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Pragmatic and Observational Research
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- Volume 17, 2026 (3)
- Volume 16, 2025 (22)
- Volume 15, 2024 (22)
- Volume 14, 2023 (13)
- Volume 13, 2022 (9)
- Volume 12, 2021 (12)
- Volume 11, 2020 (10)
- Volume 10, 2019 (8)
- Volume 9, 2018 (8)
- Volume 8, 2017 (25)
- Volume 7, 2016 (6)
- Volume 6, 2015 (4)
- Volume 5, 2014 (6)
- Volume 4, 2013 (5)
- Volume 3, 2012 (6)
- Volume 2, 2011 (5)
- Volume 1, 2010 (6)
Journal Articles:
- 170 records -
Development and Internal Validation of a Prediction Model for Major Cardiovascular and Respiratory Events in Chronic Obstructive Pulmonary Disease: Nationwide Primary Care Electronic Medical Records Cohort Study
Gale CP, Bhutani M, Chan JSK, Townend J, Patel MS, Sadatsafavi M, Henley W, Ariti C, Carter V, Couper A, Hubbard R, Kocks JWH, Pullen R, Skinner D, Price D
Pragmatic and Observational Research 2026, 17:551291
Published Date: 10 March 2026
The Potential Impact of GLP-1 Receptor Agonists on Exacerbation Risk in Patients with COPD and Type 2 Diabetes: A Real-World Population-Based Observational Study
Alcázar-Navarrete B, Heatley H, Kaplan A, Tan LT, Koh MS, Sattar N, Townend J, Skinner D, Carter V, Price D
Pragmatic and Observational Research 2026, 17:550543
Published Date: 30 January 2026
Validity of Using Prescription Medications to Classify Disease – A Retrospective Observational Study Using Routinely Collected Electronic Health Records from the UK
Schnier C, Busby J, Sheikh A, Quint JK, Price DB, Heaney LG
Pragmatic and Observational Research 2026, 17:553011
Published Date: 15 January 2026
Relapse Predictors of Idiopathic Retroperitoneal Fibrosis: A Long-Term Cohort Study
Huang S, Wang A, Jia Y, Han W, Zhao N, Wang T, Zhu W, Zhao L, Peng L, Zhou J, Li M, Zhang W, Fei Y
Pragmatic and Observational Research 2025, 16:265-277
Published Date: 20 December 2025
INSIGHTS Asthma Pragmatic Registry – A Pragmatic Approach to High-Validity Real-World Evidence for Asthma
Kilpatrick K, Chandran U, Urman R, Llanos JP, Molfino NA, Matsuno RK, Riskin DJ
Pragmatic and Observational Research 2025, 16:253-264
Published Date: 18 December 2025
Derivation and Definitions of Clinical Study Variables for Multiple Long Term Conditions in Patients with Chronic Obstructive Pulmonary Disease: Protocol for a Modified Delphi Methods and Consensus Study on Behalf of the International Cardiovascular and Respiratory Alliance
Joseph T, Bhutani M, Couper A, Pullen R, Nadarajah R, Alves L, Montero-Arias MF, Al-Lehebi R, Berg DD, Hawkins NM, Hurst JR, Jenkins CR, Kaplan A, Kocks JWH, Kostikas K, Lam CSP, Lapperre TS, Rhee CK, Sattar N, Stolz D, Tse G, Winders T, Price D, Gale CP
Pragmatic and Observational Research 2025, 16:243-251
Published Date: 12 December 2025
Evaluation of Disease Modifying Therapies and Prognostic Factors Affecting Multiple Sclerosis Progression in a Local Centre of Hong Kong
Lui BCM, Li JTC, Lo WT, Fong WC
Pragmatic and Observational Research 2025, 16:221-241
Published Date: 2 December 2025
One Year Risk Prediction Model for Cardiovascular Disease for Adults with Asthma in England
Baskaran J, Novov VA, Quint JK, Kallis C
Pragmatic and Observational Research 2025, 16:201-219
Published Date: 15 November 2025
Real-World Treatment Patterns and Overall Survival (OS) of Patients with Metastatic Castration-Resistant Prostate Cancer in Italy
