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OncoTargets and Therapy

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ISSN: 1178-6930

Archive: Volume 18, 2025

MicroRNA-29a Plays a Suppressive Role in Non-Small Cell Lung Cancer Cells via Targeting LASP1 [Retraction]

Hu ZL, Cui YH, Zhou YH, Zhou KY, Qiao XQ, Li CQ, Wang S

OncoTargets and Therapy 2025, 18:1363-1364

Published Date: 19 December 2025

Clinical Significance of MYBL2 Expression in Hepatocellular Carcinoma: Impact on Overall Survival

Chen CC, Wei CT, Hsuan CF, Yu TH, Hung WC, Wu CC, Lee TL, Tang WH, Chung FM, Lee YJ, Hsu CC

OncoTargets and Therapy 2025, 18:1353-1362

Published Date: 16 December 2025

Brain Metastatic Tumor Flare After Sunvozertinib Dose Reduction in a Patient with Surgical Resected EGFR ex20ins NSCLC

Yan W, Yang N, Wang G, Bao W, Liang Q, Lv T, Ye M, Zhang F, Yin J

OncoTargets and Therapy 2025, 18:1347-1352

Published Date: 8 December 2025

Prognostic Impact of Pre-Treatment CRP/Albumin Ratio in Patients with Advanced-Stage Epithelial Ovarian Cancer

Atalah F, Karakök A, Acarbay A, Beşiroğlu M, Gümüş M

OncoTargets and Therapy 2025, 18:1337-1346

Published Date: 5 December 2025

SNRPE is Associated with ERK/mTOR Signaling Activation and Reduced Autophagy to Promote Lung Adenocarcinoma Cell Proliferation

Yang J, Dai W, Ren B, Chen H, Dang X, Jiang L

OncoTargets and Therapy 2025, 18:1299-1312

Published Date: 15 November 2025

Icariin Inhibits Lung Adenocarcinoma Progression Through TP53-Mediated Ferroptosis

Jin Q, OuYang L, Li J, Yang X, Guo L

OncoTargets and Therapy 2025, 18:1281-1298

Published Date: 15 November 2025

Diagnosis and Management of Colorectal Cancer in the Gulf Area: Current Practice and Future Suggestions from Expert Opinions

Al-Shamsi HO, Rasul Snr K, Shablak A, ALnajjar A, Shabaan AMA, Al Sindi M, Nasr M, AlJabban A, Rafii S

OncoTargets and Therapy 2025, 18:1265-1279

Published Date: 15 November 2025

Forkhead Box S1 Inhibits the Progression of Hepatocellular Carcinoma [Retraction]

Lei D, Hu G, Chen Y, Hao T, Gao Y, Luo F

OncoTargets and Therapy 2025, 18:1257-1258

Published Date: 7 November 2025

Decoding the Prognosis-Related S100A9high Monocyte in Glioblastoma Using Single-Cell and Spatial Transcriptome Sequencing

Li X, Qin Y, Gao P, Wang H, Liu Y, Ren L, Wu D, Heng X

OncoTargets and Therapy 2025, 18:1211-1226

Published Date: 5 November 2025

miR-424-3p Contributes to the Malignant Progression and Chemoresistance of Gastric Cancer [Retraction]

Li Y, Liu H, Cui Y, Chen H, Cui X, Shao J, Su F, He X

OncoTargets and Therapy 2025, 18:1209-1210

Published Date: 1 November 2025

Real-World Experience of Niraparib as Maintenance Therapy in Patients with Newly Diagnosed Advanced Ovarian Cancer: A Single-Center Retrospective Study

Liu W, Zhang L, Wu H, Chen Y, Ma Y, Bao L, Fu X, Wang K

OncoTargets and Therapy 2025, 18:1201-1208

Published Date: 29 October 2025

Evaluating the Prognostic Value of a Pan-Cancer Circulating Tumor DNA Next-Generation Sequencing Panel in Advanced Cancer Patients

Lee J, Cho JH, Lee S, Kim HS, Han SJ, Jung Y, Byun JH, Kim M

OncoTargets and Therapy 2025, 18:1179-1188

Published Date: 25 October 2025

L-Sarcolysine Reduced the Mobility of Human Glioblastoma Cells, with Potential Involvement of Vimentin

Azadbeigi P, Moosavinejad N, Rassouli FB

OncoTargets and Therapy 2025, 18:1169-1178

Published Date: 18 October 2025

Advances in the Use of Immune Checkpoint Inhibitors for Colorectal Cancer Treatment

