu Q, Liu L, Ye S
Drug Design, Development and Therapy 2024, 18:3399-3413
Published Date: 30 July 2024
Cardioprotective Effects of α-Asarone Against Hexavalent Chromium-Induced Oxidative Damage in Mice
Alwaili MA, Elhoby AH, El-Sayed NM, Mahmoud IZ, Alharthi A, El-Nablaway M, Khodeer DM
Drug Design, Development and Therapy 2024, 18:3383-3397
Published Date: 30 July 2024
Alisol A, the Eye-Entering Ingredient of Alisma orientale, Relieves Macular Edema Through TNF-α as Revealed by UPLC-Triple-TOF/MS, Network Pharmacology, and Zebrafish Verification
Shen R, Cheng K, Li G, Pan Z, Qiaolongbatu X, Wang Y, Ma C, Huang X, Wang L, Li W, Wang Y, Jing L, Fan G, Wu Z
Drug Design, Development and Therapy 2024, 18:3361-3382
Published Date: 30 July 2024
Impact of Lipids on Insulin Resistance: Insights from Human and Animal Studies
Elkanawati RY, Sumiwi SA, Levita J
Drug Design, Development and Therapy 2024, 18:3337-3360
Published Date: 31 July 2024
Effects of Propofol, Low and High Doses of Remimazolam on Hemodynamic and Inflammatory Response in Laparoscopic Surgery
Deng W, Zeng Z, Liu Q, Deng J, Wang L, Li H, Zhang Y
Drug Design, Development and Therapy 2024, 18:3329-3336
Published Date: 30 July 2024
Revealing Changes in Celecoxib Nanostructured Lipid Carrier’s Bioavailability Using Hyaluronic Acid as an Enhancer by HPLC-MS/MS
Zhu Y, Chen M, Yang C, Lu G, Huang S, Chen M, Wang Y, Ban J
Drug Design, Development and Therapy 2024, 18:3315-3327
Published Date: 29 July 2024
Lawsone Unleashed: A Comprehensive Review on Chemistry, Biosynthesis, and Therapeutic Potentials
Nair AS, Sekar M, Gan SH, Kumarasamy V, Subramaniyan V, Wu YS, Mat Rani NNI, Ravi S, Wong LS
Drug Design, Development and Therapy 2024, 18:3295-3313
Published Date: 26 July 2024
Therapeutic Effects of Qingchang Tongluo Decoction on Intestinal Fibrosis in Crohn’s Disease: Network Pharmacology, Molecular Docking and Experiment Validation
Li Y, Hu J, Au R, Cheng C, Xu F, Li W, Wu Y, Cui Y, Zhu L, Shen H
Drug Design, Development and Therapy 2024, 18:3269-3293
Published Date: 25 July 2024
Antitumor Effects of Hydromorphone on Human Gastric Cancer Cells in vitro [Retraction]
Liang B, Li C, Zhou Z, Xie Y
Drug Design, Development and Therapy 2024, 18:3267-3268
Published Date: 25 July 2024
Research Progress of Triptolide Against Fibrosis
Jiang M, Xie Y, Wang P, Du M, Wang Y, Yan S
Drug Design, Development and Therapy 2024, 18:3255-3266
Published Date: 25 July 2024
Flavonoids and Gastric Cancer Therapy: From Signaling Pathway to Therapeutic Significance
Cai J, Tan X, Hu Q, Pan H, Zhao M, Guo C, Zeng J, Ma X, Zhao Y
Drug Design, Development and Therapy 2024, 18:3233-3253
Published Date: 25 July 2024
Chuanxiong Renshen Decoction Inhibits Alzheimer’s Disease Neuroinflammation by Regulating PPARγ/NF-κB Pathway
Hou J, Wang X, Zhang J, Shen Z, Li X, Yang Y
Drug Design, Development and Therapy 2024, 18:3209-3232
Published Date: 24 July 2024
Tongxieyaofang Decotion Alleviates IBS by Modulating CHRM3 and Gut Barrier
Feng T, Zhou Y, Lv B, Cai L
Drug Design, Development and Therapy 2024, 18:3191-3208
Published Date: 24 July 2024
Unraveling Crucial Mitochondria-Related Genes in the Transition from Ulcerative Colitis to Colorectal Cancer
Wang F, Xie L, Tang Y, Deng T
Drug Design, Development and Therapy 2024, 18:3175-3189
Published Date: 24 July 2024
Co-Expression Network Analysis and Molecular Docking Demonstrate That Diosgenin Inhibits Gastric Cancer Progression via SLC1A5/mTORC1 Pathway
Cui N, Ding F
Drug Design, Development and Therapy 2024, 18:3157-3173
Published Date: 23 July 2024
Morin Regulates M1/M2 Microglial Polarization via NF-κB p65 to Alleviate Vincristine-Induced Neuropathic Pain
Shao Y, Chen Y, Lan X, Lu J, Tang G, Tang S, Zhai R, Chen C, Xiong X, Shi J
Drug Design, Development and Therapy 2024, 18:3143-3156
Published Date: 22 July 2024
Integrating Network Pharmacology with in vitro Experiments to Validate the Efficacy of Celastrol Against Hepatocellular Carcinoma Through Ferroptosis
Cai B, Qi M, Zhang X, Zhang D
Drug Design, Development and Therapy 2024, 18:3121-3141
Published Date: 22 July 2024
Effect of Efavirenz on the Pharmacokinetics of SHR6390 in Healthy Volunteers
Wang J, Hu C, Zhang L
Drug Design, Development and Therapy 2024, 18:3113-3119
Published Date: 19 July 2024
Study on the Underlying Mechanism of Yinhua Gout Granules in the Treatment of Gouty Arthritis by Integrating Transcriptomics and Network Pharmacology
Fan QQ, Zhai BT, Zhang D, Zhang XF, Cheng JX, Guo DY, Tian H
Drug Design, Development and Therapy 2024, 18:3089-3112
Published Date: 19 July 2024
The Discovery of GIT1/β-Pix Inhibitors: Virtual Screening and Biological Evaluation of New Small-molecule Compounds with Anti-invasion Effect in Gastrointestinal Neoplasms
Wang C, Gu J, Li H, Zhao B, Yu T, Guo CL, Huang M, Jiang W, Ouyang Q
Drug Design, Development and Therapy 2024, 18:3075-3088
Published Date: 16 July 2024
Therapeutic Potential of Solanum Alkaloids with Special Emphasis on Cancer: A Comprehensive Review
Manoharan R, Nair CS, Eissa N, Cheng H, Ge P, Ren M, Jaleel A
Drug Design, Development and Therapy 2024, 18:3063-3074
Published Date: 16 July 2024
Mapping Theme Trends and Research Frontiers in Dexmedetomidine Over Past Decade: A Bibliometric Analysis
Chen Z, Zuo Z, Song X, Zuo Y, Zhang L, Ye Y, Ma Y, Pan L, Zhao X, Jin Y
Drug Design, Development and Therapy 2024, 18:3043-3061
Published Date: 16 July 2024
Evaluating the Therapeutic Potential of Ublituximab in the Treatment of MS: Design, Development and Place in Therapy
Martin SJ, Guenette M, Oh J
Drug Design, Development and Therapy 2024, 18:3025-3042
Published Date: 16 July 2024
The Application Potential of the Regulation of Tregs Function by Irisin in the Prevention and Treatment of Immune-Related Diseases
Wang Z, Xu J, Mo L, Zhan R, Zhang J, Liu L, Jiang J, Zhang Y, Bai Y
Drug Design, Development and Therapy 2024, 18:3005-3023
Published Date: 16 July 2024
Nootkatone Counteracts Melamine-Mediated Nephrotoxicity via Modulation of Intermediate Filament Proteins, Oxidative, Inflammatory, and Apoptotic Events
Abdelrahaman D, Habotta OA, Ateya A, Aldarmahi AA, El-Shafei RA, Badawy MM, El-Mansy AA, A-Elgadir TM, Nada AM, Elhadidy MG, Hamza E, Alwutayed KM, El-Sherbiny M, Fericean L, Imbrea F, Abdeen A
Drug Design, Development and Therapy 2024, 18:2989-3004
Published Date: 16 July 2024
Neuroprotective Mechanism of MOTS-c in TBI Mice: Insights from Integrated Transcriptomic and Metabolomic Analyses
Li F, Jia Y, Fang J, Gong L, Zhang Y, Wei S, Wu L, Jiang P
Drug Design, Development and Therapy 2024, 18:2971-2987
Published Date: 15 July 2024
Tangzhiping Decoction Improves Glucose and Lipid Metabolism and Exerts Protective Effects Against White Adipose Tissue Dysfunction in Prediabetic Mice
Wang C, An T, Lu C, Liu T, Shan X, Zhu Z, Gao Y
Drug Design, Development and Therapy 2024, 18:2951-2969
Published Date: 15 July 2024
Nanoparticle-Based Drug Delivery Systems for Inflammatory Bowel Disease Treatment
Gao J, Li J, Luo Z, Wang H, Ma Z
Drug Design, Development and Therapy 2024, 18:2921-2949
Published Date: 15 July 2024
Clinical Study of Flumazenil Antagonizing Remimazolam on Nausea and Vomiting After Gynecologic Day Surgery [Letter]
Satici MH, Altay N
Drug Design, Development and Therapy 2024, 18:2919-2920
Published Date: 11 July 2024
Oral Bioavailability, Tissue Distribution, Metabolism, and Excretion of Panduratin A from Boesenbergia rotunda Extract in Healthy Rats
Kongratanapasert T, Boonyarattanasoonthorn T, Supannapan K, Hongeng S, Khemawoot P
Drug Design, Development and Therapy 2024, 18:2905-2917
Published Date: 11 July 2024
Pharmacokinetics and Safety of Estradiol Valerate Tablet and Its Generic: A Phase 1 Bioequivalence Study in Healthy Chinese Postmenopausal Female Subjects
Zhang L, Li M, Fan L, Liu F, Zhang P, Huang Q, Mai G, Shentu J
Drug Design, Development and Therapy 2024, 18:2891-2904
Published Date: 10 July 2024
The Influence of Piriform Recess Instillation with Lidocaine Before Bronchoscopy on Post-General Anesthesia Cough: A Randomized Controlled Trial
Min K, Wang Y, Feng D, Jin T, Zhu W, Duan R, Lv X
Drug Design, Development and Therapy 2024, 18:2883-2890
Published Date: 9 July 2024
Integrating Network Pharmacology, Transcriptomics to Reveal Neuroprotective of Curcumin Activate PI3K / AKT Pathway in Parkinson’s Disease
Cai B, Wang Q, Zhong L, Liu F, Wang X, Chen T
Drug Design, Development and Therapy 2024, 18:2869-2881
Published Date: 9 July 2024
Exploration of Berberine Against Ulcerative Colitis via TLR4/NF-κB/HIF-1α Pathway by Bioinformatics and Experimental Validation
Li J, Dan W, Zhang C, Liu N, Wang Y, Liu J, Zhang S
Drug Design, Development and Therapy 2024, 18:2847-2868
Published Date: 9 July 2024