Dovizio M, Castelletti D, Luraghi P, Losi S, Gervasi A, Risi M, Leogrande M, Degli Esposti L, Procopio G
Pragmatic and Observational Research 2025, 16:189-199
Published Date: 11 November 2025
Clinical Outcomes of Ablation for Persistent Atrial Fibrillation with Zero or Minimal Fluoroscopy
Osorio J, Morales G, Rajendra A, Hunter TD
Pragmatic and Observational Research 2025, 16:179-187
Published Date: 23 September 2025
Expert Perspectives on Next Generation Health Guidelines: How to Integrate RWE in EBM
Del Giacco S, Canonica GW, Agache I, Price D, Roche N, Schunemann H, Allan K, Ansotegui I, Barbaglia S, Bernstein JA, Bonini M, Bosnic-Anticevich S, Bousquet J, Braido F, Carter V, Chong-Neto HJ, Di Bona D, Fletton K, Gonzalez Diaz S, Ayyar Gupta V, Hubbard R, Iaccarino J, Eguiluz-Gracia I, Jacomelli C, Kocks J, Krishnan J, Mahler V, Morais-Almeida M, Moreles D, Muti P, Palkonen S, Papadopoulos NG, Pawankar R, Reeb C, Reddel H, Rojo I, Ryan D, Sodhi L, Torres M, Winders T, Wilson KC
Pragmatic and Observational Research 2025, 16:169-177
Published Date: 11 September 2025
Evaluating the Potential of Prevalent New User Design as an Alternative When New User Design is Impractical
Koinuma T, Akazawa M
Pragmatic and Observational Research 2025, 16:155-168
Published Date: 31 July 2025
Association of Frequent Short-Acting Beta-Agonist Inhaler Prescriptions with Acute Cardiovascular Events
Pfeffer PE, Heatley H, Hubbard R, Townend J, Price D
Pragmatic and Observational Research 2025, 16:147-154
Published Date: 25 July 2025
Mapping EQ-5D-5L Score From SGRQ in Patients with Asthma and/or COPD in NOVELTY
Jackson D, Quinton A, Zhang F, Müllerová H, Janson C, Sadatsafavi M
Pragmatic and Observational Research 2025, 16:135-145
Published Date: 4 June 2025
Comprehensive Description of an Automated Drug Dispensing System Database
Wittwer NL, Meier CR, Recknagel MJ, Allemann S, Schneider C
Pragmatic and Observational Research 2025, 16:129-134
Published Date: 8 April 2025
Steroidal Mineralocorticoid Receptor Antagonist Side Effects and Reasons for Discontinuation: A Patient Survey (RELICS-PS)
Richard EL, Stephenson JJ, Desai NR, Willey VJ, Gay A, Scott C, Folkerts K, Pessina E, Singh R, Teng CC, Oberprieler NG
Pragmatic and Observational Research 2025, 16:121-127
Published Date: 3 April 2025
Shifting from Traditional to Pragmatic Randomized Controlled Trials: Insights and Lessons Learned from the Toddler Oral Health Intervention
Grift BG, van Spreuwel PCJM, Bruers JJ, Jerković-Ćosić K
Pragmatic and Observational Research 2025, 16:111-120
Published Date: 29 March 2025
Predicting Risk of Morbidities Associated with Oral Corticosteroid Prescription for Asthma
Stanley B, Chapaneri J, Khezrian M, Maslova E, Patel S, Gurnell M, Canonica GW, Reddel HK, Heaney LG, Bourdin A, Neil DL, Carter V, Price DB
Pragmatic and Observational Research 2025, 16:95-109
Published Date: 25 March 2025
Better Understanding Rehabilitation of Motor Symptoms: Insights from the Use of Wearables
Celik Y, Wall C, Moore J, Godfrey A
Pragmatic and Observational Research 2025, 16:67-93
Published Date: 19 March 2025
Real-World Biologic Use Patterns in Severe Asthma, 2015–2021: The CLEAR Study
Tran TN, Chen S, Emmanuel B, Altraja A, Bourdin A, Sheu CC, Tsai MJ, Hoyte FC, Quinton A, Cook B, Bulathsinhala L, Henley W, Goh CYY, Liu Y, Ariti C, Carter V, Price DB
