Drug Design, Development and Therapyhttps://www.dovepress.com/feed/journal/19New articles released by Dove Press for Drug Design, Development and Therapyen-us2026, Dove Pressangela@dovepress.com (Angela Jones)Dove Press Drug Design, Development and TherapyDrug Design, Development and Therapyhttps://www.dovepress.com/feed/journal/19https://www.dovepress.com/assets/img/addon/rss-banner.jpg140140Is Rituximab Suitable for Patients with Idiopathic Membranous Nephropathy Who are Seronegative for Anti-PLA2R Antibody?https://www.dovepress.com/is-rituximab-suitable-for-patients-with-idiopathic-membranous-nephropa-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 13 May 2026 00:35:00 +1200https://doi.org/10.2147/DDDT.S601777The Crosstalk Between Epithelial-Mesenchymal Transition and Anoikis Resistance: A New Perspective of Traditional Chinese Medicine to Prevent Tumor Metastasishttps://www.dovepress.com/the-crosstalk-between-epithelial-mesenchymal-transition-and-anoikis-re-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 13 May 2026 00:30:00 +1200https://doi.org/10.2147/DDDT.S596194EC50 and EC95 of Epidural Ropivacaine for Intraoperative Analgesia During High-Intensity Focused Ultrasound for Adenomyosis: A Prospective Double-Blind Up-and-Down Concentration-Finding Studyhttps://www.dovepress.com/ec50-and-ec95-of-epidural-ropivacaine-for-intraoperative-analgesia-dur-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 12 May 2026 19:40:00 +1200https://doi.org/10.2147/DDDT.S594039Anterior Quadratus Lumborum Block with Liposomal Bupivacaine versus Ropivacaine for Postoperative Recovery in Laparoscopic Colorectal Surgery: A Randomized Controlled Trialhttps://www.dovepress.com/anterior-quadratus-lumborum-block-with-liposomal-bupivacaine-versus-ro-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 12 May 2026 18:35:00 +1200https://doi.org/10.2147/DDDT.S611347Competing Death and Absolute Benefit in Dexmedetomidine-Exposed Patients with Dialysis-Requiring Acute Kidney Injury [Letter]https://www.dovepress.com/competing-death-and-absolute-benefit-in-dexmedetomidine-exposed-patien-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 12 May 2026 16:10:00 +1200https://doi.org/10.2147/DDDT.S622743Development Trends of Janus Kinase Inhibitors (JAKi) Over Three Decades: From Common to Rare Diseaseshttps://www.dovepress.com/development-trends-of-janus-kinase-inhibitors-jaki-over-three-decades--peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 12 May 2026 03:45:00 +1200https://doi.org/10.2147/DDDT.S597046GBVAM as a Novel NHE1 Inhibitor Alleviates Doxorubicin-Induced Cardiotoxicity via PI3K/Akt/mTOR Pathwayhttps://www.dovepress.com/gbvam-as-a-novel-nhe1-inhibitor-alleviates-doxorubicin-induced-cardiot-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 12 May 2026 02:40:00 +1200https://doi.org/10.2147/DDDT.S585989Intravenous Tranexamic Acid Reduces the Incidence of Postoperative Delirium in Elderly Patients Undergoing Hip Arthroplasty: A Retrospective Cohort Studyhttps://www.dovepress.com/intravenous-tranexamic-acid-reduces-the-incidence-of-postoperative-del-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 12 May 2026 02:25:00 +1200https://doi.org/10.2147/DDDT.S587510Effect of Subanesthetic Doses of Esketamine on Early Postoperative Pain Sensitivity in Patients Undergoing Salpingectomy: A Randomized Clinical Trialhttps://www.dovepress.com/effect-of-subanesthetic-doses-of-esketamine-on-early-postoperative-pai-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyMon, 11 May 2026 16:20:00 +1200https://doi.org/10.2147/DDDT.S596251Effect of Oliceridine Pretreatment on Etomidate-Induced Myoclonus: A Proof-of-Concept Randomized