Li J, Fu T, Wen Z, Liang J, Qiu Y, Li K, Yang J, Tong Y, Cai H

OncoTargets and Therapy 2025, 18:1159-1168

Published Date: 15 October 2025

Precision Nanomedicine for Cancer: Innovations, Strategies, and Translational Challenges

Wen F, Wang L, Li X, Zhao J, Xu T, Zhu J, Ma L, Wang X

OncoTargets and Therapy 2025, 18:1125-1148

Published Date: 10 October 2025

Ebp1 p48 Promotes Oncogenic Properties in Non-Small Cell Lung Cancer Through PI3K/Akt Signaling Pathways

Ma L, Wang S, Zhang J, Xin M, Xu D, Liu L, Li X

OncoTargets and Therapy 2025, 18:1093-1105

Published Date: 22 September 2025

Vitamin C Selectively Inhibits Kidney Renal Clear Cell Carcinoma Cell Growth by Suppressing the HIF-1 Pathway

Wang C, Zhou Y, Liang Y, Pan J, Qiao J, Chen L, Liu S, Chen J, Wang J, Sun X, Ma J, Cai M

OncoTargets and Therapy 2025, 18:1069-1081

Published Date: 20 September 2025

Serum Response Factor Expression, Microvascular Density, and Postoperative Recurrence in Glioblastoma

Tan B, He S, Chen T, Song P, Huang Y, Yin X

OncoTargets and Therapy 2025, 18:1043-1052

Published Date: 19 September 2025

Glycolysis-Driven Immune Evasion in Microsatellite Instability-High Colorectal Cancer: An Integrated Single-Cell and Spatial Transcriptomics Study

Li C, Cai P, Zeng H, Li J, Hu H, Zhang J, Wu Z, Qin G, Deng Y

OncoTargets and Therapy 2025, 18:1027-1042

Published Date: 18 September 2025

Can Epithelial-Myoepithelial Carcinoma of the Breast Benefit from TROP2 Antibody-Drug Conjugate?

Zhao Q, Luo X, Xing H, Jiang C, Ma J, Tang L

OncoTargets and Therapy 2025, 18:1013-1025

Published Date: 12 September 2025

The Immunomodulatory Activity of Thymosin Alpha 1 on Tumor Cell Lines and Distinct Immune Cell Subsets

Solmonese L, Lofiego MF, Fazio C, Marzani F, Piazzini F, Bello E, Celesti F, Giacobini G, Wang X, Maio M, Coral S, Di Giacomo AM, Covre A

OncoTargets and Therapy 2025, 18:995-1012

Published Date: 10 September 2025

The Dual Role of RBBP7 in Esophageal Squamous Cell Carcinoma: Cell Context-Dependent Impacts on Proliferation and Radiosensitivity

Li Y, Lu S, Yao H, Zhu G, Liu H, Ma Z, Tang H

OncoTargets and Therapy 2025, 18:979-994

Published Date: 4 September 2025

Mi-Lnc70 Regulates the Progression of Murine Pancreatic β-Cell Line and Affects the Synthesis of Insulin and Glucagon

Yuan W, Sun D, Wang J, Yue Y, Li X

OncoTargets and Therapy 2025, 18:967-978

Published Date: 3 September 2025

Immunotherapy Resistance and Therapeutic Strategies in PD-L1 High Expression Non-Small Cell Lung Cancer

Liu J, Cai Y, Liu J, Chen D, Wu X

OncoTargets and Therapy 2025, 18:953-966

Published Date: 29 August 2025

CD93: A Promising NETs-Related Biomarker for Diagnosis and Therapy in Actinic Keratosis

Ke G, Yuan T, Wu C, Gao M

OncoTargets and Therapy 2025, 18:935-951

Published Date: 27 August 2025

The Role of CELMoD Agents in Multiple Myeloma

van de Donk NW, Bahlis NJ, Pawlyn C, Gay F, Mateos MV, Weisel K, Lonial S, Richardson PG

OncoTargets and Therapy 2025, 18:921-933

Published Date: 27 August 2025

Crosstalk Between Immunity and Oncogenes Within the Tumor Microenvironment of HPV-Associated Cervical Squamous Cell Carcinoma

Alahmadi RM, Al Rawi HZ, Awadalla M, Saeed B, Abdelazeem B, Alshanbari HM, Alosaimi B

OncoTargets and Therapy 2025, 18:899-920

Published Date: 15 August 2025

Migrasome-Related Prognostic Genes in Gastric Cancer: A Transcriptomic and Immunotherapeutic Analysis