Nalbuphine in Pediatric Emergence Agitation Following Cochlear Implantation: A Randomized Trial
Li Y, Li Q, Zhao G, Zhang H, Zhong H, Zeng Y
Drug Design, Development and Therapy 2024, 18:2837-2845
Published Date: 8 July 2024
The Efficacy of Letrozole Co-Treatment in an Antagonist Protocol for Women with Polycystic Ovary Syndrome Undergoing IVF: A Retrospective Study
Lin J, Wu F, Zhu Y, Zhu Q, Du T, Lin J
Drug Design, Development and Therapy 2024, 18:2823-2835
Published Date: 8 July 2024
Determination of ED90s of Phenylephrine and Norepinephrine Infusion for Prevention of Spinal Anesthesia-Induced Hypotension in Patients with Preeclampsia During Cesarean Delivery
Tan H, Chen Y, Jiang Y, Sun X, Ye W, Zhu X, Xiong X
Drug Design, Development and Therapy 2024, 18:2813-2821
Published Date: 5 July 2024
Inflammation Can Be a High-Risk Factor for Mucosal Nonunion of MRONJ by Regulating SIRT1 Signaling When Treated with an Oncologic Dose of Zoledronate
Zhu S, Cui Y, Zhang W, Ji Y, Li L, Luo S, Cui J, Li M
Drug Design, Development and Therapy 2024, 18:2793-2812
Published Date: 4 July 2024
Thymopentapeptide Affects T-Cell Subsets by Modulating the Flora of the Skin Surface to Alleviate Psoriasis
Liu X, Xi R, Du X, Wang Y, Cheng L, Yan G, Lu H, Liu T, Li F
Drug Design, Development and Therapy 2024, 18:2775-2791
Published Date: 4 July 2024
Clinical Efficacy of Taxol Plus Platinum (TP) Chemotherapy Combined with Delayed Administration of PD-1 Inhibitors in Patients with Locally Advanced, Recurrent or Metastatic Esophageal Squamous Cell Carcinoma: A Retrospective Study
Shen L, Chen Z, Zhang Z, Wu Y, Ren Y, Li Y, Li Y, Yin X, Han F, Chen Y
Drug Design, Development and Therapy 2024, 18:2761-2773
Published Date: 3 July 2024
Schisandra chinensis Bee Pollen Extract Inhibits Proliferation and Migration of Hepatocellular Carcinoma HepG2 Cells via Ferroptosis-, Wnt-, and Focal Adhesion–Signaling Pathways
Li Z, Yang J, Sun Y, Han S, Gong J, Zhang Y, Feng Z, Yao H, Shi P
Drug Design, Development and Therapy 2024, 18:2745-2760
Published Date: 2 July 2024
Pharmacokinetics and Safety of Oliceridine Fumarate Injection in Chinese Patients with Chronic Non-Cancer Pain: A Phase I, Single-Ascending-Dose, Open-Label Clinical Trial
Ni Y, Huang R, Yang S, Yang XY, Zeng S, Yao A, Huang J, Yang G
Drug Design, Development and Therapy 2024, 18:2729-2743
Published Date: 3 July 2024
Advances in Research on the Effectiveness and Mechanism of Active Ingredients from Traditional Chinese Medicine in Regulating Hepatic Stellate Cells Autophagy Against Hepatic Fibrosis
Liu XY, Zhang W, Ma BF, Sun MM, Shang QH
Drug Design, Development and Therapy 2024, 18:2715-2727
Published Date: 2 July 2024
4-Amino-2-Trifluoromethyl-Phenyl Retinate Inhibits Proliferation, Invasion, and Migration of Breast Cancer Cells by Independently Regulating CRABP2 and FABP5 [Retraction]
Ju J, Wang N, Wang J, Wu F, Ge J, Chen F
Drug Design, Development and Therapy 2024, 18:2713-2714
Published Date: 3 July 2024
Costunolide Inhibits Chronic Kidney Disease Development by Attenuating IKKβ/NF-κB Pathway
Zhao Y, Wang YH, Tu WC, Wang DW, Lu MJ, Shao Y
Drug Design, Development and Therapy 2024, 18:2693-2712
Published Date: 2 July 2024
Etomidate Combined with Propofol versus Remimazolam for Sedation in Elderly Patients During Gastrointestinal Endoscopy: A Randomized Prospective Clinical Trial
Zhang Q, Zhao R, Wu Y, Zhang L, Feng Y
Drug Design, Development and Therapy 2024, 18:2681-2692
Published Date: 2 July 2024
Evaluation of a Covalent Library of Diverse Warheads (CovLib) Binding to JNK3, USP7, or p53
Klett T, Schwer M, Ernst LN, Engelhardt MU, Jaag SJ, Masberg B, Knappe C, Lämmerhofer M, Gehringer M, Boeckler FM
Drug Design, Development and Therapy 2024, 18:2653-2679
Published Date: 1 July 2024
Pharmacokinetic Interactions Between the Fixed-Dose Combination of Ezetimibe/Rosuvastatin 10/20 Mg and the Fixed-Dose Combination of Telmisartan/Amlodipine 80/5 Mg in Healthy Subjects
Ryu H, Kim HC, Jeon I, Jang IJ, Cho JY, Kim KT, Oh J
Drug Design, Development and Therapy 2024, 18:2641-2652
Published Date: 1 July 2024
Integration of Gut Microbiota, Serum Metabolomic, and Network Pharmacology to Reveal the Anti Insomnia Mechanism of Mongolian Medicine Sugemule-4 Decoction on Insomnia Model Rats
Du L, Yang D, Wu L, Mei L, Wu S, Ba Y, Bao Y, Su R, Song L
Drug Design, Development and Therapy 2024, 18:2617-2639
Published Date: 27 June 2024
Up-and-Down Determination of Different Crystalloid Coload Volumes on the ED 90 of Prophylactic Norepinephrine Infusion for Preventing Postspinal Anesthesia Hypotension During Cesarean Section
Chen Y, Xiong X, Qin R, Guo L, Shi Y, Ni X
Drug Design, Development and Therapy 2024, 18:2609-2616
Published Date: 26 June 2024
A Health Technology Assessment Based on Chinese Guideline: Active Vitamin D and Its Analogs in the Treatment of Osteoporosis
Huang S, Li J, Hu X, Chen J
Drug Design, Development and Therapy 2024, 18:2593-2608
Published Date: 26 June 2024
A Visual Analysis of the Research Dynamics in Resistance to EGFR Inhibitors for NSCLC
Shao J, Gu Y, Guo R, Xu J
Drug Design, Development and Therapy 2024, 18:2571-2591
Published Date: 26 June 2024
Clinical Pharmacokinetics of Semaglutide: A Systematic Review
Yang XD, Yang YY
Drug Design, Development and Therapy 2024, 18:2555-2570
Published Date: 25 June 2024
Anti-Infection of Oral Microorganisms from Herbal Medicine of Piper crocatum Ruiz & Pav
Kurnia D, Lestari S, Mayanti T, Gartika M, Nurdin D
Drug Design, Development and Therapy 2024, 18:2531-2553
Published Date: 25 June 2024
Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches
Luo Y, Bai XY, Zhang L, Hu QQ, Zhang N, Cheng JZ, Hou MZ, Liu XL
Drug Design, Development and Therapy 2024, 18:2485-2529
Published Date: 21 June 2024
Comparison of Ciprofol-Based and Propofol-Based Total Intravenous Anesthesia on Microvascular Decompression of Facial Nerve with Neurophysiological Monitoring: A Randomized Non-Inferiority Trial
Zhu T, Kang F, Han MM, He F, Jiang S, Hao LN, Huang X, Li J
Drug Design, Development and Therapy 2024, 18:2475-2484
Published Date: 21 June 2024
Short–Term Preconditioning with Insulin and Glucose Efficiently Protected the Kidney Against Ischemia-Reperfusion Injury via the P-AKT-Bax-Caspase-3 Signaling Pathway in Mice
Sun L, Bing H, Zhang C, Lin L, Lian H, Chu Q, Jin X
Drug Design, Development and Therapy 2024, 18:2461-2474
Published Date: 20 June 2024
Targeting WEE1 Kinase in Gynecological Malignancies
Zhang W, Li Q, Yin R
Drug Design, Development and Therapy 2024, 18:2449-2460
Published Date: 20 June 2024
Investigating the Impact of SN-38 on Mouse Brain Metabolism Based on Metabolomics
Zhu X, Huang Y, Ding J, Liu J, Cui C, Han G
Drug Design, Development and Therapy 2024, 18:2435-2447
Published Date: 20 June 2024
Xinfeng Capsule Inhibits Pyroptosis and Ameliorates Myocardial Injury in Rats with Adjuvant Arthritis via the GAS5/miR-21/TLR4 Axis
Fu W, Cao Y, Liu J, Huang C, Shu K, Zhu N
Drug Design, Development and Therapy 2024, 18:2421-2433
Published Date: 20 June 2024
Exploration of the Active Component and Mechanisms of Shengyu Decoction Against Myelosuppression Using Network Pharmacology and in vitro Experimental Validation
Ma B, Hou P, Liu R, Cang A, Zhao L
Drug Design, Development and Therapy 2024, 18:2405-2420
Published Date: 20 June 2024
5-Fluorouracil Combined with Rutaecarpine Synergistically Suppresses the Growth of Colon Cancer Cells by Inhibiting STAT3 [Retraction]
Yu Z, Chan S, Wang X, Sun R, Wang M, Wang Z, Zuo X, Chen J, Zhang H, Chen W
Drug Design, Development and Therapy 2024, 18:2403-2404
Published Date: 19 June 2024
Intravenous Bolus of Dexmedetomidine for Treatment of Severe Shivering After Caesarean Delivery Under Combined Spinal-Epidural Anaesthesia: A Randomized Dose-Response Study
Yang M, Li S, Drzymalski D, Chen X
Drug Design, Development and Therapy 2024, 18:2393-2402
Published Date: 19 June 2024
Esketamine Combined with Dexmedetomidine to reduce Visceral Pain During elective Cesarean Section Under Combined Spinal-Epidural Anesthesia: A double-Blind Randomized Controlled Study
Yang JR, Li YY, Ran TJ, Lin XY, Xu JY, Zhou SL, Huang PJ
Drug Design, Development and Therapy 2024, 18:2381-2392
Published Date: 18 June 2024
4-Deoxy-ϵ-Pyrromycinone: A Promising Drug/Lead Compound to Treat Tumors
Zhang J, Sang X, Yuan Y, Shen J, Fang Y, Qin M, Zheng H, Zhu Z
Drug Design, Development and Therapy 2024, 18:2367-2379
Published Date: 18 June 2024
Determining the Maximum Tolerable Concentration of Ropivacaine to Maintain Sensation of the Nerve Root in Percutaneous Endoscopic Transforaminal Lumbar Discectomy: Can Epidural Anaesthesia Achieve Pain-Tactile Separation Block to Avoid Nerve Injury?
