Journal of Pain Research
Opioids and Substance Abuse
Section Editor(s):
Dr. Timothy Atkinson, Pain Management, Opioid Safety, PDMP (PMOP), National Program Office, Department of Veterans Affairs, Washington, DC, USA
Dr. Erica Wegrzyn, Stratton VA Medical Center, Albany, NY, USA
This section covers the use of opioids analgesics to treat acute and chronic pain, along with strategies for mitigating risk associated with their utilization. More broadly, this section includes substance abuse that is often a sequela of chronic pain, particularly of that which is undertreated.
Latest articles in Opioids and Substance Abuse:
- 25 records -
Prevalence, Trajectories, and Predictors of Persistent Postoperative Opioid Use in a Swiss University Hospital: A Prospective Observational Study
Midez R, Jourdan EF, Bourezg A, Rehberg B
Journal of Pain Research 2026, 19:573377
Published Date: 17 April 2026
Towards Sex- and Gender-Sensitive Pain Management: Participatory Development of the GESCO Intervention for Chronic Non-Cancer Pain and Long-Term Opioid Therapy in Primary Care
Piotrowski A, Schmidt A, Kufeld N, Kersting C, Bencheva V, Wiese B, Bahrs O, Hunger-Schoppe C, Maas M, Preuss J, Just JM, Weckbecker K, Thürmann P, Mortsiefer A
Journal of Pain Research 2026, 19:564795
Published Date: 9 April 2026
Beyond Methodological Considerations: Clinical Implications of Real-World Evidence from the CARE Study [Response to Letter]
Überall MA, Müller-Schwefe PCG, Küster MA, Müller-Schwefe GHH
Journal of Pain Research 2026, 19:611585
Published Date: 27 March 2026
Refining Cannabinoid Ratios for Geriatric Pain: Methodological and Clinical Reflections on the CARE Study [Letter]
Qiang D, Zheng C, Xu Y
Journal of Pain Research 2026, 19:608085
Published Date: 25 March 2026
CARE – A Retrospective, Dual-Cohort, 24-Week Real-World Study from the German Pain e-Registry on the Effectiveness and Safety of CBD-Dominant Oral Cannabis Extracts versus THC/Dronabinol in Older Patients with Chronic Pain
Überall MA, Müller-Schwefe PCG, Küster MA, Müller-Schwefe GH
Journal of Pain Research 2026, 19:551457
Published Date: 7 March 2026
Effect of Intrathecal Hydromorphone on the Duration and Efficacy of Postoperative Analgesia in Patients Undergoing Benign Anorectal Surgery: Protocol for a Randomized, Double-Blind, Controlled Trial
Cao Y, Zhou Y, Zhou D, Xiong C, Fu L, Chen X, Zhang X
Journal of Pain Research 2026, 19:569284
Published Date: 26 February 2026
Adverse Drug Events Associated with Opioid Treatment for Pain After Motor Vehicle Crash
Zullo AR, Balog S, Khan MA, Pfeiffer MR, Riester MR, Curry AE, Beaudoin FL, Oganisian A, Marshall BD, Dow PM, Dana BA, Joyce NR
Journal of Pain Research 2026, 19:529856
Published Date: 27 January 2026
Comparative Safety Analysis of Hydromorphone and Morphone Sulfate: Evidence from the 2004–2024 FAERS
Chen X, Yang C, Lin Z
Journal of Pain Research 2026, 19:559014
Published Date: 13 January 2026
Evaluation of Abuse Deterrent Formulations of Oxycodone Products: Real-World Data from an Enriched Population of Substance Users Assessed with the Addiction Severity Index-Multimedia Version (ASI-MV®)
Green JL, Dailey-Govoni T, Vosburg SK
Journal of Pain Research 2026, 19:541820
Published Date: 8 January 2026
Opioid-Free Anesthesia Alleviates Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy: Study Protocol for a Randomized, Controlled Trial
Li Y, Hao D, Qi X, Song B
Journal of Pain Research 2025, 18:7077-7085
Published Date: 23 December 2025
Determining the Effective Dose of Oliceridine Compounded with Propofol for Painless Hysteroscopy: A Prospective Modified Dixon Sequential Dose-Finding Study