Qiu W, Zhang K, Hu W, Liu D

OncoTargets and Therapy 2025, 18:873-897

Published Date: 13 August 2025

Innovative Biomarkers for Diagnosing Malignant Ascites in Liver Cancer

Zhang Y, Wu J, Cui H, Zhang X, He L, Gu K, Xu A

OncoTargets and Therapy 2025, 18:865-872

Published Date: 11 August 2025

The Expression and Clinical Significance of ALDOA in Breast Cancer

Dai Y, Yang Y, Li X, Shi G, Ni T, Zhu Q, He Q, Hu A, Jiang H, Liu J, Lu T, Sun J, Yu E, Sun L

OncoTargets and Therapy 2025, 18:845-862

Published Date: 4 August 2025

Immune-Checkpoint Inhibitors in Lung Neuroendocrine Tumors – A Systematic Review and Meta-Analysis

Pichel RC, Benini L, Romelli M, Gandini S, Gervaso L, Valente M, De Sousa MJ, Araújo A, Araújo A, Di Giacomo AM, Fazio N

OncoTargets and Therapy 2025, 18:833-843

Published Date: 31 July 2025

Advances in ORMDL Research in Malignant Tumors: A Review

Wang H, Yi Z, Yan S, Wang Y, Zhang W, Guo R, Li Y, Wang R, Li H, Li X, Song J

OncoTargets and Therapy 2025, 18:821-832

Published Date: 28 July 2025

Multiclonal Profiling of FLT3-ITD in AML Using MinION Sequencing: A Tailored Clustering Approach to Enhance Subclonal Detection

Martínez-Serra J, Alonso-Carballo A, Horrillo Á, Gómez P, Vögler O, Gutiérrez A, Sampol A

OncoTargets and Therapy 2025, 18:811-820

Published Date: 19 July 2025

Biomarker and Prognostic Value of Super-ARMS Detection for EGFR Mutation in Advanced NSCLC

Liu H, Li H, Xiao L, Guo Y, Lin G

OncoTargets and Therapy 2025, 18:789-801

Published Date: 8 July 2025

Survival Outcomes in Lung Cancer Patients Newly Diagnosed Through Brain Metastasis Surgery: Impact of Druggable Mutations and Radiotherapy

Chuang TI, Hsu KH, Lee PH, Tseng JS, Hsu YW, Liao CH, Huang YH, Yang TY

OncoTargets and Therapy 2025, 18:751-761

Published Date: 25 June 2025

Lidocaine as a Potential Therapeutic Agent in Colorectal Cancer: A Study of Gene Expression and Prognosis

Li W, Gao W, Lu C, Ji M, Yin Y, Zhang H, Liu C, Yu C

OncoTargets and Therapy 2025, 18:737-749

Published Date: 18 June 2025

Studying Immunogenic Cell Death in Human Colorectal Cancer Organoids

Lisandrelli R, Winkler M, Trajanoski Z, Lamberti G

OncoTargets and Therapy 2025, 18:705-715

Published Date: 6 June 2025

MAM Domain Containing 2 (MAMDC2) Affects Invasion and Metastasis of Human Gastric Cancer

Shen J, Gao G, Liu S

OncoTargets and Therapy 2025, 18:679-693

Published Date: 26 May 2025

Validation of a Combined Prognostic Score Using Plasma Tumor DNA and Clinical Features in Metastatic Castration-Resistant Prostate Cancer Patients Treated with Taxanes

Brighi N, Schepisi G, Conteduca V, Scarpi E, Caroli P, Matteucci F, Lolli C

OncoTargets and Therapy 2025, 18:667-677

Published Date: 23 May 2025

CXCL11: A Novel Biomarker in Colorectal Cancer as Metastasis Predictor

Wibowo R, Sribudiani Y, Lukman K, Rudiman R, Ruchimat T, Sulthana BAAS, Purnama A, Wijaya A, Primastari E, Nugraha P

OncoTargets and Therapy 2025, 18:657-665

Published Date: 14 May 2025

lncSLERT Promotes Liver Metastasis in Colorectal Cancer by Down-Regulating HUNK Expression via RBM15-Mediated m6A Modification

Wang L, Zhao L, Liu J, Cheng P, Han M, Zheng Z

OncoTargets and Therapy 2025, 18:631-646

Published Date: 9 May 2025

A Pyroptosis-Related LncRNA Signature for Predicting Prognosis, Immune Features and Drug Sensitivity in Ovarian Cancer

