Pharmacology & Therapeutics

This group of journals cover all aspects of drug development, testing and applications. From theory to practice all aspects are covered – nanomedicine, clinical pharmacology, clinical trials and patient experiences.

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Recent articles:

Review

The Design Strategies and Applications of Engineered Nanoparticles for Traumatic Brain Injury

Xiang C, Zhu Y, Gao X, Guo F, He X, Luo W, Liu W, Gu R

International Journal of Nanomedicine 2026, 21:591179

Published Date: 13 May 2026

Review

Emerging Approaches for the Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease: The Application of Nanomedicines

Shi T, Yue H, Wang W, Gao Y, Xu S, Gao J, Yin C

International Journal of Nanomedicine 2026, 21:603396

Published Date: 13 May 2026

Original Research

Is Rituximab Suitable for Patients with Idiopathic Membranous Nephropathy Who are Seronegative for Anti-PLA2R Antibody?

Yang Y, Xie X, Yuan F, Zeng F, Wang Y, Zhang R, Yan W, Luo K, Ren D, Xu G

Drug Design, Development and Therapy 2026, 20:601777

Published Date: 13 May 2026

Review

The Crosstalk Between Epithelial-Mesenchymal Transition and Anoikis Resistance: A New Perspective of Traditional Chinese Medicine to Prevent Tumor Metastasis

Cui Z, Xu M, Liu J, Zhang K, Huang B

Drug Design, Development and Therapy 2026, 20:596194

Published Date: 13 May 2026

Review

Engineered Extracellular Vesicles in Glioma Therapy: Recent Advances and Applications

Xiong L, Yu X, Chen T, Gao W, Wang K, Fu Y, Yin Y, Zhou X, Xia Y, Cui X, Zeng L, Zhang L, Liu Y

International Journal of Nanomedicine 2026, 21:609673

Published Date: 13 May 2026

Review

Therapeutic Landscape of Early Symptomatic Alzheimer’s Disease Translated into Everyday Practice for Geriatric Providers

Bailey-Taylor MJ, Morrow P, Hendrix J, Galluzzi KE, Sharafsaleh G

Clinical Interventions in Aging 2026, 21:585263

Published Date: 12 May 2026

Clinical Trial Report

EC50 and EC95 of Epidural Ropivacaine for Intraoperative Analgesia During High-Intensity Focused Ultrasound for Adenomyosis: A Prospective Double-Blind Up-and-Down Concentration-Finding Study

Yang S, Zhang Y, Yang F, Luo L

Drug Design, Development and Therapy 2026, 20:594039

Published Date: 12 May 2026

Original Research

Preliminary Psychometric Evidence of an Integrated Life Autonomy and Coherence Measure (LAC-Scale) in Community-Dwelling Adults

Wu PC, Chen YJ, Lin KR, Yang YC, Yang CH, Huang TH, Hung WC, Lin CY, Su FC

Patient Preference and Adherence 2026, 20:589283

Published Date: 12 May 2026

Clinical Trial Report

Anterior Quadratus Lumborum Block with Liposomal Bupivacaine versus Ropivacaine for Postoperative Recovery in Laparoscopic Colorectal Surgery: A Randomized Controlled Trial

Liu D, Luo C, Zhang Y, Huang H, Yang Y

Drug Design, Development and Therapy 2026, 20:611347

Published Date: 12 May 2026

Letter

Competing Death and Absolute Benefit in Dexmedetomidine-Exposed Patients with Dialysis-Requiring Acute Kidney Injury [Letter]

Wang Y, Wang G, Wang C

Drug Design, Development and Therapy 2026, 20:622743

Published Date: 12 May 2026

Case Series

Recurrent/Refractory Multidrug- and Pre-Multidrug-Resistant Pseudomonas aeruginosa Infection Cases Maintained by Long-Term, Low-Dose Macrolide Administration

Seki M

Clinical Pharmacology: Advances and Applications 2026, 18:600235

Published Date: 12 May 2026

Review

Development Trends of Janus Kinase Inhibitors (JAKi) Over Three Decades: From Common to Rare Diseases