Pragmatic and Observational Research 2025, 16:51-66
Published Date: 18 March 2025
A Prospective Observational Study to Evaluate the Actual Use of 1% Pimecrolimus in Chinese Patients with Mild-to-Moderate Atopic Dermatitis Affecting Sensitive Skin Areas
Xie Z, Chang J, Ma L, Shen C, Zhang L, An Q, Wang H, Dou X, Zheng Y, Ye C, Gao Y
Pragmatic and Observational Research 2025, 16:39-49
Published Date: 7 March 2025
Treatment Patterns, Adverse Events, and Clinical Outcomes with Steroidal Mineralocorticoid Receptor Antagonists: A Retrospective Analysis of Administrative Claims Data (RELICS)
Richard EL, Desai NR, Willey VJ, Gay A, Scott C, Folkerts K, Pessina E, Singh R, Teng CC, Oberprieler NG
Pragmatic and Observational Research 2025, 16:27-37
Published Date: 26 February 2025
Validation of Mortality Data Sources Compared to the National Death Index in the Healthcare Integrated Research Database
Jamal-Allial A, Sponholtz T, Vojjala SK, Paullin M, Papazian A, Eshete B, Mahmoudpour SH, Verpillat P, Beachler DC
Pragmatic and Observational Research 2025, 16:19-25
Published Date: 7 February 2025
Review of Challenges in Performing Real-World Evidence Studies for Nonprescription Products
Maihöfner C, Mallick-Searle T, Vollert J, Kalita P, Sood Sethi V
Pragmatic and Observational Research 2025, 16:7-18
Published Date: 23 January 2025
Measuring Diagnostic Quality: The Capacity of Routinely Collected Data and Applications to Chronic Respiratory Disease
Mountain R, Gatheral T, Haslam P, Heys K, Knight J
Pragmatic and Observational Research 2025, 16:1-6
Published Date: 16 January 2025
Detection of Patient-Level Immunotherapy-Related Adverse Events (irAEs) from Clinical Narratives of Electronic Health Records: A High-Sensitivity Artificial Intelligence Model
Zitu MM, Gatti-Mays ME, Johnson KC, Zhang S, Shendre A, Elsaid MI, Li L
Pragmatic and Observational Research 2024, 15:243-252
Published Date: 20 December 2024
Validation and Final Results from the First Cardiac Lead Post-Approval Study Using Real-World Data
Mullane S, Hicks JB, Sharmin K, Harrell C, Rock A, Miller C
Pragmatic and Observational Research 2024, 15:233-241
Published Date: 19 December 2024
Preserved Ratio Impaired Spirometry in US Primary Care Patients Diagnosed with Chronic Obstructive Pulmonary Disease
Evans A, Tarabichi Y, Pace WD, Make B, Bushell N, Carter V, Chang KL, Fox C, Han MK, Kaplan A, Kocks JWH, Le Lievre C, Roussos A, Skolnik N, Soriano JB, Yawn BP, Price D
Pragmatic and Observational Research 2024, 15:221-232
Published Date: 13 December 2024
Patient Characteristics, Management, and Outcomes of Adult Asthma in a Singapore Population: Data from the SDG-CARE Asthma Registry
Koh MS, Lam SSW, Xu X, Wu JT, Ratnasingham P, Marsel R, Ong MEH, Matchar DB, Tan NC, Loo CM
Pragmatic and Observational Research 2024, 15:209-220
Published Date: 7 December 2024
Improving the Transparency and Replicability of Consensus Methods: Respiratory Medicine as a Case Example
Rolfe MJ, Winchester CC, Chisholm A, Price DB
Pragmatic and Observational Research 2024, 15:201-207
Published Date: 15 October 2024
Non-Alcoholic Steatohepatitis Patient Characterization and Real-World Management Approaches in Italy
Bugianesi E, Miele L, Donnarumma G, Grau K, Mancuso M, Prasad P, Leith A, Higgins V
Pragmatic and Observational Research 2024, 15:185-200
Published Date: 10 October 2024