Yang K, Yuan Q, Huang H, Wang L, You J, Liu Q, Zhou Y, Luo Y, Liu Q
Journal of Pain Research 2025, 18:6903-6910
Published Date: 18 December 2025
Risk of Opioid Use Disorder in Surgical Patients with Medicaid and Associations with Prescription Opioid Dose and Duration
Doan LV, Hung AM, Williams NT, Olfson M, Rudolph KE
Journal of Pain Research 2025, 18:6505-6514
Published Date: 5 December 2025
“The Fact [Is] That There Is No Easy Way”. A Qualitative Study of the Experiences of Aotearoa New Zealand Clinicians with Opioid Tapering for Chronic Non-Cancer Pain
Fu R, Bean D, Te Morenga L, Frei D, Devan H
Journal of Pain Research 2025, 18:6137-6147
Published Date: 18 November 2025
Patient-Reported Satisfaction with Non-opioid and Opioid Pain Control is Comparable Following Common Orthopedic Procedures: A Prospective Cohort Study
Bever TE, An C, Sarathy A, Callas P, Ziino C, Fujii MH
Journal of Pain Research 2025, 18:6065-6072
Published Date: 13 November 2025
Ziconotide as an Opioid Rescue: Economic, Clinical, and Subgroup Considerations [Letter]
Gan H, Zhang Y, Yang C
Journal of Pain Research 2025, 18:5909-5910
Published Date: 7 November 2025
Quadratus Lumborum Block for Pain Management After Colorectal Surgery: Systematic Review and Meta-Analysis of Analgesic and Opioid-Sparing Effects
Han C, Wang Y, Tan H
Journal of Pain Research 2025, 18:5827-5841
Published Date: 3 November 2025
The Genetic Association Between Prescription Pain Medication Use and the Risk for Fibromyalgia: A Bidirectional and Multivariable Mendelian Randomization Analysis
Zhou G, Cao W, Liang S, Ye Z, Liu Z, Zou W
Journal of Pain Research 2025, 18:5455-5465
Published Date: 16 October 2025
Comparison of Opioid Consumption During Target Controlled Infusion (TCI) Guided By Nociception Level Index (NOL) or Standard Care Undergoing Intracranial Tumor Surgery
Demirel ME, Bilgin H, Akesen S
Journal of Pain Research 2025, 18:5347-5355
Published Date: 11 October 2025
Can Ziconotide Be Used to Replace Opioids? Exploratory Clinical Experience in 5 Patients Treated in the Pain Unit
Canovas Martínez L, Gago Diéguez N, Carrera Sieiro JL, López Díez R, García González C, Ortolá Más E, Almenara S
Journal of Pain Research 2025, 18:4859-4870
Published Date: 17 September 2025
Exploring Pain Clinical Specialists’ Perspectives on Opioid Optimization for Chronic Non-Malignant Pain in England
Alenezi A, Paudyal V, Yahyouche A
Journal of Pain Research 2025, 18:4037-4051
Published Date: 13 August 2025
Postmarketing Research for Opioid Abuse-Deterrent Formulations: A Narrative Review
Webster L, Gudin J, Green JL, Argoff CE
Journal of Pain Research 2025, 18:3987-4001
Published Date: 9 August 2025
Association Between Opioid Use and Emergency Department Visits for Spine-Related Disorders
Okeke C, Okoye G, Thornton JD
Journal of Pain Research 2025, 18:3493-3504
Published Date: 10 July 2025
Exploring Racial Disparities in Chronic Pain Management
Vargas AJ, Tobey-Moore L, Curran GM, Elkhateb R, Sexton KW, Bailey BJ, Nagel C, Goree JH
Journal of Pain Research 2025, 18:2901-2908
Published Date: 9 June 2025
Examining the Effects of Interventional Pain Management Staff Controlled Substance Agreement Education for Patients with Chronic Non-Cancer Intrathecal Drug Delivery Device Opioid Therapy: A Retrospective Review
Hoffmann C, McDonald T, Gladis B, Schatman ME, Pittelkow TP
Journal of Pain Research 2025, 18:2699-2706
Published Date: 26 May 2025
Serious Adverse Drug Reactions to Long-Term Oral Liquid Morphine in Patients with Chronic Pain: A Cross-Sectional Survey in Palliative Care
Duncan B, Natuhwera G, Nassuuna D, Katusabe R, Kasozi H, Acuda W
Journal of Pain Research 2025, 18:2361-2371
Published Date: 8 May 2025