Asiri M, BinAbdu A, Al-Ammar A, Alsuaib AA, Al-Shehri A, Almazyad AA, Aloufi AM, AlGazlan N, Alrajih HS, Alkaiyat M, Ardah HI, Shehata H, Alshammari K

Journal of Hepatocellular Carcinoma 2025, 12:1623-1632

Published Date: 23 July 2025

Review

Natural Bioactive Compounds Targeting the Wnt/β-Catenin Pathway for the Treatment of Hepatocellular Carcinoma

Tian H, Wang P, Shao H

Journal of Hepatocellular Carcinoma 2025, 12:1613-1622

Published Date: 23 July 2025

Original Research

Automatic Real-Time Detection and Diagnosis of Liver Tumor with Ultrasound

Wu CH, Sheu JC, Chou PL, Lee J, Nien HC

Journal of Hepatocellular Carcinoma 2025, 12:1599-1611

Published Date: 23 July 2025

Original Research

Comparison of Long-Term Outcomes Between Repeated Hepatic Resection and Radiofrequency Ablation in Patients with Small Recurrent Hepatocellular Carcinoma After Initial Curative Resection: A Propensity Score Matched Study

Hsiao CY, Hu RH, Liang PC, Wu CH

Journal of Hepatocellular Carcinoma 2025, 12:1587-1598

Published Date: 23 July 2025

Original Research

Exploring Autophagy-Related Gene Expression in Hepatocellular Carcinoma via TCGA, GEPIA2, and HPA Databases: Implications for Prognosis

Gu X, Chen Y, Hu X, Li Y, Zhu R, Li H, Yuan Z, Wang Y

Journal of Hepatocellular Carcinoma 2025, 12:1557-1586

Published Date: 22 July 2025

Original Research

FAM105B Promotes Hepatocellular Carcinoma Progression and Metastasis by Activating the PI3K/AKT/MTOR Signaling Pathway and Inducing Epithelial-Mesenchymal Transition

Yang LL, Chen X, Tang ST, Huang KT, Ye GY, Wang JL

Journal of Hepatocellular Carcinoma 2025, 12:1541-1555

Published Date: 22 July 2025

Original Research

TACE Combined with Lenvatinib-PD-1 Versus TACE Monotherapy as Conversion Therapy Before Liver Resection in Unresectable Hepatocellular Carcinoma: A Retrospective, Propensity Score Matching Study

Lu C, Liu R, Zhang Y, Luo J, Luo C, Jiang Z, Huang M, Qiu C, Chen J

Journal of Hepatocellular Carcinoma 2025, 12:1527-1540

Published Date: 22 July 2025

Original Research

AI-Based Quantification of Enhancing Tumor Volume on Contrast-Enhanced MRI to Predict Pathologic Response and Prognosis in HCC After HAIC Plus Targeted Therapy and Immunotherapy

Zhou Y, Li J, Li Q, Liu L, Huang P, Mao Y, Yang Y, Lv F, Liu Z

Journal of Hepatocellular Carcinoma 2025, 12:1509-1525

Published Date: 21 July 2025

Original Research

Survival Benefit of Adjuvant Treatment with Huaier Granules Plus Lenvatinib in Hepatocellular Carcinoma Patients with Tumors Greater Than 5 cm After Radical Hepatectomy

Liu C, Bai Y, Bai Q, Parra MA, Zhao L, Zou J, Cao Q, Liu H, Yang H

Journal of Hepatocellular Carcinoma 2025, 12:1495-1507

Published Date: 20 July 2025

Original Research

Functional Liver Imaging Score to Predict Clinically Significant PHLF for Hepatocellular Carcinoma After Resection

Zheng X, Zhang Y, Huang H, Luo N

Journal of Hepatocellular Carcinoma 2025, 12:1483-1493

Published Date: 18 July 2025

Original Research

Prognostic Value of Gd-BOPTA Enhanced MRI in Solitary Resected Hepatocellular Carcinoma Without Microvascular Invasion

Zhang J, Luo H, Li Y, Feng Y, Pan X, Ouyang B, Nian G, Jia N, Li Y

Journal of Hepatocellular Carcinoma 2025, 12:1471-1482

Published Date: 18 July 2025

Original Research

Integrated Multi-Omics Profiling Identifies PDZ-Binding Kinase (PBK) as a Novel Prognostic Biomarker in Hepatocellular Carcinoma

Zhang J, Xu Y, Ni X, Mao Z, Xiao H, Chen M, Lin Y, Pan J, Zhang B, Zhang L, Zheng X, Song G, Ge N

Journal of Hepatocellular Carcinoma 2025, 12:1453-1469

Published Date: 17 July 2025

Original Research

Can Peritumoral Radiomics Based on MRI Predict the Microvascular Invasion Status of Combined Hepatocellular Carcinoma and Cholangiocarcinoma Before Surgery?

Guo L, Huang C, Hao P, Jia N, Zhang L

Journal of Hepatocellular Carcinoma 2025, 12:1441-1452

Published Date: 16 July 2025

Original Research

Adjuvant Hepatic Arterial Infusion Chemotherapy Versus Transarterial Chemoembolization for Preventing Early Recurrence After Surgical Resection in Hepatocellular Carcinoma

Xia Y, Wen W, Liao Y, Cai Y, Wan R

Journal of Hepatocellular Carcinoma 2025, 12:1425-1439

Published Date: 16 July 2025

Expert Opinion

A Summary of the HCC-CARE Symposium: Collaborative Approaches to Reaching Equity in Hepatocellular Carcinoma in Boston by 2030

Lau-Min KS, Abrams T, Bullock A, Kaplan A, Salas Karnes L, Kennedy MW, LeBedis CA, Lin MV, McCleary NJ, Sioshansi S, Voligny E, Walsh EP, Manz CR