Trialhttps://www.dovepress.com/effect-of-oliceridine-pretreatment-on-etomidate-induced-myoclonus-a-pr-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapySat, 09 May 2026 20:10:00 +1200https://doi.org/10.2147/DDDT.S611682Mechanistic Physiologically Based Pharmacokinetic Modeling to Predict CYP3A4-Mediated Drug–Drug Interactions of Flumatinib as Both a Victim and a Perpetratorhttps://www.dovepress.com/mechanistic-physiologically-based-pharmacokinetic-modeling-to-predict--peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapySat, 09 May 2026 03:40:00 +1200https://doi.org/10.2147/DDDT.S574169Olanzapine-Associated Hepatotoxicity in Bipolar Disorder: A Multicenter Real-World Study of Prevalence, Risk Factors, and Outcomeshttps://www.dovepress.com/olanzapine-associated-hepatotoxicity-in-bipolar-disorder-a-multicenter-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 08 May 2026 21:05:00 +1200https://doi.org/10.2147/DDDT.S598447The Median Effective Dose of Phenylephrine Infusion for Prevention of Spinal-Induced Hypotension During Cesarean Delivery in the 15° Left-Tilt vs. Supine Positions: A Randomised Control Studyhttps://www.dovepress.com/the-median-effective-dose-of-phenylephrine-infusion-for-prevention-of--peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 08 May 2026 20:05:00 +1200https://doi.org/10.2147/DDDT.S591446Cannabidiol-Induced Tumor Cell Death: Molecular Mechanisms and Translational Perspectives in Cancer Therapyhttps://www.dovepress.com/cannabidiol-induced-tumor-cell-death-molecular-mechanisms-and-translat-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 08 May 2026 20:00:00 +1200https://doi.org/10.2147/DDDT.S597740Drug-Drug Interaction of Chiglitazar with Empagliflozin, Atorvastatin, and Valsartan: An Open-Label, Single-Center, Self-Control, 3-Period Studyhttps://www.dovepress.com/drug-drug-interaction-of-chiglitazar-with-empagliflozin-atorvastatin-a-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 08 May 2026 03:05:00 +1200https://doi.org/10.2147/DDDT.S588573Efficacy and Safety of Oliceridine for Patient-Controlled Intravenous Analgesia in Elderly Patients Undergoing Laparoscopic Radical Resection Surgery for Gastrointestinal Malignant Tumors: A Prospective Randomized Controlled Non-Inferiority Clinical Trialhttps://www.dovepress.com/efficacy-and-safety-of-oliceridine-for-patient-controlled-intravenous--peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 08 May 2026 02:35:00 +1200https://doi.org/10.2147/DDDT.S593111Formulation Progress, Challenges, and Perspectives of Anti-Inflammatory Natural Productshttps://www.dovepress.com/formulation-progress-challenges-and-perspectives-of-anti-inflammatory--peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 07 May 2026 21:45:00 +1200https://doi.org/10.2147/DDDT.S606531Remimazolam versus Sevoflurane for Paediatric Circumcision: A Randomised Controlled Trial Evaluating Emergence Deliriumhttps://www.dovepress.com/remimazolam-versus-sevoflurane-for-paediatric-circumcision-a-randomise-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 07 May 2026 02:10:00 +1200https://doi.org/10.2147/DDDT.S602836The Satisfactory Analgesia and Minimal Emesis of Elderly Patients After Thoracoscopic Lung Surgery: Oliceridine versus Sufentanil in a Randomized Controlled Trialhttps://www.dovepress.com/the-satisfactory-analgesia-and-minimal-emesis-of-elderly-patients-afte-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 07 May 2026 02:05:00 +1200https://doi.org/10.2147/DDDT.S593306An Interpretable PK-Informed Hybrid Model for Voriconazole Exposure Prediction: Roles of CYP2C19 Genotype and Inflammationhttps://www.dovepress.com/an-interpretable-pk-informed-hybrid-model-for-voriconazole-exposure-pr-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 