Hu B, Kang X, Zhou C, Zhou J, Xu W, Ding W, Feng Z, Wang H
Drug Design, Development and Therapy 2024, 18:2357-2366
Published Date: 18 June 2024
ED50 and ED95 of Remimazolam Tosilate Combined with Different Doses of Fentanyl in Elderly Patients for Painless Gastroscopy
Guo Y, Yao Z, Feng Y, Wang D, Wang Y, Lin J
Drug Design, Development and Therapy 2024, 18:2347-2356
Published Date: 18 June 2024
The Role and Therapeutic Potential of Melatonin in Degenerative Fundus Diseases: Diabetes Retinopathy and Age-Related Macular Degeneration
Ma C, Li H, Lu S, Li X
Drug Design, Development and Therapy 2024, 18:2329-2346
Published Date: 18 June 2024
Comparison of the Safety and Efficacy of Remimazolam Besylate versus Dexmedetomidine for Patients Undergoing Fiberoptic Bronchoscopy: A Prospective, Randomized Controlled Trial
Xu H, Wang L, Zhu W, Ren C, Liu G, Liu Y
Drug Design, Development and Therapy 2024, 18:2317-2327
Published Date: 18 June 2024
Nepetoidin B Alleviates Liver Ischemia/Reperfusion Injury via Regulating MKP5 and JNK/P38 Pathway
Yu Q, Mei C, Cui M, He Q, Liu X, Du X
Drug Design, Development and Therapy 2024, 18:2301-2315
Published Date: 17 June 2024
Penehyclidine for Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Gynecological Laparoscopic Surgery Under Combined Intravenous and Inhalation Anesthesia: A Randomized, Double-Blind, Placebo-Controlled Trial [Letter]
Satici MH
Drug Design, Development and Therapy 2024, 18:2299-2300
Published Date: 17 June 2024
The Mechanism of Catalpol to Improve Oxidative Damage of Dermal Fibroblasts Based on Nrf2/HO-1 Signaling Pathway
Lang X, Xu L, Li L, Feng X
Drug Design, Development and Therapy 2024, 18:2287-2297
Published Date: 18 June 2024
Pharmacokinetics and Bioequivalence of Apremilast Tablets in Chinese Healthy Subjects Under Fasting and Postprandial States
Bai W, Sun X, Qiu B, Guo C, Song H, Hu Y, Zhang X, Yin P, Wang X, Dong Z
Drug Design, Development and Therapy 2024, 18:2273-2285
Published Date: 14 June 2024
The Benefit of the Optimized Formula of Yinxieling in Psoriasis Vulgaris via Regulation on Autophagy Based on microRNA Expression Profile and Network Pharmacology Analysis
Lu Y, Pan S, Li W, Qi Y, Li L, Yan YH, Wei J, Yao DN, Wu J, Deng H, Ye S, Chen H, Chen Q, Gao H, Han L, Lu C
Drug Design, Development and Therapy 2024, 18:2257-2272
Published Date: 14 June 2024
Effects of the Application Local Zoledronic Acid On Different Dental Implants in Rats On Osseointegration
Bingul MB, Gul M, Dundar S, Bozoglan A, Kirtay M, Ozupek MF, Ozcan EC, Habek O, Tasdemir I
Drug Design, Development and Therapy 2024, 18:2249-2256
Published Date: 14 June 2024
Microbiome Metabolomic Analysis of the Anxiolytic Effect of Baihe Dihuang Decoction in a Rat Model of Chronic Restraint Stress
Tang L, Liu J, Yang H, Zhao HQ, Hu C, Ma SJ, Qing YH, Yang L, Zhou RR, Zhang SH
Drug Design, Development and Therapy 2024, 18:2227-2248
Published Date: 12 June 2024
Effectiveness of Spironolactone in Reducing Osteoporosis and Future Fracture Risk in Middle-Aged and Elderly Hypertensive Patients
Song S, Cai X, Hu J, Zhu Q, Shen D, Ma H, Zhang Y, Ma R, Yang W, Hong J, Zhang D, Li N
Drug Design, Development and Therapy 2024, 18:2215-2225
Published Date: 12 June 2024
MTCH2 in Metabolic Diseases, Neurodegenerative Diseases, Cancers, Embryonic Development and Reproduction
Peng X, Yang Y, Hou R, Zhang L, Shen C, Yang X, Luo Z, Yin Z, Cao Y
Drug Design, Development and Therapy 2024, 18:2203-2213
Published Date: 12 June 2024
Development of Intratumoral Drug Delivery Based Strategies for Antitumor Therapy
Jiang Z, Fu Y, Shen H
Drug Design, Development and Therapy 2024, 18:2189-2202
Published Date: 11 June 2024
Integrating Network Pharmacology and Experimental Validation to Decipher the Mechanism of Action of Astragalus–Atractylodes Herb Pair in Treating Hepatocellular Carcinoma
Liang Y, Xie Y, Liu X, Yu L, Yan H, Shang Z, Wu Y, Cai X, Shi W, Du J, Yang Z
Drug Design, Development and Therapy 2024, 18:2169-2187
Published Date: 11 June 2024
Endocannabinoid Hydrolase Inhibitors: Potential Novel Anxiolytic Drugs
Zhao H, Liu Y, Cai N, Liao X, Tang L, Wang Y
Drug Design, Development and Therapy 2024, 18:2143-2167
Published Date: 11 June 2024
Benzoylaconine Protects Skeletal Muscle Against Ischemia-Reperfusion Injury Through Activation of IF1-Dependent AMPK/Nrf2 Axis
Cui Y, Liu Q, Zhang Q, Di X, Zhang H
Drug Design, Development and Therapy 2024, 18:2125-2142
Published Date: 10 June 2024
Extracellular Vesicles Derived from H2O2-Stimulated Adipose-Derived Stem Cells Alleviate Senescence in Diabetic Bone Marrow Mesenchymal Stem Cells and Restore Their Osteogenic Capacity
Li Y, Yue G, Yu S, Liu Z, Cao Y, Wang X
Drug Design, Development and Therapy 2024, 18:2103-2124
Published Date: 10 June 2024
Effects of Ultrasound-Guided Thoracic Paravertebral Nerve Block Combined with Perineural or IV Dexmedetomidine on Acute and Chronic Pain After Thoracoscopic Resection of Lung Lesions: A Double-Blind Randomized Trial
Chen Z, Gao C, Zhang Y, Gao Y, Zhang L, Zhao S, Zhang H, Zhao X, Jin Y
Drug Design, Development and Therapy 2024, 18:2089-2101
Published Date: 10 June 2024
Exploring the Frontier of Biopolymer-Assisted Drug Delivery: Advancements, Clinical Applications, and Future Perspectives in Cancer Nanomedicine
Alharbi HM
Drug Design, Development and Therapy 2024, 18:2063-2087
Published Date: 10 June 2024
Mechanism Investigation and Clinical Retrospective Evaluation of Qingyi Granules: Pancreas Cleaner About Ameliorating Severe Acute Pancreatitis with Acute Respiratory Distress Syndrome
Ge P, Luo Y, Zhang J, Liu J, Xu C, Guo H, Gong A, Zhang G, Chen H
Drug Design, Development and Therapy 2024, 18:2043-2061
Published Date: 7 June 2024
Intravenous Odatroltide for Acute Ischemic Stroke Within 24 Hours of Onset: A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study
Chao AC, Lee TH, Pettigrew LC, Hannawi Y, Huang HY, Chi NF, Chan L, Chen PL, Devlin T
Drug Design, Development and Therapy 2024, 18:2033-2042
Published Date: 6 June 2024
Focus on Trabectedin in Ovarian Cancer: What Do We Still Need to Know?