Journal of Hepatocellular Carcinoma 2025, 12:1417-1424

Published Date: 16 July 2025

Original Research

Efficacy Analysis of TACE Combined with Lenvatinib and PD-1 Inhibitors in the Treatment of Hepatitis B Virus-Related Unresectable Hepatocellular Carcinoma

Yu J, Zhu Y, Zhao S, Li X

Journal of Hepatocellular Carcinoma 2025, 12:1407-1415

Published Date: 15 July 2025

Original Research

Refining Intra-Arterial Therapy Selection for Large Hepatocellular Carcinoma: A Deep Learning Approach Based on Covariate Interaction Analysis

An C, Li L, Luo Y, Zuo M, Liu W, Li C, Wu P

Journal of Hepatocellular Carcinoma 2025, 12:1393-1405

Published Date: 11 July 2025

Original Research

Silencing NEDD4L Effectively Inhibits the Malignant Behaviors of Hepatocellular Carcinoma

Dai J, Zhu T, Wan J, Liu R, Song Y, Zhang D, Wang X, Zhang H, Li W, Lin J, Zhu X, Liu Y

Journal of Hepatocellular Carcinoma 2025, 12:1369-1391

Published Date: 10 July 2025

Original Research

Efficacy and Safety of Hepatic Artery Infusion Chemotherapy Combined with Donafenib and Camrelizumab in the Treatment of Patients with Unresectable Hepatocellular Carcinoma: A Retrospective, Single-Arm Study

Wu C, Fu Z, Pan L, Li J, Zhou Y, Sun R, Gou Y, Zhao Y, Wang Z, Qiu Y, Huang P

Journal of Hepatocellular Carcinoma 2025, 12:1353-1367

Published Date: 10 July 2025

Original Research

Hsa_circ_0007991 Promotes Immune Evasion in Hepatocellular Carcinoma via Regulation of the miR-505-3p/CANX Axis

Wang L, Liang L, Qian J, Yu C, Shi Y, Yan X, Chen X

Journal of Hepatocellular Carcinoma 2025, 12:1337-1351

Published Date: 7 July 2025

Original Research

Multidisciplinary Team Management of Hepatocellular Carcinoma in the MENA Region: Current Practices, Challenges, and Gaps

El-Kassas M, Khalifa R, AlNaamani KM, Shousha H, Yilmaz Y, Sanai FM, Almattooq M, Labidi A, Akroush MWI, Debzi N, Abdelmalek MO, Abdeen NS, Tumi A, Elbadry M, El Fouly A, Marwan E, Al Suwaidi J, Elzouki AN, Alswat KA

Journal of Hepatocellular Carcinoma 2025, 12:1315-1335

Published Date: 8 July 2025

Original Research

Hyper-Relapse Disease is a Special Pattern of Relapse of Hepatocellular Carcinoma After Curative Hepatectomy: A Retrospective Cohort Study

Yang ZL, Gan YX, Xu JX, Tang YH, Ouyang LY, Qi LN, Xu L

Journal of Hepatocellular Carcinoma 2025, 12:1301-1314

Published Date: 5 July 2025

Original Research

Integrating CEUS Imaging Features and LI-RADS Classification for Postoperative Early Recurrence Prediction in Solitary Hepatocellular Carcinoma: A Machine Learning-Based Prognostic Approach

Liang L, Pang J, Zhang B, Que Q, Gao R, Wu Y, Peng J, Zhang W, Bai X, Wen R, He Y, Yang H

Journal of Hepatocellular Carcinoma 2025, 12:1287-1300

Published Date: 3 July 2025

Original Research

Retrospective Multicentre Real-Life Study Evaluating the Efficacy of Atezolizumab Combined with Bevacizumab for the Treatment of Metastatic Hepatocellular Carcinoma: HIREAL Study

Barbe-Richaud JB, Moinard-Butot F, Husson-Wetzel S, Bolliet M, Chiappa P, Belletier C, Ribeiro M, Poprawa E, Bigot C, Abergel A, Ben Abdelghani M

Journal of Hepatocellular Carcinoma 2025, 12:1279-1286

Published Date: 1 July 2025

Original Research

Combining Hepatic Arterial Interventional Therapies with Lenvatinib and Programmed Cell Death-1 Inhibitors for Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis: A Single-Center, Real-World Study

Shen X, Shao T, Yu J, Zhang Z

Journal of Hepatocellular Carcinoma 2025, 12:1267-1278

Published Date: 2 July 2025

Original Research

Preoperative Prediction of a Rare and Highly Aggressive Subtype of Hepatocellular Carcinoma Based on Multimodal Imaging and Clinical Indicators

Chen K, Zhu Y, Liu H, Deng M, Kong W, Wang W

Journal of Hepatocellular Carcinoma 2025, 12:1253-1266

Published Date: 30 June 2025

Original Research

Clinical Outcomes of AFP-Negative Patients with Advanced HCC: A Propensity-Matched Analysis from a Retrospective Cohort Study

Liu X, Zhuang L, Yang F, Liu P, Xia Z, Guo Y, Dong P, Chen C, Li Z

Journal of Hepatocellular Carcinoma 2025, 12:1241-1252

Published Date: 27 June 2025

Original Research

Comparison of Computed Tomography and Ultrasound-Guided Radiofrequency Ablation for Recurrent Subdiaphragmatic Hepatocellular Carcinoma After Resection

Liu HY, Hsiao CY, Hu RH, Liang PC, Wu CH

Journal of Hepatocellular Carcinoma 2025, 12:1231-1240

Published Date: 27 June 2025

Original Research

Treatment Outcomes of Systemic Therapies for Infiltrative Hepatocellular Carcinoma