Dai R, Lou N, Zheng X, Han X

Drug Design, Development and Therapy 2026, 20:597046

Published Date: 12 May 2026

Original Research

Integrated Internet-Based Pharmaceutical Care and Its Association with Clinical Outcomes and Medication Adherence in Older Adults with Multimorbidity: A Prospective Observational Study

Zhao J, Liu P, Liao H, Chen Y, Li L, Yan Y, Li T, Tang X, Nie L, Yang J

Patient Preference and Adherence 2026, 20:608783

Published Date: 12 May 2026

Original Research

GBVAM as a Novel NHE1 Inhibitor Alleviates Doxorubicin-Induced Cardiotoxicity via PI3K/Akt/mTOR Pathway

Xu Y, Li Y, Cheng Z, Shao C, Zhao X, Liu Y, Gou X, Li C

Drug Design, Development and Therapy 2026, 20:585989

Published Date: 12 May 2026

Original Research

Intravenous Tranexamic Acid Reduces the Incidence of Postoperative Delirium in Elderly Patients Undergoing Hip Arthroplasty: A Retrospective Cohort Study

Chu J, Liu Y, Xie L, Zhang H, Chen Y, Li Z, Deng K

Drug Design, Development and Therapy 2026, 20:587510

Published Date: 12 May 2026

Original Research

Predicting Sensory Block Level in Caudal Anesthesia Based on Sacral Canal Anatomical Parameters and Height: Development of an Ordinal Logistic Regression Model and Nomogram

Li Z, Wu H, Zhang S, Yu S, Liu L, Liufu N

Therapeutics and Clinical Risk Management 2026, 22:581371

Published Date: 12 May 2026

Review

Precision Engineering of Extracellular Vesicles as Programmable Carriers for mRNA Therapeutics

Yoon H, Lee G, Jo J, Koo J, Kim EH, Choi HJ, Jung S, Shin Y, Oh KT, Lim C

International Journal of Nanomedicine 2026, 21:595161

Published Date: 11 May 2026

Clinical Trial Report

Effect of Subanesthetic Doses of Esketamine on Early Postoperative Pain Sensitivity in Patients Undergoing Salpingectomy: A Randomized Clinical Trial

Wu Y, Wu H, Dong J, Lei L, Zhou L, Yan B, Chen L, Zhou M, Ke P, Liu F, Lin X, Zheng S, Chen Y, Wu X

Drug Design, Development and Therapy 2026, 20:596251

Published Date: 11 May 2026

Original Research

Effect of Oliceridine Pretreatment on Etomidate-Induced Myoclonus: A Proof-of-Concept Randomized Trial

Guo M, Duan P, Yang X, M’Djanga Jnr M, Wang T, Bian J, Bo L

Drug Design, Development and Therapy 2026, 20:611682

Published Date: 9 May 2026

Review

Drug Delivery Engineering Strategies Targeting CD4+/CD8+ T Cell Exhaustion to Improve the Tumor Immunosuppressive Microenvironment

Yue J, Chen M, Xiong Z, Qiu J, Liu Y, Chen L

International Journal of Nanomedicine 2026, 21:595199

Published Date: 9 May 2026

Original Research

Cost-Effectiveness Analysis of the High-Dose Trivalent Influenza Vaccine in the Elderly Population in Italy

Panatto D, Bellone M, Castello L, Zanetta L, Piccolo A

ClinicoEconomics and Outcomes Research 2026, 18:588333

Published Date: 9 May 2026

Original Research

Mechanistic Physiologically Based Pharmacokinetic Modeling to Predict CYP3A4-Mediated Drug–Drug Interactions of Flumatinib as Both a Victim and a Perpetrator