Liu PW, Liu ZY, Deng SJ, Zhang X, Wang ZB, Wu NY, Liu CS, Hu MH, Wang J, Li H

OncoTargets and Therapy 2025, 18:585-601

Published Date: 23 April 2025

Therapeutic Potential of Datopotamab Deruxtecan in the Treatment of Advanced Non-Small Cell Lung Cancer: Evidence to Date

Gogtay M, Aimalla N, Thirugnanasambandam RP, Ganti AK

OncoTargets and Therapy 2025, 18:575-584

Published Date: 23 April 2025

Based on Soluble Immune Checkpoints Constructing a Random Survival Forest Model to Predict the Prognosis of Hepatitis B Virus-Associated Hepatocellular Carcinoma

Cai X, Yu L, Liu X, Yan H, Xie Y, Pu Q, Shang Z, Wu Y, Jiang T, Yang Z

OncoTargets and Therapy 2025, 18:559-573

Published Date: 19 April 2025

Research Progress of GPR137 in Malignant Tumors: A Review

Li Y, Yi Z, Li X, Wang R, Zhao M, Mi L, Zhang W, Guo R, Yan S, Song J

OncoTargets and Therapy 2025, 18:545-558

Published Date: 15 April 2025

Integrated Genomic Analysis of Lung Squamous Cell Carcinoma Subtypes Characterized by Immunogenic Cell Death-Relevant Gene Signature

Wang Y, Wang S, Ding R, Zhang Z, Kong J, Xie T, Xu B, Fu L, Zhang E

OncoTargets and Therapy 2025, 18:521-537

Published Date: 11 April 2025

Management of Regorafenib-Induced Hand-Foot Skin Reaction with Topical Chinese Medicine and Urea Ointment: A Case Report and Literature Review

Liu ZN, Shen YL, Dong HJ, Tan KX, Li J, Peng YM, Cui HJ

OncoTargets and Therapy 2025, 18:509-519

Published Date: 9 April 2025

Neoadjuvant Targeted Therapy with Dacomitinib in a Stage IIIA Non-Small-Cell Lung Cancer Patient Harboring EGFR G719X: A Case Report

Li D, Liu X, Liu Y, Zhu Y, Yang D, Song J, Dai Z

OncoTargets and Therapy 2025, 18:503-507

Published Date: 5 April 2025

Anti-Tumor Effects of Gilteritinib on FLT3 Mutations: Insights into Resistance Mechanisms in Ba/F3 Cell Models

Nakazawa T, Tsuzuki H, Kawase T, Mori M, Yoshida T

OncoTargets and Therapy 2025, 18:489-501

Published Date: 3 April 2025

Coumarins from Citrus aurantiifolia (Christm.) Swingle Peel with Potential Cytotoxic Activity Against MCF-7 Breast Cancer Cell Line: In Vitro and In Silico Studies

Julaeha E, Mulyawan FE, Anwar FM, Akili AWR, Permadi N, Darwati, Kurnia D, Herlina T

OncoTargets and Therapy 2025, 18:441-452

Published Date: 30 March 2025

Genomic Insights Into Early Relapsed Breast Cancer: Prognostic Challenges and Mutation Landscape

Wang Y, Zhang L, Du Y, Yan T, Yang F, Yang Y, Liu B, Xie L

OncoTargets and Therapy 2025, 18:429-439

Published Date: 29 March 2025

PCSK9 Manipulates Lipid Metabolism and the Immune Microenvironment in Cancer

Cui C, Yan A, Huang S, Chen Y, Zhao J, Li C, Wang X, Yang J

OncoTargets and Therapy 2025, 18:411-427

Published Date: 27 March 2025

Prognostic and Immunological Significance of NMNAT1 in Colorectal and Pan-Cancer Contexts

Wen L, Wang P, Zhang G, Ma Y, Li J, Chen D, Liu L, Hu H, Huang C, Yao X

OncoTargets and Therapy 2025, 18:389-410

Published Date: 25 March 2025

Clinical Impact of Osimertinib Dose Reduction in the First-Line Setting on EGFR Mutation-Positive Non-Small Cell Lung Cancer: A Retrospective Monocentric Study

Iso H, Yomota M, Shirakura Y, Yoshinaga T, Kawai S, Narita K, Seike M, Hosomi Y

OncoTargets and Therapy 2025, 18:379-387

Published Date: 19 March 2025

Evaluation of Indoleamine 2,3-Dioxygenase (IDO) Expression in Osteosarcoma: Insights From a 10-Year Retrospective Cohort

