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Pragmatic and Observational Research
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Archive: Volume 16, 2025
Relapse Predictors of Idiopathic Retroperitoneal Fibrosis: A Long-Term Cohort Study
Huang S, Wang A, Jia Y, Han W, Zhao N, Wang T, Zhu W, Zhao L, Peng L, Zhou J, Li M, Zhang W, Fei Y
Pragmatic and Observational Research 2025, 16:265-277
Published Date: 20 December 2025
INSIGHTS Asthma Pragmatic Registry – A Pragmatic Approach to High-Validity Real-World Evidence for Asthma
Kilpatrick K, Chandran U, Urman R, Llanos JP, Molfino NA, Matsuno RK, Riskin DJ
Pragmatic and Observational Research 2025, 16:253-264
Published Date: 18 December 2025
Derivation and Definitions of Clinical Study Variables for Multiple Long Term Conditions in Patients with Chronic Obstructive Pulmonary Disease: Protocol for a Modified Delphi Methods and Consensus Study on Behalf of the International Cardiovascular and Respiratory Alliance
Joseph T, Bhutani M, Couper A, Pullen R, Nadarajah R, Alves L, Montero-Arias MF, Al-Lehebi R, Berg DD, Hawkins NM, Hurst JR, Jenkins CR, Kaplan A, Kocks JWH, Kostikas K, Lam CSP, Lapperre TS, Rhee CK, Sattar N, Stolz D, Tse G, Winders T, Price D, Gale CP
Pragmatic and Observational Research 2025, 16:243-251
Published Date: 12 December 2025
Evaluation of Disease Modifying Therapies and Prognostic Factors Affecting Multiple Sclerosis Progression in a Local Centre of Hong Kong
Lui BCM, Li JTC, Lo WT, Fong WC
Pragmatic and Observational Research 2025, 16:221-241
Published Date: 2 December 2025
One Year Risk Prediction Model for Cardiovascular Disease for Adults with Asthma in England
Baskaran J, Novov VA, Quint JK, Kallis C
Pragmatic and Observational Research 2025, 16:201-219
Published Date: 15 November 2025
Real-World Treatment Patterns and Overall Survival (OS) of Patients with Metastatic Castration-Resistant Prostate Cancer in Italy
Dovizio M, Castelletti D, Luraghi P, Losi S, Gervasi A, Risi M, Leogrande M, Degli Esposti L, Procopio G
Pragmatic and Observational Research 2025, 16:189-199
Published Date: 11 November 2025
Clinical Outcomes of Ablation for Persistent Atrial Fibrillation with Zero or Minimal Fluoroscopy
Osorio J, Morales G, Rajendra A, Hunter TD
Pragmatic and Observational Research 2025, 16:179-187
Published Date: 23 September 2025
Expert Perspectives on Next Generation Health Guidelines: How to Integrate RWE in EBM
Del Giacco S, Canonica GW, Agache I, Price D, Roche N, Schunemann H, Allan K, Ansotegui I, Barbaglia S, Bernstein JA, Bonini M, Bosnic-Anticevich S, Bousquet J, Braido F, Carter V, Chong-Neto HJ, Di Bona D, Fletton K, Gonzalez Diaz S, Ayyar Gupta V, Hubbard R, Iaccarino J, Eguiluz-Gracia I, Jacomelli C, Kocks J, Krishnan J, Mahler V, Morais-Almeida M, Moreles D, Muti P, Palkonen S, Papadopoulos NG, Pawankar R, Reeb C, Reddel H, Rojo I, Ryan D, Sodhi L, Torres M, Winders T, Wilson KC
Pragmatic and Observational Research 2025, 16:169-177
Published Date: 11 September 2025
Evaluating the Potential of Prevalent New User Design as an Alternative When New User Design is Impractical
Koinuma T, Akazawa M
Pragmatic and Observational Research 2025, 16:155-168
Published Date: 31 July 2025
Association of Frequent Short-Acting Beta-Agonist Inhaler Prescriptions with Acute Cardiovascular Events
Pfeffer PE, Heatley H, Hubbard R, Townend J, Price D
Pragmatic and Observational Research 2025, 16:147-154