Alifu M, Chu X, Zhu X, Mak WY, Zheng A, Pan C, He Q, Zhu X, Kuai Z, Xiang X

Drug Design, Development and Therapy 2026, 20:574169

Published Date: 9 May 2026

Original Research

Olanzapine-Associated Hepatotoxicity in Bipolar Disorder: A Multicenter Real-World Study of Prevalence, Risk Factors, and Outcomes

Wang F, Lai X, Zhou S, Lin J, Xin H, Tao Z, Wang X, Zhang S, Liu Z, Tan H, Xiong Y

Drug Design, Development and Therapy 2026, 20:598447

Published Date: 8 May 2026

Original Research

Staged Management of Bone Defects in Chronic Osteomyelitis and Nonunions Using Antibiotic-Loaded Calcium Sulphate-Hydroxyapatite: A Multicenter Retrospective Analysis of 101 Cases

Armbruster J, Mattern N, Lamadé-Dootz F, Steinhausen ES, Reiter G, Dudda M, Grützner PA, Freischmidt H

Therapeutics and Clinical Risk Management 2026, 22:599996

Published Date: 8 May 2026

Review

Source-Specific Extracellular Vesicle Functions and Engineering Strategies for Chronic Pain Management: A Comprehensive Review

Yao C, Yu J, Xie D, Zhang S, Tao J, Kong L, Fang L, Zhu Q, Fang M

International Journal of Nanomedicine 2026, 21:598699

Published Date: 8 May 2026

Clinical Trial Report

The Median Effective Dose of Phenylephrine Infusion for Prevention of Spinal-Induced Hypotension During Cesarean Delivery in the 15° Left-Tilt vs. Supine Positions: A Randomised Control Study

Yu XQ, Drzymalski DM, Qian J, Hu HJ, Xiao F, Yu L

Drug Design, Development and Therapy 2026, 20:591446

Published Date: 8 May 2026

Review

Cannabidiol-Induced Tumor Cell Death: Molecular Mechanisms and Translational Perspectives in Cancer Therapy

Wang CY, Tan JX, Chen LL, Li QZ, Liu J, He X, Qin QZ, Deng T, Ruan GT, Gong YZ

Drug Design, Development and Therapy 2026, 20:597740

Published Date: 8 May 2026

Review

Role of Extracellular Vesicles in Skin Barrier Repair: Applications in Atopic Dermatitis and Chronic Wounds

Khoo L, Chin YZ, Law JX

International Journal of Nanomedicine 2026, 21:598256

Published Date: 8 May 2026

Clinical Trial Report

Drug-Drug Interaction of Chiglitazar with Empagliflozin, Atorvastatin, and Valsartan: An Open-Label, Single-Center, Self-Control, 3-Period Study

Sheng L, Li X, Yu J, Yang X, Li H, Xu H

Drug Design, Development and Therapy 2026, 20:588573

Published Date: 8 May 2026

Clinical Trial Report

Efficacy and Safety of Oliceridine for Patient-Controlled Intravenous Analgesia in Elderly Patients Undergoing Laparoscopic Radical Resection Surgery for Gastrointestinal Malignant Tumors: A Prospective Randomized Controlled Non-Inferiority Clinical Trial

Wang J, Shang Y, Wang C, Zhang D, Li H, Yu Q, Tao L, Sun L, Gao C

Drug Design, Development and Therapy 2026, 20:593111

Published Date: 8 May 2026

Original Research

Rehospitalisation Patterns in Very Old Adults with Heart Failure Managed Within an Integrated Cardiogeriatric Post-Discharge Care Pathway: The REACT-HF Study

Esser R, Larbaneix M, Mondragon A, Co M, Esteban M, Farges C, Harboun M, Pages N, Nisse Durgeat S, Maurou O

Clinical Interventions in Aging 2026, 21:597992

Published Date: 8 May 2026

Original Research

Impact of Continuous Nursing Intervention Delivered via Internet+ Platform on Inflammatory Responses in Ulcerative Colitis Patients

Zhu J, Ren X, Wang Q, Luo M

Patient Preference and Adherence 2026, 20:571511

Published Date: 8 May 2026

Review