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Therapeutics and Clinical Risk Management

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ISSN: 1178-203X

Archive: Volume 21, 2025

Electroacupuncture as a Non-Pharmacological Intervention for Nicotine Dependence: Evidence from a Randomized Clinical Trial

Lai Z, Fan Q, Lee AL, Yao X, Dai R, Liang Y

Therapeutics and Clinical Risk Management 2025, 21:1869-1885

Published Date: 30 December 2025

Helicobacter pylori Eradication: Why Recurrence Risk Should Not Dictate Treatment Decisions

Chen X, Wang Y, Dong Y, Yang J, Xie B, Zhang D

Therapeutics and Clinical Risk Management 2025, 21:1855-1867

Published Date: 26 December 2025

Free Skin Anterolateral Thigh Flap and Vacuum-Assisted Closure Therapy for Reconstruction of Snakebite-Induced Complex Hand Defects

Nghĩa PT, Sơn TT, Thúy TTH, Trọng NH, Nam ĐP

Therapeutics and Clinical Risk Management 2025, 21:1847-1853

Published Date: 26 December 2025

Zero-Balance Ultrafiltration Reduces Postoperative Delirium After Cardiac Surgery with Cardiopulmonary Bypass: A Randomized Controlled Trial

Lan X, Tang S, Lu J, Tang G, Shao Y, Zhu Z, Zhou K, Xiong X, Chen D, Shi J

Therapeutics and Clinical Risk Management 2025, 21:1807-1819

Published Date: 23 December 2025

Prognostic Factors and Clinical Prediction Score for Progressive Respiratory Failure in Severe COVID-19 Pneumonia Patients Treated with Tocilizumab: A Multicenter Study

Pongtarakulpanit N, Jayanama K, Phinyo P, Naothavorn W, Nuprom S, Pitidhammabhorn D, Ngammisri P, Ngamjanyaporn P, Suthichatchawan V, Wicharit L, Thammavaranucupt K

Therapeutics and Clinical Risk Management 2025, 21:1783-1793

Published Date: 22 December 2025

Hepatic Safety of Febuxostat and Allopurinol in Gout Patients: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials

Dewi C, Puspita F, Insani WN, Sinuraya RK, Puspitasari IM, Zakiyah N

Therapeutics and Clinical Risk Management 2025, 21:1747-1759

Published Date: 18 December 2025

Modulating Metabolic Health and Physiological Functions: Advances in Dietary Interventions Targeting Gut Microbiota

Rabbani SA, El-Tanani M, Janić M, Janež A, Tanani YE, Hajeer E, Matalka MI, Rizzo M, Kumar R

Therapeutics and Clinical Risk Management 2025, 21:1701-1733

Published Date: 13 December 2025

NLR and PLR as Adjunctive Markers of MRI-Derived Vertebral Bone Quality in a Preoperative Lumbar Cohort

Ma L, Liu Y, Qin Y, Liu Y, Yu H, Ma Z, Nan C

Therapeutics and Clinical Risk Management 2025, 21:1679-1687

Published Date: 10 December 2025

Perioperative Blood Pressure Optimization to Improve Outcomes in Orthopedic Patients: A Clinical Review

Yang YF, Ma X, Ahmad MA, Lee P, Qin Y, Ji FH, Sudhan N, Peng K

Therapeutics and Clinical Risk Management 2025, 21:1667-1677

Published Date: 8 December 2025

Early Phase Thrombolysis and Functional Outcome for Acute Ischemic Stroke Treated with Endovascular Thrombectomy After Intravenous Thrombolysis

Sun S, Yuan K, Huang H, Xie M, Huo S, Deng K, Liu R, Liu X

Therapeutics and Clinical Risk Management 2025, 21:1637-1644

Published Date: 2 December 2025

Lung Cancer Diagnosis and Prognostic Monitoring Through Cell-Free RNA via Liquid Biopsy

Pan Y, Jiang C, Ye M, Li D, Wang J

Therapeutics and Clinical Risk Management 2025, 21:1615-1636

Published Date: 2 December 2025

A Review Vancomycin Role in Gram Positive Biofilm-Associated Infections: Challenges and Emerging Solutions