Published Date: 25 July 2025
Mapping EQ-5D-5L Score From SGRQ in Patients with Asthma and/or COPD in NOVELTY
Jackson D, Quinton A, Zhang F, Müllerová H, Janson C, Sadatsafavi M
Pragmatic and Observational Research 2025, 16:135-145
Published Date: 4 June 2025
Comprehensive Description of an Automated Drug Dispensing System Database
Wittwer NL, Meier CR, Recknagel MJ, Allemann S, Schneider C
Pragmatic and Observational Research 2025, 16:129-134
Published Date: 8 April 2025
Steroidal Mineralocorticoid Receptor Antagonist Side Effects and Reasons for Discontinuation: A Patient Survey (RELICS-PS)
Richard EL, Stephenson JJ, Desai NR, Willey VJ, Gay A, Scott C, Folkerts K, Pessina E, Singh R, Teng CC, Oberprieler NG
Pragmatic and Observational Research 2025, 16:121-127
Published Date: 3 April 2025
Shifting from Traditional to Pragmatic Randomized Controlled Trials: Insights and Lessons Learned from the Toddler Oral Health Intervention
Grift BG, van Spreuwel PCJM, Bruers JJ, Jerković-Ćosić K
Pragmatic and Observational Research 2025, 16:111-120
Published Date: 29 March 2025
Predicting Risk of Morbidities Associated with Oral Corticosteroid Prescription for Asthma
Stanley B, Chapaneri J, Khezrian M, Maslova E, Patel S, Gurnell M, Canonica GW, Reddel HK, Heaney LG, Bourdin A, Neil DL, Carter V, Price DB
Pragmatic and Observational Research 2025, 16:95-109
Published Date: 25 March 2025
Better Understanding Rehabilitation of Motor Symptoms: Insights from the Use of Wearables
Celik Y, Wall C, Moore J, Godfrey A
Pragmatic and Observational Research 2025, 16:67-93
Published Date: 19 March 2025
Real-World Biologic Use Patterns in Severe Asthma, 2015–2021: The CLEAR Study
Tran TN, Chen S, Emmanuel B, Altraja A, Bourdin A, Sheu CC, Tsai MJ, Hoyte FC, Quinton A, Cook B, Bulathsinhala L, Henley W, Goh CYY, Liu Y, Ariti C, Carter V, Price DB
Pragmatic and Observational Research 2025, 16:51-66
Published Date: 18 March 2025
A Prospective Observational Study to Evaluate the Actual Use of 1% Pimecrolimus in Chinese Patients with Mild-to-Moderate Atopic Dermatitis Affecting Sensitive Skin Areas
Xie Z, Chang J, Ma L, Shen C, Zhang L, An Q, Wang H, Dou X, Zheng Y, Ye C, Gao Y
Pragmatic and Observational Research 2025, 16:39-49
Published Date: 7 March 2025
Treatment Patterns, Adverse Events, and Clinical Outcomes with Steroidal Mineralocorticoid Receptor Antagonists: A Retrospective Analysis of Administrative Claims Data (RELICS)
Richard EL, Desai NR, Willey VJ, Gay A, Scott C, Folkerts K, Pessina E, Singh R, Teng CC, Oberprieler NG
Pragmatic and Observational Research 2025, 16:27-37
Published Date: 26 February 2025
Validation of Mortality Data Sources Compared to the National Death Index in the Healthcare Integrated Research Database
Jamal-Allial A, Sponholtz T, Vojjala SK, Paullin M, Papazian A, Eshete B, Mahmoudpour SH, Verpillat P, Beachler DC
Pragmatic and Observational Research 2025, 16:19-25
Published Date: 7 February 2025
Review of Challenges in Performing Real-World Evidence Studies for Nonprescription Products
Maihöfner C, Mallick-Searle T, Vollert J, Kalita P, Sood Sethi V
Pragmatic and Observational Research 2025, 16:7-18
Published Date: 23 January 2025
Measuring Diagnostic Quality: The Capacity of Routinely Collected Data and Applications to Chronic Respiratory Disease
Mountain R, Gatheral T, Haslam P, Heys K, Knight J
Pragmatic and Observational Research 2025, 16:1-6
Published Date: 16 January 2025