Boccia SM, Sassu CM, Ergasti R, Vertechy L, Apostol AI, Palluzzi E, Fagotti A, Scambia G, Marchetti C
Drug Design, Development and Therapy 2024, 18:2021-2032
Published Date: 7 June 2024
Analysis of Clinical Trials Using Anti-Tumor Traditional Chinese Medicine Monomers
Lv D, Liu Y, Tang R, Fu S, Kong S, Liao Q, Li H, Lin L
Drug Design, Development and Therapy 2024, 18:1997-2020
Published Date: 5 June 2024
Unveiling the Pharmacological Mechanisms of Davidiin’s Anti-Diabetic Efficacy in Streptozotocin-Treated Rats: A Comprehensive Analysis of Serum Metabolome
Li M, Zhou X, Huang D, Zhao Y, Chen J, Dong Z, Chen W, Zhang F, Sun L
Drug Design, Development and Therapy 2024, 18:1981-1996
Published Date: 5 June 2024
Promising Ursolic Acid as a Novel Antituberculosis Agent: Current Progress and Challenges
Pitaloka DAE, Syaputri Y, Nurlilasari P, Khairunnisa SF, Saallah S
Drug Design, Development and Therapy 2024, 18:1969-1979
Published Date: 31 May 2024
Physicochemistry, Nutritional, and Therapeutic Potential of Ficus carica – A Promising Nutraceutical
Fazel MF, Abu IF, Mohamad MHN, Mat Daud NA, Hasan AN, Aboo Bakkar Z, Md Khir MAN, Juliana N, Das S, Mohd Razali MR, Zainal Baharin NH, Ismail AA
Drug Design, Development and Therapy 2024, 18:1947-1968
Published Date: 30 May 2024
Effectiveness of the Use of the Human Recombinant Epidermal Growth Factor in the Subsidized Regime vs The Contributive Regime in Patients with Venous Ulcers in Bogotá
Cacua Sanchez MT, Buenahora G, Carrillo Bravo CA
Drug Design, Development and Therapy 2024, 18:1933-1945
Published Date: 30 May 2024
Phytochemical Analysis and Anti-Biofilm Potential That Cause Dental Caries from Black Cumin Seeds (Nigella sativa Linn.)
Kurnia D, Padilah R, Apriyanti E, Dharsono HDA
Drug Design, Development and Therapy 2024, 18:1917-1932
Published Date: 29 May 2024
Influences of Propofol, Ciprofol and Remimazolam on Dreaming During Anesthesia for Gastrointestinal Endoscopy: A Randomized Double-Blind Parallel-Design Trial
Zhou R, Fu L, Liu S, Gao S, Zhao Z, Jiang W, Liu L, Ren W, Xiang D, You X, Tang C, Zhou Y, Song Y, Xie J, Xie L, Yu R, Zhang X, Zhou D, Han J, Xia L, Xiong L
Drug Design, Development and Therapy 2024, 18:1907-1915
Published Date: 29 May 2024
Neurovascular Adverse Effects of Sars-Cov-2 Vaccination
Panos LD, Bargiotas P, Hadjigeorgiou G, Panos GD
Drug Design, Development and Therapy 2024, 18:1891-1905
Published Date: 30 May 2024
Shen’ge Formula Protects Cardiac Function in Rats with Pressure Overload-Induced Heart Failure
Qiu B, Qiao S, Shi X, Shen L, Deng B, Ma Z, Zhou D, Wei Y
Drug Design, Development and Therapy 2024, 18:1875-1890
Published Date: 30 May 2024
Effect of Preadministration of Nalmefene on Sufentanil-Induced Cough During Induction of General Anesthesia in Patients Undergoing Breast Surgery: A Double-Blind Randomized Controlled Trial
Xie W, He H, Hong J, Feng C, Li W, Li Y
Drug Design, Development and Therapy 2024, 18:1865-1874
Published Date: 29 May 2024
Evaluation of Drug-Drug Interaction Between Henagliflozin and Hydrochlorothiazide in Healthy Chinese Volunteers
Chen Q, Yu C, Wu Q, Song R, Liu Y, Feng S, Yu C, Jia J
Drug Design, Development and Therapy 2024, 18:1855-1864
Published Date: 29 May 2024
Parabacteroides distasonis-Derived Outer Membrane Vesicles Enhance Antitumor Immunity Against Colon Tumors by Modulating CXCL10 and CD8+ T Cells
Liang R, Li P, Yang N, Xiao X, Gong J, Zhang X, Bai Y, Chen Y, Xie Z, Liao Q
Drug Design, Development and Therapy 2024, 18:1833-1853
Published Date: 28 May 2024
Notoginsenoside R1 Ameliorate High-Fat-Diet and Vitamin D3-Induced Atherosclerosis via Alleviating Inflammatory Response, Inhibiting Endothelial Dysfunction, and Regulating Gut Microbiota
Ma L, Gao Y, Yang G, Zhao L, Zhao Z, Zhao Y, Zhang Y, Li S, Li S
Drug Design, Development and Therapy 2024, 18:1821-1832
Published Date: 27 May 2024
Assessing the Impact of Morphine on Adverse Outcomes in ACS Patients Treated with P2Y12 Inhibitors: Insights from Multiple Real-World Evidence
Ouyang C, Meng C, Li F, Nie S, Gong L, Cao Y, Yuan H, Feng Z
Drug Design, Development and Therapy 2024, 18:1811-1819
Published Date: 27 May 2024
Effect of Oxycodone-Based Multimodal Analgesia on Visceral Pain After Major Laparoscopic Gastrointestinal Surgery: A Randomised, Double-Blind, Controlled Trial
Yang GW, Cheng H, Song XY, Yang YF, Liu H, Ji FH, Peng K
Drug Design, Development and Therapy 2024, 18:1799-1810
Published Date: 27 May 2024
Dexmedetomidine’s Effects on the Livers and Kidneys of Rats with Pancreatic Ischemia-Reperfusion Injury
Bostancı H, Erel S, Küçük A, Kip G, Sezen ŞC, Gokgoz S, Atlı M, Aktepe F, Dikmen K, Arslan M, Kavutçu M
Drug Design, Development and Therapy 2024, 18:1785-1797
Published Date: 27 May 2024
Population Pharmacokinetic Models of Venetoclax in Hematologic Malignancies: A Systematic Review
Zhao Y, Guo N, Zhu Y, Shang J, Chen J, Luo X, Liu Y, Zhang X, Huang L
Drug Design, Development and Therapy 2024, 18:1771-1784
Published Date: 27 May 2024
Andrographolide Attenuates NLRP3 Inflammasome Activation and Airway Inflammation in Exacerbation of Chronic Obstructive Pulmonary Disease
Yu Y, Miao TW, Xiao W, Mao B, Du LY, Wang Y, Fu JJ
Drug Design, Development and Therapy 2024, 18:1755-1770
Published Date: 24 May 2024
Comparison of Remimazolam Tosilate and Propofol Sedation on the Early Postoperative Quality of Recovery in Patients Undergoing Day Surgery: A Prospective Randomized Controlled Trial
Zhang L, Wang Z, Liu Y, Zhang X, Wu Y
Drug Design, Development and Therapy 2024, 18:1743-1754
Published Date: 23 May 2024
Effect of Continuous Infusion of Different Doses of Esketamine on the Bispectral Index During Sevoflurane Anesthesia: A Randomized Controlled Trial
Ren L, Yang J, Li Y, Wang Y
Drug Design, Development and Therapy 2024, 18:1727-1741
Published Date: 23 May 2024
Imrecoxib: Advances in Pharmacology and Therapeutics
Wang YH, Zhu LL, Li TL, Zhou Q
Drug Design, Development and Therapy 2024, 18:1711-1725
Published Date: 22 May 2024
Magnolia Officinalis Alcohol Extract Alleviates the Intestinal Injury Induced by Polygala Tenuifolia Through Regulating the PI3K/AKT/NF-κB Signaling Pathway and Intestinal Flora
Liu S, Yang D, Li W, Chen Q, Lu D, Xiong L, Wu J, Ao H, Huang L
Drug Design, Development and Therapy 2024, 18:1695-1710
Published Date: 22 May 2024
Pristimerin Exerts Pharmacological Effects Through Multiple Signaling Pathways: A Comprehensive Review
Sun J, Tian Z, Wu J, Li J, Wang Q, Huang S, Wang M
Drug Design, Development and Therapy 2024, 18:1673-1694
Published Date: 18 May 2024
Integrated Approaches Revealed the Therapeutic Mechanisms of Zuojin Pill Against Gastric Mucosa Injury in a Rat Model with Chronic Atrophic Gastritis
Chen L, He T, Wang R, Liu H, Wang X, Li H, Jing M, Zhou X, Wei S, Zou W, Zhao Y
Drug Design, Development and Therapy 2024, 18:1651-1672
Published Date: 17 May 2024
Effects of Natural Products through Inhibiting Endoplasmic Reticulum Stress on Attenuation of Idiopathic Pulmonary Fibrosis
Deng J, Liu J, Chen W, Liang Q, He Y, Sun G
Drug Design, Development and Therapy 2024, 18:1627-1650
Published Date: 17 May 2024
Preoperative Anxiolytic and Sedative Effects of Intranasal Remimazolam and Dexmedetomidine: A Randomized Controlled Clinical Study in Children Undergoing General Surgeries
Cai YH, Wang CY, Fang YB, Ma HY, Gao YQ, Wang Z, Wu J, Lin H, Liu HC
Drug Design, Development and Therapy 2024, 18:1613-1625
Published Date: 17 May 2024
Low-Dose Alfentanil Inhibits Sufentanil-Induced Cough During Anesthesia Induction: A Prospective, Randomized, Double-Blind Study
Xu Q, Zou X, Wu J, Duan G, Lan H, Wang L
Drug Design, Development and Therapy 2024, 18:1603-1612
Published Date: 17 May 2024
