ImmunoTargets and Therapy

Future-Ready CAR-T Cells: Integrating Gene Editing, Multi-Antigen Targeting, Translational Advances and Microenvironment Reprogramming

Chimeric Antigen Receptor T-cell (CAR-T) therapies have transformed the landscape of cancer treatment, offering unprecedented outcomes in relapsed and refractory hematologic malignancies. Despite these breakthroughs, significant obstacles; including antigen escape, T-cell exhaustion, off-tumor toxicity, limited durability of responses, and restricted success in solid tumors still constrain their broader therapeutic potential. In parallel, rapid innovations in gene editing, synthetic biology, vector engineering, and tumor microenvironment modulation are driving the next generation of CAR-T technologies. Given the expanding field and urgent need for new solutions, this Article Collection gathers cutting-edge research and authoritative reviews that highlight transformative advances, emerging challenges, and forward-looking strategies in CAR-T cell–based immunotherapies.