Alharbi OS, Alhazmi KA, Gazzaz M, Almuhayya S, Aldehalan FA, Sharif AT, Redwan B, Alzain MA, Alhazmi W, Altarawneh H, Hasan Alfreahat HA, Bani Abdel-Rahman S, Halabi WS, Altalhi R, Saleh BH, Alhussainy NH, Alsaedi A, Niyazi HA, Niyazi HA, Juma NA, Zubair MA, Alqarni M, Helmi N, Ibrahem K

Therapeutics and Clinical Risk Management 2025, 21:1569-1578

Published Date: 14 November 2025

The Effect of Induced Hypothermia on Postoperative Outcomes Following Hyperthermic Intraperitoneal Chemotherapy: A Negative Finding

Yang MC, Lin KL, Chung KC, Chou SE, Chien M, Hsu CY

Therapeutics and Clinical Risk Management 2025, 21:1485-1498

Published Date: 22 October 2025

Reduced Long-Term Survival After Postoperative Complications in Major Gastrointestinal Surgery

Gratama DN, Weinberg L, Raykateeraroj N, Suh JMA, Zhao J, Hu EP, Ratnasekara V, Freeman T, Liu DS, Joosten A, Muralidharan V, Nikfarjam M, Lee DK

Therapeutics and Clinical Risk Management 2025, 21:1459-1472

Published Date: 11 October 2025

The Incidence and Risk Factors for Dental Injury in Patients Undergoing General Anesthesia: A Case-Control Study

Chanthawong S, Nonphiaraj S, Vongtongchith L, Tisangka N, Kaewaun J, Sangsungnern P, Ruenhunsa T, Chairatana L

Therapeutics and Clinical Risk Management 2025, 21:1431-1441

Published Date: 9 October 2025

Analysis of Modification Zones in Mandibular Complete Denture Models Designed with the Bio-Functional Prosthetic System

Yan L, Liu Y, Yan YY, Li W, Li HW, Wang YL, Zhang ZF, Li XL

Therapeutics and Clinical Risk Management 2025, 21:1409-1418

Published Date: 30 September 2025

Incidence of Complications in High-Risk Patients Undergoing Combined Esophagogastroduodenoscopy and Colonoscopy with Total Intravenous Anesthesia: A Prospective Cohort Study

Supan W, Ongiem A, Noitasaeng P, Bunnag P, Kaosombatwattana U, Supapueng O, Vichitvejpaisal P

Therapeutics and Clinical Risk Management 2025, 21:1395-1408

Published Date: 26 September 2025

Transplant Without Borders: Clinical Outcomes and Challenges in Transborder Living Donor Pediatric Liver Transplantation in Jordan

Khdair Ahmad F, Abu Nasrieh D, Rwalah MM, Ghanma A, Rayyan Y, Hamad Y, Ahmad T, Mohammad S

Therapeutics and Clinical Risk Management 2025, 21:1383-1393

Published Date: 22 September 2025

Clinical Outcomes of Ilizarov Bone Transport for Distal Tibial Defects in Refractory Osteomyelitis: A Retrospective Study

Alimujiang A, Jia Q, Guo J, Zhang J, Wang X, Zhao M, Ouzhabayier M, Wang Y, Ma C

Therapeutics and Clinical Risk Management 2025, 21:1369-1382

Published Date: 17 September 2025

Combined Ruyi Zhenbao Pills-Baimai Ointment Therapy on Acute Ischemic Stroke: A Multi-Arm, Randomized, Double-Blind, Placebo Controlled Clinical Study

Jiang Z, Qin X, Wu X, Wang Z, Wang X, He L, Cuomu M, Mei Z, Hou H, Song H, Song J

Therapeutics and Clinical Risk Management 2025, 21:1359-1368

Published Date: 17 September 2025

Therapeutic Potential of Lumbrokinase in Acute Ischemic Stroke: A Meta-Analysis of Efficacy and Safety

Wiyarta E, Hidayat R, Kurniawan M, Saputro BIL, Maharani IL, Rampengan DDCH, Tanudharma LC, Tjandrawinata RR

Therapeutics and Clinical Risk Management 2025, 21:1319-1331

Published Date: 4 September 2025

Efficacy and Clinical Significance of Postoperative Transcutaneous Electrical Acupoint Stimulation [Response to Letter]