Integrated Network Pharmacology and Experimental Validation Approach to Investigate the Mechanisms of Radix Rehmanniae Praeparata - Angelica Sinensis - Radix Achyranthis Bidentatae in Treating Knee Osteoarthritis
Liu L, Zhang B, Zhou Z, Yang J, Li A, Wu Y, Peng Z, Li X, Liu Z, Leng X, Zhao C, Dong H, Zhao W
Drug Design, Development and Therapy 2024, 18:1583-1602
Published Date: 15 May 2024
Comparative Bleeding Risk of Brand Vs Generic Rivaroxaban in Elderly Inpatients with Atrial Fibrillation
Chen G, Chen J, Zhao Q, Zhu Y
Drug Design, Development and Therapy 2024, 18:1573-1582
Published Date: 13 May 2024
A Comprehensive Update of Anti-COVID-19 Activity of Heterocyclic Compounds
Nazir MS, Ahmad M, Aslam S, Rafiq A, Al-Hussain SA, Zaki MEA
Drug Design, Development and Therapy 2024, 18:1547-1571
Published Date: 8 May 2024
A Novel Tetramethylpyrazine Chalcone Hybrid- HCTMPPK, as a Potential Anti-Lung Cancer Agent by Downregulating MELK
Ma Y, Cui Q, Zhu W, Wang M, Zhai L, Hu W, Liu D, Liu M, Li Y, Li M, Han W
Drug Design, Development and Therapy 2024, 18:1531-1546
Published Date: 7 May 2024
Impact of Opioid-Free Anesthesia on Postoperative Quality of Recovery in Patients After Laparoscopic Cholecystectomy: A Randomized Controlled Trial [Letter]
Xue B
Drug Design, Development and Therapy 2024, 18:1529-1530
Published Date: 6 May 2024
ED-71 Improves Bone Mass in Ovariectomized Rats by Inhibiting Osteoclastogenesis Through EphrinB2-EphB4-RANKL/OPG Axis
Wang K, Kou Y, Rong X, Wei L, Li J, Liu H, Li M, Song H
Drug Design, Development and Therapy 2024, 18:1515-1528
Published Date: 6 May 2024
Naodesheng Pills Ameliorate Cerebral Ischemia Reperfusion-Induced Ferroptosis via Inhibition of the ERK1/2 Signaling Pathway
Yang YY, Deng RR, Xiang DX
Drug Design, Development and Therapy 2024, 18:1499-1514
Published Date: 2 May 2024
Network Pharmacology and Molecular Docking Identify the Potential Mechanism and Therapeutic Role of Scutellaria baicalensis in Alzheimer’s Disease [Letter]
Yulion R, Andriani L, Aliyah SH
Drug Design, Development and Therapy 2024, 18:1497-1498
Published Date: 2 May 2024
Advances in Nanotechnology for Enhancing the Solubility and Bioavailability of Poorly Soluble Drugs
Liu Y, Liang Y, Yuhong J, Xin P, Han JL, Du Y, Yu X, Zhu R, Zhang M, Chen W, Ma Y
Drug Design, Development and Therapy 2024, 18:1469-1495
Published Date: 1 May 2024
Dose-Response Study of Phenylephrine for Preventing Spinal-Induced Hypotension During Cesarean Delivery with Combined Spinal-Epidural Anesthesia Under the Effect of Prophylactic Intravenous Ondansetron
Sun XX, Qian J, Fan JM, Liu L, Jin XF, Xiao F
Drug Design, Development and Therapy 2024, 18:1459-1467
Published Date: 30 April 2024
Integrated Network Pharmacology Analysis and Experimental Validation to Elucidate the Mechanism of Acteoside in Treating Diabetic Kidney Disease
Zhang SJ, Zhang YF, Bai XH, Zhou MQ, Zhang ZY, Zhang SX, Cao ZJ, Wang L, Ding SW, Zheng HJ, Liu YN, Yu GY, Liu WJ
Drug Design, Development and Therapy 2024, 18:1439-1457
Published Date: 30 April 2024
Network and Experimental Pharmacology on Mechanism of Yixintai Regulates the TMAO/PKC/NF-κB Signaling Pathway in Treating Heart Failure
Wang Z, Liu C, Wei J, Yuan H, Shi M, Zhang F, Zeng Q, Huang A, Du L, Li Y, Guo Z
Drug Design, Development and Therapy 2024, 18:1415-1438
Published Date: 30 April 2024
The Molecular Biological Mechanism of Hydrogen Therapy and Its Application in Spinal Cord Injury
Hu Q, Li Y, Lin Z, Zhang H, Chen H, Chao C, Zhao C
Drug Design, Development and Therapy 2024, 18:1399-1414
Published Date: 29 April 2024
Research Progress of Long Non-Coding RNA in Tumor Drug Resistance: A New Paradigm
Zhang J, Wu L, Wang C, Xie X, Han Y
Drug Design, Development and Therapy 2024, 18:1385-1398
Published Date: 26 April 2024
Dynasore Alleviates LPS-Induced Acute Lung Injury by Inhibiting NLRP3 Inflammasome-Mediated Pyroptosis
Shan M, Wan H, Ran L, Ye J, Xie W, Lu J, Hu X, Deng S, Zhang W, Chen M, Wang F, Guo Z
Drug Design, Development and Therapy 2024, 18:1369-1384
Published Date: 23 April 2024
Propofol and Dexmedetomidine Ameliorate Endotoxemia-Associated Encephalopathy via Inhibiting Ferroptosis
Zhou Y, Yang Y, Yi L, Pan M, Tang W, Duan H
Drug Design, Development and Therapy 2024, 18:1349-1368
Published Date: 23 April 2024
Effect of Fluid Therapy in Early Morning on the Incidence of Post-Induction Hypotension During Non-Cardiac Surgery After Noon: A Single-Center Retrospective Study
Zhang Y, Wang X, Sang X, Zhou Z, Dai G, Zhang X
Drug Design, Development and Therapy 2024, 18:1339-1347
Published Date: 22 April 2024
Validation of Core Ingredients and Molecular Mechanism of Cinobufotalin Injection Against Liver Cancer
Chen S, Li M, Xue C, Zhou X, Wei J, Zheng L, Duan Y, Deng H, Tang F, Xiong W, Xiang B, Zhou M
Drug Design, Development and Therapy 2024, 18:1321-1338
Published Date: 23 April 2024
The Median Effective Dose of Intrathecal Hyperbaric Bupivacaine for Cesarean Section at Moderately High-Altitude
Yang C, Dong W, Luo J, Ma M, Gao Y, Ni L, Liu H, Cha C, Xiao Y, Huang S
Drug Design, Development and Therapy 2024, 18:1313-1319
Published Date: 22 April 2024
Natural and Synthetic Drugs Approached for the Treatment of Recurrent Aphthous Stomatitis Over the Last Decade
Vitamia C, Iftinan GN, Latarissa IR, Wilar G, Cahyanto A, Elamin KM, Wathoni N
Drug Design, Development and Therapy 2024, 18:1297-1312
Published Date: 22 April 2024
RNA-Based Antipsoriatic Gene Therapy: An Updated Review Focusing on Evidence from Animal Models
Lin ZC, Hung CF, Aljuffali IA, Lin MH, Fang JY
Drug Design, Development and Therapy 2024, 18:1277-1296
Published Date: 23 April 2024
Obacunone Alleviates Inflammatory Pain by Promoting M2 Microglial Polarization and by Activating Nrf2/HO-1 Signaling Pathway
Nan F, Tian Q, Chen S
Drug Design, Development and Therapy 2024, 18:1265-1275
Published Date: 18 April 2024
Cinnamaldehyde Inhibits the Function of Osteosarcoma by Suppressing the Wnt/β-Catenin and PI3K/Akt Signaling Pathways [Retraction]
Huang Y, Chen J, Yang S, Tan T, Wang N, Wang Y, Zhang L, Yang C, Huang H, Luo J, Luo X
Drug Design, Development and Therapy 2024, 18:1263-1264
Published Date: 18 April 2024
Sinomenine Hydrochloride Protects IgA Nephropathy Through Regulating Cell Growth and Apoptosis of T and B Lymphocytes
Li JJ, Li L, Li S, Tang XY, Sun HF, Liu JX
Drug Design, Development and Therapy 2024, 18:1247-1262
Published Date: 17 April 2024
Dexamethasone versus Dexmedetomidine as Adjuvants in Ultrasound Popliteal Sciatic Nerve Block for Hallux Valgus Surgery: A Mono-Centric Retrospective Comparative Study
Coviello A, Iacovazzo C, Cirillo D, Bernasconi A, Marra A, Squillacioti F, Martone M, Garone E, Coppola F, de Siena AU, Vargas M, Servillo G
Drug Design, Development and Therapy 2024, 18:1231-1245
Published Date: 17 April 2024
Clinical Application and Research Progress of Remimazolam for Pediatric Patients
Bai C, Xu M, Guo Y, Jin Y, Zhao X
Drug Design, Development and Therapy 2024, 18:1221-1229
Published Date: 17 April 2024
Network Pharmacology and Molecular Docking Identify the Potential Mechanism and Therapeutic Role of Scutellaria baicalensis in Alzheimer’s Disease
Peng Y, Zhou C
Drug Design, Development and Therapy 2024, 18:1199-1219
Published Date: 17 April 2024
Effect of S-Ketamine on Postoperative Nausea and Vomiting in Patients Undergoing Video-Assisted Thoracic Surgery: A Randomized Controlled Trial
Qi Y, Zhou M, Zheng W, Dong Y, Li W, Wang L, Xu H, Zhang M, Yang D, Wang L, Zhou H
Drug Design, Development and Therapy 2024, 18:1189-1198
Published Date: 16 April 2024
A Novel Network Pharmacology Strategy Based on the Universal Effectiveness-Common Mechanism of Medical Herbs Uncovers Therapeutic Targets in Traumatic Brain Injury
Yu Z, Ding R, Yan Q, Cheng M, Li T, Zheng F, Zhu L, Wang Y, Tang T, Hu E
