Neuropsychiatric Disease and Treatment

Cognitive Enhancement in Psychiatric Disorders

Cognitive impairment (CI) is prevalent in patients with various psychiatric conditions, e.g., schizophrenia, mood disorders, developmental disorders, and substance abuse. As CI is a major determinant of functional outcome, many years have been devoted to identifying treatment methods, including pharmacotherapy, rehabilitation and neuromodulation, that would effectively alleviate CI. While the evidence for the benefits of cognitive rehabilitation (remediation) therapy is relatively abundant, limited information has been available on cognition enhancing drugs (i.e., cognitive enhancers) that produce substantial effects on CI in psychiatric disorders.