Zhou Z, Yang X, Shi M, Huang L, Wu D, Yang H, Zhang X

Therapeutics and Clinical Risk Management 2025, 21:1317-1318

Published Date: 3 September 2025

Evaluating the Efficacy of High-Intensity Focused Electromagnetic (HIFEM) Therapy for Postprostatectomy Incontinence in Men

Tosun H, Akinsal EC, Bas U, Sonmez G, Baydilli N, Demirci D

Therapeutics and Clinical Risk Management 2025, 21:1309-1315

Published Date: 30 August 2025

Impact of Isotretinoin on Blood Lipids and Liver Enzymes: A Retrospective Cohort Study in Saudi Arabia [Corrigendum]

Alrasheed AA, Alsadhan KF, Alfawzan NF, AbuDujain NM, Alnasser AH, Almousa H

Therapeutics and Clinical Risk Management 2025, 21:1287-1288

Published Date: 19 August 2025

Risk Factors for Sigmoid Colonic Anastomosis: A Comparative and Cross-Sectional Analysis

Talih T, Sonmez G, Sozuer EM, Tombul ST, Kulturoglu MO, Islam DG, Akyıldız HY, Demirtas A, Karaagac M, Dal F

Therapeutics and Clinical Risk Management 2025, 21:1219-1226

Published Date: 4 August 2025

Risk Factors for Pleural Reaction in CT-Guided Percutaneous Lung Nodule Localization: A Single-Center Retrospective Study

Zhou N, Feng N, Jiao Z, Shi X, Wang T, Zhao G

Therapeutics and Clinical Risk Management 2025, 21:1161-1173

Published Date: 22 July 2025

Surgeons Knowledge, Attitude, and Practice Toward Preoperative Inflammatory Bowel Disease Medications and Post-Operative Complications

Alhassan N, Alnwdel AN, Beyari MB, Aldeligan SH, Alhassan R, Abdulla MH, Bin Traiki T

Therapeutics and Clinical Risk Management 2025, 21:1149-1159

Published Date: 22 July 2025

Adverse Event Management in Patients with Platinum-Resistant Ovarian Cancer Treated with Niraparib and Anlotinib: Updates from the Phase II, Multi-Center ANNIE Study

Deng T, Yan L, Li J, Liu G, Yin A, Feng Y, Zheng M, Zhang C, Huang H, Huang Q, Lin A, Jiang J, Kong B, Liu J

Therapeutics and Clinical Risk Management 2025, 21:1135-1147

Published Date: 21 July 2025

Establishment and Verification of Risk Prediction Model for Adverse Outcomes After Hip Arthroplasty in Elderly Patients

Ding J, Sun G, Ren Y, Xu J, Hu Q, Luo J, Wu Z, Chu T

Therapeutics and Clinical Risk Management 2025, 21:1047-1058

Published Date: 10 July 2025

Endovascular Treatment in Stroke Patients of Working Age: A Multicenter Observational Study of Real-World Outcomes

Zhou Y, Mofatteh M, Zheng Z, Liu F, Zhou S, Ma J, Yan Z, Lai Y, Li W, Chen W, Abdalkader M, Regenhardt RW, Liu X

Therapeutics and Clinical Risk Management 2025, 21:1009-1019

Published Date: 5 July 2025

Airway Organoid Models as Pivotal Tools for Unraveling Molecular Mechanisms and Therapeutic Targets in Respiratory Diseases: A Literature Review

Jiang SP, Lin BQ, Zhou XQ, Li MH, Feng ZC, Qin YY, Lin SQ, Zhou ZQ, Peng Y, Li L

Therapeutics and Clinical Risk Management 2025, 21:975-986

Published Date: 24 June 2025

The Application of Opacification-Development Ratio Based on CT Scan for Diagnosing Pediatric Chronic Rhinosinusitis

Zhang J, Yang A, Chen T, Cao Y, Lv Q, Xu Y, Liao Z, Chen X, Ye Z, Lai R, Hong H

Therapeutics and Clinical Risk Management 2025, 21:895-904

Published Date: 13 June 2025

Muscular and Renal Safety of Ticagrelor with High-Intensity Statins: Retrospective Cohort Findings

Alshammari AS, Shalwala AA, Alnuhait MA, Alhazmi AY, Fagieha RE, Hallabi NB, Alandijani EA, Aloufi MA, Alharbi MS, Alzahrani RS, Elkholy EM, Elrggal ME, Alotaibi AS