Drug Design, Development and Therapy 2024, 18:1175-1188
Published Date: 16 April 2024
Citric Acid Controls the Activity of YopH Bacterial Tyrosine Phosphatase
Styszko J, Kostrzewa T, Gorska-Ponikowska M, Kuban-Jankowska A
Drug Design, Development and Therapy 2024, 18:1165-1174
Published Date: 11 April 2024
Outcome of Darunavir–Cobicistat-Based Regimens in HIV-Infected People Who Have Experienced Virological Failure
Alberton F, Galli L, Lolatto R, Candela C, Gianotti N, Chiurlo M, Ranzenigo M, Strano M, Uglietti A, Castagna A
Drug Design, Development and Therapy 2024, 18:1153-1163
Published Date: 10 April 2024
The Promise of Therapeutic Psilocybin: An Evaluation of the 134 Clinical Trials, 54 Potential Indications, and 0 Marketing Approvals on ClinicalTrials.gov
Norring SA, Spigarelli MG
Drug Design, Development and Therapy 2024, 18:1143-1151
Published Date: 10 April 2024
Synthesis and Anti-Diabetic Activity of an 8-Purine Derivative as a Novel DPP-4 Inhibitor in Obese Diabetic Zücker Rats
Chayah M, Luque-González A, Gómez-Pérez V, Salagre D, Al-Shdaifat A, Campos JM, Conejo-García A, Agil A
Drug Design, Development and Therapy 2024, 18:1133-1141
Published Date: 10 April 2024
Unveiling the Mechanism of the ChaiShao Shugan Formula Against Triple-Negative Breast Cancer
Fan T, Huang Y, Liu Z, Huang J, Ke B, Rong Y, Qiu H, Zhang B
Drug Design, Development and Therapy 2024, 18:1115-1131
Published Date: 10 April 2024
Dexmedetomidine Prolongs Lidocaine Intravenous Regional Anesthesia in Rats by Blocking the Hyperpolarization-Activated Cation Current
Zhang T, Liao X, Chen Y, Shu X, Liu D, Yao Y
Drug Design, Development and Therapy 2024, 18:1103-1114
Published Date: 9 April 2024
Updated Evaluation of Agalsidase Alfa Enzyme Replacement Therapy for Patients with Fabry Disease: Insights from Real-World Data
Feriozzi S, Chimenti C, Reisin RC
Drug Design, Development and Therapy 2024, 18:1083-1101
Published Date: 3 April 2024
Mapping the Research of Ferroptosis in Parkinson’s Disease from 2013 to 2023: A Scientometric Review
Chen Y, Wu Z, Li S, Chen Q, Wang L, Qi X, Tian C, Yang M
Drug Design, Development and Therapy 2024, 18:1053-1081
Published Date: 3 April 2024
Molecular Modeling, Synthesis, and Antihyperglycemic Activity of the New Benzimidazole Derivatives – Imidazoline Receptor Agonists
Martynov A, Farber B, Bomko T, Beckles DL, Kleyn I
Drug Design, Development and Therapy 2024, 18:1035-1052
Published Date: 3 April 2024
Exploring the Median Effective Dose of Ciprofol for Anesthesia Induction in Elderly Patients: Impact of Frailty on ED50
Yuan J, Liang Z, Geoffrey MB, Xie Y, Chen S, Liu J, Xia Y, Li H, Zhao Y, Mao Y, Xing N, Yang J, Wang Z, Xing F
Drug Design, Development and Therapy 2024, 18:1025-1034
Published Date: 3 April 2024
Forsythoside B Mitigates Monocrotaline-Induced Pulmonary Arterial Hypertension via Blocking the NF-κB Signaling Pathway to Attenuate Vascular Remodeling [LETTER]
Pasiana AD, Idrus HH, Purnamasari I
Drug Design, Development and Therapy 2024, 18:1023-1024
Published Date: 2 April 2024
The Emerging Roles of Nanocarrier Drug Delivery System in Treatment of Intervertebral Disc Degeneration-Current Knowledge, Hot Spots, Challenges and Future Perspectives
Hu Y, Yang R, Liu S, Song Z, Wang H
Drug Design, Development and Therapy 2024, 18:1007-1022
Published Date: 29 March 2024
Revolutionizing Stroke Recovery: Unveiling the Promise of Stem Cell Therapy
Panos LD, Bargiotas P, Arnold M, Hadjigeorgiou G, Panos GD
Drug Design, Development and Therapy 2024, 18:991-1006
Published Date: 29 March 2024
The Potential of Exosomes for Osteoporosis Treatment: A Review
He Y, Chen Y
Drug Design, Development and Therapy 2024, 18:979-989
Published Date: 28 March 2024
The Safety and Efficacy of Remimazolam Compared to Dexmedetomidine for Awake Tracheal Intubation by Flexible Bronchoscopy: A Randomized, Double-Blind, Controlled Trial
Chen Q, Qin B, Zhang M, Zhou Y, Shi X, Xie Y
Drug Design, Development and Therapy 2024, 18:967-978
Published Date: 28 March 2024
Neurophysiological Characteristics in Type II and Type III 5q Spinal Muscular Atrophy Patients: Impact of Nusinersen Treatment
Li D, Sun N, Xiang L, Liu J, Wang X, Yang L, Huang S
Drug Design, Development and Therapy 2024, 18:953-965
Published Date: 28 March 2024
A Review of Dupilumab in the Treatment of Atopic Dermatitis in Infants and Children
Wang M, Gao XH, Zhang L
Drug Design, Development and Therapy 2024, 18:941-951
Published Date: 27 March 2024
The Impact of Baohuoside I on the Metabolism of Tofacitinib in Rats
Shi Y, Lu Z, Song W, Wang Y, Zhou Q, Geng P, Zhou Y, Wang S, Han A
Drug Design, Development and Therapy 2024, 18:931-939
Published Date: 25 March 2024
Effect of Intraoperative infusion Magnesium Sulfate Infusion on Postoperative Quality of Recovery in Patients Undergoing Total Knee Arthroplasty: A Prospective, Double-Blind, Randomized Controlled Trial
Xu H, Hao C, Wang X, Du J, Zhang T, Zhang X
Drug Design, Development and Therapy 2024, 18:919-929
Published Date: 25 March 2024
Intracranial Efficacy of Pyrotinib and Capecitabine Combination Therapy in HER2-Positive Breast Cancer with Brain Metastases
Wang C, Xiang J, Zhang Q, Li J, Liu Y, Liu J
Drug Design, Development and Therapy 2024, 18:909-917
Published Date: 23 March 2024
Harmonising IV Oxycodone with Paediatric Perioperative Medications: A Compatibility Study Through Y-Type Connectors
Youssef SH, Garg A, Song Y, Wylie NE, Garg S
Drug Design, Development and Therapy 2024, 18:899-908
Published Date: 22 March 2024
The Efficacy of Chaihu-Guizhi-Ganjiang Decoction on Chronic Non-Atrophic Gastritis with Gallbladder Heat and Spleen Cold Syndrome and Its Metabolomic Analysis: An Observational Controlled Before-After Clinical Trial
Wen T, Liu X, Pang T, Li M, Jiao G, Fan X, Tang J, Zhang C, Wang Z, Yue X, Chen W, Zhang F
Drug Design, Development and Therapy 2024, 18:881-897
Published Date: 21 March 2024
Optimal Once-Daily Busulfan Administration in Pediatric Patients: A Simulation-Based Investigation of Intravenous Infusion Times
Kim Y, Moon S, Rhee SJ
Drug Design, Development and Therapy 2024, 18:871-879
Published Date: 20 March 2024
A Novel DNA Aptamer Probe Recognizing Castration Resistant Prostate Cancer in vitro and in vivo Based on Cell-SELEX
Zhong J, Liu D, Yang Q, Ding J, Chen X
Drug Design, Development and Therapy 2024, 18:859-870
Published Date: 18 March 2024
Comparison of the Efficacy of Anti-Obesity Medications in Real-World Practice
Song JE, Ko HJ, Kim AS
Drug Design, Development and Therapy 2024, 18:845-858
Published Date: 18 March 2024
Understanding Sorafenib-Induced Cardiovascular Toxicity: Mechanisms and Treatment Implications
Li J, Zhang L, Ge T, Liu J, Wang C, Yu Q
Drug Design, Development and Therapy 2024, 18:829-843
Published Date: 18 March 2024
Development and Characterization of a Novel Carbon-11 Labeled Positron Emission Tomography Radiotracer for Neuroimaging of Sirtuin 1 with Benzoxazine-Based Compounds
Wang Y, Liu Y, Wang Y, Bai P, Hallisey MR, Varela BL, Siewko A, Wang C, Xu Y
Drug Design, Development and Therapy 2024, 18:819-827
Published Date: 15 March 2024
Model-Informed Precision Dosing of Isoniazid: Parametric Population Pharmacokinetics Model Repository
Ju G, Liu X, Yang W, Xu N, Chen L, Zhang C, He Q, Zhu X, Ouyang D
Drug Design, Development and Therapy 2024, 18:801-818
Published Date: 14 March 2024
Qifu Yixin Formula Improves Heart Failure by Enhancing β-Arrestin2 Mediated the SUMOylation of SERCA2a
Wang X, Yang J, Lu C, Hu Y, Xu Z, Wan Q, Zhang M, Shi T, Liu Z, Liu Y
Drug Design, Development and Therapy 2024, 18:781-799
Published Date: 11 March 2024
Forsythoside B Mitigates Monocrotaline-Induced Pulmonary Arterial Hypertension via Blocking the NF-κB Signaling Pathway to Attenuate Vascular Remodeling