Chen PY, Chang CK, Chen BB, Hsu CH, Cheng AL, Shao YY

Journal of Hepatocellular Carcinoma 2025, 12:1221-1229

Published Date: 23 June 2025

Review

Application of Robotic Surgery in Hepatocellular Carcinoma

Li PH, Ding ZW, Ye YQ

Journal of Hepatocellular Carcinoma 2025, 12:1217-1220

Published Date: 19 June 2025

Original Research

Hepatic Arterial Infusion Chemotherapy Combined Apatinib/Camrelizumab for Recurrent Hepatocellular Carcinoma After Hepatectomy

Zheng X, Qian K

Journal of Hepatocellular Carcinoma 2025, 12:1205-1215

Published Date: 17 June 2025

Original Research

In Situ Vaccination with Poly-ICLC Combined with Systemic Nivolumab for the Treatment of Unresectable Hepatocellular Carcinoma

Liang JD, Liang PC, Shun CT, Chen CH, Wu YM, Hsu YC, Lee YT, Yang PM, Huang GT, Salazar AM, Lee HS, Sheu JC, Weng MT

Journal of Hepatocellular Carcinoma 2025, 12:1191-1204

Published Date: 14 June 2025

Original Research

Intravoxel Incoherent Motion Improves the Accuracy of Preoperative Prediction of Vessels Encapsulating Tumor Clusters in Hepatocellular Carcinoma

Li M, Zhang G, Li J, Ren Y, Jin X, Ke Q, Guo C, Lv J, Lu H, Xu Y, Liang W, Quan X, Li X

Journal of Hepatocellular Carcinoma 2025, 12:1177-1190

Published Date: 11 June 2025

Original Research

Early Recurrence of Hepatocellular Carcinoma in Patients without Microscopic Vascular Invasion: Clinicopathological Characteristics and Risk Factors

Ngo HTT, Nguyen DD, Dang MX, Doan TTP, Thai TT

Journal of Hepatocellular Carcinoma 2025, 12:1167-1175

Published Date: 11 June 2025

Original Research

Genetic Variants of UGP2 and FBP2 in the Glycolysis Pathway Independently Predict Survival of Patients with HBV-Related Hepatocellular Carcinoma

Gong R, Qiu M, Liu Y, Cao J, Zhou Z, Lin Q, Jiang Y, Liang X, Wei Y, Wen Q, Chen P, Wei X, Wei J, Zhan S, Zhang R, Ye D, Yu H

Journal of Hepatocellular Carcinoma 2025, 12:1155-1166

Published Date: 7 June 2025

Original Research

Factor Analysis of the Effect of Hepatitis B-Related Liver Cancer Treatment Efficacy

Liu SW, Zhou Y, Feng XY, Hai L, Ma WL, Ma LN, Ding XC, Luo X

Journal of Hepatocellular Carcinoma 2025, 12:1141-1154

Published Date: 5 June 2025

Review

Radiomics and Deep Learning as Important Techniques of Artificial Intelligence — Diagnosing Perspectives in Cytokeratin 19 Positive Hepatocellular Carcinoma

Wang F, Yan C, Huang X, He J, Yang M, Xian D

Journal of Hepatocellular Carcinoma 2025, 12:1129-1140

Published Date: 5 June 2025

Original Research

Predicting Resistance and Survival of HCC Patients Post-HAIC: Based on Shapley Additive exPlanations and Machine Learning

Yao F, Miao J, Quan B, Li J, Tang B, Lu S, Yin X

Journal of Hepatocellular Carcinoma 2025, 12:1111-1128

Published Date: 31 May 2025

Original Research

Effectiveness and Safety of Systemic Therapy and Stereotactic Body Radiotherapy in Oligoprogressive and Oligometastatic Hepatocellular Carcinoma

Song Z, Zheng X, Wang H, Dong D, Zhu X, Geng J, Li S, Song M, Du R, Zhang Y, Liu Z, Cai Y, Li Y, Wang W

Journal of Hepatocellular Carcinoma 2025, 12:1097-1110

Published Date: 31 May 2025

Original Research

Intratumoral and Peritumoral Radiomics Based on DCE-MRI for Prediction of Microvascular Invasion Grading in Solitary Hepatocellular Carcinoma (≤3 cm)

Li Y, Li H, Feng Y, Lu L, Zhang J, Jia N

Journal of Hepatocellular Carcinoma 2025, 12:1083-1095

Published Date: 30 May 2025

Original Research

Spleen Volume Dynamics and Survival Outcomes in HCC Patients Undergoing Immune Checkpoint Inhibitors: A Retrospective Analysis

Fu X, Jiang S, Li Y, Guo Y, Gong B, Lou J, Li Y, Wang S, Sun Y, Ren Y, Chen Q, Yang L

Journal of Hepatocellular Carcinoma 2025, 12:1069-1082

Published Date: 30 May 2025

Original Research

Primary Prophylaxis for High-Risk Varices in Patients with Hepatocellular Carcinoma and Portal Vein Tumor Thrombus Delayed Hepatic Decompensation: A Retrospective, Propensity Score Matching Study

Chen YJ, Hou MC, Yang TC, Lee PC, Lu HS, Huang HC, Huang YH, Luo JC

Journal of Hepatocellular Carcinoma 2025, 12:1057-1067

Published Date: 28 May 2025

Clinical Trial Report

Adjuvant Lenvatinib for High-Risk CNLC IIb/IIIa Hepatocellular Carcinoma After Curative Hepatectomy: A Prospective Exploratory Study

Sun HC, Huang ZY, Wen T, Liu L, Zhu XD, Zhang E, Li C, Zhang X, Wang J, Fan J, Zhou J

Journal of Hepatocellular Carcinoma 2025, 12:1043-1056

Published Date: 22 May 2025

Original Research

Transarterial Chemoembolization, Molecular Targeted Treatments, and Programmed Death-(Ligand)1 Inhibitors, for Hepatocellular Carcinoma with Lung Metastasis: A Retrospective Cohort Study