Therapeutics and Clinical Risk Management 2025, 21:861-867

Published Date: 8 June 2025

Effect of Low-Dose Esketamine Combined with Propofol on Postoperative Fatigue in Colonoscopy: A Randomized Clinical Trial

Sun X, Du Q, Liang Y, Tang L, Wei Q, Guo P, Liu X

Therapeutics and Clinical Risk Management 2025, 21:807-816

Published Date: 29 May 2025

Long-Term Benefits of N-Butylphthalide in Preventing Ischemic Stroke Recurrence: A 12-Month Prospective Study

Liu W, Shao Y, Liu J, Hao J, Lu Y, Yang L, Wang J, Ning X

Therapeutics and Clinical Risk Management 2025, 21:781-792

Published Date: 27 May 2025

Cerebrovascular Autoregulation-Based Optimal Mean Arterial Pressure During Prostate Surgery – A Secondary Analysis of a Prospective Cohort Study

Mewes C, Wei P, Yang Y, Kainz E, Kahl U, Beck S, Graefen M, Zöllner C, Fischer M

Therapeutics and Clinical Risk Management 2025, 21:757-767

Published Date: 27 May 2025

Relationship Between Timing of PCSK9 Inhibitor Monoclonal Antibody Initiation and Clinical Outcomes in Patients with Prior Cardiovascular Events

Sidelnikov E, Kalich BA, Miglins ML, Multani JK, Tuly R, Hawkins K, Baber U

Therapeutics and Clinical Risk Management 2025, 21:727-736

Published Date: 21 May 2025

Elevated MPV: A Key Indicator of Acute Anterior Circulation Stroke Prognosis in Mechanical Thrombectomy

Tian SY, Yu MJ, Mei K, Xu B, Xiao LC, Wen HB, Shang FR

Therapeutics and Clinical Risk Management 2025, 21:715-725

Published Date: 19 May 2025

Corticosteroid Therapy for Diffuse Alveolar Hemorrhage with Respiratory Failure in Hematologic Malignancies: A Retrospective Cohort Study

Ahn JH, Song KM, Huh JW, Lee JH, Hong SB, Lee JH, Lim CM, Lee KH, Koh Y

Therapeutics and Clinical Risk Management 2025, 21:705-714

Published Date: 17 May 2025

Lessons Learned From Awake ECMO Approach in Covid-19-Related Acute Respiratory Distress Syndrome - a Scoping Review

Sklienka P, Burša F, Frelich M, Máca J, Romanová T, Vodička V, Straková H, Bílená M, Jor O, Neiser J, Tomášková H

Therapeutics and Clinical Risk Management 2025, 21:655-668

Published Date: 13 May 2025

Improved Tubeless Airway Management in JORRP Surgery: Comparative Analysis of Pre- and Post-THRIVE Implementation

Lei G, Yang S, Wu L, Yin Y, Xi C, Xiao Y, Wang G

Therapeutics and Clinical Risk Management 2025, 21:647-654

Published Date: 8 May 2025

Impact of Relaxation and Music Intervention on Psychological and Gastrointestinal Health in Military Recruits: A Prospective Study

Liu J, Liu T, Lu H, Zhao X, Ma S, Song F, Qiao N, Cheng W, Qi X

Therapeutics and Clinical Risk Management 2025, 21:593-608

Published Date: 2 May 2025

Higher Neutrophil-Percentage-to-Albumin Ratio Was Associated with Poor Outcome in Endovascular Thrombectomy Patients

Xu M, Zhai Q, Wei B, Chen S, E Y, Huang Z, Qi J, Xu Y

Therapeutics and Clinical Risk Management 2025, 21:565-573

Published Date: 26 April 2025

Feasibility and Outcomes of Vessel-Sparing Surgery for Soft Tissue Sarcoma of the Thigh Adjacent to Femoral Vessels

Yang ZM, Qu H, Wang KY, Wu JD, Liu B, Jin LB, Huang X, Lin N, Tao HM, Ye ZM

Therapeutics and Clinical Risk Management 2025, 21:553-564

Published Date: 25 April 2025

Advanced Therapies in Elderly Patients With Inflammatory Bowel Disease: A Comparative Retrospective Cohort Study in Taiwan