Liu J, Fang G, Lan C, Qiu C, Yao L, Zhang Q, Hu J, Zhang Y, Yang Y, Zhang Y
Drug Design, Development and Therapy 2024, 18:767-780
Published Date: 11 March 2024
Mechanisms of Action of Potentilla discolor Bunge in Type 2 Diabetes Mellitus Based on Network Pharmacology and Experimental Verification in Drosophila
Li Y, Wu F, Zhang J, Xu Y, Chang H, Yu Y, Jiang C, Gao X, Liu H, Chen Z, Wu C, Li JA
Drug Design, Development and Therapy 2024, 18:747-766
Published Date: 11 March 2024
Bibliometric and Visualization Analysis of Stem Cell Therapy for Erectile Dysfunction
Sun T, Liu Y, Yuan P, Jia Z, Yang J
Drug Design, Development and Therapy 2024, 18:731-746
Published Date: 8 March 2024
UHPLC-qTOF-MS-Based Nontargeted Metabolomics to Characterize the Effects of Capsaicin on Plasma and Skin Metabolic Profiles of C57BL/6 Mice-An In vivo Experimental Study
Xiao Z, Yu S, Zhang D, Li C
Drug Design, Development and Therapy 2024, 18:719-729
Published Date: 5 March 2024
Integrated Network Pharmacology and in vivo Experimental Validation Approach to Explore the Potential Antioxidant Effects of Annao Pingchong Decoction in Intracerebral Hemorrhage Rats
Zhou X, Wang X, Li J, Zhang M, Yang Y, Lei S, He Y, Yang H, Zhou D, Guo C
Drug Design, Development and Therapy 2024, 18:699-717
Published Date: 4 March 2024
Penehyclidine for Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Gynecological Laparoscopic Surgery Under Combined Intravenous and Inhalation Anesthesia: A Randomized, Double-Blind, Placebo-Controlled Trial
Zhao K, Gao Y, Zhang J, Wang S, Chen J, Guo F, Wang S
Drug Design, Development and Therapy 2024, 18:685-697
Published Date: 1 March 2024
Safety and Effectiveness of a Biosimilar Recombinant Human Growth Hormone in Children Requiring Growth Hormone Treatment: Analysis of Final Data from PATRO Children, an International, Post-Marketing Surveillance Study
Loche S, Kanumakala S, Backeljauw P, Schwab KO, Lechuga-Sancho AM, Esmael A, Urosevic D, Boldea A, Zabransky M
Drug Design, Development and Therapy 2024, 18:667-684
Published Date: 2 March 2024
Exploration of the in vitro Antiviral Effects and the Active Components of Changyanning Tablets Against Enterovirus 71
Ge Q, Zhang Z, Cao Z, Wu D, Xu C, Yao J, Gao J, Feng Y
Drug Design, Development and Therapy 2024, 18:651-665
Published Date: 2 March 2024
Randomized Double-Blinded Comparison of Intermittent Boluses Phenylephrine and Norepinephrine for the Treatment of Postspinal Hypotension in Patients with Severe Pre-Eclampsia During Cesarean Section
Pan ZB, Sheng ZM, Zhu M, Mei Z, Shen YP, Liu JP, Qian XW
Drug Design, Development and Therapy 2024, 18:639-650
Published Date: 29 February 2024
Clinical Study of Flumazenil Antagonizing Remimazolam on Nausea and Vomiting After Gynecologic Day Surgery
Wei Y, Zhu M, Man Y, Xiao H, Dong G, Shi X, Ji F
Drug Design, Development and Therapy 2024, 18:631-638
Published Date: 4 March 2024
A Window for Enhanced Oral Delivery of Therapeutics via Lipid Nanoparticles
Amekyeh H, Sabra R, Billa N
Drug Design, Development and Therapy 2024, 18:613-630
Published Date: 29 February 2024
Synthesis of a New Series of Anthraquinone-Linked Cyclopentanone Derivatives: Investigating the Antioxidant, Antibacterial, Cytotoxic and Tyrosinase Inhibitory Activities of the Mushroom Tyrosinase Enzyme Using Molecular Docking
Mullaivendhan J, Akbar I, Ahamed A, Gatasheh MK, Hatamleh AA, Raman G, Manilal A, Kuzhunellil Raghavanpillai S
Drug Design, Development and Therapy 2024, 18:597-612
Published Date: 27 February 2024
Effects of Remifentanil Gradual Withdrawal Combined with Postoperative Infusion on Postoperative Hyperalgesia in Patients Undergoing Laparoscopic hysterectomy: A Factorial Design, Double-Blind, Randomized Controlled Trial
Luo M, Han X, Li H, Zhou G, Chen H, Gao F
Drug Design, Development and Therapy 2024, 18:583-595
Published Date: 27 February 2024
Pharmacokinetics, Pharmacodynamics, and Safety of Evocalcet (KHK7580), a Novel Calcimimetic Agent: An Open-Label, Single- and Multiple-Dose, Phase I Trial in Healthy Chinese Subjects
He X, Narushima K, Kojima M, Nagai C, Li K
Drug Design, Development and Therapy 2024, 18:567-581
Published Date: 26 February 2024
Protective Effects of Red Ginseng Against Tacrine-Induced Hepatotoxicity: An Integrated Approach with Network Pharmacology and Experimental Validation
Kim BJ, Bak SB, Bae SJ, Jin HJ, Park SM, Kim YR, Jung DH, Song CH, Kim YW, Kim SC, Lee WY, Park SD
Drug Design, Development and Therapy 2024, 18:549-566
Published Date: 23 February 2024
The Effects of Different Doses of Sufentanil on Intraoperative Cardiovascular Response and Postoperative Recovery in Patients Undergoing Cardiac Surgery: A Retrospective Cohort Study
Li M, Li X, Wu Y, Zhang T, Li M, Chen Y
Drug Design, Development and Therapy 2024, 18:535-547
Published Date: 23 February 2024
Immunomodulatory Role of Plants and Their Constituents on the Management of Metabolic Disorders: An Evidence-Based Review
Febriyanti RM, Levita J, Diantini A
Drug Design, Development and Therapy 2024, 18:513-534
Published Date: 23 February 2024
Network Pharmacology with Metabolomics Study to Reveal the Mechanisms of Bushen Huoxue Formula in Intervertebral Disc Degeneration Treatment
Guo J, Yang S, Zhai W, Xie Y, Shen Z, Zhang J, Jia Y
Drug Design, Development and Therapy 2024, 18:493-512
Published Date: 21 February 2024
Hydroxy-Safflower Yellow A Mitigates Vascular Remodeling in Rat Pulmonary Arterial Hypertension
Ji XY, Lei CJ, Kong S, Li HF, Pan SY, Chen YJ, Zhao FR, Zhu TT
Drug Design, Development and Therapy 2024, 18:475-491
Published Date: 20 February 2024
Efficacy of Intravenous Administration of Esketamine in Preventing and Treating Rebound Pain After Thoracic Paravertebral Nerve Block: A Prospective Randomized, Double-Blind, Placebo-Controlled Trial
Zeng X, Zhang X, Jiang W, Zhou X
Drug Design, Development and Therapy 2024, 18:463-473
Published Date: 17 February 2024
The Protective Effect of Roflumilast Against Acute Hepatotoxicity Caused by Methotrexate in Wistar Rats: In vivo Evaluation
Almalki RS
Drug Design, Development and Therapy 2024, 18:453-462
Published Date: 15 February 2024
Beneficial Effects of Low-Dose Intravenous Dexmedetomidine Premedication in Patient Undergoing Laparoscopic Cholecystectomy Under General Anesthesia: A Prospective, Double-Blind, Randomized Controlled Trial
Zheng L, Fang T, Zhang W, Zhang X, Ren Z, Qin W, Liang W, Ma Q, Yin N
Drug Design, Development and Therapy 2024, 18:443-452
Published Date: 13 February 2024
Molecular Mechanism of Salvia miltiorrhiza in the Treatment of Colorectal Cancer Based on Network Pharmacology and Molecular Docking Technology
Jiang YL, Xun Y
Drug Design, Development and Therapy 2024, 18:425-441
Published Date: 12 February 2024
Zishen Yutai Pills Promote Angiogenesis at the Maternal-Fetal Interface in Recurrent Spontaneous Abortion Mice by Regulating miR-187/VEGF Axis
Wang X, Hu H, Yu X, Liang C, Han Y, Chen H, Chu J
Drug Design, Development and Therapy 2024, 18:407-423
Published Date: 12 February 2024
Pharmacokinetic Comparison Between a Fixed-Dose Combination of Atorvastatin/Omega-3-Acid Ethyl Esters and the Corresponding Loose Combination in Healthy Korean Male Subjects
Khwarg J, Lee S, Jang IJ, Kang WH, Lee HJ, Kim KY, Jeong KS, Won C, Choi YW, Ha DC, Jung R, Han MG, Jung WT, Nam KY, Kim YS, Yu KS, Oh J
Drug Design, Development and Therapy 2024, 18:395-406
Published Date: 8 February 2024
A Comprehensive Study to Investigate the Tumor-Suppressive Role of Radix Bupleuri on Gastric Cancer with Network Pharmacology and Molecular Docking
Lv L, Du J, Wang D, Yan Z
Drug Design, Development and Therapy 2024, 18:375-394
Published Date: 8 February 2024
Ranibizumab Biosimilars in Treating Retinal Disorders: A Cost-Effective Revolution?
