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Journal of Inflammation Research

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ISSN: 1178-7031

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Integrating Artificial Intelligence into Inflammation and Cancer Immunology: From Biomarkers Discovery and Mechanistic Insights to Precision Therapeutics

Inflammation exerts a complex and context-dependent influence on both oncogenesis and the efficacy of cancer therapies. Acute inflammatory responses may enhance anti-tumor immunity; however, chronic inflammation is more commonly implicated in tumor initiation, progression, and the facilitation of immune evasion. Persistent inflammatory signaling contributes to the development of an immunosuppressive tumor microenvironment (TME) by promoting the infiltration of immunoregulatory cell populations, including regulatory T cells, myeloid-derived suppressor cells, and M2-polarized macrophages. This Article Collection gathers interdisciplinary research that investigate the role and underlying mechanisms of epigenetic alterations in the regulation of inflammation and tumor immunity.