Comparing Machine Learning and Advanced Methods with Traditional Methods to Generate Weights in Inverse Probability of Treatment Weighting: The INFORM Study
Kwak D, Liang Y, Shi X, Tan X
Pragmatic and Observational Research 2024, 15:173-183
Published Date: 4 October 2024
Involvement of Root Canal Treatment in Pro-Inflammatory Processes – A Real-World Study
Diederich J, Müller KE
Pragmatic and Observational Research 2024, 15:165-172
Published Date: 24 September 2024
UK Electronic Healthcare Records for Research: A Scientometric Analysis of Respiratory, Cardiovascular, and COVID-19 Publications
Massen GM, Blamires O, Grainger M, Matta M, Twumasi RMG, Joshi T, Laity A, Nakariakova E, Thavaranjan T, Sheikh A, Quint JK
Pragmatic and Observational Research 2024, 15:151-164
Published Date: 15 August 2024
A Real-World Study on the Short-Term Efficacy of Amlodipine in Treating Hypertension Among Inpatients
Wang T, Tan J, Wang T, Xiang S, Zhang Y, Jian C, Jian J, Zhao W
Pragmatic and Observational Research 2024, 15:121-137
Published Date: 6 August 2024
Therapeutic Advances in Obesity: How Real-World Evidence Impacts Affordability Beyond Standard of Care
Patoulias D, Koufakis T, Ruža I, El-Tanani M, Rizzo M
Pragmatic and Observational Research 2024, 15:139-149
Published Date: 6 August 2024
Quality of Life in Patients Affected by Facial Basal Cell Carcinoma: Prospective Longitudinal Pilot Study and Validation of Skin Cancer Index in Lithuanian Language
Stundys D, Kučinskaitė A, Gervickaitė S, Tarutytė G, Grigaitienė J, Tutkuviene J, Jančorienė L
Pragmatic and Observational Research 2024, 15:103-119
Published Date: 5 August 2024
Advanced Multi-Layer Watertight Closure versus Conventional Closure in Total Hip and Knee Replacement Surgery
Flener JL, Chen BPH, Ernst FR, Libolt A, Gunja NJ, Barrett WP
Pragmatic and Observational Research 2024, 15:93-102
Published Date: 19 July 2024
Critique on “Real-World Effectiveness of First-Line Lenvatinib Therapy in Advanced Hepatocellular Carcinoma: Current Insights” [Response to Letter]
Biachi de Castria T, Kim RD
Pragmatic and Observational Research 2024, 15:91-92
Published Date: 10 July 2024
Critique on “Real-World Effectiveness of First-Line Lenvatinib Therapy in Advanced Hepatocellular Carcinoma: Current Insights” [Letter]
Goyal MK, Khubber M, Mehta V
Pragmatic and Observational Research 2024, 15:89-90
Published Date: 1 July 2024
Real-World Effectiveness of First Line Lenvatinib Therapy in Advanced Hepatocellular Carcinoma: Current Insights
Biachi de Castria T, Kim RD
Pragmatic and Observational Research 2024, 15:79-87
Published Date: 10 June 2024
Using Claims Data to Predict Pre-Operative BMI Among Bariatric Surgery Patients: Development of the BMI Before Bariatric Surgery Scoring System (B3S3)
Wong J, Li X, Arterburn DE, Li D, Messenger-Jones E, Wang R, Toh S
Pragmatic and Observational Research 2024, 15:65-78
Published Date: 27 March 2024
Trends in Systemic Glucocorticoid Utilization in the United Kingdom from 1990 to 2019: A Population-Based, Serial Cross-Sectional Analysis
Menzies-Gow AN, Tran TN, Stanley B, Carter VA, Smolen JS, Bourdin A, Fitzgerald JM, Raine T, Chapaneri J, Emmanuel B, Jackson DJ, Price DB
Pragmatic and Observational Research 2024, 15:53-64
Published Date: 15 March 2024
Difficult-To-Treat and Severe Asthma: Can Real-World Studies On Effectiveness of Biological Treatments Change the Lives of Patients?