Lu J, Chen X, Liu Y, Ding Y, Li B, Yang J, Peng W, Yang X

Journal of Hepatocellular Carcinoma 2025, 12:1031-1041

Published Date: 23 May 2025

Original Research

Combination of Hepatic Arterial Infusion Chemotherapy with Tyrosine Kinase Inhibitor Provides Better Survival in Advanced Hepatocellular Carcinoma Patients

Liu CW, Lin PT, Teng W, Chen WT, Su CW, Hsieh YC, Lin CC, Lin CY, Lin SM

Journal of Hepatocellular Carcinoma 2025, 12:1017-1029

Published Date: 21 May 2025

Original Research

Radiomics of Dynamic Contrast-Enhanced MRI for Predicting Radiation-Induced Hepatic Toxicity After Intensity Modulated Radiotherapy for Hepatocellular Carcinoma: A Machine Learning Predictive Model Based on the SHAP Methodology

Liu F, Chen L, Wu Q, Li L, Li J, Su T, Li J, Liang S, Qing L

Journal of Hepatocellular Carcinoma 2025, 12:999-1015

Published Date: 17 May 2025

Original Research

MRI Radiomics to Predict Early Treatment Response to TACE Combined with Lenvatinib Plus a PD-1 Inhibitor for Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Lu D, Zhou L, Zuo Z, Zhang Z, Zheng X, Weng J, Yu Z, Ji J, Xia J

Journal of Hepatocellular Carcinoma 2025, 12:985-998

Published Date: 16 May 2025

Original Research

Atezolizumab Plus Bevacizumab Combined with or without Transarterial Chemoembolization in the Treatment of Advanced Hepatocellular Carcinoma: A Single-Center Retrospective Study

Li J, Bai Y, Xiong F, Liu X, Hu J, Zhang G, Liu J, Wu S, Zheng C, Kan X

Journal of Hepatocellular Carcinoma 2025, 12:973-984

Published Date: 15 May 2025

Original Research

The Real-World Prevalence of Esophagogastric Varices, Bleeding, Emergency Room Visits, and Hospitalization Among Patients with Advanced Hepatocellular Carcinoma in the United States: A Retrospective Cohort Study

Parikh ND, Park NJ, Locker M, Chopra I, Yeaw J, Yu S

Journal of Hepatocellular Carcinoma 2025, 12:961-972

Published Date: 15 May 2025

Original Research

Can Intra-Operative Ablation-Specific Features Based on Ultrasound Fusion Imaging be Used to Predict Early Recurrence of Hepatocellular Carcinoma After Microwave Ablation: A Proof-of-Concept Study

Kang H, Liu Z, Huang B, Liang S, Yang K, Liu H, Lu M, Yan R, Chen X, Xu E

Journal of Hepatocellular Carcinoma 2025, 12:949-960

Published Date: 12 May 2025

Original Research

Machine Learning Radiomics for Predicting Response to MR-Guided Radiotherapy in Unresectable Hepatocellular Carcinoma: A Multicenter Cohort Study

Su K, Liu X, Zeng YC, Xu J, Li H, Wang H, Du S, Wang H, Yue J, Yin Y, Li Z

Journal of Hepatocellular Carcinoma 2025, 12:933-947

Published Date: 9 May 2025

Original Research

Decoding ARF4 and EIF5B-Based Prognostic Signatures and Immune Landscape Following Insufficient Radiofrequency Ablation in Hepatocellular Carcinoma: Through Multi-Omics and Experimental Validation

Zhang Y, Lu Y, Zheng S, Luo W, Tan M, Luo B

Journal of Hepatocellular Carcinoma 2025, 12:909-931

Published Date: 9 May 2025

Original Research

NRF1-Induced lncRNA DDX11-AS1 Contributes to the Progression of Hepatocellular Carcinoma via Activating CA9 Expression and the MEK/ERK Pathway

Li Y, Shi M, Bie B, Tian H, Li J, Li Z, Sun J

Journal of Hepatocellular Carcinoma 2025, 12:891-908

Published Date: 7 May 2025

Original Research

Effectiveness of Minimally Invasive Hepatectomy in Patients with Early or Intermediate-Stage Hepatocellular Carcinoma: A Multi-Institutional Cohort Study in an Asian Population

Chen HK, Chang KC, Shao SC, Soong RS, Chen YC, Wu CF, Wu TH, Chou TS, Chan SC, Lai ECC

Journal of Hepatocellular Carcinoma 2025, 12:879-890

Published Date: 7 May 2025

Original Research

Post-TACE ALBI-Score Trajectory in Intermediate and Advanced Hepatocellular Carcinoma: Prognostic Implications and Influencing Factors Analysis

Li J, Feng T, Cui C, Wang H, Su T, Jin L, Zhao X, Xiao W

Journal of Hepatocellular Carcinoma 2025, 12:865-878

Published Date: 5 May 2025

Original Research

Prognostic Significance of Elevated Platelet Count (>200 x 10^9 per L) in BCLC Stages B and C of Hepatocellular Carcinoma: A Retrospective Multicenter Analysis

Munker S, Rodriguez I, Bernhart K, Ben Khaled N, Findik M, Siegmund LK, Ye L, Reiter FP, Roessler D, Nasseh D, Balcar L, Pomej K, Scheiner B, Weiss C, Pinter M, Seidensticker M, Mayerle J, Philipp AB, De Toni EN

Journal of Hepatocellular Carcinoma 2025, 12:855-864

Published Date: 5 May 2025

Review

The Synergistic Mechanisms and Prospects of Transarterial Chemoembolization Combined with Immunotherapy for Hepatocellular Carcinoma

