Journal of Pain Research

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ISSN: 1178-7090

Pre-Clinical/Scientific


Section Editor(s):

Dr Wendy Imlach, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Vic, Australia
Professor E. Alfonso Romero-Sandoval, Pain Mechanisms Laboratory, Wake Forest University School of Medicine, Winston Salem, NC, USA

The section on pre-clinical models is a broad one, and notably includes the investigation of changes in the nervous system that drive and maintain chronic pain states. The section seeks to understand the origin and persistence of different types of pain and the translation of scientific discoveries into clinical practice.

Latest articles in Pre-Clinical/Scientific:

- 25 records -

Metabolomics Analysis Reveals Gut Microbiota-Associated Sakuranin Modulates Endometrial Stem Cell Differentiation and Inflammation to Alleviate Pain in Endometriosis [Response to Letter]

Shi W, Wang M, Jin Z, Chen X, Li J, Lai H, Li X, Zhong Q, Chen Y, Chen S

Journal of Pain Research 2026, 19:608988

Published Date: 16 April 2026

Exploring the Influence of Testosterone on Pain Perception and Modulation Among Men with Low and Normal Testosterone Concentrations

Vincenot M, Bordeleau M, le Blanc F, Pagé C, Gaumond I, Léonard G, Marchand S

Journal of Pain Research 2026, 19:571741

Published Date: 27 March 2026

Experimental Investigation of Fentanyl Analgesic Potency and Its Relationship with Endogenous Adrenaline Levels in Rats

Ates I, Isik B, Sezgin ET, Altuner D, Coban TA, Suleyman H

Journal of Pain Research 2026, 19:582322

Published Date: 25 March 2026

Differences in Experimental Pain Sensitivity Between Non-African and African American Healthy Individuals and Patients with Painful Chronic Pancreatitis

Phillips AE, Faghih M, Ramsey ML, Han S, Hart PA, Afghani E, Bick BL, Easler JJ, Yadav D, Wilcox CM, Olesen SS, Drewes AM, Singh VK

Journal of Pain Research 2026, 19:562097

Published Date: 25 February 2026

Reliability and Validity of Non-Invasive Electrical Detection and Pain Thresholds Using PainVision® in Healthy Young Adults

Yu S, Yang Z, Chen B, Wang L, Huang J, Gou L, Yang L

Journal of Pain Research 2026, 19:561240

Published Date: 17 February 2026

Metabolomics Analysis Reveals Gut Microbiota-Associated Sakuranin Modulates Endometrial Stem Cell Differentiation and Inflammation to Alleviate Pain in Endometriosis

Shi W, Wang M, Jin Z, Chen X, Li J, Lai H, Li X, Zhong Q, Chen Y, Chen S

Journal of Pain Research 2026, 19:557430

Published Date: 17 February 2026

An Overview of Ischemic Preconditioning as a Potential Therapeutic Target for Chronic Muscle Pain

Zhang Q, Luo J

Journal of Pain Research 2026, 19:546782

Published Date: 13 January 2026

Ginger Moxibustion Activates TRPV1 to Modulate the Locus Coeruleus-Spinal Cord-Uterus Pathway and Alleviates Primary Dysmenorrhea in Rats

Wang X, Yang L, Bi K, Zhou M, Wang D, Zhao Z, Mi S, Li X

Journal of Pain Research 2025, 18:7109-7125

Published Date: 25 December 2025

LncRNA-Associated ceRNA Network in the Spinal Cord Reveals the Central Mechanism of Chronic Inflammatory Visceral Pain

Li X, Wang X, Dong X, Li Z, Lu Y, Liu L, Yang G, Hong J, Yang Y, Zhang C, Wu H, Zhang D, Ma X

Journal of Pain Research 2025, 18:6853-6868

Published Date: 17 December 2025

Modulatory Effects of “Minor” Cannabinoids in an in vitro Model of Neuronal Hypersensitivity

Anand U, Anand P, Sodergren MH

Journal of Pain Research 2025, 18:6259-6274

Published Date: 24 November 2025

Unexpected Role of TNFα Signaling in the Resolution of Postoperative Pain in Mice

Laumet S, Edwards AM, Inyang KE, Laumet G

Journal of Pain Research 2025, 18:6057-6063

Published Date: 12 November 2025

Microglia’s Phenotypic Heterogeneity in Pain Pathogenesis and Electroacupuncture Analgesia: Mechanisms and Therapeutic Potential

Ji D, Lyu Z, Erasmus S, Wu Y, Li X, Chen X, Fang J, Du J, Fang J, Zhou J, Liang Y

Journal of Pain Research 2025, 18:6007-6022

Published Date: 11 November 2025

Monosodium Iodoacetate Induces Knee Osteoarthritis in Rats in a Dose- and Time-Dependent Manner

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Song M, Han W, Li J, Wu G, Yu H, Yuan Q, Yu J

Journal of Pain Research 2025, 18:5507-5522

Published Date: 17 October 2025

Low-Dose IL-2 Attenuates Neuropathic Pain via Treg Expansion in Rats

Zhao Y, Shen L, Huang Y

Journal of Pain Research 2025, 18:5011-5022

Published Date: 26 September 2025

Immune Cells Mediate the Causal Pathway Linking Multisite Chronic Pain to Asthma: A Mediation Mendelian Randomization Study

Chen JH, Deng NH, Li YC, Zhu XC, Ge P, Wang XD, Jiang P, Wen ZW, Huang GT, Luo QM, Tu YY

Journal of Pain Research 2025, 18:5023-5035

Published Date: 25 September 2025

Effect of Acupotomy Modulation of NLRP3/Caspase-1/GSDMD Pathway on Chondrocyte Pyroptosis in Knee Osteoarthritis

Wang Y, Chen Y, Yang Y, Zhou Y, Yang Y, Zhu J

Journal of Pain Research 2025, 18:4935-4945

Published Date: 23 September 2025

Oxymatrine Alleviates Central Post-Stroke Pain in Rats by Reducing the Inflammatory Response

Li HL, Tan XP, Wang XD, Guo RT, Wang JL

Journal of Pain Research 2025, 18:4401-4412

Published Date: 27 August 2025

A Study of the Safety of Low Temperature Plasma Radiofrequency Ablation on Rat Sciatic Nerve

Zhang K, Xu Y, Yin T, Ji F, Xu H

Journal of Pain Research 2025, 18:4109-4121

Published Date: 14 August 2025

Borneol’s Pre-Clinical Analgesic Efficacy: Mediated by Receptor and Immune Mechanisms

Zhou Y, Mei X, Wang C

Journal of Pain Research 2025, 18:4085-4104

Published Date: 13 August 2025

Activation of TLR4/CCL2 in Intact Neurons Drives Radicular Injury-Induced Global Nerve Trunk Hypersensitivity in Radiculopathy Preclinical Models

Tong SH, Zhou J, Ye F, Ding P, Mei JL, Liao P, Lu YF, Zong Y, Gao CA, Zhang SY, Gao JJ, Liu DL, Huang YG

Journal of Pain Research 2025, 18:3903-3918

Published Date: 4 August 2025

GPER Enhances Chronic Burn Pain via PKC-Mediated Mu-Opioid Receptor Phosphorylation in the Rostral Ventromedial Medulla

Zhu X, Zhang Y, Zhang Q, Zhang Z

Journal of Pain Research 2025, 18:3859-3878

Published Date: 2 August 2025


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