Pelaia C, Giacalone A, Ippolito G, Pastore D, Maglio A, Piazzetta GL, Lobello N, Lombardo N, Vatrella A, Pelaia G
Pragmatic and Observational Research 2024, 15:45-51
Published Date: 11 March 2024
Obesity Paradox in Heart Failure with Mildly Reduced Ejection Fraction
Reinhardt M, Schupp T, Abumayyaleh M, Lau F, Schmitt A, Abel N, Akin M, Rusnak J, Akin I, Behnes M
Pragmatic and Observational Research 2024, 15:31-43
Published Date: 5 March 2024
Drug Repurposing in Crohn’s Disease Using Danish Real-World Data
Shakibfar S, Allin KH, Jess T, Barbieri MA, Battini V, Simoncic E, Kirchgesner J, Ulven T, Sessa M
Pragmatic and Observational Research 2024, 15:17-29
Published Date: 21 February 2024
Risk of Pneumonia in Patients with COPD Initiating Fixed Dose Inhaled Corticosteroid (ICS) / Long-Acting Bronchodilator (LABD) Formulations Containing Extrafine Beclometasone Dipropionate versus Patients Initiating LABD Without ICS
Price D, Henley W, Cançado JED, Fabbri LM, Kerstjens HA, Papi A, Roche N, Şen E, Singh D, Vogelmeier CF, Nudo E, Carter V, Skinner D, Vella R, Soriano JB, Kots M, Georges G
Pragmatic and Observational Research 2024, 15:1-16
Published Date: 20 January 2024
Prediction Model with Validation for Polioseronegativity in Malnourished Children from Poliomyelitis Transmission High-Risk Area of the Democratic Republic of the Congo (DRC)
Mwamba GN, Kabamba M, Hoff NA, Mukadi PK, Musene KK, Gerber SK, Halbrook M, Sinai C, Fuller T, Voorman A, Mawaw PM, Numbi OL, Wemakoy EO, Mechael PN, Tamfum JJM, Mapatano MA, Rimoin AW, Lusamba Dikassa PS
Pragmatic and Observational Research 2023, 14:155-165
Published Date: 21 December 2023
Avelumab for Advanced Merkel Cell Carcinoma: Global Real-World Data on Patient Response and Survival
Lohray R, Verma KK, Wang LL, Haynes D, Lewis DJ
Pragmatic and Observational Research 2023, 14:149-154
Published Date: 16 November 2023
Adult Severe Asthma Registries: A Global and Growing Inventory
Cushen B, Koh MS, Tran TN, Martin N, Murray R, Uthaman T, Goh CYY, Vella R, Eleangovan N, Bulathsinhala L, Maspero JF, Peters MJ, Schleich F, Pitrez P, Christoff G, Sadatsafavi M, Torres-Duque CA, Porsbjerg C, Altraja A, Lehtimäki L, Bourdin A, Taube C, Papadopoulos NG, Zsuzsanna C, Björnsdóttir U, Salvi S, Heffler E, Iwanaga T, al-Ahmad M, Larenas-Linnemann D, van Boven JF, Aarli BB, Kuna P, Loureiro CC, Al-lehebi R, Lee JH, Marina N, Bjermer L, Sheu CC, Mahboub B, Busby J, Menzies-Gow A, Wang E, Price DB
Pragmatic and Observational Research 2023, 14:127-147
Published Date: 20 October 2023