Chen QF, Chen S, Zhao M

Journal of Hepatocellular Carcinoma 2025, 12:841-854

Published Date: 30 April 2025

Perspectives

Hepatic Arterial Infusion Chemotherapy for Hepatocellular Carcinoma: A Three-Dimensional Visualization Perspective

Tan Y, Li PP, Liu H, Zhu JY, Wu QS

Journal of Hepatocellular Carcinoma 2025, 12:837-840

Published Date: 28 April 2025

Original Research

The Impact of Microwave Ablation on Recurrence and Metastasis of Hepatocellular Carcinoma: Insights From Animal Studies and Cytokine Profiling

Wang Y, Tan H, Wen C, Chen S, Zheng G, Qi H, Xie L, Shen L, Cao F, Fan W

Journal of Hepatocellular Carcinoma 2025, 12:825-835

Published Date: 26 April 2025

Original Research

A Novel Prognostic Signature Integrating Immune and Glycolytic Pathways for Enhanced Prognosis and Immunotherapy Prediction in Hepatocellular Carcinoma

Zhang Z, Zhao H, Wang P, Geng X, Yin M, Liu Y, Zhang S, Liang Y, Ji J, Zheng G

Journal of Hepatocellular Carcinoma 2025, 12:805-823

Published Date: 18 April 2025

Original Research

Atezolizumab Plus Bevacizumab in Patients with Unresectable Hepatocellular Carcinoma: Real-World Experience From a US Community Oncology Network

Cosgrove D, Tan R, Osterland AJ, Hernandez S, Ogale S, Mahrus S, Murphy J, Wilson T, Patton G, Loaiza-Bonilla A, Singal AG

Journal of Hepatocellular Carcinoma 2025, 12:791-804

Published Date: 18 April 2025

Review

Optimizing Treatment Selection for Early Hepatocellular Carcinoma Based on Tumor Biology, Liver Function, and Patient Status

Li X, Xu Y, Ou Y, Li H, Xu W

Journal of Hepatocellular Carcinoma 2025, 12:777-790

Published Date: 16 April 2025

Original Research

A Novel Nomogram Model for Predicting the Risk of Hepatocellular Carcinoma in Patients with Chronic Hepatitis B Infection

Wu Y, Wang M, Zhang Z, Chen G, Zhang B

Journal of Hepatocellular Carcinoma 2025, 12:765-775

Published Date: 16 April 2025

Original Research

Prognostic Analysis of Elderly Patients with Hepatocellular Carcinoma: an Exploration and Machine Learning Model Prediction Based on Age Stratification and Surgical Approach

Cai C, Zhu H, Li B, Tang C, Ren Y, Guo Y, Li J, Wang L, Li D, Li D

Journal of Hepatocellular Carcinoma 2025, 12:747-764

Published Date: 14 April 2025

Original Research

Serum Osteopontin Enhances Hepatocellular Carcinoma Diagnosis and Predicts Anti-PD-L1 Immunotherapy Benefit

Wu M, Zou F, He S, Pi Y, Song Y, Chen S, Li L

Journal of Hepatocellular Carcinoma 2025, 12:729-745

Published Date: 13 April 2025

Original Research

Preoperative Prediction of Macrotrabecular-Massive Hepatocellular Carcinoma Using Machine Learning-Based Ultrasomics

Li Y, Duan S, Ren S, Li D, Ma Y, Bu D, Liu Y, Li X, Cai X, Zhang L

Journal of Hepatocellular Carcinoma 2025, 12:715-727

Published Date: 12 April 2025

Case report

Rare Gingival Metastasis Occurring After Conversion Therapy Followed by Resection of Initially Unresectable Hepatocellular Carcinoma: A Case Report

Zhan J, Huang H, Zhan T, Liu X, Cheng Q

Journal of Hepatocellular Carcinoma 2025, 12:705-713

Published Date: 9 April 2025

Original Research

Identification of FDFT1 and PGRMC1 as New Biomarkers in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocellular Carcinoma by Deep Learning

Liu Q, Yang Y, Wang Y, Wei S, Yang L, Liu T, Yu Z, Feng Y, Yao P, Zhu Q

Journal of Hepatocellular Carcinoma 2025, 12:685-704

Published Date: 5 April 2025

Original Research

ALBI Grade Enables Risk Stratification for Bleeding Events and Refines Prognostic Prediction in Advanced HCC Following Atezolizumab and Bevacizumab

Stefanini B, Fulgenzi CAM, Scheiner B, Korolewicz J, Cheon J, Nishida N, Ang C, Marron TU, Wu YL, Saeed A, Wietharn B, Rimassa L, Pirozzi A, Cammarota A, Pressiani T, Pinter M, Balcar L, Huang YH, Mehan A, Phen S, Vivaldi C, Salani F, Masi G, Bettinger D, Vogel A, Schönlein M, von Felden J, Schulze K, Wege H, Samson A, Galle PR, Kudo M, Manfredi GF, Celsa C, Awosika N, Cortellini A, Singal AG, Sharma R, Chon HJ, Tovoli F, Piscaglia F, Pinato DJ, D’Alessio A

Journal of Hepatocellular Carcinoma 2025, 12:671-683

Published Date: 4 April 2025

Original Research

Machine Learning-Based Model Used for Predicting the Risk of Hepatocellular Carcinoma in Patients with Chronic Hepatitis B

Wu T, Yan J, Xiong F, Liu X, Zhou Y, Ji X, Meng P, Jiang Y, Hou Y

Journal of Hepatocellular Carcinoma 2025, 12:659-670

Published Date: 3 April 2025

Editorial

Access to Medical Research is a Basic Human Right: A Roadmap to Research Integration Into a Practical Hepatocellular Carcinoma Treatment Allocation Algorithm (HCC-TAA)

Kaseb AO

Journal of Hepatocellular Carcinoma 2025, 12:649-657

Published Date: 28 March 2025

Original Research

The Expression of Ferroptosis-Related Genes in Hepatocellular Carcinoma and Their Relationships With Prognosis