07 May 2026 02:00:00 +1200https://doi.org/10.2147/DDDT.S489712The Effect of Intraoperative Infusion of Different Doses of Esketamine on the Quality of Recovery in Elderly Patients Undergoing Knee Arthroplastyhttps://www.dovepress.com/the-effect-of-intraoperative-infusion-of-different-doses-of-esketamine-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 06 May 2026 03:30:00 +1200https://doi.org/10.2147/DDDT.S590805Effects of Oliceridine versus Sufentanil on Postoperative Nausea and Vomiting in Patients Undergoing Modified Radical Mastectomy: A Double-Blind Randomized Controlled Trialhttps://www.dovepress.com/effects-of-oliceridine-versus-sufentanil-on-postoperative-nausea-and-v-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 06 May 2026 03:25:00 +1200https://doi.org/10.2147/DDDT.S602305Advances in PARP Inhibition in Improving Outcomes of Breast Cancer, Ovarian Cancer, and Other Solid Tumors: Journey of Discovery, Development, and Clinical Updates of Talazoparibhttps://www.dovepress.com/advances-in-parp-inhibition-in-improving-outcomes-of-breast-cancer-ova-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 06 May 2026 02:45:00 +1200https://doi.org/10.2147/DDDT.S575152Effect of Rho Kinase Inhibitor RKI-1447 on Dexamethasone-Induced Ocular Hypertension and Its Molecular Mechanisms in Sprague-Dawley Ratshttps://www.dovepress.com/effect-of-rho-kinase-inhibitor-rki-1447-on-dexamethasone-induced-ocula-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 06 May 2026 02:05:00 +1200https://doi.org/10.2147/DDDT.S605489Optimal Piperacillin/Tazobactam Dosing in Adults with Low Body Weight: A Population Pharmacokinetic and Simulation-Based Studyhttps://www.dovepress.com/optimal-piperacillintazobactam-dosing-in-adults-with-low-body-weight-a-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 05 May 2026 23:00:00 +1200https://doi.org/10.2147/DDDT.S602835Pathogenesis of Osteoarthritis: Mechanisms of Action of Disulfidptosis and Targeted Therapeutic Strategieshttps://www.dovepress.com/pathogenesis-of-osteoarthritis-mechanisms-of-action-of-disulfidptosis--peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 05 May 2026 22:50:00 +1200https://doi.org/10.2147/DDDT.S606941Integrating Therapeutic Drug Monitoring and Metabolomics to Explore Interindividual Variability in Lamotrigine Response in Epilepsyhttps://www.dovepress.com/integrating-therapeutic-drug-monitoring-and-metabolomics-to-explore-in-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 05 May 2026 03:40:00 +1200https://doi.org/10.2147/DDDT.S593268Identification of a Quinolone-Based Scaffold as a Dual SARS-COV-2 PLᵖʳᵒ and Mᵖʳᵒ Inhibitor: An Integrated Molecular Modeling and In-vitro Evaluation Approachhttps://www.dovepress.com/identification-of-a-quinolone-based-scaffold-as-a-dual-sars-cov-2-pl-a-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyMon, 04 May 2026 21:40:00 +1200https://doi.org/10.2147/DDDT.S593126Preserving Airway Reflexes During Awake Intubation: A Cautionary Note on Deep Sedation Protocols [Letter]https://www.dovepress.com/preserving-airway-reflexes-during-awake-intubation-a-cautionary-note-o-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyMon, 04 May 2026 21:35:00 +1200https://doi.org/10.2147/DDDT.S615555The Effects of Remimazolam Tosylate on Postoperative Memory Function in Young and Middle-Aged Patients Undergoing Laparoscopic Surgery [Corrigendum]https://www.dovepress.com/corrigendum-the-effects-of-remimazolam-tosylate-on-postoperative-memor-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyMon, 04 May 2026 17:05:00 +1200https://doi.org/10.2147/DDDT.S620897