Journal of Inflammation Research

Inflammaging in Cardiovascular and Chronic Disease

Inflammaging is a persistent, low-grade sterile inflammation associated with aging. It is characterized by elevated circulation of proinflammatory cytokines, chemokines and other inflammatory mediators in the circulation, reflecting a fundamental imbalance in intercellular communication and inflammatory control. Multiple lines of evidence indicate that inflammaging arises from a convergence of factors including immune cell dysregulation, immunosenescence, chronic infections, cellular senescence and genetic predisposition. This Article Collection focuses on the latest developments in understanding the role of inflammaging in the pathogenesis of cardiovascular and chronic inflammatory diseases.