Li H, Hu X, Wang L, Gu X, Chen S, Tang Y, Chen Y, Chen J, Yuan Z, Wang Y

Journal of Hepatocellular Carcinoma 2025, 12:629-648

Published Date: 20 March 2025

Original Research

Prediction Model of Survival in Unresectable HCC with Central Bile Duct Invasion Receiving TACE After Biliary Drainage: TEMP Score

Fan W, Zheng X, Zhang W, Zhu B, Wu Y, Xue M, Tang R, Huang Z, Qiao L, Lu M, Wu J, Tang Y, Chen J, Huang S, Bai M, Li J

Journal of Hepatocellular Carcinoma 2025, 12:615-628

Published Date: 20 March 2025

Original Research

Study on the Mechanism of QRICH1 Mediating PRMT1 to Regulate the Arginine Methylation Modification of cGAS to Promote Arsenics-Induced Pyroptosis in Hepatocellular Carcinoma Cells

Zhang J, Tian T, Tian S, Yao J, Zhang Y, Xie R, Yang T, Han B

Journal of Hepatocellular Carcinoma 2025, 12:597-614

Published Date: 19 March 2025

Original Research

A Chemotherapy Response-Related Gene Signature and DNAJC8 as Key Mediators of Hepatocellular Carcinoma Progression and Drug Resistance

Ye Y, Zeng Y, Huang S, Zhu C, Wang Q

Journal of Hepatocellular Carcinoma 2025, 12:579-595

Published Date: 20 March 2025

Original Research

Combined TACE with Targeted and Immunotherapy versus TACE Alone Improves DFS in HCC with MVI: A Multicenter Propensity Score Matching Study

Chen X, Wu X, Peng W, Liu L, Liu X, Wan X, Xu H, Zheng Y, Zhao H, Mao Y, Lu X, Sang X, Chang X, Zhou K, Pan J, Guan M, Hu D, Tan H, Zhang Y, Du S

Journal of Hepatocellular Carcinoma 2025, 12:561-577

Published Date: 19 March 2025

Rapid Communication

Radiation Segmentectomy or Ablative External Beam Radiation Therapy as Initial Treatment for Solitary Hepatocellular Carcinoma: A Multicenter Experience

De la Garza-Ramos C, Montazeri SA, LeGout JD, Lewis AR, Frey GT, Paz-Fumagalli R, Hallemeier CL, Rutenberg MS, Ashman JB, Toskich BB

Journal of Hepatocellular Carcinoma 2025, 12:553-559

Published Date: 13 March 2025

Original Research

Lasso-Based Nomogram for Predicting Early Recurrence Following Radical Resection in Hepatocellular Carcinoma

Zheng G, Zheng M, Hu P, Zhu Y, Zhang W, Zhang F

Journal of Hepatocellular Carcinoma 2025, 12:539-552

Published Date: 12 March 2025

Original Research

Efficacy and Safety of Ipilimumab Plus Anti-PD-1/PD-L1 Antibodies Combination Therapy in Advanced Hepatocellular Carcinoma Patients Progressing After Multiple Lines of Treatment: A Retrospective Multicenter Study

Zheng SS, Wu JF, Zhang ZZ, Wu YF, Chen YJ, Qian S, Zhang BH

Journal of Hepatocellular Carcinoma 2025, 12:527-537

Published Date: 11 March 2025

Original Research

The Diagnostic Performance of AFP, AFP-L3, DCP, CA199, and Their Combination for Primary Liver Cancer

Liu Y, Jiang W, Li X, Zhao H, Wang S

Journal of Hepatocellular Carcinoma 2025, 12:513-526

Published Date: 6 March 2025

Review

Improving Health-Related Quality of Life in Hepatocellular Carcinoma Patients: Key Methodologies for Assessing Patient Reported Outcomes and Intervention Targets

Moon AM, Kappelman MD, Barritt IV AS, Evon DM, Sanoff HK, Wagner LI

Journal of Hepatocellular Carcinoma 2025, 12:497-511

Published Date: 5 March 2025

Original Research

Prognostic Value of Changes in Combined Child–Pugh Class and ALBI Grade in Hepatocellular Carcinoma Treated with Transcatheter Intra-Arterial Therapy Plus Targeted Therapy and PD-(L)1 Inhibitors

Huang X, Cao X, Kong Y, Tang F, Cong T, Zhou X

Journal of Hepatocellular Carcinoma 2025, 12:481-496

Published Date: 4 March 2025

Review

Research Progress of Liver Cancer Recurrence Based on Energy Metabolism of Liver Cancer Stem Cells

Wu M, Wang H, Wu X, Zeng H, Miao M, Song Y

Journal of Hepatocellular Carcinoma 2025, 12:467-480

Published Date: 3 March 2025

Case report

A Case of DEB-TACE Combined with Anlotinib for Treatment of Liver Metastasis from Retroperitoneal Leiomyosarcoma

Cui H, Xu Q, Han Z, Zhang S

Journal of Hepatocellular Carcinoma 2025, 12:459-465

Published Date: 2 March 2025

Original Research

Efficacy and Safety of Transarterial Chemoembolization Combined with Hepatic Arterial Infusion Chemotherapy Plus Lenvatinib for Intermediate-Stage Hepatocellular Carcinoma Beyond Up-To-Seven: A Multicentre, Retrospective Propensity Score Matching Analysis

Zhong S, Zhang F, Zhang H, Hu H, Zeng Q, Li Y, Wei Q

Journal of Hepatocellular Carcinoma 2025, 12:445-458

Published Date: 1 March 2025

Original Research

Integrative Analysis of scRNA-Seq and Bulk RNA-Seq Identifies Plasma Cell Related Genes and Constructs a Prognostic Model for Hepatocellular Carcinoma