Farooq A, Amin A, Bashir S, Fatima M, Hassan M, Sheikh AZ, Tahseen M, Sheikh UN, Asghar K

OncoTargets and Therapy 2025, 18:367-377

Published Date: 17 March 2025

CYP3A5 Polymorphism in Circulating Tumor Cells Confers an Increased Disease-Free Survival in DLBCL Patients Treated with R-CHOP

Cerón Maldonado R, Martínez Tovar A, Ramos Peñafiel CO, De la Cruz Rosas A, García Laguna AI, Mendoza Salas I, Martínez Murillo C, Barranco Lampón GI, Montaño Figueroa EH, Jiménez-Morales S, Olarte Carrillo I

OncoTargets and Therapy 2025, 18:355-366

Published Date: 14 March 2025

Comprehensive Treatment of Anaplastic Thyroid Cancer: A Case Report

Liu J, Chu J

OncoTargets and Therapy 2025, 18:325-333

Published Date: 10 March 2025

Patient-Derived Organoids for Guiding Neoadjuvant Chemotherapy in Bilateral Primary Breast Cancer: A Case Report

Cao M, Wang R, Cheng X, Yu H, Tong Q, Yao Y

OncoTargets and Therapy 2025, 18:319-324

Published Date: 6 March 2025

The Landscape of PARP Inhibitors in Solid Cancers

Muzzana M, Broggini M, Damia G

OncoTargets and Therapy 2025, 18:297-317

Published Date: 2 March 2025

Profiling the Tumor Immune Microenvironment of HPV-Associated Base of Tongue Squamous Cell Carcinoma

Alahmadi RM, Awadalla M, Marraiki N, Alswayyed M, Alshehri HA, Alsahli A, Khoja HA, Khojah OT, Alahmadi RM, Farid N, Alosaimi B

OncoTargets and Therapy 2025, 18:263-281

Published Date: 20 February 2025

Exploring TGF-β Signaling in Cancer Progression: Prospects and Therapeutic Strategies

Sheikh KA, Amjad M, Irfan MT, Anjum S, Majeed T, Riaz MU, Jassim AY, Sharif EAM, Ibrahim WN

OncoTargets and Therapy 2025, 18:233-262

Published Date: 18 February 2025

Molecular and Cellular Machinery of Lymphatic Metastasis in Breast Cancer

Cong B, Cao X, Jiang WG, Ye L

OncoTargets and Therapy 2025, 18:199-209

Published Date: 4 February 2025

Mechanism of microRNA-152-3p-Mediated Regulation of Autophagy and Sensitivity in Paclitaxel-Resistant Ovarian Cancer Cells

Wu D, Zhang Y, Zhang L, Xia W, Cai B, Dong F, Wu K, Cheng L, Shao M, Ma H, Hu Z, Lu H

OncoTargets and Therapy 2025, 18:179-197

Published Date: 4 February 2025

Exploration and Identification of Vitamin D and Related Genes as Potential Biomarkers for Colorectal Tumors

Wang L, Xu R, Wang M, Wang M, Su S, Nian Y, Chen X

OncoTargets and Therapy 2025, 18:129-145

Published Date: 22 January 2025

Pan-Cancer Analysis Identifies YKT6 as a Prognostic and Immunotherapy Biomarker, with an Emphasis on Cervical Cancer

Liu J, Zhang Q, He L, Hu H, Wang Y, Xie P

OncoTargets and Therapy 2025, 18:107-127

Published Date: 22 January 2025

Research Progress of NK Cells in Glioblastoma Treatment

Wu H, Liu Q, Wang F, Gao W, Zhou F, Zhao H

OncoTargets and Therapy 2025, 18:87-106

Published Date: 18 January 2025

Roles of SPOCK1 in the Formation Mechanisms and Treatment of Non-Small-Cell Lung Cancer and Brain Metastases from Lung Cancer

Zhang X, Zhang X, Yin H, Li Q, Fan B, Jiang B, Xie A, Guo D, Hao H, Zhang B

OncoTargets and Therapy 2025, 18:35-47

Published Date: 16 January 2025

High Intelectin‐1 Expression Associated with Aggressive Tumor Behavior and Worse Survival in Rectal Cancer

Chou CL, Lin CW, Li WS, Chen TJ, Lee SW, Tian YF, Kuo YH, Tsai HH, Wu LC, Yeh CF, Shiue YL, Lai HY, Yang CC

OncoTargets and Therapy 2025, 18:15-26

Published Date: 13 January 2025