Lin SH, Chiu HY, Kuo CJ, Chen CM, Su MY, Wu RC, Chiu CT, Chang CW, Chung CS, Pan YB, Le PH

Therapeutics and Clinical Risk Management 2025, 21:533-542

Published Date: 25 April 2025

Posterior Pericardial Window and a Single Pleural Drain: A Dual Defence Against Post-CABG Pericardial Effusion and Atrial Fibrillation

Ranjan R, Kapetanakis S, Chandrasekaran V, Kaba RA, Momin AU

Therapeutics and Clinical Risk Management 2025, 21:481-487

Published Date: 15 April 2025

Association of Prognostic Nutritional Index with Post-Discharge Bleeding After Percutaneous Coronary Intervention in ACS Patients on DAPT

Elkenany NM, Sabah ZU, Agiba NA, Elmahdy HK, Elsherbiny EAY, Said SRA, Nassef EM, Alhawy AME, Ahmed MSM, Elsharkawy AMS, Hussein AMM, Elmalah AA

Therapeutics and Clinical Risk Management 2025, 21:455-466

Published Date: 10 April 2025

Recurrent Rhegmatogenous Retinal Detachment: Characteristics, Risk Factors, and Outcomes

Aleshawi A, Al-Dwairi R, Saleh OA, Adi S, Al Beiruti S, Alasheh A, Alsaadi MA, Ouda ZH, Allouh MZ

Therapeutics and Clinical Risk Management 2025, 21:425-440

Published Date: 1 April 2025

A Novel Three-Step Technique for the Simple, Safe, and Efficient Complete Removal of Idiopathic Epiretinal Membrane

Wei Q, Cai C, Yi L, Li M, Zhang W, Chen J, Qiu Q

Therapeutics and Clinical Risk Management 2025, 21:407-413

Published Date: 24 March 2025

Serum RIPK1, Acute Lung Injury, and Outcomes in Severe Traumatic Brain Injury: A Multicenter Prospective Study

Cai L, Dou X, Dong W, Zou K, Zhang L, Hong H, Zhang X, Liu J, Tian D, Wu X, Zhang J

Therapeutics and Clinical Risk Management 2025, 21:385-405

Published Date: 20 March 2025

Therapeutics and Clinical Risk Management - 20th Anniversary

Walsh GM, Wang DY

Therapeutics and Clinical Risk Management 2025, 21:383-384

Published Date: 19 March 2025

Hepatic Safety Considerations in the Use of Ulipristal Acetate for Symptomatic Uterine Fibroids

Semmler A, de Lange ME, Drenth JPH, Vermeer NS, Bet PM, Huirne JAF, Hehenkamp WJK

Therapeutics and Clinical Risk Management 2025, 21:367-382

Published Date: 19 March 2025

Risk of Serious Immune-Related Adverse Events with Various PD1 and PD-L1 Inhibitors: A Single-Institution, Real-Life, Comparative Study

Boucheron T, Chiche L, Penaranda G, Souquet M, Pegliasco H, Deturmeny J, Brunel V, Barrière N, Arbault-Bitton C, Coquet E, Diaz L, Escoda T

Therapeutics and Clinical Risk Management 2025, 21:273-282

Published Date: 5 March 2025

Health and Economic Advantages Associated With the Use of TachoSil: An Update of Systematic Review

Colombo GL, Droghetti A, Di Matteo S, Ottenjann H, Bruno GM

Therapeutics and Clinical Risk Management 2025, 21:257-271

Published Date: 1 March 2025

Nomogram-Based Prediction of 3-Month Unfavorable Outcome and Early Neurological Deterioration After Endovascular Thrombectomy in Acute Ischemic Stroke

Wu Y, Han J, Cheng Y, Wei M, Liu F, Chen C, Tan Y, Ma W, Yu J, Han J, Luo G, Huo K

Therapeutics and Clinical Risk Management 2025, 21:239-256

Published Date: 27 February 2025

Advancing Heart Valve Replacement: Risk Mitigation of Decellularized Pulmonary Valve Preparation for Its Implementation in Public Tissue Banks

Rodríguez Martínez JI, Castells-Sala C, Piteira AR, Montagner G, Trojan D, Martinez-Legazpi P, Acosta Ocampo A, Fernández-Santos ME, Bermejo J, Jashari R, Pérez ML, Agustí E, Tabera J, Vilarrodona A