Chatzimichail E, Pfau K, Gatzioufas Z, Panos GD
Drug Design, Development and Therapy 2024, 18:365-374
Published Date: 8 February 2024
Comparative Study Between Dexmedetomidine with Bupivacaine and Bupivacaine Alone in Erector Spinae Plane Block for Postoperative Pain Control of Posterior Lumbosacral Spine Fixation Surgeries: A Randomized Controlled Trial
Abu El Hassan SH, Wahsh EA, Mousa AM, Ibrahim ARN, Mohammed EL
Drug Design, Development and Therapy 2024, 18:351-363
Published Date: 7 February 2024
Remifentanil is Superior to Propofol for Treating Emergence Agitation in Adults After General Anesthesia
Li J, Zhu H, Wang Y, Chen J, He K, Wang S
Drug Design, Development and Therapy 2024, 18:341-350
Published Date: 7 February 2024
The Effect of Ciprofol on Postoperative Delirium in Elderly Patients Undergoing Thoracoscopic Surgery for Lung Cancer: A Prospective, Randomized, Controlled Trial
Liu Z, Jin Y, Wang L, Huang Z
Drug Design, Development and Therapy 2024, 18:325-339
Published Date: 5 February 2024
The Potential Application of Aloe Barbadensis Mill. as Chinese Medicine for Constipation: Mini-Review
Huang WR, Fang QH, Yu XB, Ge WH, Yu Y
Drug Design, Development and Therapy 2024, 18:307-324
Published Date: 3 February 2024
Developments in the Management of Growth Hormone Deficiency: Clinical Utility of Somapacitan
Miller BS, Blair J, Horikawa R, Linglart A, Yuen KC
Drug Design, Development and Therapy 2024, 18:291-306
Published Date: 3 February 2024
Dupilumab Treatment in Pediatric Patients Aged 6–11 Years with Severe Atopic Dermatitis Whose Disease Is Not Adequately Controlled: A Review
Cork MJ, Danby SG, Rossi AB, Bansal A
Drug Design, Development and Therapy 2024, 18:277-289
Published Date: 3 February 2024
Systematic Pharmacology and Experimental Validation to Reveal the Alleviation of Astragalus membranaceus Regulating Ferroptosis in Osteoarthritis
Chen K, Yu Y, Wang Y, Zhu Y, Qin C, Xu J, Zou X, Tao T, Li Y, Jiang Y
Drug Design, Development and Therapy 2024, 18:259-275
Published Date: 1 February 2024
Berberine Nanoparticles with Enhanced in vitro Bioavailability: Characterization and Antimicrobial Activity [Retraction]
Sahibzada MUK, Sadiq A, Faidah HS, Khurram M, Amin MU, Haseeb A, Kakar M
Drug Design, Development and Therapy 2024, 18:257-258
Published Date: 2 February 2024
Guidelines for Rational Clinical Use of Fentanyl Transdermal Patch
Fu Q, Han N, Li N, Gui L, Shi C, Rong P, Zeng F, Rao H, Chen Y
Drug Design, Development and Therapy 2024, 18:233-255
Published Date: 1 February 2024
Effect of Perioperative Nicorandil on Myocardial Protection in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass, a Retrospective Study
Chen Y, Liu Y, Lv H, Li Q, Shen J, Chen W, Shi J, Zhou C
Drug Design, Development and Therapy 2024, 18:223-231
Published Date: 31 January 2024
Synthesis and Characterization of a New Carbon-11 Labeled Positron Emission Tomography Radiotracer for Orexin 2 Receptors Neuroimaging
Wang Y, Wang Y, Liu Y, Cheng H, Dagnew TM, Xu Y, Wang C
Drug Design, Development and Therapy 2024, 18:215-222
Published Date: 31 January 2024
Plants with Anti-Ulcer Activity and Mechanism: A Review of Preclinical and Clinical Studies
Prayoga DK, Aulifa DL, Budiman A, Levita J
Drug Design, Development and Therapy 2024, 18:193-213
Published Date: 1 February 2024
Review of the Protective Mechanism of Curcumin on Cardiovascular Disease
Yang C, Zhu Q, Chen Y, Ji K, Li S, Wu Q, Pan Q, Li J
Drug Design, Development and Therapy 2024, 18:165-192
Published Date: 30 January 2024
Interactive Nutrient Process (INP) in a Generative AI of a New Drug—6-Shogaol as a Potential Case
Badmaev V
Drug Design, Development and Therapy 2024, 18:161-163
Published Date: 27 January 2024
In vitro and in vivo Biological Evaluation of Newly Tacrine-Selegiline Hybrids as Multi-Target Inhibitors of Cholinesterases and Monoamine Oxidases for Alzheimer’s Disease
Huang ST, Luo JC, Zhong GH, Teng LP, Yang CY, Tang CL, Jing L, Zhou ZB, Liu J, Jiang N
Drug Design, Development and Therapy 2024, 18:133-159
Published Date: 24 January 2024
Comparison of Remimazolam versus Sevoflurane on the Postoperative Quality of Recovery in Cervical Spine Surgery: A Prospective Randomized Controlled Double-Blind Trial
Lee J, Han DW, Kim NY, Kim KS, Yang Y, Yang J, Lee HS, Kim MH
Drug Design, Development and Therapy 2024, 18:121-132
Published Date: 23 January 2024
The Effect of Platelet Activity, ABCB1 Genetic Polymorphism, and Renal Function on the Development of Ticagrelor-Related Dyspnea in Patients with Acute Coronary Syndrome
Tamakauskas V, Žaliūnas R, Lesauskaitė V, Kupstytė-Krištaponė N, Čiapienė I, Šakalytė G, Plisienė J, Skipskis V, Tatarūnas V
Drug Design, Development and Therapy 2024, 18:109-119
Published Date: 23 January 2024
The Role of Rho Kinase Inhibitors in Corneal Diseases
Futterknecht S, Chatzimichail E, Gugleta K, Panos GD, Gatzioufas Z
Drug Design, Development and Therapy 2024, 18:97-108
Published Date: 19 January 2024
Population Pharmacokinetics and Model-Based Dose Optimization of Vancomycin in Sudanese Adult Patients with Renal Impairment
Ahmed KA, Ibrahim A, Gonzalez D, Nur AO
Drug Design, Development and Therapy 2024, 18:81-95
Published Date: 16 January 2024
Nicotine Diminishes Alpha2-Adrenergic Receptor-Dependent Protection Against Oxidative Stress in H9c2 Cardiomyocytes
Del Calvo G, Pollard CM, Baggio Lopez T, Borges JI, Suster MS, Lymperopoulos A
Drug Design, Development and Therapy 2024, 18:71-80
Published Date: 12 January 2024
Immunosuppression with Generics in Liver and Kidney Transplantation: A Real-World Evidence Study
Finocchietti M, Marino ML, Rosa AC, Bellini A, Masiero L, Cardillo M, Massari M, Spila Alegiani S, Pierobon S, Ferroni E, Zanforlini M, Leoni O, Ledda S, Garau D, Davoli M, Addis A, Belleudi V
Drug Design, Development and Therapy 2024, 18:53-69
Published Date: 12 January 2024
Effect of High-Fat Meal on the Pharmacokinetics and Safety of Valsartan/Amlodipine Fixed Dose Combination Tablets in Healthy Subjects
Song H, Qiu B, Sun X, Guo C, Hu Y, Bai W, Dong Z
Drug Design, Development and Therapy 2024, 18:43-51
Published Date: 11 January 2024
Synthesis and Application of a Near-Infrared Light-Emitting Fluorescent Probe for Specific Imaging of Cancer Cells with High Sensitivity and Selectivity
Li S, Lin Z, Chen H, Luo Q, Han S, Huang K, Chen R, Zhan Y, Chen B, Yao H
Drug Design, Development and Therapy 2024, 18:29-41
Published Date: 10 January 2024
Huang Gan Formula Alleviates Systemic Inflammation and Uremia in Adenine-Induced Chronic Kidney Disease Rats May Associate with Modification of Gut Microbiota and Colonic Microenvironment
Zhao J, Zhao C, Xun T, Wang X, Wei S, Ye C, Zhang M, Guo D, Yang X
Drug Design, Development and Therapy 2024, 18:13-28
Published Date: 6 January 2024
Pharmacokinetics, Bioavailability, and Tissue Distribution of the Kirsten Rat Sarcoma Inhibitor Adagrasib in Rats Using UPLC-MS/MS
Lei P, Shen W, Tang H, You L, Chen G, Tang Y, Lu W
Drug Design, Development and Therapy 2024, 18:1-12
Published Date: 5 January 2024