Tang M, Xu Y, Pan M

Journal of Hepatocellular Carcinoma 2025, 12:427-444

Published Date: 26 February 2025

Original Research

Increment of Skeletal Muscle Mass Predicts Survival Benefit for Hepatocellular Carcinoma Treated with Transarterial Chemoembolization Combining Molecular Targeted Agents and Immune Checkpoint Inhibitors

Chen W, Yan HT, Zhang JX, Shen X, Liu J, Liu S, Shi HB, Ding Y, Zu QQ

Journal of Hepatocellular Carcinoma 2025, 12:415-426

Published Date: 27 February 2025

Review

Systemic Treatment for Unresectable Hepatocellular Carcinoma: A Surgeon’s Perspective

Zhu XD, Zhao L, Li B, Cheng Y, Sun HC

Journal of Hepatocellular Carcinoma 2025, 12:399-413

Published Date: 26 February 2025

Original Research

Application of Intravoxel Incoherent Motion in the Prediction of Intra-Tumoral Tertiary Lymphoid Structures in Hepatocellular Carcinoma

Ma L, Liao S, Zhang X, Zhou F, Geng Z, Hu J, Zhang Y, Zhang C, Meng T, Wang S, Xie C

Journal of Hepatocellular Carcinoma 2025, 12:383-398

Published Date: 22 February 2025

Original Research

Coilin Affects the Prognosis of Hepatocellular Carcinoma Through Cell Cycle and Apoptosis

Lu L, Zhou X, Zheng J, Li D

Journal of Hepatocellular Carcinoma 2025, 12:367-382

Published Date: 21 February 2025

Original Research

Machine Learning Prognostic Model for Post-Radical Resection Hepatocellular Carcinoma in Hepatitis B Patients

Zhu D, Tulahong A, Abuduhelili A, Liu C, Aierken A, Lin Y, Jiang T, Lin R, Shao Y, Aji T

Journal of Hepatocellular Carcinoma 2025, 12:353-365

Published Date: 19 February 2025

Original Research

Outcomes and Prognostic Factors in Cirrhotic Patients with Acute Variceal Bleeding and Hepatocellular Carcinoma: A Nested Case–Control Study

Liu G, Xiao S, Xiang T, Wang X, Shen Y, Yang L, Luo X

Journal of Hepatocellular Carcinoma 2025, 12:343-352

Published Date: 19 February 2025

Original Research

Comprehensive Analysis of the Role of Heat Shock Proteins in the Immune Microenvironment and Clinical Significance of Hepatocellular Carcinoma

Xiao H, Wang B, Xiong S, Li C, Ding Y, Chao D, Mei B, Shen N, Luo G

Journal of Hepatocellular Carcinoma 2025, 12:325-342

Published Date: 17 February 2025

Original Research

Apolipoprotein E: A Potential Prognostic and Diagnostic Biomarker for Hepatocellular Carcinoma

Li Y, Lu R, Abuduhailili X, Feng Y

Journal of Hepatocellular Carcinoma 2025, 12:301-324

Published Date: 17 February 2025

Original Research

Risk Factors and Predictive Analysis of Acute Severe Abdominal Pain After Hepatic Artery Infusion Chemotherapy in Patients with Hepatocellular Carcinoma

Li J, Shi C, Chen J, Zhao Y, Du J, Song J

Journal of Hepatocellular Carcinoma 2025, 12:289-299

Published Date: 17 February 2025

Original Research

MRI Features and Neutrophil-to-Lymphocyte Ratio (NLR)-Based Nomogram to Predict Prognosis of Microvascular Invasion-Negative Hepatocellular Carcinoma

Wei Y, Huang X, Pei W, Zhao Y, Liao H

Journal of Hepatocellular Carcinoma 2025, 12:275-287

Published Date: 15 February 2025

Original Research

Effect of Narrow-Margin Hepatectomy Combined with Intraoperative Radiotherapy on Long-Term Prognosis of Patients with Centrally Located Hepatocellular Carcinoma: A Propensity Score Matching Analysis

Tao C, Liu L, Hu N, Wang H, Zhang K, Liu Y, Wu F, Wang L, Rong W, Wu J

Journal of Hepatocellular Carcinoma 2025, 12:261-274

Published Date: 15 February 2025

Original Research

Assessment of Tumor Burden Score as a Feasible and Reliable Tool for Prognosis Prediction for Hepatocellular Carcinoma Undergoing Hepatectomy: A Multicenter, Retrospective Study

Guan R, Zheng Z, Deng M, Mei J, Lin Y

Journal of Hepatocellular Carcinoma 2025, 12:247-260

Published Date: 10 February 2025

Original Research

Tolerability and Effectiveness of Regorafenib Treatment in Patients with Unresectable Hepatocellular Carcinoma: Real-World Data from the United States

Finn RS, Iyer R, Kalman RS, Parikh ND, Cabrera R, Babajanyan S, Kaseb AO

Journal of Hepatocellular Carcinoma 2025, 12:231-246

Published Date: 7 February 2025

Original Research

Simultaneous Liver Venous Deprivation Following Hepatic Arterial Chemoembolization Before Major Hepatectomy for Hepatocellular Carcinoma: A New Methods to Achieve Hypertrophy Liver Remnant

Zhang S, Song R, Hou C, Yao H, Xu J, Zhou H, Li S, Cai W, Fei Y, Meng F, Yin D, Wang J, Zhang S, Liu Y, Wang J, Liu L

Journal of Hepatocellular Carcinoma 2025, 12:219-229

Published Date: 5 February 2025

Original Research

Long-Term Analysis of Recurrence Beyond Milan Criteria Following Ablation of Solitary Early-Stage Hepatocellular Carcinoma ≤3 cm in Potentially Transplantable Patients: A Over 10-Year Survival Study