Therapeutics and Clinical Risk Management 2025, 21:209-228

Published Date: 26 February 2025

Outperforming Traditional Staging: A Novel Nomogram for HR-Positive Breast Cancer

Liu C, Ding J, Xu J, Fang C, Zhang G, Shi C, Qiu F

Therapeutics and Clinical Risk Management 2025, 21:191-208

Published Date: 25 February 2025

The Impact of Early Protein Advancement in Critically Ill Patients with COVID-19: A Multicenter Cardinality Matching Study

Alissa A, Korayem GB, Aljuhani O, AlFaifi M, Alnajjar LI, Souaan NAL, Albassam M, Alrayes A, Albishi S, Alqahtani RA, Alharthi AF, Alkhushaym N, Alhammad MA, Vishwakarma R, Alharbi A, Alsohimi S, Ababtain A, Al-Dorzi HM, Alqahtani R, Almuaither G, Alarifi LA, Almutairi A, Alharbi MB, Alghamdi AA, Alhmoud MF, Al Sulaiman K

Therapeutics and Clinical Risk Management 2025, 21:177-189

Published Date: 21 February 2025

Serum Periostin as a Novel Biomarker for Predicting 30-Day Major Adverse Cardiac Events After Off-Pump Coronary Artery Bypass Grafting

Su Q, Deng Z, Wei X, Li L, Du B, Guo F, Gu Y, Song J, Yao L

Therapeutics and Clinical Risk Management 2025, 21:161-176

Published Date: 18 February 2025

The Development of Publications on Catheter-Related Bladder Discomfort: A Bibliometric Analysis

Jiang W, Chen X, Peng Y, Zhai W, Zhang X, Zhou Y, Zhou R

Therapeutics and Clinical Risk Management 2025, 21:137-147

Published Date: 4 February 2025

Mesalazine-Induced Acute Pancreatitis in Inflammatory Bowel Disease Patients: A Systematic Review

Pan J, Li Z, Ye C, Zhang X, Yang Q, Zhang X, Zhou Y, Zhang J

Therapeutics and Clinical Risk Management 2025, 21:113-123

Published Date: 27 January 2025

Video Laryngoscopy for Endotracheal Intubation: A Consideration for Manual In-Line Stabilization Without Cervical Collar Versus Full Immobilization

Aramvanitch K, Leela-Amornsin S, Tienpratarn W, Nuanprom P, Aussavanodom S, Yuksen C, Boonsri S, Boonjarus N, Sanepim S

Therapeutics and Clinical Risk Management 2025, 21:103-109

Published Date: 25 January 2025

Obstacles to Early Diagnosis of Gaucher Disease

Nishimura S, Ma C, Sidransky E, Ryan E

Therapeutics and Clinical Risk Management 2025, 21:93-101

Published Date: 25 January 2025

Improving Patient Outcomes in mTBI: The Role of Integrated Nursing Interventions in the Emergency Department

Feng T, Zhao P, Wang J, Du X, Ai M, Yang J, Li J

Therapeutics and Clinical Risk Management 2025, 21:69-80

Published Date: 22 January 2025

Development and Validation of a Prognostic Molecular Phenotype and Clinical Characterization in Grade III Diffuse Gliomas Treatment with Radio-Chemotherapy

Gu W, Tang J, Liu P, Gan J, Lai J, Xu J, Deng J, Liu C, Wang Y, Zhang G, Yu F, Shi C, Fang K, Qiu F

Therapeutics and Clinical Risk Management 2025, 21:35-53

Published Date: 6 January 2025

Thyroid Dysfunction After Intensity-Modulated Radiotherapy and PD⁃1 Inhibitor Treatment for Locally Advanced Nasopharyngeal Carcinoma

Shang K, He Q, Xu X, Luo X, Zhao C, Liu L, Li Z, Li Y, Jin F

Therapeutics and Clinical Risk Management 2025, 21:15-25

Published Date: 6 January 2025

Environmental PM2.5 Exposure: An Ignored Factor Associated with Blood Cadmium Level in Hemodialysis Patients

Hsu CW, Chan MJ, Weng CH, Tsai TY, Yen TH, Huang WH

Therapeutics and Clinical Risk Management 2025, 21:1-13

Published Date: 3 January 2025