Chen S, Qi H, Tan H, Cao F, Xie L, Huang T, Wu Y, Wen C, Wang Y, Shen L, Fan W

Journal of Hepatocellular Carcinoma 2025, 12:205-218

Published Date: 3 February 2025

Original Research

TRACE Model: Predicting Treatment Response to Transarterial Chemoembolization in Unresectable Hepatocellular Carcinoma

Wang W, Zhang Q, Cui Y, Zhang S, Li B, Xia T, Song Y, Zhou S, Ye F, Xiao W, Cao K, Chi Y, Qu J, Zhou G, Chen Z, Zhang T, Chen X, Ju S, Wang YC

Journal of Hepatocellular Carcinoma 2025, 12:193-203

Published Date: 29 January 2025

Original Research

The Clinical Characteristics, Patterns of Recurrence, and Long-Term Survival Outcomes of Dual-Phenotype Hepatocellular Carcinoma After Curative Liver Resection

Yu ZC, Fang ZK, Yu Y, Liu SY, Wang KD, Shi ZJ, Jin LM, Huang XK, Lu Y, Shen GL, Liu JW, Huang DS, Zhang CW, Liang L

Journal of Hepatocellular Carcinoma 2025, 12:183-192

Published Date: 30 January 2025

Original Research

Clinical Outcomes of Hepatic Arterial Infusion Chemotherapy Plus Lenvatinib and Tislelizumab for Treating Hepatocellular Carcinoma and Type IV Portal Vein Tumor Thrombus

Li X, Cao K, Fu Z, Chen X, Zhong J, Liu L, Ding N, Zhang X, Qu Z, Zhu L, Zhai J

Journal of Hepatocellular Carcinoma 2025, 12:169-182

Published Date: 25 January 2025

Original Research

Design and Mechanism Study of 6c, a Novel Artesunate Derivatives, for Anti-Hepatocellular Carcinoma

Xiong SS

Journal of Hepatocellular Carcinoma 2025, 12:149-167

Published Date: 25 January 2025

Original Research

The Prognostic Value of Peripheral Blood Inflammatory Markers in Hepatocellular Carcinoma Treated with Lenvatinib Combined with PD-1 Inhibitors

Xin Y, Liu N, Peng G, Huang X, Cao X, Zhou X

Journal of Hepatocellular Carcinoma 2025, 12:135-147

Published Date: 24 January 2025

Original Research

Impact of Timing the Combination of Radiotherapy and PD-1 Inhibitors on Outcomes in Patients with Hepatocellular Carcinoma

Zhong L, Peng W, Sun J, Luo Y, Sheng H, Wu Y, Zhou T, Zhou C, Cao C

Journal of Hepatocellular Carcinoma 2025, 12:123-134

Published Date: 22 January 2025

Original Research

A New Risk Score Based on Lipid Indicators for Patients with Advanced Hepatocellular Carcinoma

Wei X, Guo Z, Zhang T, Liang J

Journal of Hepatocellular Carcinoma 2025, 12:107-121

Published Date: 21 January 2025

Original Research

Risk and Prognosis of Hepatocellular Carcinoma in Mexican Americans with Type 2 Diabetes Mellitus

Hatia RI, Hwang LY, Li R, Troisi C, Jalal PK, Amos CI, Gomez HF, Chun YS, Rashid A, Kaseb AO, Scheet PA, Hassan MM

Journal of Hepatocellular Carcinoma 2025, 12:93-106

Published Date: 21 January 2025

Original Research

A Machine Learning Model for Predicting Prognosis in HCC Patients With Diabetes After TACE

Wu L, Chen L, Zhang L, Liu Y, Ouyang D, Wu W, Lei Y, Han P, Zhao H, Zheng C

Journal of Hepatocellular Carcinoma 2025, 12:77-91

Published Date: 21 January 2025

Review

Progress in the Study of Intratumoral Microorganisms in Hepatocellular Carcinoma

Song Y, Tian S, Li Z, Miao J, Wu M, Xu T, Wu X, Qiao J, Zhang X, Zhao H, Kang L, Cao L, Zhu P, Miao M

Journal of Hepatocellular Carcinoma 2025, 12:59-76

Published Date: 18 January 2025

Original Research

Prediction of Pathologic Response in Unresectable Hepatocellular Carcinoma After Downstaging with Locoregional and Systemic Combination Therapy

Yang C, Chen Y, Sheng L, Wang Y, Zhang X, Yang Y, Ronot M, Jiang H, Song B

Journal of Hepatocellular Carcinoma 2025, 12:43-58

Published Date: 16 January 2025

Original Research

Fully Covered Stent-TIPS for Advanced HCC Patients with Portal Vein Tumor Thrombus-Related Severe Symptomatic Portal Hypertension

Liu Z, Lyu T, Yang J, Xie Y, Fan S, Song L, Zou Y, Wang J

Journal of Hepatocellular Carcinoma 2025, 12:29-41

Published Date: 14 January 2025

Original Research

Transarterial Chemoembolization Plus Radiofrequency Ablation and Iodine-125 Seed Implantation for Hepatocellular Carcinoma in High-Risk Locations: A Propensity Score-Matched Analysis

Zhang G, Ren Y, Liu J, Cao Y, Xiong F, Liang B, Zheng C, Kan X

Journal of Hepatocellular Carcinoma 2025, 12:15-27

Published Date: 10 January 2025

Original Research

Correlation Between Dynamic Contrast-Enhanced CT Imaging Signs and Differentiation Grade and Microvascular Invasion of Hepatocellular Carcinoma

Liu Y, Zhou Y, Liao C, Li H, Zhang X, Gong H, Pu H

Journal of Hepatocellular Carcinoma 2025, 12:1-14

Published Date: 8 January 2025